Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli

Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma

(2011) Wei-Tien Tai et al.   JOURNAL OF HEPATOLOGY

Hepatocellular Carcinoma: Novel Molecular Approaches for Diagnosis, Prognosis, and Therapy

(2010) Augusto Villanueva et al.   Annual Review of Medicine

Induction of DNA Damage-Inducible Gene GADD45  Contributes to Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Cells

(2010) D.-L. Ou et al.   CANCER RESEARCH

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Development of Molecularly Targeted Therapies in Hepatocellular Carcinoma: Where Do We Go Now?

(2010) R. S. Finn   CLINICAL CANCER RESEARCH

Sorafenib Overcomes TRAIL Resistance of Hepatocellular Carcinoma Cells through the Inhibition of STAT3

(2010) K.-F. Chen et al.   CLINICAL CANCER RESEARCH

Novel inhibitors in development for hepatocellular carcinoma

(2010) Marcus Alexander Wörns et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib

(2010) Hayato Hikita et al.   HEPATOLOGY

Gene signatures in hepatocellular carcinoma (HCC)

(2010) Ourania M. Andrisani et al.   SEMINARS IN CANCER BIOLOGY

Sorafenib Induces Apoptosis Specifically in Cells Expressing BCR/ABL by Inhibiting Its Kinase Activity to Activate the Intrinsic Mitochondrial Pathway

(2009) T. Kurosu et al.   CANCER RESEARCH

Overactivation of the MEK/ERK Pathway in Liver Tumor Cells Confers Resistance to TGF- -Induced Cell Death through Impairing Up-regulation of the NADPH Oxidase NOX4

(2009) L. Caja et al.   CANCER RESEARCH

Induction of Bim Expression Contributes to the Antitumor Synergy Between Sorafenib and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Inhibitor CI-1040 in Hepatocellular Carcinoma

(2009) D.-L. Ou et al.   CLINICAL CANCER RESEARCH

Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2

(2009) Boris R. A. Blechacz et al.   HEPATOLOGY

JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis

(2009) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines

(2009) Paola Ulivi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo

(2009) Pippa Newell et al.   JOURNAL OF HEPATOLOGY

AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)

(2009) Hung Huynh et al.   JOURNAL OF HEPATOLOGY

PUMA, a potent killer with or without p53

(2009) J Yu et al.   ONCOGENE

PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells

(2009) Q Sun et al.   ONCOGENE

Dysregulation of apoptosis in hepatocellular carcinoma cells

(2009) Isabel Fabregat   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells

(2008) Conrad Ortiz et al.   BIOCHEMICAL PHARMACOLOGY

Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation

(2008) G. Zhang et al.   CLINICAL CANCER RESEARCH

Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway

(2008) W Zhang et al.   LEUKEMIA

Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

(2008) Scott M. Wilhelm et al.   MOLECULAR CANCER THERAPEUTICS

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE