Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 119, Issue 12, Pages 10406-10414Publisher
WILEY
DOI: 10.1002/jcb.27389
Keywords
biomarker; colorectal neoplasia differentially expressed (CRNDE); metastasis; renal carcinoma
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Funding
- Scientific and Technological Project of Shaanxi Province [2016SF-246]
- National Nature Science Foundation of China [81670681]
- Major Clinical Research Projects of the First Affiliated Hospital of Xi'an Jiao Tong University [XJTU1AF-CRF-2015-005]
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Colorectal neoplasia differentially expressed (CRNDE) served as an oncogenic long noncoding RNA (lncRNA) to be involved in the initialization and development of human cancers. However, the clinical significance and biological function of CRNDE in clear cell renal cell carcinoma (ccRCC) was not fully understood. In our study, we found CRNDE levels were increased in ccRCC tissue specimens and cell lines, and corrected with advanced clinical stage, large tumor size, lymph node metastasis, distant metastasis, and poor pathological grade in patients with ccRCC. Furthermore, levels of CRNDE were negatively correlated with overall survival of patients with ccRCC, and high-expression of CRNDE was an independent poor prognostic factor for patients with ccRCC. Moreover, loss-of-function and gain-of-function approaches showed CRNDE-enhanced ccRCC cell migration and invasion through modulating EMT-associated genes. In conclusion, CRNDE acts as an oncogenic lncRNA in ccRCC.
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