Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 226, Issue 1, Pages 46-51Publisher
WILEY
DOI: 10.1002/jcp.22379
Keywords
-
Categories
Funding
- NHLBI [HL93149]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL093149] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Adenosine is an important mediator of inhibition of platelet activation. This metabolite is released from various cells, as well as generated via activity of ecto-enzymes on the cell surface. Binding of adenosine to A(2) subtypes (A(2A) or A(2B)), G-protein coupled adenosine receptors, results in increased levels of intracellular cyclic adenosine monophosphate (cAMP), a strong inhibitor of platelet activation. The role and importance of adenosine and its receptors in platelet physiology are addressed in this review, including recently identified roles for the A(2B) adenosine receptor as a modulator of platelet activation through its newly described role in the control of expression of adenosine diphosphate (ADP) receptors. J. Cell. Physiol. 226: 46-51, 2010. (C) 2010 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available