Article
Plant Sciences
Yue Shen, Li Teng, Yuhan Qu, Jie Liu, Xudong Zhu, Shan Chen, Longfei Yang, Yuehui Huang, Qin Song, Qiang Fu
Summary: The dried aboveground part of Geranium Wilfordii Maxim., known as lao-guan-cao in Traditional Chinese Medicine, has been used for its anti-inflammatory and anti-proliferation activities. Specifically, the compound Corilagin (COR) found in this plant has shown various pharmacological effects, such as anti-inflammatory, anti-tumor, and anti-microbial properties. In a study focusing on rheumatoid arthritis (RA), COR demonstrated anti-proliferation and anti-inflammation effects by inhibiting synovial fibroblasts and suppressing inflammatory responses through NF-kappa B and MAPK signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Immunology
Yuan Qu, Yang Fu, Yuan Liu, Chuanguo Liu, Bing Xu, Qian Zhang, Ping Jiang
Summary: Transient receptor potential cation channel subfamily V member 1 (TRPV1) has been found to play a role in immune regulation and its dysregulation affects the development of rheumatoid arthritis. Understanding the mechanism of TRPV1 can lead to the design of new drugs and improved treatment of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hui Jiang, Kefeng Cao, Chang Fan, Xiaoya Cui, Yanzhen Ma, Jian Liu
Summary: This study identified changes in m6A methlyation of genes related to inflammation, cell proliferation, and apoptosis in rheumatoid arthritis cells. Validation confirmed the expression levels of WTAP, RIPK2, JAK3, and TNFRSF10A were consistent with the sequencing results.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Correction
Rheumatology
Christopher D. Buckley, Caroline Ospelt, Steffen Gay, Kim S. Midwood
Summary: A correction to this paper has been published and can be found at the provided link.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Article
Immunology
Juan He, Yu Li, Jian Chen, Qi Wu, Hongying Shan, Xiaocheng Wang, Miaomiao Zhang, Liping Nie, Qingwen Wang
Summary: Different subsets of CD8+ T cells are associated with clinical features and serological parameters in rheumatoid arthritis (RA). Naive CD8+ T cells are negatively correlated with disease activity, while CD8+ CD28-T cells and CD8+ CD27-T cells are positively correlated with disease activity. Activated CD8+ T cells and TCR gamma E+ CD8+ T cells may be involved in inflammation and lipid metabolism in RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Xiao Wang, Dexi Zhou, Wanwan Zhou, Jian Liu, Qiuyun Xue, Yurong Huang, Chenglong Cheng, Yuting Wang, Jun Chang, Peng Wang, Chenggui Miao
Summary: CAR from CCO can inhibit the circPTN/miR-145-5p/FZD4 signal axis by combining with FZD4, thereby improving the pathology of RA. This finding is of great importance for the treatment of RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Yue Shen, Xinting Fan, Yuhan Qu, Min Tang, Yuehui Huang, Yi Peng, Qiang Fu
Summary: This study explored the anti-inflammatory effects of magnoflorine (MAG) in rheumatoid arthritis (RA) and its molecular mechanisms. The results showed that MAG inhibited cell proliferation, migration, invasion, and reactive oxygen species levels while promoting cell apoptosis and cell cycle arrest. Furthermore, MAG reduced inflammatory cytokines and MMPs expression to alleviate the inflammation response. In vivo experiments demonstrated that MAG significantly improved severe symptoms in an arthritis rat model.
Editorial Material
Rheumatology
Camilla R. L. Machado, Gary S. Firestein
Summary: Rheumatoid arthritis synovium contains fibroblast-like synoviocytes that are phenotypically and functionally heterogeneous. Advanced analyses have identified at least four distinct cell states, which are determined by the cells' location in the synovium, epigenetic imprinting, and the influence of microenvironment mediators.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Juan Zhang, Yeye Ma, Yue Zhang, Sijia Niu, Maolin Chu, Zhiyi Zhang
Summary: Angiogenesis is a crucial process in the development of rheumatoid arthritis (RA), and arsenic trioxide (ATO) has been found to inhibit synovial angiogenesis through VEGF modulation in RA fibroblast-like synoviocytes (RA-FLS). CircHIPK3, a circRNA, is significantly upregulated in RA-FLS and plays a role in regulating VEGF expression via targeting miR-149-5p and FOXO1. ATO can downregulate the angiogenic functional module of circHIPK3/miR-149-5p/FOXO1/VEGF, providing a protective effect on RA-FLS and CIA synovium.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Chao Zhu, Shuang Wen, Junyong Li, Hongyu Meng, Junzhe Zhang, Kuo Zhao, Ling Wang, Yingze Zhang
Summary: The study demonstrated that Fingolimod exerts beneficial effects in collagen-induced arthritis (CIA) mice by inhibiting the recruitment of CD4(+) T lymphocytes to the affected joints. Additionally, Fingolimod inhibits TNF-alpha-induced inflammation by suppressing the AKT/PI3K/NF-kappa B signaling pathway in MH7A cells.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Rheumatology
Farzin Khosrow-Khavar, Seoyoung C. Kim, Hemin Lee, Su Been Lee, Rishi J. Desai
Summary: The study did not find evidence of increased cardiovascular risk with tofacitinib in patients with RA in a real-world setting. However, tofacitinib was associated with an increased risk of cardiovascular outcomes, although statistically non-significant, in patients with RA with cardiovascular risk factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Vincent Millischer, Matthias Heinzl, Anthi Faka, Michael Resl, Ada Trepci, Carmen Klammer, Margot Egger, Benjamin Dieplinger, Martin Clodi, Lilly Schwieler
Summary: The study investigates the effects of acute intravenous LPS administration on tryptophan and kynurenine metabolites in healthy male subjects. It found that LPS led to changes in these metabolites and activated both the neurotoxic and neuroprotective branches of the kynurenine pathway.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Yat-Yin Law, Wei-Fang Lee, Chin-Jung Hsu, Yen-You Lin, Chun-Hao Tsai, Chien-Chung Huang, Min-Huan Wu, Chih-Hsin Tang, Ju-Fang Liu
Summary: The research on OA and RA revealed that miR-let-7c-5p and miR-149-5p have inhibitory effects on the transcription of proinflammatory cytokines, suggesting that increasing the expression of these two miRNAs is a novel therapeutic strategy for OA and RA.
Article
Rheumatology
Roswitha Dietzel, Sabine Wiegmann, Diana Borucki, Christian Detzer, Kim Nikola Zeiner, Desiree Schaumburg, Bjoern Buehring, Frank Buttgereit, Gabriele Armbrecht
Summary: In patients with rheumatoid arthritis (RA), chronic inflammation can lead to muscle depletion. The study found that sarcopenia is more common in RA patients and is associated with factors such as body weight, BMI, inflammation markers, and disease duration.
Article
Agriculture, Dairy & Animal Science
Nicole Reisinger, Dominik Wendner, Nora Schauerhuber, Elisabeth Mayer
Summary: This study found that endotoxins, specifically LPS, have significant impacts on rumen and claw tissues, inducing local inflammatory responses. LPS had a stronger effect on the expression of inflammatory genes in rumen epithelial cells compared to LTA, while increasing LPS concentrations led to decreased tissue integrity in claw explants. The results suggest that endotoxins play a crucial role in ruminant health by affecting local inflammatory responses and potentially negatively impacting claw health.