Article
Pharmacology & Pharmacy
Liping Zhou, Ka-Ying Wong, Wenxuan Yu, Christina Chui-Wa Poon, Huihui Xiao, Chi-On Chan, Daniel Kam-Wah Mok, Yan Zhang, Man-Sau Wong
Summary: Herba epimedii (HEP) shows bone protective activity when used alone or in combination with Selective Estrogen Receptor Modulators (SERMs) in rat models with estrogen deficiency, restoring changes in bone mineral density and turnover biomarkers. HEP interacts with SERMs to promote bone health without altering the individual effects of both substances in preventing bone loss caused by hormonal deficiency.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Adam Olaitan Abdulkareem, Priya Tiwari, Zahid Rasool Lone, Hina Iqbal, Satish Gupta, Rajesh Kumar Jha, Debabrata Chanda, Kumaravelu Jagavelu, Kashif Hanif
Summary: This study investigated the ameliorative effects of ormeloxifene, a selective estrogen receptor modulator, in pulmonary hypertension. The results showed that ormeloxifene promoted the synthesis of 17β-estradiol, alleviated inflammation, and improved the NOX4/HO1/Nrf/PPAR gamma/PGC-1 alpha axis, thereby attenuating pulmonary hypertension.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Iwona Szydlowska, Marta Grabowska, Jolanta Nawrocka-Rutkowska, Malgorzata Piasecka, Andrzej Starczewski
Summary: The results of the study suggest that a good response to UPA treatment in fibroids may be associated with a decrease in fibrosis, ER/PR and PCNA and Ki67 immunoexpression, as well as an increase in cell apoptosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Ravindran Vini, Vishnu Sunil Jaikumar, Viji Remadevi, Swathy Ravindran, Juberiya M. Azeez, Anjana Sasikumar, Shankar Sundaram, Sreeharshan Sreeja
Summary: 27-hydroxycholesterol (27-HC) is an endogenous selective estrogen receptor modulator (SERM) that has adverse effects on breast cancer. Pomegranate extract, which contains ellagitannins and ellagic acid, can compete with 27-HC. Urolithins, especially urolithin A (UA) and urolithin B (UB), derived from pomegranate, have antiproliferative and estrogenic activities, and UA can act as an antagonist to 27-HC in breast cancer cells, making it a potential SERM.
PHYTOTHERAPY RESEARCH
(2023)
Article
Virology
Scott F. Grady, Amelia K. Pinto, Mariah Hassert, June A. D'Angelo, James D. Brien, Christopher K. Arnatt
Summary: Zika virus has been identified as an increasing risk, prompting urgent development of treatment options. Research has found that tamoxifen may be repurposed as a promising antiviral drug against ZIKV.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Tai-Han Lin, Hong-Wei Gao, Guo-Shiou Liao, Jyh-Cherng Yu, Ming-Shen Dai, Jar-Yi Ho, Cheng-Ping Yu
Summary: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death of women worldwide. This retrospective study aimed to propose better prognostic cut-off levels for ER and PgR, and found that patients with PgR expression <= 50% or an Allred score <= 5 exhibited a poor prognosis, needing more attention during follow-up.
Article
Chemistry, Medicinal
Pu Xu, Shaoyun Li, Qing Wu, Luxi Yang, Na Zheng, Chao Zhu, Peng Liu, Ning Li, Libo Zou
Summary: With the increasing incidence of Alzheimer's disease (AD), there is a lack of effective therapeutic drugs for treatment. Phytoestrogens (PEs), similar to endogenous estrogens, have potential in AD treatment due to their neuroprotective properties. The active ingredient loureirin C from Chinese Dragon's Blood shows partial agonistic activity on ER alpha. However, it is still unclear if loureirin C has estrogenic effects in the body and if it exerts anti-AD effects through ER alpha.
Review
Chemistry, Medicinal
Teesha Downton, Fiona Zhou, Davendra Segara, Rinath Jeselsohn, Elgene Lim
Summary: The translated article discusses the limitations of current endocrine therapies for ER-positive breast cancer and the mechanisms of drug resistance, focusing on ESR1 mutations. It also provides an overview of the development and research progress of oral SERDs in improving treatment outcomes.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Agriculture, Dairy & Animal Science
Jianchuan Zhou, Lihong Zhao, Shimeng Huang, Qingxiu Liu, Xiang Ao, Yuanpei Lei, Cheng Ji, Qiugang Ma
Summary: In this study, the effects of low-dose ZEA feeding on reproduction in pregnant sows during their first parity were investigated. Feeding low-dose ZEA alters the concentrations of estrogen receptor-alpha and -beta in specific organs, disrupts reproductive hormones secretion and vulva swelling, and causes mild organ histopathological damage and increased apoptosis in sow models. The addition of Bacillus subtilis ANSB01G culture to the diet can alleviate the negative effects of ZEA on gilts to some extent.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alina Kurylowicz
Summary: Menopausal decline in estrogen levels leads to changes in adipose tissue distribution and increased obesity prevalence in women. Hormone replacement therapy can partially restore these effects, indicating the significant role of estrogen in adipocyte regulation. Preclinical studies have shown involvement of estrogen in adipose tissue development, metabolism, and inflammation. However, the relationship between estrogen and obesity is bidirectional, as estrogen deficiency leads to fat accumulation and impairs adipocyte function, while obese individuals have altered expression of estrogen receptors and key enzymes involved in their synthesis. This narrative review provides an overview of estrogen's role in adipose tissue development, physiology, and obesity-related dysfunction, as well as discussing potential therapeutic applications in obesity treatment.
Article
Oncology
Yutaka Natori, Junko Suga, Emi Tokuda, Kazunoshin Tachibana, Jun-ichi Imai, Reiko Honma, Yusuke Azami, Masaru Noda, Eisaku Sasaki, Shinya Watanabe, Tohru Ohtake, Shigehira Saji
Summary: Hormone therapy targeting estrogen receptors is used to inhibit the growth of breast cancer cells. This study investigates the role of NEDD4 in hormone therapy and prognosis in hormone receptor-positive breast cancer patients. Patients with low NEDD4 expression have a good prognosis, and NEDD4 expression may be a predictive factor for the response to hormone therapy.
Article
Endocrinology & Metabolism
Ravindran Vini, Arumugam Rajavelu, Sreeja Sreeharshan
Summary: 27-HC, the first known endogenous selective estrogen receptor modulator, is closely associated with breast cancer. This study reveals that 27-HC may induce aberrant DNA methylation changes on gene promoters through modulating the ER-alpha and DNMT3B complexes, thereby affecting drug responses and breast cancer development.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Peik M. A. Brundin, Britt-Marie Landgren, Peter Fjallstrom, Mohamed M. M. Shamekh, Jan-Ake Gustafsson, Anders F. F. Johansson, Ivan Nalvarte
Summary: The study reveals the expression patterns of sex hormone receptors in different immune cells and the lack of significant correlation between sex hormone levels and expression of SHR or immune response genes. However, there is a positive correlation between sex hormone-binding globulin and the expression of certain genes. Additionally, immune response genes show significant differences in expression between different phases of the menstrual cycle, suggesting a potential role for sex hormones in immune response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jane Y. Xu, Michele A. O'Connell, Lauren Notini, Ada S. Cheung, Sav Zwickl, Ken C. Pang
Summary: Gender dysphoria is the distress associated with having a gender identity different from one's birth-assigned sex. Hormonal treatment guidelines primarily cater to those transitioning from male to female or vice versa, leaving limited options for non-binary trans individuals seeking an androgynous appearance. There is potential for Selective Estrogen Receptor Modulators (SERMs) to be a gender-affirming treatment for non-binary individuals assigned male at birth (AMAB), but further research is needed on their effects and safety.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Food Science & Technology
Yuan Liang, Qiuyan Jiang, Haoyang Zou, Jingqi Zhao, Jie Zhang, Li Ren
Summary: This study confirms that withaferin A can bind to glucocorticoid receptor (GR) and act as a potential selective GR modulator with anti-inflammatory effect. It inhibits the production of cytokines and decreases the expression of GR-related proteins, providing a basis for developing dietary supplements and nutraceuticals against inflammation.
FOOD AND CHEMICAL TOXICOLOGY
(2023)