Article
Multidisciplinary Sciences
Ovgu Isbilen, Ender Volkan
Summary: Ethanolic extracts of Allium willeanum Holmboe showed significant cytotoxic and apoptotic activities on both MCF-7 and MDA-MB-231 breast cancer cell lines in vitro, with a more pronounced effect on highly metastatic breast cancer cells.
Article
Biochemistry & Molecular Biology
Keng-Shiang Huang, Yi-Ting Wang, Omkar Byadgi, Ting-Yu Huang, Mi-Hsueh Tai, Jei-Fu Shaw, Chih-Hui Yang
Summary: The study found that chlorophyllides composites can modulate the expression of various genes in breast cancer cells, including those associated with the endocrine and nervous systems. These findings provide valuable information for further research and development of novel cancer therapies.
Article
Biochemistry & Molecular Biology
Magdalena Izdebska, Wioletta Zielinska, Adrian Krajewski, Marta Halas-Wisniewska, Klaudia Mikolajczyk, Maciej Gagat, Alina Grzanka
Summary: Metastasis is a pressing issue in breast cancer patients, with ECM remodeling playing a key role in cell migration. High levels of MMPs, particularly MMP-9, have been linked to aggressive tumors. Research suggests that CP treatment can reduce breast cancer cell survival, with downregulation of MMP-9 enhancing this effect through apoptosis induction. Combination therapy targeting MMP-9 alongside CP might improve treatment effectiveness. Additionally, a relationship between MMP-9 levels and cytokeratin 19 (CK19) has been confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aykut Ozgur, Altan Kara, Nazan Goksen Tosun, Saban Tekin, Isa Gokce
Summary: Heat shock protein 90 (Hsp90) is a key chaperone overexpressed in cancer cells, making it a potential target for cancer therapy. Debio-0932, a second-generation inhibitor, showed promising anticancer activity by binding strongly to Hsp90 and inducing apoptosis in breast cancer cells.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Bashir Mosayyebi, Leila Mohammadi, Ashkan Kalantary-Charvadeh, Mohammad Rahmati
Summary: The study demonstrated that amygdalin has cytotoxic effects on breast cancer cell lines, while being non-toxic to human skin fibroblast cell line. Amygdalin treatment resulted in decreased adhesion of cancer cells to fibronectin and collagen I, as well as reduced cell migration, particularly in MDA-MB-231 cells. Integrin alpha and beta levels were differentially regulated by amygdalin in both cancer cell lines, suggesting a role in cancer cell adhesion and migration.
CURRENT MOLECULAR PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Mar'iyah Najihah Abdullah, Shafida Abd Hamid, Salizawati Muhamad Salhimi, Nurul Awani Syazzira Jalil, Mohammad Al -Amin, Nor Saliyana Jumali
Summary: Breast cancer, the most common cancer among women, is facing a challenge in the development of new anticancer drugs due to increasing drug resistance. Benzimidazole derivatives with various functional groups have shown excellent anticancer activity. In this study, two series of N-sec and tert-butyl-2-phenylbenzimidazoles were designed and synthesized, and their inhibitory effects on MDA-MB-231 and MCF-7 cell lines were evaluated. Chloro-substituted benzimidazoles exhibited better inhibitory effects compared to nitro-substituted ones, and some derivatives showed selectivity towards specific cell lines.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Nutrition & Dietetics
Monika Kalinowska, Ewelina Golebiewska, Grzegorz Swiderski, Sylwia Meczynska-Wielgosz, Hanna Lewandowska, Anna Pietryczuk, Adam Cudowski, Aleksander Astel, Renata Swislocka, Mariola Samsonowicz, Anna Barbara Zlowodzka, Waldemar Priebe, Wlodzimierz Lewandowski
Summary: The study investigated seven derivatives of plant-derived hydroxybenzoic acid for their structural and biological properties, including antioxidant, lipophilicity, antimicrobial activity, and cytotoxicity. It discussed the relationship between the molecular structure and biological activity of hydroxybenzoic acids, providing valuable information for their potential application in dietary supplements, functional foods, or drugs.
Article
Biotechnology & Applied Microbiology
Neelam Mishra, Kavita Rana, Siva Deepthi Seelam, Rakesh Kumar, Vijyendra Pandey, Bharathi P. Salimath, Dayanand Agsar
Summary: Pseudomonas aeruginosa DNM50 was identified as a biosurfactant-producing bacterium with 12 different congeners of rhamnolipid identified through structural characterization. The rhamnolipid showed radical scavenging activity with an IC50 value of 101.8 μg/ml and exhibited cytotoxic activity against MDA-MB-231 breast cancer cell line with a low IC50 of 0.05 μg/ml at 72 h of treatment. This suggests that DNM50RL may have potential in breast cancer treatment by targeting inhibition of p38MAPK.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Remi Cousin, Hugo Groult, Chanez Manseur, Romain Ferru-Clement, Mario Gani, Rachel Havret, Claire Toucheteau, Gregoire Prunier, Beatrice Colin, Franck Morel, Jean-Marie Piot, Isabelle Lanneluc, Kevin Baranger, Thierry Maugard, Ingrid Fruitier-Arnaudin
Summary: This study investigated the effects of a marine-derived lambda-carrageenan oligosaccharide on breast cancer cells, finding that it effectively reduced cell migration and invasion in an HPSE-dependent manner. Additionally, lambda-CO tightly controlled a HPSE/MMP-14/MMP-2 axis, leading to reduced MMP-2 activity.
Article
Biochemistry & Molecular Biology
Scott D. Hargrave, Anna M. Joubert, Barry V. L. Potter, Wolfgang Dohle, Sumari Marais, Anne E. Mercier
Summary: The non-steroidal THIQ-based microtubule disruptor STX3451, with enhanced pharmacokinetic and pharmacodynamic profiles, was explored for the first time in radiation biology. Pre-treatment with STX3451 increased cytotoxicity in breast cancer cells when combined with radiation, inducing more double-strand DNA breaks and potentially delaying DNA repair mechanisms through the repression of the DNA damage response element ATM. These findings may lead to the reduction of radiation and drug doses for optimal clinical efficacy.
Article
Food Science & Technology
Paula Moyano, Jose Manuel Garcia, Jimena Garcia, Adela Pelayo, Pilar Munoz-Calero, Maria Teresa Frejo, Maria Jose Anadon, Maria Victoria Naval, Andrea Flores, Vega Alejandra Mirat, Javier Del Pino
Summary: The study found that chlorpyrifos may promote breast cancer cell proliferation through various mechanisms, including increasing reactive oxygen species, acetylcholine accumulation, and alterations in the Wnt/beta-catenin pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Chun-Wen Cheng, Gwo-Tarng Sheu, Jing-Shiuan Chou, Pei-Han Wang, Yu-Chun Cheng, Chane-Yu Lai
Summary: The study demonstrated that soluble PM2.5 from building demolition sites can promote the survival and metastasis of triple-negative breast cancer cells, with increased cell viability, migration capacity, and activation of malignant signaling pathways in cancer cells exposed to the particulates.
Article
Biochemistry & Molecular Biology
Atsunobu Sagara, Shotaro Miura, Akinori Kobinata, Risa Naganawa, Saki Yaginuma, Suguru Saito, Rintaro Saito, Hidenori Kominato, Tetsuro Yumoto, Fumiaki Sato
Summary: This study demonstrated that COL8A1 promotes invasion and metastasis in the mesenchymal stem-like subtype of triple-negative breast cancer (TNBC) through the induction of IL1B and MMP1 expression. COL8A1 may serve as a prognostic marker and therapeutic target in TNBC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biophysics
Rahman Hallaj, Zhaleh Ghafary, Osama kamal Mohammed, Raheleh Shakeri
Summary: The study developed an electrochemical biosensor for detecting the endogenous protein of breast cancer cells using RNA-cleaving DNAzymes. Thionine-modified gold nanoparticles and modified magnetic nanoparticles were used to prepare a probe, which was then pulled to the electrode surface with the help of a magnetic field. The presence of gold nanoparticle-thionine hybrid as an electroactive label ensured strong detection signals. The biosensor showed a linear range of (1.0E-06 to 1.0E+01) pg/ml for the protein marker and a detection limit of (1.0129E-07 pg/ml) using differential pulse voltammetry and electrochemical impedance spectroscopy (EIS).
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Multidisciplinary Sciences
Xingjian Zhang, Trevor Chan, Michael Mak
Summary: This study investigated the phenotypes of highly aggressive cancer cells in confined microenvironments, revealing two distinct migratory phenotypes in fast migrating single cells and an increase in protrusions at the leading edge of cells under geometric confinement. The findings elucidate the impact of geometric constraints on cell behavior and morphodynamics associated with different cell phenotypes.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
David J. Orchard-Webb, Thong Chuan Lee, Graham P. Cook, G. Eric Blair
Meeting Abstract
Oncology
D. J. Orchard-Webb, G. P. Cook, G. E. Blair
Review
Gastroenterology & Hepatology
David Orchard-Webb
JOURNAL OF THE PANCREAS
(2015)
Meeting Abstract
Oncology
R. M. Elghazawy, N. Fox, D. Orchard-Webb, V. Speirs, A. M. Smith, J. P. A. Lodge, C. S. Verbeke, G. E. Blair
JOURNAL OF PATHOLOGY
(2012)
Meeting Abstract
Oncology
D. Orchard-Webb, N. Fox, R. M. Elghazawy, V. Speirs, A. M. Smith, J. P. A. Lodge, A. A. Melcher, C. S. Verbeke, G. E. Blair
JOURNAL OF PATHOLOGY
(2012)