Journal
NEUROLOGIA
Volume 30, Issue 3, Pages 163-168Publisher
ELSEVIER ESPANA SLU
DOI: 10.1016/j.nrl.2013.11.002
Keywords
Malignant glioma; Glioblastoma; 5-aminolevulinic acid; Fluorescence-guided surgery; Cost-effectiveness
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Objective: This study evaluates the cost-effectiveness of 5-aminolevulinic acid (5-ALA, Gliolan (R)) in patients undergoing surgery for malignant glioma, in standard clinical practice conditions in Spain. Material and methods: Cost-effectiveness ratios were determined in terms of incremental cost per complete resection (CR) and incremental cost per additional quality-adjusted life year (QALY), based on data collected in the VISIONA observational study. Results: Incremental cost with 5-ALA versus conventional surgery using white light only amounts to 4550 per additional CR achieved and (sic) 9021 per QALY gained. A sensitivity analysis shows these results to be robust. Conclusion: Malignant glioma surgery guided by 5-ALA fluorescence entails a moderate increase in hospital costs compared to current surgical practice and can be considered a cost-effective innovation. (C) 2013 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L.U. All rights reserved.
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