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Cell Biology
Rui Chen, Thomas Skutella
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Oncology
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Summary: CDK4/6 inhibitors (CDKis) are effective in treating hormone-receptor-positive breast cancer, but resistance is common. This study found that pretreatment with palbociclib can promote metastasis of CDKi-resistant cancer cells in the lungs by inducing cellular senescence in host tissues. Palbociclib-induced gene expression changes and altered immune populations were observed in the lungs, and senescent endothelial cells were identified in lung metastases. In vitro, palbociclib-treated endothelial cells exhibited senescent features and increased tumor cell migration and invasion. These findings highlight the impact of CDKi-induced cellular senescence on metastasis and provide insights into the tumor microenvironment.
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Cell Biology
Debora Bencivenga, Emanuela Stampone, Angela Vastante, Myassar Barahmeh, Fulvio Della Ragione, Adriana Borriello
Summary: It has been established that a significant portion of the human genome is transcribed, but only a small percentage of the transcripts are translated into proteins. Most of the transcripts belong to different RNA families with various functions, including the long non-coding RNA family. Long non-coding RNAs play important roles in gene regulation, DNA modification, cellular organization, and disease development. This review focuses on the role of long non-coding RNAs in regulating cyclin-dependent kinase inhibitors' levels and activities, which are crucial for cell division control. Despite existing evidence, the importance of long non-coding RNAs in CDKI modulation and cell proliferation control is still underestimated.
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Cell Biology
Hiroyuki Tomita, Kaori Tanaka, Akihiro Hirata, Hideshi Okada, Hisashi Imai, Yohei Shirakami, Kotaro Ohnishi, Shigeyuki Sugie, Hitomi Aoki, Yuichiro Hatano, Kei Noguchi, Tomohiro Kanayama, Ayumi Niwa, Natsuko Suzui, Tatsuhiko Miyazaki, Takuji Tanaka, Haruhiko Akiyama, Masahito Shimizu, Kazuhiro Yoshida, Akira Hara
Summary: The study demonstrates that FGF10-induced IPNB in mice mimics human IPNB phenotypes, with a pathway involving FGF10-FGFR2-RAS-ERK. Inhibition of this pathway suppresses papillary changes and progression of IPNB, making it a potential therapeutic target.
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Pathology
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AMERICAN JOURNAL OF PATHOLOGY
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Developmental Biology
Yumeko Satou, Kohei Minami, Erina Hosono, Hajime Okada, Yuuri Yasuoka, Takashi Shibano, Toshiaki Tanaka, Masanori Taira
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Oncology
Dai Susuki, Sotai Kimura, Seiji Naganuma, Katsuki Tsuchiyama, Toshiaki Tanaka, Naomi Kitamura, Shigeharu Fujieda, Hiroshi Itoh
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Oncology
Hitomi Fujie, Toshiaki Tanaka, Masatoshi Tagawa, Niu Kaijun, Mika Watanabe, Takashi Suzuki, Katsutoshi Nakayama, Muneo Numasaki
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Tomofumi Fujino, Airi Takeuchi, Akiko Maruko-Ohtake, Yosuke Ohtake, Junichi Satoh, Tomonori Kobayashi, Toshiaki Tanaka, Haruka Ito, Ryosuke Sakamaki, Ryo Kashimura, Ken Ando, Tomoko Nishimaki-Mogami, Yasuhito Ohkubo, Naomi Kitamura, Ryuichiro Sato, Kiyomi Kikugawa, Makio Hayakawa
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Biochemistry & Molecular Biology
Hidetaka Tanno, Takeshi Shigematsu, Shuhei Nishikawa, Akira Hayakawa, Kimitoshi Denda, Toshiaki Tanaka, Masayuki Komada
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Cell Biology
Koji Moriya, Miho Tamai, Takumi Koga, Toshiaki Tanaka, Yoh-ichi Tagawa
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Developmental Biology
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DEVELOPMENTAL BIOLOGY
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Meeting Abstract
Cell Biology
M. Hara, Y. Abe, T. Tanaka, T. Kishimoto
MOLECULAR BIOLOGY OF THE CELL
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