Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 107, Issue 3, Pages 393-399Publisher
WILEY
DOI: 10.1002/jcb.22150
Keywords
Runx1; AML1; HEMATOPOIETIC STEM CELL; NICHE
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Funding
- A*STAR
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Cancer is the result of a combination of genetic alterations, which aid transformation of cells. However, oncogenic alterations also simultaneously induce some detrimental effects on the cells such as apoptosis, senescence, and differentiation. Such negative effects caused by certain oncogenic events are overcome by other cooperating genetic hits. We propose stem cell exhaustion as a novel detrimental effect that is caused by a wide variety of oncogenic alterations. Interestingly, in most cases, the stern cell exhaustion due to oncogenic alterations is preceded by an abnormal expansion of stem/progenitor cells. This preceding stem/progenitor cell expansion may be a key feature that still promotes cancer development, along with cooperating hits that rescue stem cell exhaustion. This review summarizes current knowledge about hematopoietic stern cell exhaustion and the mechanisms to overcome stem cell exhaustion in cancer development. J. Cell. Biochem. 107: 393-399, 2009. (C) 2009 Wiley-Liss, Inc.
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