Review
Biochemistry & Molecular Biology
Hadla Hariri, Rene St-Arnaud
Summary: This review highlights recent research on the regulatory functions of ubiquitin-specific peptidases (USPs) in osteoblasts and provides insight into the molecular mechanisms governing their actions. It also discusses the role of USP53 in osteoblasts and the complex layers of regulation exerted by USPs on osteoblast signaling. Further studies using knockout mouse models are necessary for a full understanding of the mechanisms underpinning USPs actions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Tsz Long Chu, Peikai Chen, Anna Xiaodan Yu, Mingpeng Kong, Zhijia Tan, Kwok Yeung Tsang, Zhongjun Zhou, Kathryn Song Eng Cheah
Summary: This study reveals that MMP14 plays a crucial role in the regulation of PTH signaling, thus contributing to bone homeostasis. During the development of osteoblasts from HC-descendent cells, MMP14 and the PTH pathway are activated. MMP14 cleaves PTH1R to dampen PTH signaling, thereby regulating bone synthesis.
Article
Cell & Tissue Engineering
C-H Chen, L. Kang, L-H Chang, T-L Cheng, S-Y Lin, S-C Wu, Y-S Lin, S-C Chuang, T-C Lee, J-K Chang, M-L Ho
Summary: Intra-articular injections of PTH in guinea pigs improved endurance, preserved glycosaminoglycans, and reduced OA symptoms, suggesting a potential therapeutic effect on age-related OA.
BONE & JOINT RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jiao Zuo, Ahmed A. Hasan, Carl-Friedrich Hocher, Philipp Kalk, Burkhard Kleuser, Bernhard K. Kraemer, Berthold Hocher
Summary: This study investigated the relationship between 25(OH)D and 1,25(OH)2D with PTH. The results showed a negative correlation between all forms of PTH and 25(OH)D, while there was no significant correlation between 1,25(OH)2D and PTH. This finding suggests an inhibitory effect of 25(OH)D on the synthesis of all forms of PTH in the chief cells of the parathyroid gland.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Karina A. Pena
Summary: The canonical model for GPCR activation assumes that activation occurs only at the cell surface and is turned off by receptor internalization. However, recent research has shown that some internalized GPCRs can continue to signal from endosomes, which has physiological implications.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Sofia Ish-Shalom, Yoseph Caraco, Nariman Saba Khazen, Michal Gershinsky, Auryan Szalat, Phillip Schwartz, Ehud Arbit, Hillel Galitzer, Jonathan C. Y. Tang, Gregory Burshtein, Ariel Rothner, Arthur Raskin, Miriam Blum, William D. Fraser
Summary: Oral hPTH(1-34) treatment as an adjunct to standard therapy in adult patients with hypoparathyroidism was found to be safe and effective, allowing for a reduction in exogenous calcium supplementation while maintaining normocalcemia.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Editorial Material
Biochemistry & Molecular Biology
Jean-Pierre Vilardaga, Ieva Sutkeviciute, Karina A. Pena
Summary: The study demonstrates the significant impact of localized cAMP production on cellular functions, particularly in phospho-responses, as revealed through phospho-proteomic analysis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Cell Biology
Ping Lyu, Bo Li, Peiran Li, Ruiye Bi, Chen Cui, Zhihe Zhao, Xuedong Zhou, Yi Fan
Summary: This article reviews the effects of PTH, PTHrP, and PTH1R signaling on MSCs in the orofacial region, as well as the potential therapeutic applications for dental and bone regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Analytical
Guan-Cheng Chen, Chi-Hsien Liu, Wei-Chi Wu
Summary: An electrochemical platform based on a screen-printed carbon electrode (SPCE) was developed to detect parathyroid hormone (PTH). The nanocomposite of multi-walled carbon nanotube (MWCNT) and gold nanoparticles (AuNP) deposited on the SPCE improved the stability and conductivity of the immunosensor, while enhancing the electrochemical signal for enzyme-linked immunosensing.
ANALYTICA CHIMICA ACTA
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yuan Li, Yuran Qian, Hui Qiao, Weiyi Pan, Liang Xie, Yu Li
Summary: This study compared the effects of two osteoanabolic drugs, ABL and TPTD, on protecting alveolar bone in experimental periodontitis. The results showed that both ABL and TPTD reduced alveolar bone loss, with ABL having better osteoanabolic effects. In vitro experiments also demonstrated that ABL had higher alkaline phosphatase activity and osteoblastic gene expression compared to TPTD.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Veterinary Sciences
Awf A. Al-Khan, Noora R. Al Balushi, Samantha J. Richardson, Janine A. Danks
Summary: Osteosarcoma is a common primary bone tumor that primarily affects children and adolescents, with a 5-year survival rate of 60 to 65% and limited improvement in prognosis in the past four decades. Studies have shown the important roles of PTHrP and PTHR1 in the development, progression, and metastasis of osteosarcoma, but their specific mechanisms have not been fully elucidated.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Surgery
Yuxuan Qiu, Yuan Fei, Zhichao Xing, Jingqiang Zhu, Yan Luo, Anping Su
Summary: Autotransplantation of parathyroid glands (PGs) is an effective strategy for preserving parathyroid function in the mid and long term. Although transient hypoparathyroidism is positively correlated with the number of autotransplanted PGs, there is no remarkable correlation with permanent hypoparathyroidism.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Engineering, Multidisciplinary
Yi Wang, Zhuowen Hao, Yufeng Zhang, Yingkun Hu, Tianhong Chen, Feifei Yan, Minhao Wu, Chong Zhang, Renxin Chen, Beihai Li, Xinxin Wu, Hanke Li, Qixin Zheng, Xiaodong Guo, Guohui Liu, Zhenwei Zou, Jingfeng Li, Lin Cai
Summary: Bone regeneration requires the interaction of multiple factors, including osteogenesis, osteolysis, angiogenesis, and an appropriate immune microenvironment. Recombinant human parathyroid hormone (PTH1-34) has been proven effective for clinical treatment of osteoporosis. However, its use in local bone repair is limited due to net bone resorption. This study proposes a strategy using multifunctional calcium phosphate (CaP) ceramics to modulate the effects of M1 macrophages and promote bone regeneration. The functionalization of the CaP ceramic scaffold with parathyroid hormone related peptide-1 (PTHrP-1) improves the osteogenic microenvironment, retains osteogenic and angiogenic properties, and achieves slow release of PTHrP-1. The results show that PTHrP-1-TBC is more suitable for bone regeneration than the unmodified peptide or the TBC scaffold alone.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Tadatoshi Sato, Christian D. Castro Andrade, Sung-Hee Yoon, Yingshe Zhao, William J. Greenlee, Patricia C. Weber, Usha Viswanathan, John Kulp, Daniel J. Brooks, Marie B. Demay, Mary L. Bouxsein, Bruce Mitlak, Beate Lanske, Marc N. Wein
Summary: This study identifies SIK2/SIK3 as potential drug targets for treating osteoporosis and successfully develops an orally available SIK2/SIK3 inhibitor. The inhibitor stimulates bone formation and increases bone density without apparent toxicity. These findings provide a new approach for the pharmacological treatment of osteoporosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medical Laboratory Technology
Etienne Cavalier, Samuel Vasikaran, Harjit P. Bhattoa, Annemieke C. Heijboer, Konstantinos Makris, Candice Z. Ulmer
Summary: Determining PTH levels is crucial for patients with parathyroid gland disorders and CKD for bone turnover monitoring. However, the lack of standardization in PTH assays on the market has led to confusion in CKD patient care. The IFCC Committee for Bone Metabolism aims to address and improve the variability in PTH testing methods.
CLINICA CHIMICA ACTA
(2021)
Article
Endocrinology & Metabolism
Ichiro Tatsuno, Takashi Terano, Mitsugu Nakamura, Kiminori Suzuki, Kazuko Kubota, Jyunichi Yamaguchi, Tomohiko Yoshida, Sawako Suzuki, Tomoaki Tanaka, Makio Shozu
Article
Endocrinology & Metabolism
Tomohiko Yoshida, Paula H. Stern
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
(2012)
Article
Medicine, General & Internal
Takao Sugiyama, Sawako Suzuki, Tomohiko Yoshida, Takafumi Mayama, Naoko Hashimoto, Keiko Suyama, Tomoaki Tanaka, Makoto Sueishi, Ichiro Tatsuno
Article
Engineering, Biomedical
Zhendong Hong, Alexandre Mello, Tomohiko Yoshida, Lan Luan, Paula H. Stern, Alexandre Rossi, Don E. Ellis, John B. Ketterson
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2010)
Letter
Rheumatology
Ichiro Tatsuno, Sawako Suzuki, Tomohiko Yoshida, Hidekazu Nagano, Naoko Hashimoto, Takafumi Mayama, Tomoaki Tanaka, Tokao Sugiyama
JOURNAL OF RHEUMATOLOGY
(2011)
Article
Endocrinology & Metabolism
Tomohiko Yoshida, Akitoshi Nakayama, Ai Tamura, Seiichiro Higuchi, Ikki Sakuma, Hidekazu Nagano, Saulo J. A. Felizola, Naoko Hashimoto, Minoru Takemoto, Ichiro Tatsuno, Hisashi Koide, Koutaro Yokote, Tomoaki Tanaka
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Tomohiko Yoshida, Minoru Takemoto
Summary: Insulin treatment for diabetic ketoacidosis can occasionally result in hypophosphatemia, which may cause severe complications even in cases of mild hypophosphatemia. Physicians should closely monitor and promptly replace phosphates levels in patients undergoing insulin therapy to prevent adverse outcomes.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Akiko Ishida, Katsushi Igarashi, Yutaro Ruike, Kazuki Ishiwata, Kumiko Naito, Satomi Kono, Hanna Deguchi, Masanori Fujimoto, Akina Shiga, Sawako Suzuki, Tomohiko Yoshida, Tomoaki Tanaka, Ichiro Tatsuno, Koutaro Yokote, Hisashi Koide
Summary: Mild autonomous cortisol secretion (ACS) is associated with an increased risk of vertebral fractures (VFx). However, the impact of this condition on bone turnover or its association with mild ACS remains controversial. This study suggests that urinary free cortisol may be useful for predicting bone formation in mild ACS patients.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Toshiki Namiki, Yuichiro Takeshita, Tomohiko Yoshida
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Pediatrics
Tomohiko Yoshida, Toshiki Namiki, Masaya Yamaga, Shunichiro Onishi, Minoru Takemoto
Summary: This study explores the relationship between liver dysfunction and nutritional markers in patients with anorexia nervosa (AN). The findings suggest that improving nutritional status in AN may help alleviate liver dysfunction and facilitate iron transport. Additionally, HCT-adjusted albumin may be a better marker than raw data for assessing changes in nutritional status in AN.
Article
Endocrinology & Metabolism
Tomohiko Yoshida, Hidenori Masuyama, Hiroki Yamagata, Makoto Miyabayashi, Shunichiro Onishi, Yosuke Inaba, Minoru Takemoto
Summary: This study investigated the frequency and risk factors of hyponatremia in pulmonary tuberculosis (PTB) patients. The results revealed that hyponatremia is common in PTB patients and may be caused by the syndrome of inappropriate antidiuresis (SIAD). Advanced age and high C-reactive protein levels were strongly associated with hyponatremia in these patients.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Article
Medicine, General & Internal
Masahiro Ohira, Sawako Suzuki, Tomohiko Yoshida, Hisashi Koide, Tomoaki Tanaka, Ichiro Tatsuno
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2020)
Article
Endocrinology & Metabolism
Rena Oka, Masahiro Ohira, Sawako Suzuki, Tomohiko Yoshida, Hisashi Koide, Tomoaki Tanaka, Ichiro Tatsuno
Article
Endocrinology & Metabolism
Takashi Miki, Eun Young Lee, Akifumi Eguchi, Kenichi Sakurai, Yuji Sawabe, Tomohiko Yoshida, Keiko Saito, Hidetaka Yokoh, Ko Ishikawa, Koutaro Yokote, Takeshi Kuzuya, Eishi Miki, Chisato Mori, Fumio Nomura
JOURNAL OF DIABETES INVESTIGATION
(2018)
Article
Endocrinology & Metabolism
Takashi Terano, Sawako Suzuki, Tomohiko Yoshida, Hidekazu Nagano, Naoko Hashimoto, Takafumi Mayama, Hisashi Koide, Keiko Suyama, Tomoaki Tanaka, Kyohei Yamamoto, Ichiro Tatsuno
DIABETOLOGY INTERNATIONAL
(2012)