Review
Neurosciences
Carla Belmonte-Mateos, Cristina Pujades
Summary: The central nervous system exhibits a wide diversity of neurons with specific cell types and proportions in the appropriate locations. The coordination of proliferation and differentiation is crucial for generating brains with specific size and cell composition. Understanding how cell diversity arises from pluripotent progenitor cells and how progenitor potential changes over time is an important focus in developmental neurobiology.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Mohaddeseh Sadat Alavi, Sajad Sahab Negah, Ahmad Ghorbani, Azar Hosseini, Hamid R. Sadeghnia
Summary: The study demonstrates that LEV can enhance the proliferation of rat embryonic neural stem cells and promote neuronal differentiation mainly through an NMDA receptor-mediated mechanism.
Article
Multidisciplinary Sciences
Mergim Ramosaj, Sofia Madsen, Vanille Maillard, Valentina Scandella, Daniel Sudria-Lopez, Naoya Yuizumi, Ludovic Telley, Marlen Knobloch
Summary: Lipid droplets play a key role in regulating neural stem cell proliferation and metabolic activity, and their abundance and behavior change in response to differentiation or quiescence.
NATURE COMMUNICATIONS
(2021)
Article
Developmental Biology
Toshiyuki Ohtsuka, Ryoichiro Kageyama
Summary: Hes1 overexpression expands the pool of embryonic NSCs, prolongs the generation of later-born neurons, and leads to the expansion of NSC reservoir in the postnatal and adult brain.
Review
Cell Biology
Bruno L. Marques, Giovana Figueiredo Maciel, Marcello R. Brito Junior, Lucas D. Dias, Sergio Scalzo, Anderson K. Santos, Alexandre Hiroaki Kihara, Helton da Costa Santiago, Ricardo C. Parreira, Alexander Birbrair, Rodrigo R. Resende
Summary: As the world population's life expectancy increases, more efficient therapies are needed for neurodegenerative disorders common in old age. Neural stem cells (NSCs) play a crucial role in the development and functioning of the nervous system and have broad therapeutic applications for neurodegenerative diseases. Understanding the mechanisms that govern NSC self-renewal, differentiation, and cell signaling is essential for these therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Neurosciences
Gaifen Li, Jia Liu, Yuying Guan, Xunming Ji
Summary: Hypoxia plays a crucial role in regulating various cell functions, including stem cells and neural stem cells. Hypoxia stimulation in specific brain regions can promote proliferation, migration, and maturation of neural stem cells, potentially offering a promising strategy for treating central nervous system diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Jana Pereckova, Michaela Pekarova, Nikoletta Szamecova, Zuzana Hoferova, Kristyna Kamarytova, Martin Falk, Tomas Perecko
Summary: NO2-OA modulates the pluripotency of mESC by reducing STAT3 phosphorylation, attenuating cardiac differentiation, and directing mESC into neural fate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Anny W. Robert, Marco A. Stimamiglio
Summary: This study evaluated the effects of conditioned medium (CM) collected at different time points during in vitro cardiomyogenesis and found that CM obtained at the initial time points could promote cell proliferation. However, the secretome derived from cardiac committed cells during cardiomyogenesis was unable to improve angiogenesis or migration in endothelial cells, or to stimulate the differentiation of cardioblasts.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Cell Biology
Arianna Minoia, Luca Dalle Carbonare, Jens Christian Schwamborn, Silvia Bolognin, Maria Teresa Valenti
Summary: Degenerative diseases affecting bone tissues and the brain have significant socioeconomic impact. Osteoporosis and neurodegenerative diseases are often linked, with bone fractures and reduced mobility being common in patients. Bone is not only involved in movement but also plays a role in mineral metabolism and the production of stem cells. The interaction between the nervous system and bone is bidirectional, with bone influencing neuronal regulation and vice versa. This review summarizes recent knowledge on this interaction and emphasizes its importance. Experimental models and suggestions for evaluating molecular interactions between nerve and skeletal cells are also discussed.
Article
Cell Biology
Michaela Mrugala Rothova, Alexander Valentin Nielsen, Martin Proks, Yan Fung Wong, Alba Redo Riveiro, Madeleine Linneberg-Agerholm, Eyal David, Ido Amit, Ala Trusina, Joshua Mark Brickman
Summary: Using single-cell transcriptomics, researchers have studied the different pathways of cell differentiation and identified an intermediate state in which cells transition from an extra-embryonic identity to an embryonic one. This finding has important implications for understanding organ differentiation in vitro.
NATURE CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katerina Skopalova, Katarzyna Anna Radaszkiewicz, Vera Kasparkova, Jaroslav Stejskal, Patrycja Bober, Ita Junkar, Miran Mozetic, Zdenka Capakova, Marian Lehocky, Martina Kasparova, Jiri Pachernik, Petr Humpolicek
Summary: Polypyrrole, as a representative of electro-conducting biomaterials, has been found to induce neurogenesis in embryonic bodies formed from embryonic stem cells through modulating signaling pathways. This effect is attributed to low-molecular-weight compounds present in aqueous polypyrrole extracts, leading to the importance of considering stem cell differentiation modulation when using polypyrrole as a biomaterial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Jingran Zhang, Guang Shi, Junjie Pang, Xing Zhu, Qingcai Feng, Jie Na, Wenbin Ma, Dan Liu, Songyang Zhou
Summary: Induced crotonylation in hESCs resulted in differentiation into the endodermal lineage. This induced modification led to transcriptomic changes and decreased glycolysis in hESCs.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Cell & Tissue Engineering
Sonam Raj, Sushil K. Jaiswal, Melvin L. DePamphilis
Summary: This review article addresses the enigmatic role of the p53 transcription factor and tumor suppressor in programmed cell death during embryonic development. Contradictory results regarding the dependence of pluripotent embryonic stem cells on p53 for cell death are reconciled based on experimental conditions. The review concludes that p53 is not required for mouse embryonic development, but can accelerate programmed cell death in certain conditions. Additionally, DNA damage in differentiated cells induces p53-dependent cell cycle arrest and senescence.
Article
Medicine, Research & Experimental
Afsaneh Asgari Taei, Sanaz Nasoohi, Gholamreza Hassanzadeh, Mehdi Kadivar, Leila Dargahi, Maryam Farahmandfar
Summary: The study demonstrates that conditioned medium (CM) derived from human embryonic mesenchymal stem cells (hESC-MSC) can significantly improve neurological deficits and infarct volume in rats with experimental stroke. Ischemic stroke is associated with higher levels of neurogenesis and angiogenesis markers, and treatment with CM further enhances these markers in the brain regions. This suggests that the therapeutic benefits of CM from hESC-MSCs are mediated through improved neurogenesis and angiogenesis to accelerate the recovery from cerebral ischemic insult.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Edward J. Calabrese
Summary: This paper provides a thorough assessment of hormetic dose responses in embryonic stem cells, suggesting that this response may serve as a fundamental and highly conserved evolutionary strategy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Orthopedics
B. Fafilek, M. Hampl, N. Ricankova, I. Vesela, L. Balek, M. Kunova Bosakova, I. Gudernova, M. Varecha, M. Buchtova, P. Krejci
OSTEOARTHRITIS AND CARTILAGE
(2017)
Article
Oncology
Vlastimil Kulda, Martin Svaton, Petr Mukensnabl, Kristyna Hrda, Pavel Dvorak, Zbynek Houdek, Katerina Houfkova, Radana Vrzakova, Vaclav Babuska, Milos Pesek, Martin Pesta
Review
Medicine, Research & Experimental
Miriama Stiavnicka, Laura Abril-Parreno, Jan Nevoral, Milena Kralickova, Olga Garcia-Alvarez
MEDICAL SCIENCE MONITOR
(2017)
Article
Agriculture, Dairy & Animal Science
Katerina Adamkova, Young-Joo Yi, Jaroslav Petr, Tereza Zalmanova, Kristyna Hoskova, Pavla Jelinkova, Jiri Moravec, Milena Kralickova, Miriam Sutovsky, Peter Sutovsky, Jan Nevoral
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2017)
Review
Medicine, General & Internal
Jiri Polivka, Milena Kralickova, Jiri Polivka, Christina Kaiser, Walther Kuhn, Olga Golubnitschaja
Article
Anatomy & Morphology
Miroslav Jirik, Martin Bartos, Petr Tomasek, Anna Maleckova, Tomas Kural, Jana Horakova, David Lukas, Tomas Suchy, Petra Kochova, Marie Hubalek Kalbacova, Milena Kralickova, Zbynek Tonar
MICROSCOPY RESEARCH AND TECHNIQUE
(2018)
Article
Acoustics
B. Wirleitner, J. Okhowat, L. Vistejnova, M. Kralickova, M. Karlikova, P. Vanderzwalmen, F. Ectors, L. Hradecky, M. Schuff, M. Murtinger
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2018)
Article
Multidisciplinary Sciences
Tereza Zalmanova, Kristyna Hoskova, Jan Nevoral, Katerina Adamkova, Tomas Kott, Miloslav Sulc, Zora Kotikova, Sarka Prokesova, Frantisek Jilek, Milena Kralickova, Jaroslav Petr
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Juan C. Lopez-Ramos, Zbynek Houdek, Jan Cendelin, Frantisek Vozeh, Jose M. Delgado-Garcia
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Pavel Ostasov, Jan Tuma, Pavel Pitule, Jiri Moravec, Zbynek Houdek, Frantisek Vozeh, Milena Kralickova, Jan Cendelin, Vaclav Babuska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Hwa Kyung Nam, Iva Vesela, Sara Dean Schutte, Nan E. Hatch
Article
Engineering, Biomedical
M. Rampichova, J. Chvojka, V. Jencova, T. Kubikova, Z. Tonar, J. Erben, M. Buzgo, J. Dankova, A. Litvinec, K. Vocetkova, M. Plencner, E. Prosecka, V. Sovkova, V. Lukasova, M. Kralickova, D. Lukas, E. Amler
BIOMEDICAL MATERIALS
(2018)
Article
Anatomy & Morphology
Tereza Kubikova, Petra Kochova, Jan Brazdil, Jaroslav Spatenka, Jan Burkert, Milena Kralickova, Zbynek Tonar
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2017)
Article
Medicine, General & Internal
Michaela Kripnerova, Hamendra Singh Parmar, Jiri Sana, Alena Kopkova, Lenka Radova, Sieghart Sopper, Krzysztof Biernacki, Jan Jedlicka, Michaela Kohoutova, Jitka Kuncova, Jan Peychl, Emil Rudolf, Miroslav Cervinka, Zbynek Houdek, Pavel Dvorak, Katerina Houfkova, Martin Pesta, Zdenek Tuma, Martina Dolejsova, Filip Tichanek, Vaclav Babuska, Martin Leba, Ondrej Slaby, Jiri Hatina
Summary: Sarcomas are a heterogeneous group of mesenchymal tumors with varying clinical behaviors. The JUN-murine fibrosarcoma progression series provides insights into the transformation characteristics, metabolic profiles, and transcriptomic features of different sarcoma cell lines. Understanding these aspects could help in deciphering crucial aspects of sarcoma progression and identifying new prognostic markers and potential therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Physiology
D. Mullerova, M. Pesta, J. Dvorakova, M. Cedikova, V. Kulda, P. Dvorak, V. Bouchalova, M. Kralickova, V. Babuska, J. Kuncova, J. Langmajerova, L. Muller
PHYSIOLOGICAL RESEARCH
(2017)
