Article
Medicine, Research & Experimental
Yishu Luo, Chen Huang
Summary: The study showed that circSFMBT2 is upregulated in neointimal tissue and PDGF-BB-treated VSMCs, and its knockdown inhibits VSMC proliferation and migration while enhancing the expression of contractile markers. CircSFMBT2 was found to regulate VSMC proliferation and migration through the miR-331/HDAC5/Aggf1 axis, suggesting a potential novel target for treating proliferative vascular diseases.
Article
Medicine, Research & Experimental
Fen Zheng, Chao Ye, Rui Ge, Yu Wang, Xiao-Lei Tian, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Bing Zhou
Summary: This study demonstrates the important roles of EVs-mediated miR21-3p transfer in promoting VSMC proliferation and migration in SHR and identifies SORBS2 as a target of miR-21-3p in this process.
Article
Physiology
Yi-Qi Li, Ye-Li Li, Xiao-Tong Li, Jun-Yuan Lv, Yang Gao, Wen-Na Li, Qi-Hai Gong, Dan-Li Yang
Summary: The study demonstrated that osthole significantly inhibits PDGF-BB-induced VSMC proliferation by regulating cell cycle progression and proliferation, indicating its potential in alleviating neointimal hyperplasia caused by arterial wall injury.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chao Ye, Ying Tong, Nan Wu, Guo-wei Wan, Fen Zheng, Jing-yu Chen, Jian-zhen Lei, Hong Zhou, Ai-dong Chen, Jue-jin Wang, Qi Chen, Yue-hua Li, Yu-ming Kang, Guo-qing Zhu
Summary: The study demonstrated that miR-135a-5p promotes vascular smooth muscle cell (VSMC) proliferation in spontaneously hypertensive rats (SHRs), while FNDC5 inhibits it. Silencing miR-135a-5p or upregulating FNDC5 could attenuate VSMC proliferation and vascular remodeling in SHRs. These findings suggest that manipulating miR-135a-5p or FNDC5 levels may be a therapeutic strategy for reducing vascular remodeling and hypertension.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Bing Zhou, Nan Wu, Yuan Yan, Lu-Lu Wu, Guo-Qing Zhu, Xiao-Qing Xiong
Summary: This study demonstrates that the upregulation of miR-31-5p and the downregulation of FNDC5 contribute to Ang II-induced VSMC proliferation and migration.
EXPERIMENTAL CELL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Jingying Liu, Xingbo Long, Hexin Li, Qiuxia Yan, Lu Wang, Ziyu Qin, Hong Zhang
Summary: This study reveals that C1QTNF4 is involved in the migration and proliferation of vascular smooth muscle cells. It inhibits abnormal neointimal formation by downregulating the FAK/PI3K/AKT pathway, thus protecting blood vessels. These findings provide new insights and potential treatments for vascular stenosis diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Xiaolong Qiao, Yinan Chen, Zixuan Wang, Nan Peng, Wanxiang Niu, Shiqiang Hou, Jiaying Wu, Ying Ji, Chaoshi Niu, Chuandong Cheng
Summary: The study shows that GTF2E2 is overexpressed in glioma and is associated with poor prognosis. The biological functions of GTF2E2 were investigated in vitro and in vivo, and it was found to be regulated by miR-340-5p, affecting downstream gene expressions and glioma progression.
CANCER GENE THERAPY
(2023)
Article
Cell & Tissue Engineering
Qing Zhang, Ting Chen, Yun Zhang, Lingxia Lyu, Bohuan Zhang, Chengchen Huang, Xuhao Zhou, Yutao Wu, Zhoubin Li
Summary: The expression of miR-30c-5p was significantly decreased in atherosclerotic arteries, and it inhibited VSMC differentiation from adventitial Sca-1(+) progenitor cells through targeting OPG, suggesting a new therapeutic target for VSMC-associated diseases.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Genetics & Heredity
Mostafa Saleban, Erica L. Harris, James A. Poulter
Summary: D-type cyclins encode G1/S cell cycle checkpoint proteins, which are crucial for determining cell cycle exit and progression. Proper control of cell cycle exit is essential during embryonic development, and defects in the regulation of intracellular D-type cyclins can lead to abnormal initiation of stem cell differentiation in various organ systems. Additionally, abnormal stabilization of D-type cyclins is observed in diseases characterized by excessive cell proliferation, such as cancer and overgrowth disorders. In this review, we will summarize and compare the roles of each D-type cyclin in development and provide examples of how their dysregulation can contribute to disease.
Article
Cardiac & Cardiovascular Systems
Junchul Shin, Svyatoslav Tkachenko, Delphine Gomez, Rupande Tripathi, Gary K. Owens, Olga A. Cherepanova
Summary: OCT4 is quickly activated in SMC after acute vascular injury, inhibiting SMC hyperproliferation and potentially preventing excessive neointima formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cell Biology
Ling Ding, Guang-Ling Liu, Lu Lu, Lei Ge, Jin-Ya Wang
Summary: This study revealed the up-regulation of circ_CSNK1E in asthma samples and PDGF-BB induced ASMCs. Inhibition of circRNA_CSNK1E suppressed proliferation and migration of ASMCs. CircRNA_CSNK1E acted as a sponge for miR-34a-5p, which in turn inhibited the proliferation and migration of ASMCs. VAMP2 was identified as a direct target of miR-34a-5p. Inhibition of circRNA_CSNK1E suppressed proliferation and migration of PDGF-BB induced ASMCs through the miR-34a-5p/VAMP2 axis.
CELLULAR SIGNALLING
(2022)
Article
Cardiac & Cardiovascular Systems
Xi Fu, Tiesheng Niu, Tiangui Yang, Xiaodong Li
Summary: This study investigated the role of circRNAs in atherosclerosis using a mouse model and high-throughput sequencing. The results showed that circMAPK1 promotes the proliferation and migration of VSMCs through the miR-22-3p/MECP2 axis. Inhibition of miR-22-3p rescued the effects of circMAPK1 silencing on VSMCs proliferation and migration.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Anatomy & Morphology
Liu Li, Shuo Wang, Ming Wang, Gang Liu, Zhiyu Yang, Le Wang
Summary: Coronary artery disease (CAD) is the leading cause of death worldwide, and new therapeutic strategies are needed. MicroRNA-654-5p (miR-654-5p) has been found to have anti-cancer activities in various cancers and plays critical roles in cell migration, invasion, and proliferation, which are important in CAD. This study aimed to evaluate the role of miR-654-5p in vascular smooth muscle cells (VSMCs) related to CAD. The results showed that miR-654-5p was significantly downregulated in CAD patients and stimulated VSMCs. It was found that miR-654-5p inhibited VSMC proliferation and migration by directly targeting ADAMTS-7, suggesting that miR-654-5p could be a novel therapeutic target for CAD treatment.
CELLS TISSUES ORGANS
(2023)
Article
Engineering, Biomedical
Deborah D. Chin, Christopher Poon, Jonathan Wang, Johan Joo, Victor Ong, Zhangjingyi Jiang, Kayley Cheng, Anastasia Plotkin, Gregory A. Magee, Eun Ji Chung
Summary: The delivery of miR-145 micelles to VSMCs shows promise in mitigating atherosclerosis progression by altering cell phenotypes and reducing plaque growth. In mouse experiments, miR-145 micelles significantly inhibited the advancement of atherosclerosis.
Article
Cardiac & Cardiovascular Systems
Hyemoon Chung, Yoonjung Kim, Chul Hwan Park, In-Soo Kim, Jong-Youn Kim, Pil-Ki Min, Young Won Yoon, Tae Hoon Kim, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Kyung-A Lee, Eui-Young Choi
Summary: Pathogenic or likely pathogenic sarcomere gene mutations are related to left atrial enlargement and dysfunction in patients with hypertrophic cardiomyopathy, indicating their contribution to atrial pathology in HCM.
CARDIOVASCULAR ULTRASOUND
(2021)
Article
Cardiac & Cardiovascular Systems
Chul Shin, Young Won Yoon, In-Soo Kim, Jong-Youn Kim, Pil-Ki Min, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Eui-Young Choi
Summary: The study found that there were changes in heart function after device closure of atrial septal defect, with some patients experiencing initial abnormalities that stabilized over time. Older patients with heart dysfunction may benefit from preload reduction therapy before and after surgery.
JOURNAL OF INTERVENTIONAL CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Young Hak Chung, Byoung-Kwon Lee, Hyuck Moon Kwon, Pil-Ki Min, Eui-Young Choi, Young Won Yoon, Bum-Kee Hong, Se-Joong Rim, Jong-Youn Kim
Summary: The study found that Lp (a) has an impact on CAC in asymptomatic individuals, especially in men. Older men need to pay more attention to their Lp (a) levels and consider intensive treatment to lower it.
Article
Biophysics
Dong Wook Choi, Yeon Jin Roh, Seahyun Kim, Hae Min Lee, Minseo Kim, Donghyuk Shin, Jong Ho Park, Yongmin Cho, Hee Ho Park, Yong Sik Ok, Donghyun Kang, Jin-Hong Kim, Lionel Tarrago, Nika N. Danial, Vadim N. Gladyshev, Pil-Ki Min, Byung Cheon Lee
Summary: This study developed a genetically-encoded fluorescent biosensor TYfR with remarkable specificity and sensitivity towards fMetRO, allowing dynamic quantification of physiological levels of fMetRO. The study also observed significant fMetRO enrichment in serum from patients with acute coronary syndrome.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemistry & Molecular Biology
Byeong-Wook Song, Chang Youn Lee, Ran Kim, Won Jung Kim, Hee Won Lee, Min Young Lee, Jongmin Kim, Jee-Yeong Jeong, Woochul Chang
Summary: Enhancing microRNA-210 activity has been shown to inhibit heart cell death, reduce fibrosis, and enhance heart cell regeneration, offering a new therapeutic approach for heart disease recovery.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
In-Soo Kim, Yeon-Jik Choi, Eui-Young Choi, Pil-Ki Min, Young Won Yoon, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Jong-Youn Kim
Summary: This study identified that age, gender, and medical history are related to atrial fibrillation (AF), and the risk profile for new-onset AF differs between age groups. Especially in the <60 years age group, modifiable risk factors such as obesity and hypertension have a greater impact on AF incidence. Different management strategies to prevent AF development may be needed based on age groups.
Article
Cardiac & Cardiovascular Systems
Dae-Young Kim, In-Soo Kim, Yo Han Jung, Kyung Yul Lee, Jong-Youn Kim, Pil-Ki Min, Young Won Yoon, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Eui-Young Choi
Summary: Patients with ischemic stroke are at risk of developing heart failure with preserved ejection fraction (HFpEF) due to shared risk factors. The study found that the grade of aortic atheroma was significantly related to left ventricular diastolic function, especially in women, indicating a potential role in arterial stiffness and HFpEF risk.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jung-Joon Cha, Jong-Youn Kim, Hyoeun Kim, Young-Guk Ko, Donghoon Choi, Jae-Hwan Lee, Chang-Hwan Yoon, In-Ho Chae, Cheol Woong Yu, Seung Whan Lee, Sang-Rok Lee, Seung Hyuk Choi, Yoon Seok Koh, Pil-Ki Min
Summary: This study investigated the long-term outcomes of chronic limb threatening ischemia (CLTI) patients who underwent endovascular therapy (EVT). The results showed that age, end-stage renal disease (ESRD), Rutherford category 6, and suboptimal EVT were predictors of major amputation or death, while smoking provided protection. Low body mass index, ESRD, femoropopliteal lesion, Rutherford category 6, and suboptimal EVT were predictors of major adverse limb events (MALE). The highest hazard rates were observed within the first 6 months, followed by a decrease and then a rise after 3-4 years.
KOREAN CIRCULATION JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Jung-Joon Cha, In-Soo Kim, Jong-Youn Kim, Eui-Young Choi, Pil-Ki Min, Young Won Yoon, Byoung Kwon Lee, Bum-Kee Hong, Hyuck Moon Kwon, Han Eol Cho, Won Ah Choi, Seong-Woong Kang, Se-Joong Rim
Summary: This study investigated the long-term clinical outcomes and associated factors in patients with late-stage Duchenne muscular dystrophy (DMD).
Article
Cardiac & Cardiovascular Systems
Jong-Il Park, Young-Guk Ko, Yong-Joon Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Myeong-Ki Hong, Cheol-Woong Yu, Seung-Woon Rha, Jong-Kwan Park, Pil-Ki Min, Chang-Hwan Yoon, Sang-Rok Lee, Sang-Ho Park, Dong-Hoon Choi
Summary: This study compared the clinical outcomes of long drug-eluting stents (DES) and spot DES for the treatment of long femoropopliteal (FP) lesions. The results showed that long DES were more effective in terms of primary patency rate and survival free from target lesion revascularization at 12 months.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Hyemoon Chung, Jiwon Seo, In Soo Kim, Jong-Youn Kim, Pil-Ki Min, Young Won Yoon, Byoung Kwon Lee, Bum -Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Eui-Young Choi
Summary: Arterial stiffness index, exercise hemodynamic parameters, and echocardiographic left ventricular functional parameters are related to exercise-induced ST depression. Older age, higher pulmonary arterial systolic pressure, left atrial volume index, baPWV, ankle brachial index at rest, hypertensive response, higher heart rate, and rate-pressure product at peak exercise are significantly associated with ST depression. Higher peak heart rate, PASP, and baPWV are independently related to ST depression.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ji Woong Roh, Sanghoon Shin, Young-Guk Ko, Nak-Hoon Son, Chul-Min Ahn, Pil-Ki Min, Jae-Hwan Lee, Chang-Hwan Yoon, Cheol Woong Yu, Seung Whan Lee, Sang-Rok Lee, Seung Hyuk Choi, In-Ho Chae, Donghoon Choi
Summary: This study investigated the long-term outcomes of iliac artery endovascular therapy (EVT) and analyzed the results according to TASC classifications. The study found that EVT achieved excellent technical success and 5-year TLR-free survival. However, patients with TASC D lesions had a lower TLR-free survival rate and a higher complication rate compared to other TASC groups.
KOREAN CIRCULATION JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Chewan Lim, Hoyoun Won, Young Guk Ko, Seung Jun Lee, Chul Min Ahn, Pil Ki Min, Jae Hwan Lee, Chang Hwan Yoon, Cheol Woong Yu, Seung Whan Lee, Sang Rok Lee, Seung Hyuk Choi, In Ho Chae, Donghoon Choi
Summary: In PAD patients undergoing EVT, being underweight is an independent predictor for MACE and MALE, while the risk of MACE is lower for overweight patients compared to those with normal weight.
KOREAN CIRCULATION JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Dae Young Kim, Young Guk Ko, Seung Jun Lee, Chul Min Ahn, Seung Woon Rha, Cheol Ung Choi, Jong Kwan Park, Chang Hwan Yoon, Seung Hyuk Choi, Pil Ki Min, Jang Whan Bae, Jung Kyu Han, Sang Ho Park, Donghoon Choi
Summary: The study found that the EPICT stents showed excellent immediate and 1-year efficacy and safety outcomes in iliac artery lesions in this multicenter, prospective, registry-based study.
KOREAN CIRCULATION JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Hyemoon Chung, Yoonjung Kim, Chul-Hwan Park, Jong-Youn Kim, Pil-Ki Min, Young Won Yoon, Tae Hoon Kim, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Kyung-A Lee, Eui-Young Choi
Summary: Sarcomere mutations are significantly associated with an increase in myocardial fibrosis, while mitochondria-related mutations do not have a significant impact. Patients with sarcomere mutations show higher levels of myocardial fibrosis, while those with mitochondria-related mutations do not exhibit a significant increase in myocardial fibrosis.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)