Review
Cell Biology
Xiaoqing Li, Yixue Li, Qinru Yu, Pengxu Qian, He Huang, Yu Lin
Summary: This review discusses the metabolic reprogramming of MDSCs in cancer and inflammation-derived microenvironment and the impact of core metabolic pathways on their phenotype and functions in various pathological conditions.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Rui Zhang, Christiane Neuhoff, Qin Yang, Mehmet U. Cinar, Muhammad J. Uddin, Ernst Tholen, Karl Schellander, Dawit Tesfaye
Summary: This study found that sulforaphane (SFN) can enhance the proliferation of porcine satellite cells (PSCs), alter the gene expression levels of myogenic regulatory factors, inhibit histone deacetylase (HDAC) activity, and increase the expression of Smad family member 7 (SMAD7) in PSCs. Furthermore, SFN was found to increase the acetylation level of histone H4 in the SMAD7 promoter and decrease the expression of certain microRNAs that target SMAD7 in PSCs.
Article
Multidisciplinary Sciences
Mohammad H. Ghazimoradi, Kouichi Hasegawa, Ehsan Zolghadr, Samaneh Montazeri, Shirin Farivar
Summary: Researchers attempted to induce totipotent stem cells by mimicking DNA demethylation patterns of the embryo, successfully generating cells positive for Nanog and Cdx2. These cells could differentiate into pluripotent and trophoblast lineage cells in-vitro and form embryo-like structures when transferred to the uterus. This study demonstrates the importance of DNA demethylation in totipotent stem cell induction and presents a new and easy method for inducing this cell type.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Xueli Bai, Fengping Shan, Na Qu, Hai Huang, Mike Handley, Noreen Griffin, Shuling Zhang, Xia Cao
Summary: The study identified the mechanism by which methionine enkephalin suppresses cutaneous squamous cell carcinoma cell growth, including inducing G0/G1 cell cycle arrest and promoting apoptosis. Furthermore, it was found that MENK can reduce immunosuppression and inhibit the JAK2/STAT3 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Benjamin T. Himes, Cori E. Fain, Zachariah P. Tritz, Cody L. Nesvick, Helen J. Jin-Lee, Philipp A. Geiger, Timothy E. Peterson, Mi-Yeon Jung, Ian F. Parney
Summary: This study investigates the immunosuppressive effects in glioblastoma (GBM) patients and finds that GBM-derived extracellular vesicles (EVs) can induce the formation of immunosuppressive monocytes. The researchers show that heparin can disrupt the interaction between GBM EVs and monocytes, thereby mitigating immune suppression. Additionally, they demonstrate that inhibiting MDSC formation with heparin partially rescues immune suppression.
JOURNAL OF NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Panpan Liu, Cong Peng, Xiang Chen, Lisha Wu, Mingzhu Yin, Jie Li, Qunshi Qin, Yehong Kuang, Wu Zhu
Summary: The study found that increased numbers of myeloid-derived suppressor cells (MDSCs) are involved in the development of psoriasis. Acitretin, a treatment for psoriasis, was shown to reduce the number of MDSCs and promote their differentiation into macrophages and dendritic cells. This effect was mediated by acitretin's regulation of glutathione synthesis and activation of extracellular signal-regulated kinase 1/2.
FRONTIERS IN MEDICINE
(2021)
Article
Cell & Tissue Engineering
Congshan Sun, Suraj Kannan, In Young Choi, HoTae Lim, Hao Zhang, Grace S. Chen, Nancy Zhang, Seong-Hyun Park, Carlo Serra, Shama R. Iyer, Thomas E. Lloyd, Richard M. Lovering, Su Bin Lim, Peter Andersen, Kathryn R. Wagner, Gabsang Lee, Chulan Kwon
Summary: Human pluripotent stem cell (hPSC)-derived myogenic progenitor cell (MPC) transplantation can contribute to muscle fiber regeneration in mice, providing a proof of principle for future hPSC-based cell therapy for muscle disorders.
Article
Immunology
Ke Rui, Yue Hong, Qiugang Zhu, Xiaofei Shi, Fan Xiao, Hailong Fu, Qing Yin, Yida Xing, Xinfeng Wu, Xiaodan Kong, Huaxi Xu, Jie Tian, Shengjun Wang, Liwei Lu
Summary: The study demonstrated that murine olfactory ecto-mesenchymal stem cell-derived exosomes can effectively attenuate the progression of experimental Sjogren's syndrome (ESS) by enhancing the immunosuppressive function of myeloid-derived suppressor cells (MDSCs). These exosomes activated the Jak2/Stat3 pathway in MDSCs through IL-6 secretion, and promoted the endogenous production of IL-6 via TLR4 signaling, indicating a potential autocrine pathway for MDSC functional modulation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Rebecca Wuest, Lisanne Terrie, Thomas Muentefering, Tobias Ruck, Lieven Thorrez
Summary: Vascularization is a challenge in skeletal muscle tissue engineering. This study introduces a novel method for co-isolation of human skeletal muscle microvascular endothelial cells and satellite cell-derived myoblasts, enabling further studies on cell communication and the engineering of physiologically relevant functional tissue.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Immunology
Amelie Marguier, Caroline Laheurte, Benoit Lecoester, Marine Malfroy, Laura Boullerot, Adeline Renaudin, Evan Seffar, Abhishek Kumar, Charlee Nardin, Francois Aubin, Olivier Adotevi
Summary: This study investigates a novel subset of monocytic MDSCs called TIE-2(+) M-MDSCs in melanoma patients. These cells show a highly immunosuppressive phenotype and are associated with the pro-angiogenic factor ANGPT2. The study demonstrates that exposure to ANGPT2 increases the immune suppressive function of TIE-2(+) M-MDSCs and that active TIE-2 signaling is required for optimal suppressive activity. This suggests that the TIE-2(+) M-MDSC/ANGPT2 axis may play a role in immune escape in melanoma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Fani Tsitouroudi, Vasiliki Sarli, Dimitrios Poulcharidis, Maria Pitou, Alexandros Katranidis, Theodora Choli-Papadopoulou
Summary: Reversine is a small organic molecule that induces dedifferentiation of myoblasts and selectively leads cancer cells to cell death. Aza-Reversine and its biotinylated derivative can reprogram cells and promote osteoblast differentiation.
Article
Medicine, Research & Experimental
Genyu Liu, Qingyang Wang, Lijiao Deng, Xiaofeng Huang, Guang Yang, Qianqian Cheng, Tingting Guo, Lu Guo, Chunxiao Niu, Xiqin Yang, Jie Dong, Jiyan Zhang
Summary: Research has found that hepatic RACK1 deficiency can protect mice from fulminant hepatitis (FH). RACK1-deficient livers accumulate myeloid-derived suppressor cells (MDSCs) under steady-state conditions, which inhibit the production of inflammatory cytokines and enhance the activation of the IKK/NF-kappa B pathway. The interaction between RACK1 and HDAC1 regulates the acetylation of Cxcl1 and S100a9, further affecting the accumulation of MDSCs and their protective effects. During FH induction, phosphorylation of RACK1 enhances its binding to E2T, promoting its ubiquitination and degradation, and increasing the expression of CXCL1/S100A9 and accumulation of MDSCs.
Article
Plant Sciences
Gan Zhang, Xinying Zhu, Fan Yang, Juan Li, Xiao Leng, Chunfen Mo, Limei Li, Yantang Wang
Summary: This study evaluated the effects of pseudolycorine chloride (PLY), a constituent of Narcissus tazetta L. var. Chinensis Roem, on myeloid-derived suppressor cells (MDSCs) expansion and differentiation, and examined its therapeutic potential in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). In vitro and in vivo experiments showed that PLY inhibited MDSCs proliferation, expansion, and differentiation, and alleviated EAE symptoms by reducing inflammatory infiltration and demyelination.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Immunology
Jiali Ni, Xiaoying Li, Xiaodi Tu, Haiyan Zhu, Shiqi Wang, Yayi Hou, Huan Dou
Summary: This study found that Halofuginone (HF), a traditional Chinese medicine, could alleviate the progression of lupus mice by targeting and promoting the apoptosis of myeloid-derived suppressor cells (MDSCs) through B lymphoid tyrosine kinase (Blk). This indicates the potential of HF as an immunotherapeutic agent for the treatment of systemic lupus erythematosus (SLE).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Jiaxin Qiao, Shanshan Wang, Jian Zhou, Baohua Tan, Zicong Li, Enqin Zheng, Gengyuan Cai, Zhenfang Wu, Linjun Hong, Ting Gu
Summary: This study revealed that the ITGB6 gene is regulated by H3K27me3 during muscle development in pigs and has an inhibitory effect on the proliferation of porcine skeletal muscle satellite cells.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Zhili Chu, Bowen Niu, Na Li, Yue Hu, Jian Li, Ping Yu, Chongyang Wu, Xinrong Yan, Anmin Lei, Jinlian Hua
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Yan-Qing Jia, Xing-Long Wang, Xiang-Wei Wang, Chuan-Qi Yan, Chang-Jie Lv, Xiao-Qin Li, Zhi-Li Chu, Fathalrhman Eisa Addoma Adam, Sa Xiao, Shu-Xia Zhang, Zeng-Qi Yang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Virology
Xinglong Wang, Qiuxia Tang, Zhili Chu, Peixin Wang, Chen Luo, Yajie Zhang, Xiaoyu Fang, Li Qiu, Ruyi Dang, Zengqi Yang
Article
Cell Biology
Z. Chu, B. Niu, H. Zhu, X. He, C. Bai, G. Li, J. Hua
CELL PROLIFERATION
(2015)
Article
Virology
Zhili Chu, Jiangang Ma, Caiying Wang, Kejia Lu, Xiaoqin Li, Haijin Liu, Xinglong Wang, Sa Xiao, Zengqi Yang
Article
Immunology
Zhili Chu, Caiying Wang, Qiuxia Tang, Xiaolei Shi, Xiaolong Gao, Jiangang Ma, Kejia Lu, Qingsong Han, Yanqing Jia, Xiangwei Wang, Fathalrhman Eisa Addoma Adam, Haijin Liu, Sa Xiao, Xinglong Wang, Zengqi Yang
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Microbiology
Xiaoqin Li, Yanqing Jia, Haijin Liu, Xiangwei Wang, Zhili Chu, Ruochen Hu, Juan Ren, Sa Xiao, Shuxia Zhang, Xinglong Wang, Zengqi Yang
VETERINARY MICROBIOLOGY
(2019)
Article
Immunology
Qingsong Han, Xiaolong Gao, Zhili Chu, Xiangwei Wang, Fathalrhman Eisa Addoma Adam, Shuxia Zhang, Yanqing Jia, Xinxin Qiu, Xinglong Wang, Zengqi Yang
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2019)
Article
Agriculture, Dairy & Animal Science
Mengqing Yang, Jiangang Ma, Zhili Chu, Xuhong Cao, Kejia Lu, Xiaolei Shi, Lina Tong, Chuanqi Yan, Haijin Liu, Xinglong Wang, Sa Xiao, Zengqi Yang
Summary: The study revealed a potential interaction between MSI1 and NDV V protein, indicating that MSI1 may act as a new antiviral molecule by inhibiting viral release and blocking apoptosis to inhibit the release of NDV.
Article
Microbiology
Lina Tong, Zhili Chu, Xiaolong Gao, Mengqing Yang, Fathalrhman Eisa A. Adam, Daguia Wenam Prince Theodore, Haijin Liu, Xinglong Wang, Sa Xiao, Zengqi Yang
Summary: The study reveals that Newcastle disease virus (NDV) V protein can interact with heterogeneous nuclear ribonucleoprotein H1 (hnRNP H1) to enhance viral replication. V protein modulates hnRNP H1 expression at the protein level, impacting NDV replication. Furthermore, V protein may regulate cell proliferation by controlling hnRNP H1 expression.
VETERINARY MICROBIOLOGY
(2021)
Review
Microbiology
Chongyang Wang, Ting Wang, Liuyuan Duan, Hui Chen, Ruochen Hu, Xiangwei Wang, Yanqing Jia, Zhili Chu, Haijin Liu, Xinglong Wang, Shuxia Zhang, Sa Xiao, Juan Wang, Ruyi Dang, Zengqi Yang
Summary: Paramyxoviruses have developed multiple strategies to evade host antiviral innate immunity, with accessory proteins playing a key role in antagonizing type I interferon production and other antiviral innate immune responses. The mechanisms by which these accessory proteins target adaptors in the antiviral innate immune signaling pathway to facilitate virus replication vary among viruses. Additionally, cellular responses involved in viral replication will be briefly summarized.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chongyang Wang, Ting Wang, Jiangkun Dai, Zhiyuan An, Ruochen Hu, Liuyuan Duan, Hui Chen, Xiangwei Wang, Zhili Chu, Haijin Liu, Juan Wang, Na Li, Zengqi Yang, Junru Wang
Summary: In this study, three 1-formyl-beta-carboline derivatives were found to be potent inhibitors of NDV, reducing virus titers through suppressing adsorption and entry processes. These compounds are identified as novel HN inhibitors, directly interacting with the NDV HN protein to affect virus adsorption and entry. Additionally, they inhibit NDV entry by suppressing the PI3K/Akt pathway, representing a unique mechanism for restraining NDV infection.
Article
Veterinary Sciences
Zhili Chu, Xiaolong Gao, Haijin Liu, Jiangang Ma, Caiying Wang, Kejia Lu, Qingsong Han, Yanhong Wang, Chongyang Wang, Fathalrhman E. A. Adam, Xinglong Wang, Sa Xiao, Zengqi Yang
VETERINARY RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Xinglong Wang, Yanqing Jia, Xiangwei Wang, Chongyang Wang, Changjie Lv, Xiaoqin Li, Zhili Chu, Qingsong Han, Sa Xiao, Shuxia Zhang, Zengqi Yang
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2019)
Article
Veterinary Sciences
Caiying Wang, Zhili Chu, Wenkai Liu, Yu Pang, Xiaolong Gao, Qiuxia Tang, Jiangang Ma, Kejia Lu, Fathalrhman E. A. Adam, Ruyi Dang, Sa Xiao, Xinglong Wang, Zengqi Yang
VETERINARY RESEARCH
(2018)