Plectin protects podocytes from adriamycin-induced apoptosis and F-actin cytoskeletal disruption through the integrin α6β4/FAK/p38 MAPK pathway

FAK contributes to proteinuria in hypercholesterolaemic rats and modulates podocyte F-actin re-organizationviaactivating p38 in response to ox-LDL

(2016) Mengsi Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes

(2016) Lisa Buvall et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NFκB-Induced Periostin Activates Integrin-β3 Signaling to Promote Renal Injury in GN

(2016) Niki Prakoura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly

(2016) Guilherme P. F. Nader et al.   NATURE CELL BIOLOGY

MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling

(2016) I Lakshmanan et al.   ONCOGENE

Endosomes: Emerging Platforms for Integrin-Mediated FAK Signalling

(2016) Jonna Alanko et al.   TRENDS IN CELL BIOLOGY

Metadherin facilitates podocyte apoptosis in diabetic nephropathy

(2016) Wen-Ting Liu et al.   Cell Death & Disease

GADD45B mediates podocyte injury in zebrafish by activating the ROS-GADD45B-p38 pathway

(2016) Z Chen et al.   Cell Death & Disease

Transient knockdown-mediated deficiency in plectin alters hepatocellular motility in association with activated FAK and Rac1-GTPase

(2015) Chiung-Chi Cheng et al.   Cancer Cell International

Impaired Podocyte Autophagy Exacerbates Proteinuria in Diabetic Nephropathy

(2015) Atsuko Tagawa et al.   DIABETES

Albumin overload down-regulates integrin-β1 through reactive oxygen species-endoplasmic reticulum stress pathway in podocytes

(2015) Yu-Chi Cheng et al.   JOURNAL OF BIOCHEMISTRY

KANK deficiency leads to podocyte dysfunction and nephrotic syndrome

(2015) Heon Yung Gee et al.   JOURNAL OF CLINICAL INVESTIGATION

Podocyte-Specific Deletion of Yes-Associated Protein Causes FSGS and Progressive Renal Failure

(2015) M. Schwartzman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Clinical significance of the integrin α6β4 in human malignancies

(2015) Rachel L Stewart et al.   LABORATORY INVESTIGATION

Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models

(2015) Mario Schiffer et al.   NATURE MEDICINE

Actin cytoskeleton alterations in podocytes: a therapeutic target for chronic kidney disease

(2015) Susan J. Allison   Nature Reviews Nephrology

Structural Insights into Ca 2+ -Calmodulin Regulation of Plectin 1a-Integrin β4 Interaction in Hemidesmosomes

(2015) Jae-Geun Song et al.   STRUCTURE

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers

(2015) Yaming Jiu et al.   Cell Reports

Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis

(2014) Ilse Daehn et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemical chaperone ameliorates pathological protein aggregation in plectin-deficient muscle

(2014) Lilli Winter et al.   JOURNAL OF CLINICAL INVESTIGATION

Fluvastatin attenuated the effect of expression of β1 integrin in PAN-treated podocytes by inhibiting reactive oxygen species

(2014) Jia Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

SYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells

(2014) X Zhou et al.   ONCOGENE

Phosphorylation and nuclear translocation of integrin β4 induced by a chemical small molecule contribute to apoptosis in vascular endothelial cells

(2013) Di Ge et al.   APOPTOSIS

Mechanosensing through focal adhesion-anchored intermediate filaments

(2013) Martin Gregor et al.   FASEB JOURNAL

Inhibition of the TRPC5 ion channel protects the kidney filter

(2013) Thomas Schaldecker et al.   JOURNAL OF CLINICAL INVESTIGATION

Profilin-1 promotes the development of hypertension-induced cardiac hypertrophy

(2013) Shao-hua Zhao et al.   JOURNAL OF HYPERTENSION

Plakins, a Versatile Family of Cytolinkers: Roles in Skin Integrity and in Human Diseases

(2013) Jamal-Eddine Bouameur et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Angiopoietin-Like 3 Induces Podocyte F-Actin Rearrangement through IntegrinαVβ3/FAK/PI3K Pathway-Mediated Rac1 Activation

(2013) Yi Lin et al.   Biomed Research International

Podocyte Biology and Pathogenesis of Kidney Disease

(2012) Jochen Reiser et al.   Annual Review of Medicine

Effect of ouabain on myocardial ultrastructure and cytoskeleton during the development of ventricular hypertrophy

(2012) Shao-hua Zhao et al.   HEART AND VESSELS

Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly

(2012) Evelyne Frijns et al.   MOLECULAR BIOLOGY OF THE CELL

The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis

(2011) Jyotirmoy Ghosh et al.   BIOMATERIALS

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival

(2011) Suma Yaddanapudi et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice

(2011) Harold A. Chapman et al.   JOURNAL OF CLINICAL INVESTIGATION

Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma

(2011) Koji Katada et al.   Journal of Proteomics

Synemin down-regulation in human hepatocellular carcinoma does not destabilize cytoskeletons in vivo

(2010) Yi-Hsiang Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice

(2010) Natalia Papeta et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Podocyte FAK Protects against Proteinuria and Foot Process Effacement

(2010) H. Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

SHP2 Mediates the Localized Activation of Fyn Downstream of the  6 4 Integrin To Promote Carcinoma Invasion

(2010) X. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization

(2009) Takayoshi Niwa et al.   CANCER SCIENCE

Structural basis of the interaction between integrin α6β4 and plectin at the hemidesmosomes

(2009) José M de Pereda et al.   EMBO JOURNAL

Plectin Isoform-dependent Regulation of Keratin-Integrin α6β4 Anchorage via Ca2+/Calmodulin

(2009) Julius Kostan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin ( 6 4) Signals Through Src to Increase Expression of S100A4, a Metastasis-Promoting Factor: Implications for Cancer Cell Invasion

(2009) T. H. Kim et al.   MOLECULAR CANCER RESEARCH

A Key Tyrosine (Y1494) in the β4 Integrin Regulates Multiple Signaling Pathways Important for Tumor Development and Progression

(2008) Udayan Dutta et al.   CANCER RESEARCH

Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (Review)

(2008) Kate L. Wegener et al.   MOLECULAR MEMBRANE BIOLOGY

The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A

(2008) Christian Faul et al.   NATURE MEDICINE