Article
Cell Biology
Rebecca J. Burgess, Zhiyu Zhao, Daisuke Nakada, Sean J. Morrison
Summary: The study showed that deficiency of Bmi1 leads to increased division of HSCs without inducing senescence. Bmi1 promotes HSC quiescence by negatively regulating ARX expression and promoting proteostasis by suppressing protein synthesis.
GENES & DEVELOPMENT
(2022)
Article
Neurosciences
Kuan Tian, Andi Wang, Junbao Wang, Wei Li, Wenchen Shen, Yamu Li, Zhiyuan Luo, Ying Liu, Yan Zhou
Summary: This study used a bioinformatics pipeline to investigate the dynamic expression and potential cis-regulatory effects of mouse lncRNAs in the development of the cerebral cortex. A novel sense lncRNA, SenZfp536, was identified to regulate the proliferation of cortical neural progenitor cells by cis-regulating Zfp536. These findings enhance our understanding of how lncRNAs modulate the propagation of cortical NPCs through cis-regulatory mechanisms.
NEUROSCIENCE BULLETIN
(2021)
Article
Cell Biology
Rong Mu Xia, Dong Bo Yao, Xue Min Cai, Xiu Qin Xu
Summary: This study elucidated the regulatory role of histidine phosphatase LHPP in ESCs self-renewal through histidine dephosphorylation. LHPP negatively regulated the Wnt/β-catenin pathway by modulating histidine dephosphorylation, thereby inhibiting the self-renewal of ESCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hui Guo, Jiahang Zhang, Zhimin Jiang, Xiaoxiao Zhu, Jing Yang, Rui Mu, Ying Du, Yong Tian, Pingping Zhu, Zusen Fan
Summary: Intestinal stem cells (ISCs) play a crucial role in the regeneration of the intestinal epithelium. This study identifies a circular RNA, circBtnl1, that is highly expressed in ISCs. Loss of circBtnl1 enhances ISC self-renewal capacity and epithelial regeneration by promoting Atf4 mRNA stability and ATF4 expression, which in turn activates Sox9 transcription and potentiates ISC stemness.
Article
Oncology
Ziwei Liang, Bingrui Wu, Zhi Ji, Weitao Liu, Danfang Shi, Xiaoning Chen, Yuanyan Wei, Jianhai Jiang
Summary: LDN193189 inhibits liver TIC self-renewal, tumorigenicity, and immune escape by targeting CD133 phosphorylation, providing a potential therapeutic approach to targeting the CD133-Galectin-3 axis for liver cancer treatment.
Article
Cell Biology
Agnieszka Smieszek, Klaudia Marcinkowska, Ariadna Pielok, Mateusz Sikora, Lukas Valihrach, Elaine Carnevale, Krzysztof Marycz
Summary: This study investigated the effects of obesity on the cellular features of equine endometrial progenitor cells. It found that obesity leads to a decline in cell proliferation, metabolic activity, and an increase in oxidative stress. Obesity also alters the expression of functional markers and impairs the regenerative capacity of endometrial progenitor cells.
Article
Cell & Tissue Engineering
Angela Picerno, Francesca Giannuzzi, Claudia Curci, Giuseppe De Palma, Maria Giovanna Di Chiano, Simona Simone, Rossana Franzin, Anna Gallone, Vito Francesco Di Lorenzo, Alessandra Stasi, Giovanni Battista Pertosa, Carlo Sabba, Loreto Gesualdo, Fabio Sallustio
Summary: The lncRNA HOTAIR is highly expressed in renal progenitor cells and plays a key role in maintaining their proliferative capacity and limiting apoptosis. Knockout of HOTAIR leads to senescence of renal progenitor cells and decreased expression of the stem cell marker CD133. HOTAIR exerts its function through epigenetic silencing of cell cycle inhibitor p15.
Article
Cell Biology
Hirofumi Kiyokawa, Akira Yamaoka, Chisa Matsuoka, Tomoko Tokuhara, Takaya Abe, Mitsuru Morimoto
Summary: During development, TGF-beta signaling inhibits Id2 to slow down the cell cycle and specify slow-cycling basal cells. In adult tissue regeneration, reduced TGF-beta signaling restores Id2 expression and initiates regeneration.
DEVELOPMENTAL CELL
(2021)
Article
Oncology
Zhi-Qin Xie, Hong-Xia Li, Xiao-Juan Hou, Mei-Yuan Huang, Ze-Min Zhu, Li-Xin Wei, Cai-Xi Tang
Summary: This study demonstrates that capsaicin can suppress hepatocarcinogenesis by inhibiting the stemness of HPCs via the SIRT1/SOX2 signaling pathway. Therefore, it may be a promising therapeutic candidate for liver cancer.
Article
Biochemistry & Molecular Biology
Chen Wang, Xinlu Yu, Sai Ding, Yang Liu, Hongxia Zhang, Jingbo Fu, Bing Yu, Haiying Zhu
Summary: In this study, the role and mechanism of Tet1-regulated demethylation in the self-renewal of induced hepatic stem cells (iHepSCs) were investigated. It was found that high expression of Tet1 in iHepSCs correlated with high levels of 5hmC and low levels of 5mC. Knockdown of Tet1 inhibited the proliferation and self-renewal capacities of iHepSCs and decreased the expression of Myc. Tet1 and CTCF co-regulated the expression of Myc by directly binding to specific regions of the Myc promoter and demethylating CpG cytosines.
CELL AND BIOSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Lifa Li, Jingxiao Zhang, Hong Peng, Xianhong Jiang, Zuoliang Liu, Hongpeng Tian, Songlin Hou, Xingjiang Xie, Qiang Peng, Tong Zhou
Summary: This study investigates the role of miR-92a in colorectal cancer (CRC). It is found that miR-92a functions as an oncogene by directly binding and repressing SOCS3, resulting in the regulation of stemness and proliferation of CRC cells.
Article
Cell & Tissue Engineering
Hector Huerga Encabo, Iker Valle Aramburu, Manuel Garcia-Albornoz, Marion Piganeau, Henry Wood, Anna Song, Alessandra Ferrelli, Aneesh Sharma, Carlos M. Minutti, Marie-Charlotte Domart, Despoina Papazoglou, Kristian Gurashi, Miriam Llorian Sopena, Robert Goldstone, Todd Fallesen, Qian Wang, Linda Ariza-McNaughton, Daniel H. Wiseman, Kiran Batta, Rajeev Gupta, Venizelos Papayannopoulos, Dominique Bonnet
Summary: Somatic mutations in hematopoietic stem cells (HSCs) can lead to clonal hematopoiesis (CH) and the production of mutated immune cells, increasing the risk of leukemia and inflammatory diseases. Through genetic engineering and transplantation, researchers found that loss of the TET2 gene in human HSCs resulted in abnormal development and function of neutrophils, leading to heightened inflammatory responses and compact chromatin structure. These findings provide insights into detecting TET2-CH and preventing CH-associated pathologies mediated by neutrophil extracellular traps (NET).
Article
Cell Biology
Fatemeh Safi, Parashar Dhapola, Sarah Warsi, Mikael Sommarin, Eva Erlandsson, Jonas Ungerback, Rebecca Warfvinge, Ewa Sitnicka, David Bryder, Charlotta Boiers, Ram Krishna Thakur, Goran Karlsson
Summary: By investigating the chromatin accessibility of single cells, it has been found that there is a population of cells that display both stem-like and lineage-affiliated chromatin signatures. These cells are positioned between stem cells and committed progenitors, showing multi-lineage potential but lacking self-renewal activity.
Article
Immunology
Giovanni Cova, Chiara Taroni, Marie-Celin Deau, Qi Cai, Vincent Mittelheisser, Muriel Philipps, Matthieu Jung, Marie Cerciat, Stephanie Le Gras, Christelle Thibault-Carpentier, Bernard Jost, Leif Carlsson, M. Angela Thornton, M. Ethan Shevach, Peggy Kirstetter, Philippe Kastner, Susan Chan
Summary: The transcription factor Helios plays a crucial role in suppressing the megakaryocyte lineage and maintaining pluripotency of hematopoietic stem cells in mice. Its absence leads to bias towards megakaryocyte lineage and partial resemblance to cells of aging animals, indicating the importance of negative and positive priming events in lineage commitment.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Itishree Kaushik, Sanjay K. Srivastava
Summary: In this study, moxidectin, a GABAA receptor agonist, was found to inhibit the proliferation of Sonic hedgehog-activated subgroup of medulloblastoma (SHH-MB) cells by inducing apoptosis. Moxidectin also suppressed the expression of related signaling pathways and cancer stem cell molecules. In mouse models, oral administration of moxidectin significantly suppressed the growth of SHH-MB tumors. These findings suggest that moxidectin may be a potential therapeutic option for treating SHH-MB patients.
Article
Cell Biology
Junnan Liang, Tongtong Liu, Jingyu Liao, Lu Zhang, Mi Zhou, Weiqi Xu, Yi He, Guangzhen Cai, Guannan Jin, Jia Song, Ganxun Li, Huifang Liang, Zeyang Ding, Bixiang Zhang
Summary: The study identified a CIMP-related methylation signature specific for CCA (CMSC) that can classify patients into different risk groups and predict patient outcomes. Additionally, a subset of patients with an unfavorable prognosis correlated with CIMP-H was identified. Gene enrichment analysis suggested a potential mechanism of CIMP as a promoter of carcinogenesis by regulating proliferation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xin Liu, Ningbing Ye, Sha Liu, Jiankun Guan, Qingyuan Deng, Zhijie Zhang, Chen Xiao, Ze-yang Ding, Bi-xiang Zhang, Xiao-ping Chen, Zifu Li, Xiangliang Yang
Summary: This study utilized hyperbaric oxygen (HBO) to overcome mechanical and immunosuppressive limitations of T cell immune checkpoint inhibitors, such as PD-1 Ab, against solid tumors. HBO enhanced PD-1 Ab delivery and T cell infiltration, disrupting immunosuppression and promoting robust immune responses to inhibit tumor relapses. Such enhanced efficacy was observed in solid tumors in rodents and hepatocellular carcinoma patients, highlighting the potential of HBO-PD-1 Ab combination therapy in stroma-rich solid tumors.
Article
Oncology
Yao Chen, Jianping Zhao, Zhanguo Zhang, Zeyang Ding, Yifa Chen, Xiaoping Chen, Wanguang Zhang
Summary: This study developed a DVT risk prediction model (TRN) based on data from a large number of hepatocellular carcinoma patients who underwent laparoscopic hepatectomy, demonstrating good predictive value in both internal and external validation.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Biochemistry & Molecular Biology
Junnan Liang, Ganxun Li, Jingyu Liao, Zhao Huang, Jingyuan Wen, Yu Wang, Zeyu Chen, Guangzhen Cai, Weiqi Xu, Zeyang Ding, Huifang Liang, Pran K. Datta, Liang Chu, Xiaoping Chen, Bixiang Zhang
Summary: This study reveals the role of SNORD17 in hepatocellular carcinoma (HCC) and its interaction with p53, suggesting it as a potential therapeutic target for HCC.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Xiaochao Zhang, Yabing Hu, Yonglong Pan, Yixiao Xiong, Yuxin Zhang, Mengzhen Han, Keshuai Dong, Jia Song, Huifang Liang, Zeyang Ding, Xuewu Zhang, He Zhu, Qiumeng Liu, Xun Lu, Yongdong Feng, Xiaoping Chen, Zhanguo Zhang, Bixiang Zhang
Summary: DDR1 is upregulated in hepatocellular carcinoma (HCC) tissues and high expression of DDR1 is associated with poor prognosis. DDR1 promotes HCC metastasis through collagen-induced signaling.
Article
Oncology
Yonglong Pan, Mengzhen Han, Xiaochao Zhang, Yi He, Chaoyi Yuan, Yixiao Xiong, Xinxin Li, Chenglong Zeng, Kan Lu, He Zhu, Xun Lu, Qiumeng Liu, Huifang Liang, Zhibin Liao, Zeyang Ding, Zhanguo Zhang, Xiaoping Chen, Wanguang Zhang, Bixiang Zhang
Summary: The study reveals that DDR1 promotes liver cancer cell proliferation and tumor growth, while downregulation of DDR1 has the opposite effect. DDR1 interacts with SLC1A5 to regulate the mTORC1 signaling pathway. DDR1 serves as an independent prognostic marker, and its expression is positively correlated with SLC1A5 in clinical samples, providing new insights into HCC development and potential targets for treatment.
Article
Oncology
Qian Yun Ge, Jin Chen, Gan Xun Li, Xiao Long Tan, Jia Song, Deng Ning, Jie Mo, Peng Cheng Du, Qiu Meng Liu, Hui Fang Liang, Ze Yang Ding, Xue Wu Zhang, Bi Xiang Zhang
Summary: GRAMD4 inhibits the migration and metastasis of HCC by promoting the degradation of TAK1, which leads to the inactivation of MAPK and NF-kappa B signalling pathways.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Guangzhen Cai, Jinghan Zhu, Deng Ning, Ganxun Li, Yuxin Zhang, Yixiao Xiong, Junnan Liang, Chengpeng Yu, Xiaoping Chen, Huifang Liang, Zeyang Ding
Summary: The role of hypoxia in hepatocellular carcinoma and its impact on the tumor microenvironment and drug sensitivity are not well understood. This study found that the Hypoxia_DEGs_Score model has excellent predictive value for survival. Hypoxia is closely related to somatic mutation, copy number variation, and DNA methylation, which affect tumor development, metastasis, and drug resistance. Aggravated hypoxic stress leads to immune exclusion phenotype and increased infiltration of immunosuppressive cells. Patients with high Hypoxia_DEGs_Score have worse immunotherapeutic outcomes and prognosis, and may benefit from drugs targeting cell cycle signaling pathways rather than those inhibiting the PI3K/mTOR pathway. Hypoxia_DEGs_Score can predict changes in the tumor microenvironment, the efficacy of immunotherapy, and drug response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Yiyang Liu, Yufei Wang, Sheng Sun, Zeyu Chen, Shuai Xiang, Zeyang Ding, Zhao Huang, Bixiang Zhang
Summary: This article investigates the role of EpCAM in cancer and its communication with other signaling pathways. It introduces the impact on the biology of cancers and the latest clinical applications of EpCAM, aiming to shed light on its translational prospects.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chen Xiao, Jiayuan Li, Xing Wang, Shiyou Li, Chen Xu, Zhijie Zhang, Ao Hua, Ze-yang Ding, Bi-xiang Zhang, Xiangliang Yang, Zifu Li
Summary: Cancer stem cells (CSCs) are responsible for tumor progression, treatment resistance, metastasis, and recurrence, but few drugs have successfully eliminated CSCs by increasing oxidative stress. In this study, we introduced hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanoparticles (CuET@HES NPs) that effectively suppressed CSCs in vitro and in various in vivo tumor models. The CuET@HES NPs also showed great efficacy in inhibiting CSCs in fresh tumor tissues from hepatocellular carcinoma patients. This research has significant implications for the development of CSC-targeting nanomedicines.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Urology & Nephrology
Chaoyi Yuan, Guannan Jin, Pengcheng Li, Wei Wang, Chang Ge, Yonglong Pan, Qiaofeng Zhang, Jie Mo, Dong Kuang, Liu Liu, Xuewu Zhang, Huifang Liang, Wanguang Zhang, Xi Tang, Zifu Li, Jihong Liu, Gang Xu, Xiaoping Chen, Ze-yang Ding, Bixiang Zhang
Summary: Tubulointerstitial fibrosis is the final path of progressive chronic kidney diseases regardless of the cause. The transcriptional intermediary factor 1y (TIF1y) has been found to be highly expressed in the kidney tubules and inhibits the progression of fibrosis. Loss of TIF1y exacerbates tubular cell polyploidy and fibrosis, while overexpression protects against kidney fibrosis. TIF1y exerts its antifibrotic role by inhibiting TGF-D and EGFR signaling pathways.
KIDNEY INTERNATIONAL
(2023)
Review
Cell Biology
Kan Lu, Yonglong Pan, Zhao Huang, Huifang Liang, Ze-Yang Ding, Bixiang Zhang
Summary: The TRIM protein family is a versatile and highly conserved group of proteins that function as E3 ligases, regulating the development of hepatocellular carcinoma.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Medicine, Research & Experimental
Jitang Chen, Ze-yang Ding, Si Li, Sha Liu, Chen Xiao, Zifu Li, Bi-xiang Zhang, Xiao-ping Chen, Xiangliang Yang
Summary: Targeting TGF beta signaling for cancer therapy presents challenges and opportunities, as inhibitors can enhance chemotherapy efficacy but must also consider the dual role of TGF beta in normal tissues and tumors to avoid unwanted side effects.
Article
Medicine, Research & Experimental
Jia Song, Yachong Liu, Furong Liu, Lu Zhang, Ganxun Li, Chaoyi Yuan, Chengpeng Yu, Xun Lu, Qiumeng Liu, Xiaoping Chen, Huifang Liang, Zeyang Ding, Bixiang Zhang
Summary: The 14-3-3 sigma protein plays a pivotal role in anoikis resistance and metastasis of hepatocellular carcinoma cells by inhibiting EGFR degradation and regulating the activation of the EGFR-dependent ERK1/2 pathway. This study offers new research directions for targeting 14-3-3 sigma in the treatment of metastatic cancer.
Article
Oncology
Qianyun Ge, Ganxun Li, Jin Chen, Jia Song, Guangzhen Cai, Yi He, Xuewu Zhang, Huifang Liang, Zeyang Ding, Bixiang Zhang
Summary: APBB1IP can serve as a prognostic biomarker in pan-cancer analysis. Upregulation of APBB1IP correlated with increased immune-cell infiltration, with its expression in different tumors possibly being related to the tumor immune microenvironment.