Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 120, Issue 2, Pages 2554-2559Publisher
WILEY
DOI: 10.1002/jcb.27550
Keywords
inflammation; pancreatitis; trypsin
Categories
Funding
- Natural Science Foundation of Jiangxi Province [20151BAB205087]
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Sepsis is usually accompanied by pulmonary inflammations, leading to acute lung injury. During this process, endogenous factors that play a regulatory role could be exploited to therapeutically alleviate such lethal tissue injury. Here, we showed that ulinastatin (UTI) administration could reduce lung tissue necrosis and swelling during sepsis in rats. UTI treatment also decreased the levels of inflammatory mediators both in the lung and in the serum. Mechanistically, we showed that the phosphorylation levels of JAK2 and STAT3 in the lung of UTI-treated rats were lower than control rats and were correlated with the decreased levels of inflammatory mediators. Taken together, these results demonstrate the protective role of UTI in sepsis-induced acute lung injury.
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