Article
Biochemistry & Molecular Biology
Jesus Delgado-Calle, Kevin McAndrews, Gerald Wu, Ashley L. Orr, Adam Ferrari, Xiaolin Tu, Venkatesan Srinivasan, G. David Roodman, Frank H. Ebetino, Robert K. Boeckman, Teresita Bellido
Summary: This study reveals that PTH signaling upregulates Notch pathway components, and Notch activation contributes to the catabolic actions of PTH in bone. Deleting the PTH receptor or overexpressing sclerostin in osteocytes abolishes the increase in Notch components caused by PTH. Moreover, bone-targeted Notch inhibition enhances the bone anabolic effects of intermittent PTH.
Article
Endocrinology & Metabolism
V. A. Shahen, A. Schindeler, M. S. Rybchyn, C. M. Girgis, B. Mulholland, R. S. Mason, I. Levinger, T. C. Brennan-Speranza
Summary: Patients with type 2 diabetes mellitus have a higher risk of fractures despite normal to high bone mineral density. This study investigated the effects of high glucose levels on human osteoblasts and tested the efficacy of parathyroid hormone and cinacalcet in promoting cell growth and matrix mineralization. The findings suggest that combination therapy with these two agents may ameliorate the negative impact of chronic high blood glucose on bone remodeling.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Krishnakali Dasgupta, Samantha Lessard, Steven Hann, Megan E. Fowler, Alexander G. Robling, Matthew L. Warman
Summary: In this study, the researchers investigated the effects of somatic activating mutations in the PIK3CA gene on skeletal overgrowth in mice. They found that differences in phenotype between Tg(BGLAP-Cre) and Tg(DMP1-Cre) mice with PIK3CA activation may be attributed to differences in recombination rates at non-skeletal sites outside of the bone system. The development of droplet digital PCR assays allowed for the detection and quantification of recombination efficiency in various tissues, providing insights into the potential impact of off-targeting in experiments involving conditional alleles.
Article
Sport Sciences
Bronwen Lundy, Alannah K. A. Mckay, Nikita C. Fensham, Nicolin Tee, Bryce Anderson, Aimee Morabito, Megan L. R. Ross, Marc Sim, Kathryn E. Ackerman, Louise M. Burke
Summary: Although acute exercise increases bone turnover markers, the impact of subsequent sessions and preexercise calcium intake remains unclear. This study found that preexercise intake of calcium-rich foods can stabilize blood calcium levels and reduce markers of bone resorption during exercise. These practical strategies can be integrated into athletes' sports nutrition plans to safeguard long-term bone health and reduce the risk of bone stress injuries.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Review
Endocrinology & Metabolism
T. John Martin
Summary: Parathyroid hormone (PTH) activates adenylyl cyclase in cells of the osteoblast lineage, indirectly regulating osteoclast formation. PTH1R, shared by PTH and PTHrP, activates adenylyl cyclase with similar potency. PTH1R is translocated from the plasma membrane to the endosome, but the influence of endosomal translocation on PTH1R activity is not yet known.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiaoying Liu, Bu B. Yeap, Kaye E. Brock, Itamar Levinger, Jonathan Golledge, Leon Flicker, Tara C. Brennan-Speranza
Summary: The study found that lower levels of serum ucOC and cOC, as well as %cOC, were associated with less favorable metabolic parameters and a higher risk of MetS. Conversely, a lower proportion of ucOC was linked to better metabolic parameters and reduced risk of MetS. Further research is needed to determine if ucOC and cOC are suitable biomarkers for cardiometabolic risk in men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xiaoying Liu, Bu B. Yeap, Kaye E. Brock, Itamar Levinger, Jonathan Golledge, Leon Flicker, Tara C. Brennan-Speranza
Summary: The study demonstrated that lower levels of serum ucOC or cOC were associated with less favorable metabolic parameters and a higher risk of MetS, while a lower proportion of ucOC was associated with better metabolic parameters and lower MetS risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Qingyun Zheng, Thomas Kernozek, Adam Daoud-Gray, Katarina T. Borer
Summary: The study found that 40 minutes of downhill exercise with enhanced speed could effectively increase osteogenic ratios, preventing or mitigating postmenopausal osteoporosis in women. In contrast, 40 minutes of uphill exercise did not show the same osteogenic effects, and differed from the effects of exercise performed after a meal.
Article
Endocrinology & Metabolism
Phuong T. Le, Hanghang Liu, Lama Alabdulaaly, Yosta Vegting, Isabella L. Calle, Francesca Gori, Beate Lanske, Roland Baron, Clifford J. Rosen
Summary: Conditional deletion of the PTH receptor in mesenchymal progenitors leads to a reduction in osteoblast differentiation and bone mass, while enhancing adipogenesis and bone marrow adipose tissue. The deficiency of Pth1r in mesenchymal progenitors increases the expression of the pro-adipogenic zinc finger transcription factor Zfp467. Genetic loss of Zfp467 results in a shift towards osteogenesis and increased bone mass.
Article
Endocrinology & Metabolism
Takaharu Kimura, Cristina Panaroni, Erinn B. Rankin, Louise E. Purton, Joy Y. Wu
Summary: PTH1R signaling in osteoprogenitors affects multiple maturing hematopoietic cell populations, potentially through regulation of cell adhesion molecules and chemokine expression that impact cell trafficking.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Emira D'Amico, Tania Vanessa Pierfelice, Stefania Lepore, Giovanna Iezzi, Camillo D'Arcangelo, Adriano Piattelli, Ugo Covani, Morena Petrini
Summary: This study aimed to explore the structural features and biological activities of a hemostatic collagen sponge on human gingival fibroblasts (HGFs) and human oral osteoblasts (HOBs). The collagen sponge had a highly porous 3D structure and good cell adhesion properties. It promoted cell proliferation and the mineralization ability of osteoblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Deepti K. Sharma, Paul H. Anderson, Howard A. Morris, Peter M. Clifton
Summary: The study finds that intake of 1000 mg calcium from milk or calcium carbonate is effective in acutely suppressing bone resorption in postmenopausal women, regardless of visceral fat levels.
JOURNAL OF NUTRITION
(2022)
Editorial Material
Urology & Nephrology
Tilman B. Drueeke, Juergen Floege
Summary: In chronic kidney disease, there may be structural and functional changes in parathyroid hormone (PTH) due to oxidation, leading to difficulties in accurately measuring PTH-related bone and cardiovascular abnormalities. However, recent studies have shown strong correlations between non-oxidized and total PTH levels, as well as associations with bone turnover markers, disputing this hypothesis.
KIDNEY INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Joanne M. Walker, Gang-Qing Yao, Edwin Siu, Meiling Zhu, Ben-hua Sun, Christine Simpson, Karl L. Insogna
Summary: SPHK2 plays an important role in both normal bone remodeling and the anabolic response to PTH.
Article
Sport Sciences
Michal Brzezianski, Monika Migdalska-Sek, Michal Stuss, Zbigniew Jastrzebski, Lukasz Radziminski, Ewa Brzezianska-Lasota, Ewa Sewerynek
Summary: The aim of this study was to assess the impact of vitamin D supplementation and regular physical activity on 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH) and bone turnover marker concentrations in healthy male athletes. The results showed that a vitamin D dose of 20,000 IU twice a week for 8 weeks effectively compensated for vitamin D deficiency and maintained the correct PTH concentration, leading to intensive bone remodeling and protective effects on bone under intensive physical effort in athletes.