Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 105, Issue 2, Pages 414-423Publisher
WILEY
DOI: 10.1002/jcb.21837
Keywords
pregabalin; gabapentin; substance P; NF-KB; neuroblastoma; glioma
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Pregabalin and gabapentin are lipophilic amino acid derivatives of gamma-amino butyric acid that show anticonvulsant and analgesic activity against neuropathic pain. In this study, we investigated their actions on substance P-induced NF-kappa B activation in human neuroblastoma and rat glioma cells. Pregabalin and gabapentin decreased substance P-induced NF-kappa B activation in these cells. These drugs also inhibited NF-kappa B activation in rat spinal dorsal root ganglia cells pre-treated in vitro with substance P. These results suggest a previously undefined role of pregabalin and gabapentin in the regulation of inflammation-related intracellular signaling in both neuronal and glial cells.
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