Article
Biochemistry & Molecular Biology
Hannah L. L. Smith, Juliet C. C. Gray, Stephen A. A. Beers, Janos M. M. Kanczler
Summary: Osteosarcoma, a bone cancer typically found in adolescents, is closely related to the conversion of bone marrow during adolescence. This study compared the differentiation potential of bone marrow cells from different regions with osteosarcoma cell lines. The results showed distinct differences in the differentiation abilities of hematopoietic and adipocyte-rich bone marrow, which correlated with specific characteristics of the osteosarcoma cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Teru Hideshima, Kenneth C. Anderson
Summary: The bone marrow microenvironment in multiple myeloma is crucial for disease pathogenesis and involves complex interplay between different cells and signaling pathways. Development of combination treatment strategies to target these activated pathways is essential for improving patient outcomes.
Article
Cell Biology
Michaela Ferencakova, Andrea Benova, Ivan Raska Jr, Pavel Abaffy, Radek Sindelka, Martina Dzubanova, Eliska Pospisilova, Katarina Kolostova, Tomas Cajka, Ales Paclik, Vit Zikan, Michaela Tencerova
Summary: This study investigated the impact of anticoagulants on the molecular characteristics of human BMSCs during isolation and cultivation. The results showed that the type of anticoagulant did not significantly affect the molecular characteristics and cellular composition of BMSCs, while in vitro cultivation caused significant changes in the transcriptomics of BMSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Health Care Sciences & Services
Suncica Kapor, Milica Vukotic, Tijana Suboticki, Dragoslava Dikic, Olivera Mitrovic Ajtic, Milica Radojkovic, Vladan P. Cokic, Juan F. Santibanez
Summary: The study found that HU inhibits the growth of BMMSC, causing senescence-like changes and affecting cellular differentiation and immunoregulatory functions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biology
Zheting Liao, Yu Jin, Yuhao Chu, Hansen Wu, Xiaoyu Li, Zhonghao Deng, Shuhao Feng, Nachun Chen, Ziheng Luo, Xiaoyong Zheng, Liangxiao Bao, Yongqing Xu, Hongbo Tan, Liang Zhao
Summary: A study using single-cell RNA sequencing explored the transcriptomic landscape of alcohol-induced osteonecrosis of the femoral head (ONFH). The study revealed the relevance of stromal and endothelial cells to the pathogenesis of the disease and provided resources for developing cell type-specific therapeutic strategies.
COMMUNICATIONS BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Viktorija Avilkina, Damien Leterme, Guillaume Falgayrac, Jerome Delattre, Flore Miellot, Veronique Gauthier, Christophe Chauveau, Olfa Ghali Mhenni
Summary: This study demonstrates, for the first time, that the duration and severity of energy deficits are critical for changes in bone parameters, BMSC differentiation, and Sirt1 expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Sarah Hochmann, Kristy Ou, Rodolphe Poupardin, Michaela Mittermeir, Martin Textor, Salaheddine Ali, Martin Wolf, Agnes Ellinghaus, Dorit Jacobi, Juri A. J. Elmiger, Samantha Donsante, Mara Riminucci, Richard Schaefer, Uwe Kornak, Oliver Klein, Katharina Schallmoser, Katharina Schmidt-Bleek, Georg N. Duda, Julia K. Polansky, Sven Geissler, Dirk Strunk
Summary: Multipotent stromal cells are attractive sources for cell therapy and tissue engineering, but their application is limited due to functional diversity. In this study, we compared the regenerative potential of different stromal cell types in vitro and in vivo and found that only bone marrow stromal cells (BMSCs) could fully regenerate critical-size femoral defects. This ability was attributed to cell type-specific epigenetic landscapes controlling transcriptional stromal differentiation networks. BMSCs initiated defect healing and eventually contributed to tissue remodeling.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yoona Jung, Jooseong Kim, Sukyoung Kim, Shin Hye Chung, Jinhong Wie
Summary: Bioceramics, such as calcium-phosphate-based materials, are used in medical and dental implants for bone tissue replacement or repair. The effect of bioceramic sintering on intracellular signaling pathways is still unknown. This study analyzed the impact of sintering on osteoblast cell signaling pathways using sintered and non-sintered hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP). The findings showed that sintering affects multiple signaling pathways, providing insights into bioceramic function and expanding their application scope in clinical settings.
Article
Biochemistry & Molecular Biology
Shuang Zhang, Jeroen van de Peppel, Marijke Koedam, Johannes P. T. M. van Leeuwen, Bram C. J. van der Eerden
Summary: In this study, TNS3 was found to be involved in the fate decision of human bone marrow-derived stromal cells (BMSCs), regulating osteogenesis and adipogenesis through the control of RhoA activity and cytoskeletal reorganization. The findings highlight the crucial role of TNS3 in bone metabolism.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell & Tissue Engineering
Shuang Zhang, Jeroen van de Peppel, Marijke Koedam, Johannes P. T. M. van Leeuwen, Bram C. J. van der Eerden
Summary: The study identifies HSPB7 as a regulator of osteogenic and adipogenic differentiation in bone marrow-derived mesenchymal stromal cells (BMSCs), with a positive role in osteoblastic differentiation and maintaining the balance between osteogenesis and adipogenesis. HSPB7 shows potential as a therapeutic target for bone metabolic diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Pharmacology & Pharmacy
Tomislav Smoljo, Barbara Tomic, Hrvoje Lalic, Vilma Dembitz, Josip Batinic, Antonio Bedalov, Dora Visnjic
Summary: This study demonstrates that bone marrow stroma reduces differentiation of acute myeloid leukemia (AML) induced by low-dose cytarabine (LDAC). These findings provide insights into the limited occurrence of terminal differentiation observed in AML patients and suggest a potential explanation for this observation.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Jiayu Chen, Xiao Lin, Chaojie Yao, Lebohang Anesu Bingwa, Hao Wang, Zhongxiao Lin, Kunlin Jin, Qichuan Zhuge, Su Yang
Summary: FG-4592 pretreated BMSCs improve neurological function recovery after stroke by inhibiting apoptosis and neuronal activation, and reducing levels of inflammatory cytokines.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Samantha Donsante, Biagio Palmisano, Marta Serafini, Pamela G. Robey, Alessandro Corsi, Mara Riminucci
Summary: Bone formation begins in the embryonic stage and continues throughout life, involving stages of bone modeling and growth, remodeling, and regeneration. Osteoblasts produce, assemble, and control mineralization of the bone matrix, while regulating other cell processes and metabolic activities. Osteoblasts are derived from different skeletal stem cells under the control of multiple regulators at different developmental stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Jean-Guillaume Letarouilly, Julien Paccou, Sammy Badr, Christophe Chauveau, Odile Broux, Aline Clabaut
Summary: This study found that Tofa has a stimulatory effect on the commitment and differentiation of bone marrow adipocytes, but its effect on bone is not positive.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Dominik Hanetseder, Tina Levstek, Andreas Herbert Teuschl-Woller, Julia Katharina Frank, Barbara Schaedl, Heinz Redl, Darja Marolt Presen
Summary: This study used human-induced pluripotent stem cells to generate an engineered extracellular matrix (iECM) and tested its effects on the osteogenic capacity of human bone-marrow mesenchymal stromal cells (BMSCs). The results showed that BMSCs cultured on iECM exhibited increased proliferation, osteogenic marker expression, and mineralization. When cultured in 3D iECM/silk scaffolds, BMSCs also showed increased osteogenic gene expression levels and bone matrix deposition. These findings suggest that iECM can enhance the osteogenic activity of BMSCs, providing a bioactive and scalable biomaterial strategy for bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
