Article
Medicine, General & Internal
Katherine Kelda Gomes de Castro, Pedro Henrique Lopes da Silva, Luciana Nahar dos Santos, Julia Monteiro Pereira Leal, Mylena Masseno de Pinho Pereira, Iris Maria Peixoto Alvim, Danuza Esquenazi
Summary: The study found that Treg cells decrease during leprosy reactional episodes, indicating an enhanced immune response. Changes in cytokine profile were also observed during reactional episodes.
FRONTIERS IN MEDICINE
(2022)
Article
Biology
Daniil Shevyrev, Valeriy Tereshchenko, Elena Blinova, Nadezda Knauer, Ekaterina Pashkina, Alexey Sizikov, Vladimir Kozlov
Summary: The study revealed that the proliferation of Treg cells in patients with rheumatoid arthritis under HP cytokine stimulation is lower compared to healthy individuals, and the suppressive activity decreases, which may lead to the proliferation of self-reactive T cell clones.
Article
Cell Biology
Douglas Grant Osborne, Joanne Domenico, Mayumi Fujita
Summary: In this study, we demonstrated that ectopic expression of IL-37 in non-Treg CD4+ T cells can induce a Treg phenotype and function. The stable human Treg-like cell line created in this study offers convenience for in vitro studies of human Treg cells and provides new insights into Treg cell biology and function.
Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Valentina Rubino, Anna Teresa Palatucci, Giuliana La Rosa, Angela Giovazzino, Francesco Aruta, Simona Damiano, Flavia Carriero, Mariarosaria Santillo, Rosa Iodice, Paolo Mondola, Giuseppina Ruggiero, Giuseppe Terrazzano
Summary: Reactive oxygen species (ROS) play a role in T-cell activation, with SOD-1 production and secretion influenced by antigen-dependent activation. In patients with MS, SOD-1 levels are associated with T cell function and regulatory T cell populations, impacting cytokine secretion.
Article
Immunology
Huanhuan Yan, Baochen Li, Rui Su, Chong Gao, Xiaofeng Li, Caihong Wang
Summary: This study compared immune cell abnormalities in antiphospholipid syndrome (APS) patients and healthy controls, and analyzed the correlation between antiphospholipid antibody titres and T cell subsets, as well as the correlation between cytokine profiles and clinical characteristics. The results showed that APS patients have immune disturbances, characterized by an increase in the Th17/Treg ratio and a decrease in Treg cell numbers. Additionally, primary APS patients had higher levels of peripheral blood lymphocytes compared to secondary APS patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dao X. Nguyen, Helen M. Baldwin, Amara N. Ezeonyeji, Mohammed Rohan Butt, Michael R. Ehrenstein
Summary: The study revealed that patients with PsA have an increased Th17:Treg ratio, which can be reversed by anti-TNF therapy. Treg from patients treated with different therapies showed contrasting effects on regulating effector T-cell migration, with TNF blockade boosting Treg suppression of migration.
Article
Immunology
Rui Zhang, Jinlin Miao, Kui Zhang, Bei Zhang, Xing Luo, Haoyang Sun, Zhaohui Zheng, Ping Zhu
Summary: This study investigated the changes in quantity and function of Treg cell subsets in RA patients, finding that Th1-like Treg cells are the predominant subset in the synovial fluid of RA patients but with defective suppressive function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Payal Grover, Peeyush N. Goel, Mark I. Greene
Summary: T regulatory cells employ various immunosuppressive mechanisms to limit immune responses, including secretion of cytokines, cell cytolysis, metabolic perturbation, guiding antigen-presenting cell function, etc.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Murilo Delgobo, Emil Weiss, DiyaaElDin, Ashour Leon Richter, Lisa Popiolkowski, Panagiota Arampatzi, Verena Stangl, Paula Arias-Loza, Encarnita Mariotti-Ferrandiz, Peter P. Rainer, Antoine-Emmanuel Saliba, Burkhard Ludewig, Ulrich Hofmann, Stefan Frantz, Gustavo Campos Ramos
Summary: In this study, the researchers investigated how antigen-specific T-helper cells differentiate in the myocardial environment. They used a transgenic T cell receptor model and single-cell transcriptomics to study the cells in the murine infarcted myocardium. The results showed that these cells acquired a regulatory phenotype and influenced tissue repair.
CIRCULATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Tyler C. Moore, Kim J. Hasenkrug
Summary: B lymphocytes play important roles during viral infections by producing antibodies, acting as antigen-presenting cells, regulating immune responses, and inducing Tregs. In the Friend virus model, Tregs inhibit effector CD8+ T-cell responses and contribute to virus persistence. Research focuses on the interactions between B cells and Tregs during FV infection.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Cell Biology
Sabrina Ceeraz, Charlotte R. Thompson, Richard Beatson, Ernest H. Choy
Summary: T regulatory cell therapy offers a new approach for treating autoimmune diseases and transplantation. CD8(+) Treg cells, particularly the CD8(+)CD28(-) subset, have been shown to be effective in preclinical models, although their impaired functionality in disease limits their effectiveness in immunosuppression. The review focuses on harnessing CD8(+) Treg cell therapy in clinical settings to aid current treatments for autoimmune and inflammatory conditions.
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Bayley R. McRitchie, Billur Akkaya
Summary: The concept of cancer immunotherapy has made significant progress, but challenges related to the relationship between CD4(+) T cells and CD8(+) T cells and the immunosuppressive actions of Treg cells still require attention.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Construction & Building Technology
Miaomiao Zhang, Hongren Gong, Rui Xiao, Xi Jiang, Yuetan Ma, Baoshan Huang
Summary: This study evaluated the cost-effectiveness of different overlay strategies using life-cycle cost analysis and probabilistic pavement performance models based on survival analysis. The results showed that there was a significant difference in survival probabilities between thin and thick overlays, while the overlay material type or milling had no significant impact on pavement service life. Thin overlays were more cost-effective in terms of life-cycle cost when traffic was not considered, while thick overlays were more cost-effective for pavements in wet areas with high traffic volumes.
ROAD MATERIALS AND PAVEMENT DESIGN
(2023)
Article
Oncology
Jiannan Chen, Jianhua Hu, Lili Gu, Feng Ji, Fan Zhang, Miaomiao Zhang, Jun Li, Zhengliang Chen, Longwei Jiang, Yan Zhang, Ruifang Shi, Lihua Ma, Shaochang Jia, Ying Zhang, Qi Zhang, Junqing Liang, Shunyu Yao, Zhigang Hu, Zhigang Guo
Summary: This study demonstrates the efficacy of anti-MSLN CAR-T treatment for ovarian cancer through the screening and design of antibodies and CAR-T cells, and successful clinical trials have been conducted to preliminarily evaluate the safety and effectiveness.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Engineering, Environmental
Miaomiao Zhang, Yibo Gao, Yanpeng Mao, Wenlong Wang, Jian Sun, Zhanlong Song, Jing Sun, Xiqiang Zhao
Summary: Efficient syngas production can be achieved through the use of lanthanum nickelate catalyst and deposited carbon under microwave irradiation, enhancing catalytic performance and process stability.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Zhuoxin Li, Lingyi Zhou, Yuyan Qin, Xin Sun, Qianzhe Li, Mengyu Yang, Beibei Yu, Fengyi Du, Miaomiao Zhang
Summary: In this study, a NIR responsive nano-immunostimulant was developed, which could induce immunogenic cell death of tumor cells through photothermal conversion and promote the maturation and antigen cross-presentation ability of dendritic cells. The multifunctional nano-immunostimulant provided a combined treatment strategy for tumor therapy, integrating photothermal therapy, chemo-dynamic therapy, and immune activation.
Article
Agronomy
Bing Wang, Xiang Zhou, Jun-Le Ren, Miao-Miao Zhang, Qing-Feng Wu, Shan Yuan, Wei Liu, Dong Lu
Summary: In this study, molasses was pretreated to meet the requirements of Clostridium tyrobutyricum fermentation. Through microbial adaptive laboratory evolution, C. tyrobutyricum was able to convert fructose and glucose in the treated molasses into butyric acid.
Article
Genetics & Heredity
Long Chen, Miaomiao Zhang, Xue Li, Qimin Wu, Xingfan Xue, Tingting Zhang, Renfei Lu, Yiquan Zhang
Summary: The study elucidated the regulatory mechanism of AphA on the colony morphology variation of Vibrio parahaemolyticus biofilm, which was achieved through its regulation of EPS gene expression.
Article
Immunology
Juan He, Yu Li, Jian Chen, Qi Wu, Hongying Shan, Xiaocheng Wang, Miaomiao Zhang, Liping Nie, Qingwen Wang
Summary: Different subsets of CD8+ T cells are associated with clinical features and serological parameters in rheumatoid arthritis (RA). Naive CD8+ T cells are negatively correlated with disease activity, while CD8+ CD28-T cells and CD8+ CD27-T cells are positively correlated with disease activity. Activated CD8+ T cells and TCR gamma E+ CD8+ T cells may be involved in inflammation and lipid metabolism in RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Polymer Science
Jun Li, Miaomiao Zhang, Gaolei Ni, Hao-Yang Mi, BinBin Dong, Chuntai Liu, Changyu Shen
Summary: This research proposes a method to fabricate thermoplastic polyurethane foams with surface wrinkly structures using a dynamic supercritical carbon dioxide foaming technique. The surface wrinkled TPU film paired with a surface structured polydimethylsiloxane film in a TENG showed enhanced output voltage, current, and maximum transfer charge. The flexible TENG demonstrated outstanding stability in long-term continuous operation and can be used for charging, power supply, and self-powered sensing.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Meteorology & Atmospheric Sciences
Miaomiao Zhang, Wenxiong Jia, Guofeng Zhu, Fuhua Zhang, Hui Xiong, Le Yang, Yue Zhang, Xin Lan
Summary: This study analyzes the stable isotopes of hydrogen and oxygen in the Shiyang River Basin to investigate the moisture sources and transport processes in this arid area. The results show that westerly winds and monsoons play important roles in moisture flux, and there is spatial variation in the isotopic values of precipitation. Precipitation from maritime sources is depleted in oxygen-18 compared to continental sources, while enrichment of oxygen-18 is associated with continental sources affected by evapotranspiration and secondary evaporation.
THEORETICAL AND APPLIED CLIMATOLOGY
(2023)
Article
Engineering, Civil
Miaomiao Zhang, Hongren Gong, Yuetan Ma, Xi Jiang, Baoshan Huang
Summary: This study establishes a predictive model for post-treatment pavement roughness using data from the LTPP program. A nomogram is provided to help highway agencies obtain predicted post-treatment roughness values. Results show that post-treatment roughness is significantly higher in dry and non-freeze areas, and the effect of pavement structure is time-dependent.
TRANSPORTATION RESEARCH RECORD
(2023)
Article
Immunology
Huimin Zhou, Qiugang Zhu, Zhenwei Mao, Min Li, Yue Zhang, Jun Yang, Jie Ma, Jie Tian, Shengjun Wang
Summary: In this study, it was found that miR-10a-5p carried by MDSC-EVs inhibited the generation of GC B cells by targeting Bcl-6, thereby alleviating the progression of pSS, and providing novel therapeutic targets for the treatment of pSS.
IMMUNOLOGIC RESEARCH
(2023)
Article
Oncology
Xueli Xia, Zhenwei Mao, Wenxin Wang, Jie Ma, Jie Tian, Shengjun Wang, Kai Yin
Summary: Netrin-1 secreted by tumor cells activates the cAMP/PKA signaling pathway through interaction with A2BR on MDSCs, enhancing their immunosuppressive function. High levels of netrin-1 are correlated with MDSCs in colorectal cancer patients.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Oncology
Yungang Wang, Hongli Liu, Zhe Zhang, Dezhi Bian, Keke Shao, Shengjun Wang, Yanxia Ding
Summary: In the microenvironment of inflammatory bowel disease, the transdifferentiation of myeloid-derived suppressor cells (MDSCs) and the accumulation of M2 macrophages are crucial for the transition from colitis to cancer. New insights into the cross-talk and underlying mechanisms between MDSCs and M2 macrophages are opening new avenues for the prevention and treatment of colitis-associated cancer (CAC).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Lili Feng, Rongrong Du, Baitong Chang, Min Li, Jie Tian, Shengjun Wang
Summary: This review summarizes the regulatory mechanisms of N6-methyladenosine (m6A) RNA modification from the perspectives of expression, posttranslational modification, and protein interaction. It also highlights the functions of m6A RNA modification in tumors and the influence of external and internal environmental factors.
Article
Geochemistry & Geophysics
Heping Sun, Xiaoming Cui, Jianqiao Xu, Hao Ding, Miaomiao Zhang, Hang Li, Zhenyu Wang, Jiangcun Zhou, Xiaodong Chen
Summary: This paper briefly introduces the recent important research progress in background noise analysis, gravity tides, liquid core dynamics, hum signal, and normal mode detection based on China's gravity network and its cooperation with the international gravity network.
PURE AND APPLIED GEOPHYSICS
(2023)