Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Alessandro Fulgenzi, Anita Ferraretto
Summary: Bone metastasis is a severe complication of common cancers like breast and prostate cancer, reducing survival rates and quality of life. Following a Mediterranean diet can prevent cancer and improve patient health, potentially impacting the spread of cancer to the bones.
Article
Urology & Nephrology
Bruce J. Trock, Yuezhou Jing, Brent Mabey, Zaina Sangale, Lauren Lenz, Nora Haney, Igor Vidal, Stephanie A. Glavaris, Gunes Guner, Onur Ertunc, Ibrahim Kulac, Javier A. Baena Del Valle, Tracy Jones, Misop Han, Alan W. Partin, Todd Cohen, Steven Stone, Angelo M. De Marzo
Summary: The study showed that cell-cycle progression was independently associated with metastasis-free survival in prostate cancer patients, particularly those receiving salvage radiotherapy, while phosphatase and tensin homolog had weaker correlation with metastasis after adjustment for post-surgical risk assessment.
JOURNAL OF UROLOGY
(2022)
Article
Multidisciplinary Sciences
Daniela I. Staquicini, Marina Cardo-Vila, Jimmy A. Rotolo, Fernanda I. Staquicini, Fenny H. F. Tang, Tracey L. Smith, Aditya Ganju, Carmine Schiavone, Prashant Dogra, Zhihui Wang, Vittorio Cristini, Ricardo J. Giordano, Michael G. Ozawa, Wouter H. P. Driessen, Bettina Proneth, Glauco R. Souza, Lina M. Brinker, Achraf Noureddine, Ashley J. Snider, Daniel Canals, Juri G. Gelovani, Irina Petrache, Rubin M. Tuder, Lina M. Obeid, Yusuf A. Hannun, Richard N. Kolesnick, C. Jeffrey Brinker, Renata Pasqualini, Wadih Arap
Summary: The vascular endothelium in individual organs has specialized functions and unique molecular targets. This study identifies a lipid-based receptor system in the lung vascular endothelium, where CGSPGWVRC peptide interacts with C16-ceramide to trigger ceramide-rich platform formation and activate ceramide production. This peptide shows lung selectivity dependent on ceramide production and has potential applications in pulmonary imaging and lung immunization against COVID-19.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Mariarita Spampinato, Cesarina Giallongo, Alessandra Romano, Lucia Longhitano, Enrico La Spina, Roberto Avola, Grazia Scandura, Ilaria Dulcamare, Vincenzo Bramanti, Michelino Di Rosa, Nunzio Vicario, Rosalba Parenti, Giovanni Li Volti, Daniele Tibullo, Giuseppe A. Palumbo
Summary: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by clonal proliferation of hematopoietic stem cells leading to bone marrow fibrosis. The main consequences of PMF include neoangiogenesis, megakaryocytes hyperplasia, extensive bone marrow fibrosis, osteosclerosis, and bone damage. The involvement of cytokines, growth factors, and resident cells in the bone marrow microenvironment are linked to disease progression in PMF.
Article
Urology & Nephrology
Kenneth J. Pienta, Michael A. Gorin, Steven P. Rowe, Peter R. Carroll, Frederic Pouliot, Stephan Probst, Lawrence Saperstein, Mark A. Preston, Ajjai S. Alva, Akash Patnaik, Jeremy C. Durack, Nancy Stambler, Tess Lin, Jessica Jensen, Vivien Wong, Barry A. Siegel, Michael J. Morris
Summary: The study aimed to evaluate the diagnostic performance of F-18-DCFPyL positron emission tomography/computerized tomography in detecting metastatic sites of prostate cancer. The results showed high specificity and positive predictive value, but moderate sensitivity.
JOURNAL OF UROLOGY
(2021)
Article
Endocrinology & Metabolism
Malin Hagberg Thulin, Jorma Maatta, Anna Linder, Simona Sterbova, Claes Ohlsson, Jan-Erik Damber, Anders Widmark, Emma Persson
Summary: This study demonstrated the effectiveness of the STAT3 inhibitor Napabucasin in impairing metastatic potential of PC cells and preventing metastatic establishment in tibial bones in mice. Napabucasin treatment also significantly reduced tumor burden in established bone CRPC and altered gene expression in the bone marrow niche towards maintenance of hematopoietic stem cells and the myeloid lineage.
Article
Chemistry, Analytical
Yanbo Wang, Mingyang Wang, Haipeng Yu, Ge Wang, Pengxin Ma, Shuang Pang, Yiming Jiao, Aihua Liu
Summary: PSA is an important index for prostate cancer diagnosis and treatment. In this study, a biopanning method for PSA was established using a pIII phage display library. Two phage monoclonal antibodies specific to PSA were obtained, and an ELISA system was constructed for detecting tPSA with high accuracy.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Urology & Nephrology
Jack R. Andrews, Mohamed E. Ahmed, Vidit Sharma, Cameron Britton, Bradley Stish, Ryan Phillips, A. Tuba Kendi, Vidhu B. Joshi, Akshay Sood, Mathew K. Tollefson, Stephen A. Boorjian, R. Jeffery Karnes, Eugene D. Kwon
Summary: This study characterizes the outcomes of metastasis-directed therapy without concurrent androgen deprivation therapy in patients with solitary metastatic lesions in prostate cancer. The results demonstrate that this approach can delay the initiation of systemic therapy and call for further prospective studies in patients with solitary recurrent prostate cancer metastases.
JOURNAL OF UROLOGY
(2022)
Article
Oncology
Juening Kang, Federico La Manna, Francesco Bonollo, Natalie Sampson, Ian L. Alberts, Clemens Mingels, Ali Afshar-Oromieh, George N. Thalmann, Sofia Karkampouna
Summary: During the progression of prostate cancer, particularly in bone metastases, the tumor microenvironment (TME) undergoes changes that support tumor spread and colonization at distant sites. This article discusses the profile of advanced metastatic prostate cancer and genetic alterations. It also explores the role of the TME, particularly the extracellular matrix and fibroblast cells, in different stages of metastatic spread and bone metastasis. Evidence of premetastatic niche formation, stromal similarities between primary prostate cancer and bone metastasis, and the contribution of the TME to androgen deprivation therapy resistance are presented. The article also provides an overview of transgenic mouse models for studying bone metastasis and current diagnostic and therapeutic strategies.
Article
Medicine, Research & Experimental
Fabiola Lili Sarmiento-Salinas, Andrea Perez-Gonzalez, Adilene Acosta-Casique, Adrian Ix-Ballote, Alfonso Diaz, Samuel Trevino, Nora Hilda Rosas-Murrieta, Lourdes Millan-Perez-Pena, Paola Maycotte
Summary: Cancer is a major global cause of death, with the role of reactive oxygen species (ROS) in cancer development and progression being extensively studied. However, conflicting evidence exists regarding the specific impact of ROS on cancer, which may vary depending on the type of cancer and stage of tumorigenesis. Recent research has focused on exploring the diverse aspects of ROS interaction with cancer at different stages of cancer progression.
Article
Oncology
Ofri Doppelt-Flikshtain, Amin Younis, Tal Tamari, Ofir Ginesin, Talia Shentzer-Kutiel, David Nikomarov, Gil Bar-Sela, Benjamin R. Coyac, Yehuda G. Assaraf, Hadar Zigdon-Giladi
Summary: Despite progress in the treatment of various cancers, the prognosis for patients with metastatic osteosarcoma remains poor. This study demonstrated that endothelial progenitor cells (EPCs) play a role in promoting osteosarcoma progression and aggressiveness through non-physical interactions, and revealed a potential underlying molecular mechanism. These findings suggest the possibility of developing EPCs-targeted therapies to inhibit osteosarcoma metastasis and improve treatment efficacy.
Article
Oncology
Daniel J. Herr, David A. Elliott, Gillian Duchesne, Kristian D. Stensland, Megan E. V. Caram, Christina Chapman, Jennifer A. Burns, Brent K. Hollenbeck, Jordan B. Sparks, Chris Shin, Alexander Zaslavsky, Alexander Tsodikov, Ted A. Skolarus
Summary: This study aims to examine the 10-year clinical outcomes of patients with localized prostate cancer undergoing radiation therapy within a national healthcare system. The results showed improved survival rates for high-risk disease, providing important benchmarks for clinical decision-making.
Review
Urology & Nephrology
Jong Hyun Tae, In Ho Chang
Summary: The development of novel treatment agents for bone metastatic prostate cancer relies on understanding the underlying mechanisms of metastasis and treatment resistance. Animal models have played a vital role in cancer research, but current models only partially reproduce the process of bone metastasis. Therefore, knowledge of available models and their limitations is crucial for achieving research objectives.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Oncology
Estefania Labanca, Jun Yang, Peter D. A. Shepherd, Xinhai Wan, Michael W. Starbuck, Leah D. Guerra, Nicolas Anselmino, Juan A. Bizzotto, Jiabin Dong, Arul M. Chinnaiyan, Murali K. Ravoori, Vikas Kundra, Bradley M. Broom, Paul G. Corn, Patricia Troncoso, Geraldine Gueron, Christopher J. Logothethis, Nora M. Navone
Summary: This study found that FGFR1 expression plays an important role in bone metastasis of prostate cancer, and its activity enhanced bone metastasis and survival rate in mice, and the human samples also showed that FGFR1 were enriched in bone metastasis of castration-resistant prostate cancer. In addition, the study also found that the LAD1 protein co-expressed with FGFR1 plays an important role in the bone metastasis of prostate cancer.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mari I. Suominen, Matias Knuuttila, Christoph A. Schatz, Andreas Schlicker, Jukka Vaaraniemi, Birgitta Sjoholm, Esa Alhoniemi, Bernard Haendler, Dominik Mumberg, Sanna-Maria Kakonen, Arne Scholz
Summary: In this study, the antitumor efficacy of radium-223, enzalutamide, and their combination was evaluated in a model of prostate cancer metastasis to bone. The combination treatment showed synergistic efficacy and enhanced antitumor effect in vitro and in vivo without compromising healthy bone integrity. These results support the ongoing phase 3 trial of radium-223 and enzalutamide combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Brian D. Piening, Alexa K. Dowdell, Mengqi Zhang, Bao-Li Loza, David Walls, Hui Gao, Maede Mohebnasab, Yun Rose Li, Eric Elftmann, Eric Wei, Divya Gandla, Hetal Lad, Hassan Chaib, Nancy K. Sweitzer, Mario Deng, Alexandre C. Pereira, Martin Cadeiras, Abraham Shaked, Michael P. Snyder, Brendan J. Keating
Summary: The current clinical standard-of-care for heart transplant acute rejection (AR) relies on histopathological assessment, but this study demonstrates that adding RNA sequencing analysis of endomyocardial biopsies (EMBs) can improve the sensitivity and specificity of diagnosis. Furthermore, the study shows that transcriptional hallmarks of rejection can be detected months before the actual event, which is not visible using traditional histopathology.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Morgan D. Kuczler, Richard C. Zieren, Liang Dong, Theo M. de Reijke, Kenneth J. Pienta, Sarah R. Amend
Summary: This study proposes EV-derived mRNA as a potential diagnostic biomarker for detecting the presence of ccRCC. Four EV-derived mRNA transcripts specific to urine and tumor tissue samples were identified.
Review
Biochemistry & Molecular Biology
Luke Loftus, Sarah R. Amend, Kenneth J. Pienta
Summary: Cell division and cell death are essential processes in growth and development. Cancer is caused by abnormal regulation of these processes, and traditional anti-cancer treatments trigger apoptosis, to which cancer cells are resistant. Understanding how drugs kill cancer cells is crucial for developing more effective treatments. Cell cycle-independent forms of cell death, such as necroptosis or ferroptosis, have potential immunogenic effects, providing alternative strategies against tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Gao Wang, Trung Phan, Shengkai Li, Jing Wang, Yan Peng, Guo Chen, Junle Qu, Daniel Goldman, Simon A. Levin, Kenneth Pienta, Sarah Amend, Robert H. Austin, Liyu Liu
Summary: Experimental robobiological physics explores the impact of genetic diversity and different landscapes on the survival of autonomous robots, shedding light on biological evolution.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Genetics & Heredity
Winston R. Becker, Stephanie A. Nevins, Derek C. Chen, Roxanne Chiu, Aaron M. Horning, Tuhin K. Guha, Rozelle Laquindanum, Meredith Mills, Hassan Chaib, Uri Ladabaum, Teri Longacre, Jeanne Shen, Edward D. Esplin, Anshul Kundaje, James M. Ford, Christina Curtis, Michael P. Snyder, William J. Greenleaf
Summary: Single-cell ATAC-seq and RNA-seq profiling were used to study the transformation process from healthy colon to precancerous adenomas to colorectal cancer. Most of the polyp and CRC cells exhibited a stem-like phenotype. The study identified a continuum of epigenetic and transcriptional changes that occur in stem-like cells as they progress from homeostasis to CRC. The results also revealed the presence of T cell exhaustion and specific fibroblast subtypes in advanced polyps and cancerous states. Additionally, DNA methylation changes were found to be negatively correlated with accessibility changes, providing potential regulatory markers for polyp staging.
Article
Materials Science, Multidisciplinary
A. El Kissani, D. Ait Elhaj, S. Drissi, A. Abali, A. Agdad, H. Ait Dads, L. Nkhaili, A. El Mansouri, H. Chaib, K. El Assali, A. Outzourhit
Summary: This study investigated the deposition of copper-cobalt tin sulfide thin films using a sol-gel spin-coating method. The annealing process at 300 degrees C in a nitrogen atmosphere for 60 minutes was found to produce pure CCTS thin films with promising properties for low-cost thin-film solar cells.
Article
Oncology
Peng Huang, Peter B. Illei, Wilbur Franklin, Pei-Hsun Wu, Patrick M. Forde, Saeed Ashrafinia, Chen Hu, Hamza Khan, Harshna V. Vadvala, Ie-Ming Shih, Richard J. Battafarano, Michael A. Jacobs, Xiangrong Kong, Justine Lewis, Rongkai Yan, Yun Chen, Franck Housseau, Arman Rahmim, Elliot K. Fishman, David S. Ettinger, Kenneth J. Pienta, Denis Wirtz, Malcolm Brock, Stephen Lam, Edward Gabrielson
Summary: There have been few significant advances in predicting lung cancer progression risk after surgical removal of tumor in stage IA non-small-cell lung cancers (NSCLCs). This study developed an integrated deep learning evaluation (IDLE) score that combines preoperative lung CT image findings and postoperative pathologic assessment, which was found to better predict cancer progression risk compared to traditional TNM staging and tumor grade. The improved predictive value of the IDLE score was due to the use of tumor measurements in CT images and microscopic tissue characteristics. integrating measurements from different aspects of tumor morphology can increase prediction accuracy.
Review
Endocrinology & Metabolism
Andrea K. K. Miyahira, Jessica E. E. Hawley, Remi Adelaiye-Ogala, Jeremie Calais, Lucia Nappi, Ravi Parikh, Tyler M. M. Seibert, Elizabeth V. V. Wasmuth, Xiao X. X. Wei, Kenneth J. J. Pienta, Howard R. R. Soule
Summary: This article provides an overview of the 2022 Coffey-Holden Prostate Cancer Academy Meeting, highlighting the major topic areas discussed and summarizing the scientific presentations. The goal is to disseminate this knowledge and contribute to the advancement of global prostate cancer research efforts.
Article
Physics, Condensed Matter
Said Amounas, Abdellah Hbab, Hassan Chaib, Thami Ait-Taleb
Summary: In this study, the structural, electrical, and optical properties of barium titanate (BaTiO3) and lead titanate (PbTiO3) were investigated using the plane wave pseudopotential method and the PBESOL approximation in the framework of density functional theory (DFT). The calculations using different types of pseudopotentials show good agreement with experimental values, especially for ultrasoft pseudopotentials (USPP) and projector-augmented wave (PAW) pseudopotentials.
PHYSICA B-CONDENSED MATTER
(2023)
Review
Oncology
Judd W. Moul, Neal D. Shore, Kenneth J. Pienta, Johannes Czernin, Martin T. King, Stephen J. Freedland
Summary: This narrative review examines the clinical evidence on the utility of next-generation imaging (NGI) for patients with biochemical recurrence (BCR) in prostate cancer. NGI technologies have demonstrated increased sensitivity and selectivity for diagnosing BCR, but limited clinical evidence exists on the application of NGI to treatment decision-making and patient outcomes.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Review
Oncology
Neal D. Shore, Judd W. Moul, Kenneth J. Pienta, Johannes Czernin, Martin T. King, Stephen J. Freedland
Summary: Risk stratification is crucial for the management of patients with biochemical recurrence, as it guides the selection of treatment strategies and estimation of adverse events.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Lisa Welter, Serena Zheng, Sonia Maryam Setayesh, Michael Morikado, Arushi Agrawal, Rafael Nevarez, Amin Naghdloo, Milind Pore, Nikki Higa, Anand Kolatkar, Jana-Aletta Thiele, Priyanka Sharma, Halle C. F. Moore, Jennifer K. Richer, Anthony Elias, Kenneth J. Pienta, Amado J. Zurita, Mitchell E. Gross, Stephanie N. Shishido, James Hicks, Carmen Ruiz Velasco, Peter Kuhn
Summary: In addition to normal blood cells, the blood of cancer patients contains rare cell types associated with the tumor. A liquid biopsy can provide important information about the disease status no matter where it exists in the body. This study describes a method for imaging and characterizing these rare cells in blood samples, and shows that it is valid across different cancer types.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tushar Garg, Rudolf A. Werner, Hyun Woo Chung, Wajahat Khatri, Kenneth J. Pienta, Martin G. Pomper, Michael A. Gorin, Elie Saad, Steven P. Rowe
Summary: The use of prostate-specific membrane antigen targeted PET imaging for the evaluation of prostate cancer has significantly increased in recent decades. PSMA-RADS-3A lesions, which are indeterminate for the presence of disease, are commonly seen. PSA levels can indicate true positivity in patients with PSMA-RADS-3A lesions.
Article
Materials Science, Multidisciplinary
Mourad Najjaoui, Thami Ait-Taleb, Abdelhalim Abdelbaki, Zaki Zrikem, Hassan Chaib
Summary: This study optimizes the geometry of concrete hollow bricks to increase thermal resistance and reduce energy consumption. The aspect ratio does not affect the nature of fluid flow, but it does affect the extension of circulation cells. Cavities with a large aspect ratio significantly reduce heat transfer.
FDMP-FLUID DYNAMICS & MATERIALS PROCESSING
(2022)
Article
Materials Science, Multidisciplinary
Mourad Najjaoui, Thami Ait-taleb, Abdelhalim Abdelbaki, Zaki Zrikem, Hassan Chaib
Summary: This work presents steady-state numerical simulations on heat transfer in hollow blocks, considering the influence of coupled natural convection, conduction, and radiation. The study reveals that the number of holes in the hollow blocks has a significant impact on the heat transfer.
FDMP-FLUID DYNAMICS & MATERIALS PROCESSING
(2022)