Article
Biochemistry & Molecular Biology
Ran Wei, Qiushuang Wu, Nana Ai, Lei Wang, Mei Zhou, Chris Shaw, Tianbao Chen, Richard Dequan Ye, Wei Ge, Shirley W. I. Siu, Hang Fai Kwok
Summary: A novel Vasostatin-1-derived peptide (V1DP) was synthesized with inhibitory effects on cancer cell proliferation, cell migration, and angiogenesis. The peptide acts by inhibiting the VEGFR signaling pathway, as confirmed through docking simulations and free energy calculations.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chih-Hsien Wu, Yi-Lin Chiu, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai
Summary: Cilostazol exerts antithrombotic and vasculoprotective effects in endothelial cells by activating KLF2 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Y. Xu, C. Li, G. Liu, H. Zhang, S. Tian, H. Hao, Y. Hao
Summary: This study found that Ang 1-7 significantly increased NO synthesis in rat VSMCs cultured under high glucose conditions by regulating Cav-1 expression, Cav-1-eNOS interaction, oxidative stress, and intracellular Ca2+ levels.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Medical Laboratory Technology
Giuseppe Pinto, Barbara Colombo, Adriano Autieri, Luca Foppoli, Roberto Spoladore, Valentina Ardizzone, Alberto Margonato, Angelo Corti, Gabriele Fragasso
Summary: In patients with chronic systolic heart failure, vasostatin-1 and chromogranin A may serve as prognostic markers for cardiovascular events, providing complementary information to NT-proBNP and age, distinct from the association with left ventricular ejection fraction.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Sung Il Bae, Ji-Yoon Kim, Kyeong-Eon Park, Yeran Hwang, Ju-Tae Sohn
Summary: This study found that lipid emulsion enhanced the vasoconstriction induced by dexmedetomidine by inhibiting nitric oxide synthesis, potentially through reducing dexmedetomidine concentration. Dexmedetomidine-induced nitric oxide synthesis may be caused by Src kinase-induced caveolin-1 phosphorylation leading to increased eNOS (Ser1177) phosphorylation and decreased eNOS (Thr495) phosphorylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Wenhua Lei, Junli Li, Changming Li, Li Chen, Fangyang Huang, Dan Xiao, Jialiang Zhang, Jiahao Zhao, Guoyong Li, Tianyi Qu, Hao Zhou, Yanbiao Liao, Mao Chen
Summary: The study demonstrated that MARCH5 acts as a protective factor in myocardial infarction-related endothelial cell injury and hypoxia-induced endothelial cell injury, potentially through the Akt/eNOS signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Raul Lopez-Fernandez-Sobrino, Jorge R. Soliz-Rueda, Javier Avila-Roman, Anna Arola-Arnal, Manuel Suarez, Begona Muguerza, Francisca Isabel Bravo
Summary: The study found that wine lees powder has antihypertensive effects related to flavanols, anthocyanins, and endothelial factors, reducing blood pressure by affecting NO and prostacyclin production. Additionally, the antihypertensive effect of wine lees powder is mediated by SIRT1, leading to increased expression of eNos and Sirt1 genes.
Article
Biochemistry & Molecular Biology
Huong Nguyen, Jia Yi Koh, Hainan Li, Argel Islas-Robles, Sai Pranathi Meda Venkata, Jie-Mei Wang, Terrence J. Monks
Summary: This study identified a novel pro-angiogenic agent IMZ that enhances angiogenesis by activating specific signaling pathways, providing a new mechanism for treating peripheral arterial disease.
Article
Biochemistry & Molecular Biology
Giulia Querio, Susanna Antoniotti, Federica Geddo, Renzo Levi, Maria Pia Gallo
Summary: TMAO may be involved in impairing the endothelial-dependent vasodilatory mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carmine Rocca, Teresa Pasqua, Maria Carmela Cerra, Tommaso Angelone
ANTIOXIDANTS & REDOX SIGNALING
(2020)
Review
Medicine, General & Internal
Claudia Penna, Saveria Femmino, Giuseppe Alloatti, Maria F. Brizzi, Tommaso Angelone, Pasquale Pagliaro
Summary: Extracellular vesicles (EV) are emerging as early markers of myocardial damage and key mediators of cardioprotection, offering potential for preventing cardiovascular disease and limiting ischaemia/reperfusion injury. Actions to reduce risk factors related to comorbidities predisposing to cardiac ischaemic disease are crucial for preventing maladaptive ventricular remodelling and preserving cardiac function. Personalized medicine and early diagnosis, taking into account sex differences, are essential for primary or secondary prevention.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Teresa Pasqua, Carmine Rocca, Anita Giglio, Tommaso Angelone
Summary: Cardiac metabolism plays a crucial role in maintaining the physiological structure and function of the heart, with the flexibility of metabolic networks influencing the heart's ability to adapt to pathophysiological changes. Targeting cardiac metabolism may offer promising avenues for future pharmacological interventions to modulate heart metabolic pathways.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Fedora Grande, Anna De Bartolo, Maria Antonietta Occhiuzzi, Anna Caruso, Carmine Rocca, Teresa Pasqua, Alessia Carocci, Vittoria Rago, Tommaso Angelone, Maria Stefania Sinicropi
Summary: The study demonstrates that indole derivatives 8 and 10 have potential as potent beta 1-blockers, effectively inhibiting cardiac hypertrophy even at lower concentrations and with limited side effects.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Waqas Alam, Carmine Rocca, Haroon Khan, Yaseen Hussain, Michael Aschner, Anna De Bartolo, Nicola Amodio, Tommaso Angelone, Wai San Cheang
Summary: Metabolic syndrome and its associated disorders are prevalent globally. Studies have shown promising efficacy of isolated pure compounds from medicinal plant extracts, such as the natural bioactive flavonoid apigenin, in the treatment of metabolic syndrome. Apigenin exerts protective effects attributed to its antioxidant action and has shown potential in preventing and treating metabolic syndrome.
Article
Biochemistry & Molecular Biology
Giulia Querio, Susanna Antoniotti, Federica Geddo, Renzo Levi, Maria Pia Gallo
Summary: TMAO may be involved in impairing the endothelial-dependent vasodilatory mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carmine Rocca, Anna De Bartolo, Maria Concetta Granieri, Vittoria Rago, Daniela Amelio, Flavia Falbo, Rocco Malivindi, Rosa Mazza, Maria Carmela Cerra, Loubna Boukhzar, Benjamin Lefranc, Jerome Leprince, Youssef Anouar, Tommaso Angelone
Summary: The cell-permeable PSELT provides pharmacological preconditioning cardioprotection by mitigating ERS and oxidative stress, and by regulating endogenous SELENOT.
Article
Biochemistry & Molecular Biology
Carmine Rocca, Ernestina Marianna De Francesco, Teresa Pasqua, Maria Concetta Granieri, Anna De Bartolo, Maria Eugenia Gallo Cantafio, Maria Grazia Muoio, Massimo Gentile, Antonino Neri, Tommaso Angelone, Giuseppe Viglietto, Nicola Amodio
Summary: Mitochondria play a crucial role in maintaining myocardial tissue homeostasis and their impairments can lead to cardiovascular diseases. Anti-cancer drugs can induce mitochondrial toxicity, resulting in cell death.
Review
Pharmacology & Pharmacy
Francis Schneider, Raphael Clere-Jehl, Francesco Scavello, Thierry Lavigne, Angelo Corti, Tommaso Angelone, Youssef Haikel, Philippe Lavalle
Summary: CGA may serve as a biomarker in critically ill patients, associated with short-term death, systemic inflammation, and multiple organ failure; Vasostatin-I, when associated with age and lactate, could be an early prognostic indicator; Catestatin impacts immunity-related proteins and helps fight infections.
Review
Biochemistry & Molecular Biology
Giulia Querio, Susanna Antoniotti, Federica Geddo, Renzo Levi, Maria Pia Gallo
Summary: Endothelial function is crucial for systemic homeostasis and depends on the activity of tissue-specific angiocrine factors. Recent evidence highlights the relationship between endothelial factors and gut microbiota-derived molecules, particularly trimethylamine N-oxide (TMAO), which is involved in the development of endothelial dysfunction and its associated pathologies. TMAO modulates factors related to endothelial dysfunction, such as nitric oxide, adhesion molecules, and IL-6. This review presents the latest studies on the direct role of TMAO in modulating angiocrine factors involved in vascular pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Carmine Rocca, Anna De Bartolo, Rita Guzzi, Maria Caterina Crocco, Vittoria Rago, Naomi Romeo, Ida Perrotta, Ernestina Marianna De Francesco, Maria Grazia Muoio, Maria Concetta Granieri, Teresa Pasqua, Rosa Mazza, Loubna Boukhzar, Benjamin Lefranc, Jerome Leprince, Maria Eugenia Gallo Cantafio, Teresa Soda, Nicola Amodio, Youssef Anouar, Tommaso Angelone
Summary: Cardiac lipotoxicity is a major factor in cardiovascular complications during obesity. A small peptide (PSELT), derived from SELENOT, has been found to protect cardiomyocytes against lipotoxicity. PSELT counteracts cell death, oxidative stress, and lipid accumulation induced by palmitate, and it regulates mitochondrial function and ER network.
Review
Medicine, Research & Experimental
Carmine Rocca, Teresa Soda, Ernestina Marianna De Francesco, Marco Fiorillo, Francesco Moccia, Giuseppe Viglietto, Tommaso Angelone, Nicola Amodio
Summary: There is a complex pathophysiological relationship between cardiovascular diseases and cancer. The optimal activity of mitochondria is crucial and regulated by quality control systems. Impaired mitochondrial quality control is involved in the development of heart diseases and cancer. Modulating mitochondrial homeostasis may be a promising therapeutic strategy for both cardiology and oncology.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Carmine Rocca, Tommaso Angelone
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Federica Geddo, Giulia Querio, Alberto Asteggiano, Susanna Antoniotti, Alessandra Porcu, Andrea Occhipinti, Claudio Medana, Maria Pia Gallo
Summary: A healthy endothelium is important for regulating vascular tone through the production and release of vasoactive factors like NO. Endothelial dysfunction (ED) leads to the inability to properly regulate vascular tone, resulting in hypertension and other cardiovascular risks. Hydrogen sulfide (H2S), along with NO, plays a key role in vasodilation and antioxidant activities. The study focused on S-allyl cysteine (SAC), a sulfur-containing amino acid found in black garlic, which has antioxidant, anti-diabetic, and anti-hypertensive properties. The study showed that SAC could protect against ED by increasing H2S release, reducing ROS production, and enhancing eNOS phosphorylation and NO release in endothelial cells.
Article
Environmental Sciences
Maria Luigia Vommaro, Caroline Zanchi, Tommaso Angelone, Anita Giglio, Joachim Kurtz
Summary: This study evaluated the effects of a commercial herbicide residue on the biological interaction between mealworm beetle and entomopathogenic fungus. The results showed that the herbicide residue had no significant effect on the survival of the beetles, but it may temporarily affect fungal germination. These findings raise questions about the compatibility of bioinsecticides with synthetic pesticides and the effects of herbicide residues on host-pathogen interactions.
ENVIRONMENTAL POLLUTION
(2023)