Review
Cell & Tissue Engineering
Shengxi Zhou, Mengbo Xie, Jingjing Su, Bingjie Cai, Jingan Li, Kun Zhang
Summary: Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar-free wound repair has been greatly expanded. This paper reviews the types of wounds, the mechanism of scar formation in the healing process, and the current research progress on scar prevention and strategies for scar-free wound repair.
JOURNAL OF TISSUE ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Marilia Sanches Santos Rizzo Zuttion, Sarah Kathryn Littlehale Moore, Peter Chen, Andrew Kota Beppu, Jaime Lynn Hook
Summary: This review examines the role of the alveolar epithelium in maintaining efficient gas exchange and its involvement in the development of acute respiratory distress syndrome (ARDS). The focus is on virus-induced lung injury and the coordination of injury-induced lung inflammation by the alveolar epithelium, as well as maladaptive lung responses leading to ARDS and pathological lung remodeling.
Article
Health Care Sciences & Services
Thomas Iosifidis, Erika N. Sutanto, Samuel T. Montgomery, Patricia Agudelo-Romero, Kevin Looi, Kak-Ming Ling, Nicole C. Shaw, Luke W. Garratt, Jessica Hillas, Kelly M. Martinovich, Elizabeth Kicic-Starcevich, Shyan Vijayasekaran, Francis J. Lannigan, Paul J. Rigby, Darryl A. Knight, Stephen M. Stick, Anthony Kicic
Summary: The study found dysregulation of the Notch pathway in airway epithelial cells of children with wheeze, potentially contributing to defective repair. Primary AEC from children with wheeze showed significantly lower NOTCH2 expression and higher JAG1 expression.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Neha Raina, Rakesh Pahwa, Vijay Kumar Thakur, Madhu Gupta
Summary: Polysaccharides have extensive potential applications in wound healing due to their availability, harmlessness, and biodegradability. Polysaccharide-derived hydrogels mimic the natural extracellular matrix and promote cell proliferation, effectively protecting wounds from bacterial infection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mei-Ling Tan, Wen-Jie Huang, Yue Wang, Lei Liu, Yan Pan, Jing-Jing Li, Jiang Zhang, Mingxing Ouyang, Xiang-Ping Qu, Hui-Jun Liu, Chi Liu, Dan Zeng, Xiao-Qun Qin, Linhong Deng, Yang Xiang
Summary: This study investigates the role of integrin-beta 4 in regulating EMT phenotypes in airway epithelial cells. The results show that integrin-beta 4 expression plays an important role in the changes of EMT phenotypes during injury and repair processes in airway epithelial cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Cell Biology
Jiali Chen, Renjie Yang, Jiayi Yin, Bing Shi, Hanyao Huang
Summary: This review provides insights into preclinical studies on poor palatal wound healing after cleft palate repair, including the establishment of animal models and related treatment research, offering promising directions for better management of palatal wound healing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Nutrition & Dietetics
Alexandra Bekiaridou, Eleni Karlafti, Ilias Marios Oikonomou, Aristidis Ioannidis, Theodossis S. Papavramidis
Summary: Skin tissue repair is essential for maintaining homeostasis, with wound healing being a complex process that can be affected by infections. The combination of probiotics and nanotechnology has shown promising results in promoting surgical wound healing.
Article
Multidisciplinary Sciences
Wentao Liang, Li Huang, Amy Whelchel, Tian Yuan, Xiang Ma, Rui Cheng, Yusuke Takahashi, Dimitrios Karamichos, Jian-Xing Ma
Summary: Diabetes impairs corneal wound healing through dysregulation of mitochondrial function. Downregulation of PPAR & alpha; is critical for impaired mitochondrial function and delayed corneal wound healing in diabetic cornea.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Nihal Kaplan, Min Liu, Junyi Wang, Wending Yang, Elaina Fiolek, Han Peng, Robert M. Lavker
Summary: This study demonstrates a link between miR-210 and EphA2/Ephrin-A1 signaling that potentially regulates corneal epithelial migration.
Review
Cell Biology
Ming-Li Zou, Si-Yu Liu, Zi-Li Sun, Jun-Jie Wu, Zheng-Dong Yuan, Ying-Ying Teng, Yi Feng, Feng-Lai Yuan
Summary: The incidence of acute and chronic wound diseases is increasing, causing a significant burden on patients, their families, and society due to their complex pathogenesis, long course, and difficult treatment. Research is focusing on identifying new ideas and methods for treatment, with adipose stem cells potentially playing a key role in wound healing.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Thambirajoo Maheswary, Asma Abdullah Nurul, Mh Busra Fauzi
Summary: The diversity of normal flora on human skin varies between individuals and parts of the skin. A symbiotic relationship has been formed over time between humans and normal flora. In chronic wounds, particularly in patients with diabetes, the conditions become favorable for microbes to colonize and establish infections within the skin. Antibiotics and wound dressings are the targeted therapy to treat chronic wounds, although prolonged usage may lead to ineffectiveness or resistance. Further studies are needed to comprehensively understand the role of human skin normal flora in chronic injuries at the cellular and molecular level.
Review
Gastroenterology & Hepatology
J. Scott Lee, Ruth X. Wang, Erica E. Alexeev, Sean P. Colgan
Summary: Inflammatory bowel disease is associated with significant changes in microbiota and host metabolic energy supply and demand. Components of the microbiota play important roles in various biochemical pathways within and outside of the mucosa, and adjusting energy acquisition in the gut may be beneficial for disease treatment.
Review
Neurosciences
Rafal Butowt, Katarzyna Bilinska, Christopher S. von Bartheld
Summary: The precise mechanisms of olfactory dysfunction in COVID-19 are still unclear. This review explores potential mechanisms including the death of support cells, altered composition of mucus, and retraction of cilia on olfactory receptor neurons. The most plausible explanation is the lack of glucose in the mucus, derived from support cells, which powers olfactory signal transduction within the cilia.
TRENDS IN NEUROSCIENCES
(2023)
Review
Cell Biology
Yang Liu, Xiaofan Yang, Yutian Liu, Tao Jiang, Sen Ren, Jing Chen, Hewei Xiong, Meng Yuan, Wenqing Li, Hans-Gunther Machens, Zhenbing Chen
Summary: The NRF2 signaling pathway plays a crucial role in wound healing by regulating anti-inflammatory and antioxidant effects, and it has important clinical significance in this process.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Giulia Carozza, Annamaria Tisi, Annamaria Capozzo, Benedetta Cinque, Aldo Giovannelli, Marco Feligioni, Vincenzo Flati, Rita Maccarone
Summary: This study reveals the dose-dependent mechanisms of action of Cur in ARPE-19 cells. Cur at 0.01 mM promotes cell proliferation, while Cur at 0.05 mM and 0.1 mM blocks cell proliferation and induces S-phase cell cycle arrest. Furthermore, Cur at 0.05 mM and 0.1 mM activates autophagy in the cells. These findings have significant implications for the treatment of ocular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Ilene Boucher, Amanuel Kehasse, Meredith Marcincin, Celeste Rich, Nader Rahimi, Vickery Trinkaus-Randall
AMERICAN JOURNAL OF PATHOLOGY
(2011)
Article
Cell Biology
Ilene Boucher, Celeste Rich, Albert Lee, Meredith Marcincin, Vickery Trinkaus-Randall
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2010)
Article
Biotechnology & Applied Microbiology
Nima Saeidi, Xiaoqing Guo, Audrey E. K. Hutcheon, Edward A. Sander, Shyam Sundar Bale, Suzanna A. Melotti, James D. Zieske, Vickery Trinkaus-Randall, Jeffrey W. Ruberti
BIOTECHNOLOGY AND BIOENGINEERING
(2012)
Article
Hematology
Jennifer Ellis Ward, Ruiyi Ren, Gianluca Toraldo, Pam SooHoo, Jian Guan, Carl O'Hara, Ravi Jasuja, Vickery Trinkaus-Randall, Ronglih Liao, Lawreen H. Connors, David C. Seldin
Review
Ophthalmology
Mary Ann Stepp, James D. Zieske, Vickery Trinkaus-Randall, Briana M. Kyne, Sonali Pal-Ghosh, Gauri Tadvalkar, Ahdeah Pajoohesh-Ganji
EXPERIMENTAL EYE RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
Ruiyi Ren, Zhenning Hong, Haiyan Gong, Kate Laporte, Martha Skinner, David C. Seldin, Catherine E. Costello, Lawreen H. Connors, Vickery Trinkaus-Randall
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Xiaobo Wang, Karine Belguise, Christine F. O'Neill, Nuria Sanchez-Morgan, Mathilde Romagnoli, Sean F. Eddy, Nora D. Mineva, Ziyang Yu, Chengyin Min, Vickery Trinkaus-Randall, Dany Chalbos, Gail E. Sonenshein
MOLECULAR AND CELLULAR BIOLOGY
(2009)
Article
Multidisciplinary Sciences
Courtney Mankus, Celeste Rich, Martin Minns, Vickery Trinkaus-Randall
Article
Multidisciplinary Sciences
Duane J. Oswald, Albert Lee, Monique Trinidad, Cheryl Chi, Ruiyi Ren, Celeste B. Rich, Vickery Trinkaus-Randall
Article
Anatomy & Morphology
Obianamma E. Onochie, Anwuli J. Onyejose, Celeste B. Rich, Vickery Trinkaus-Randall
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Yoonjoo Lee, Min Tae Kim, Garrett Rhodes, Kelsey Sack, Sung Jun Son, Celeste B. Rich, Vijaya B. Kolachalama, Christopher Gabel, Vickery Trinkaus-Randall
Article
Oncology
Garrett Rhodes, Kristen L. Segars, Yoonjoo K. Lee, Audrey E. K. Hutcheon, Celeste B. Rich, Vickery Trinkaus-Randall
Summary: The study showed that the interaction between pannexin1 and P2X7 is altered in pretype 2 diabetic tissue, and pannexin1 plays a role in the healing response. The irregular cell morphology and reduced cell-cell communication in DiO tissue suggest the importance of pannexin1 in the coordinated movement of epithelial sheets during wound healing.
ANALYTICAL CELLULAR PATHOLOGY
(2021)
Article
Ophthalmology
Dimitrios Karamichos, Celeste B. Rich, Ramin Zareian, Audrey E. K. Hutcheon, Jeffrey W. Ruberti, Vickery Trinkaus-Randall, James D. Zieske
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2013)
Article
Biochemistry & Molecular Biology
Courtney Mankus, Cheryl Chi, Celeste Rich, Ruiyi Ren, Vickery Trinkaus-Randall