Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 120, Issue 3, Pages 4333-4341Publisher
WILEY
DOI: 10.1002/jcb.27719
Keywords
Bak-1; itraconazole; pancreatic cancer; proliferation
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Funding
- Hubei provincial health and Family Planning Commission 2018 Youth Fund Project [WJ2018H0049]
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Itraconazole is an FDA-approved antifungal agent, which has been reported to possess promising anticancer activities in recent years. This study investigates the antiproliferative effects of itraconazole on pancreatic cancer cells and the molecular mechanism of its apoptosis-inducing effects. In this study, our results showed that itraconazole inhibited the growth of pancreatic cancer cells in vitro, and it also significantly inhibited the tumor growth of CFPAC-1 xenografts in vivo. Itraconazole induced apoptosis through ROS generation and mitochondrial membrane depolarization. A Bak-1 activation dependent apoptosis was identified in CFPAC-1 cells. These data suggested that itraconazole exhibited antiproliferative effects in pancreatic cancer cells by inducing apoptosis through Bak-1 activation.
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