Article
Medicine, General & Internal
Fatema Said, Jozine M. ter Maaten, Pieter Martens, Kevin Vernooy, Mathias Meine, Cornelis P. Allaart, Bastiaan Geelhoed, Marc A. Vos, Maarten J. Cramer, Isabelle C. van Gelder, Wilfried Mullens, Michiel Rienstra, Alexander H. Maass
Summary: Women showed a greater echocardiographic response to CRT at 6 months follow-up in two study cohorts. However, after adjustment for body surface area and ischemic etiology, no differences were found in LV-function measures or survival between women and men, suggesting that non-ischemic etiology may be responsible for the superior response rates seen in women treated with CRT.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Javier Morales, Yehuda Handelsman
Summary: Chronic kidney disease (CKD) and cardiovascular disease (CVD) are significantly related in diabetic patients. Controlling blood pressure, dyslipidemia, and glucose levels is a common treatment approach, but a high residual risk remains. This review focuses on pharmacotherapy for patients, exploring new and existing cardiorenal therapies to reduce cardiovascular risk beyond traditional treatments. Ongoing studies are expected to provide further insights into potential synergistic effects.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Frank Yu, Bianca McLean, Mitesh Badiwala, Filio Billia
Summary: Cardiovascular disease is the leading cause of mortality globally, with heart failure affecting millions of people. The use of metabolomics and lipidomics has improved our understanding of heart failure and revealed new pathways and potential interventions. The discovery of metabolic effects of heart failure drugs, particularly sodium-glucose transport protein 2 inhibitors, has revolutionized the treatment of heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Lubomir T. Lubomirov, Monique Heidrun Jaensch, Symeon Papadopoulos, Mechthild M. Schroeter, Doris Metzler, Maria Bust, Juergen Hescheler, Olaf Grisk, Oliver Ritter, Gabriele Pfitzer
Summary: This study found that senescent murine femoral arteries undergo vascular remodeling associated with increased stretch-activated contractility and sensitivity to the NO/cGMP/PKG system.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Cell Biology
Katarzyna Ptaszynska-Kopczynska, Andrzej Eljaszewicz, Marta Marcinkiewicz-Siemion, Emilia Sawicka-Mmiarowska, Ewa Tarasiuk, Anna Lisowska, Marlena Tynecka, Kamil Grubczak, Urszula Radzikowska, Adrian Janucik, Marcin Moniuszko, Karol Charkiewicz, Piotr Laudanski, Bozena Sobkowicz, Karol A. Kaminski
Summary: The study revealed altered monocyte composition in HFrEF patients, with CRT leading to changes in monocyte subsets that reached levels similar to controls without HFrEF.
Article
Cardiac & Cardiovascular Systems
Robert Pietschner, Agnes Bosch, Dennis Kannenkeril, Kristina Striepe, Mario Schiffer, Stephan Achenbach, Roland E. Schmieder, Julie Kolwelter
Summary: Vascular remodeling and functional impairment in chronic heart failure patients are independent of cardiovascular risk factors.
Review
Cardiac & Cardiovascular Systems
Stefan Frantz, Moritz Jens Hundertmark, Jeanette Schulz-Menger, Frank Michael Bengel, Johann Bauersachs
Summary: Most patients survive acute myocardial infarction, but the prevalence of heart failure is increasing, leading to economic strain on healthcare systems. Pathological changes in the heart significantly impact patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, and female sex can distinctively shape the progression towards heart failure.
EUROPEAN HEART JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Henry Sutanto, Dobromir Dobrev, Jordi Heijman
Summary: The RAAS system plays a crucial role in cardiovascular health and disease, with short-term activation being beneficial but long-term activation detrimental. Natriuretic peptides are activated to counterbalance the effects of RAAS, facilitating water and salt excretion and causing vasodilation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Guoqi Li, Yihui Shao, Hong-Chang Guo, Ying Zhi, Bokang Qiao, Ke Ma, Jie Du, Yong-Qiang Lai, Yulin Li
Summary: miR-27b-3p induces pathological cardiac remodelling and inhibition of endogenous miR-27b-3p or administration of FGF1 might suppress cardiac remodelling.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Mareomi Hamada, Yuji Shigematsu, Shuntaro Ikeda, Kiyotaka Ohshima, Akiyoshi Ogimoto
Summary: Cibenzoline treatment significantly reduced cardiovascular complications and death, especially due to LVHF, in patients with HOCM. LV reverse remodelling was confirmed in Group A, while LV remodelling advanced in Group B.
Article
Cardiac & Cardiovascular Systems
Mareomi Hamada, Yuji Shigematsu, Shuntaro Ikeda, Kiyotaka Ohshima, Akiyoshi Ogimoto
Summary: The study aimed to clarify the long-term effect of cibenzoline therapy on cardiovascular complications and prognosis in patients with hypertrophic obstructive cardiomyopathy (HOCM). It was found that cibenzoline treatment significantly reduced all cardiovascular complications and death due to LVHF, making it a promising treatment for patients with HOCM.
Article
Gastroenterology & Hepatology
Oveis Jamialahmadi, Federica Tavaglione, Araz Rawshani, Charlotta Ljungman, Stefano Romeo
Summary: Sufficient evidence supports the link between fatty liver disease and cardiac dysfunction and remodelling, which can lead to cardiovascular disease and heart failure. This study found that fatty liver disease is independently associated with higher heart rate, cardiac remodelling, and reduced ventricular volumes.
LIVER INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Ziying Lin, Louisa Y. F. Wong, Bernard M. Y. Cheung
Summary: Diuretic-induced hypokalaemia is a common and potentially life-threatening adverse drug reaction, which may lead to cardiovascular events and mortality. The most effective treatments for hypokalaemia include reducing diuretic dose, potassium supplementation, and combining with a potassium-sparing diuretic or blocker of the renin-angiotensin system.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Li Shen, Pardeep Singh Jhund, Kieran Francis Docherty, Muthiah Vaduganathan, Mark Colquhoun Petrie, Akshay Suvas Desai, Lars Kober, Morten Schou, Milton Packer, Scott David Solomon, Xingwei Zhang, John Joseph Valentine McMurray
Summary: Previous guidelines for treating heart failure with reduced ejection fraction recommended initiating therapy in a chronological order based on trial history. However, this study suggests that accelerating treatment titration and optimizing treatment ordering may improve patient outcomes.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Elena Galli, Emmanuel Oger, John M. Aalen, Jurgen Duchenne, Camilla K. Larsen, Elif Sade, Arnaud Hubert, Alban Gallard, Martin Penicka, Cecilia Linde, Virginie Le Rolle, Alfredo Hernandez, Christophe Leclercq, Jens-Uwe Voigt, Otto A. Smiseth, Erwan Donal
Summary: This study investigated the effect of cardiac resynchronization therapy (CRT) on left atrium (LA) morphology and function, and found that LA reservoir strain (LARS) is an independent predictor of left ventricular (LV) systolic and diastolic remodelling after CRT. The study also showed that CRT induced significant improvement in LA volume index (LAVI) and LARS in responders, highlighting the importance of evaluating LARS before CRT in predicting LV remodelling.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Review
Cardiac & Cardiovascular Systems
Floriana Maria Farina, Christian Weber, Donato Santovito
Summary: Most of our genome is transcribed into ncRNAs, including miRNAs, lncRNAs, circRNAs, etc., which play important roles in regulating gene expression at various levels. They are involved in chromatin remodeling, transcriptional regulation, mRNA splicing, stability, and decay, and ultimately affect physiological and pathological mechanisms in vascular biology and atherosclerosis. Recent research has revealed unexpected findings, expanding the functional repertoire of ncRNAs beyond gene regulation and highlighting an additional layer of biological control. This review discusses emerging aspects of ncRNA biology, their implications for vascular biology and atherosclerosis, and possible translational applications.
Review
Cardiac & Cardiovascular Systems
Menno P. J. de Winther, Magnus Back, Paul Evans, Delphine Gomez, Isabel Goncalves, Helle F. Jorgensen, Rory R. Koenen, Esther Lutgens, Giuseppe Danilo Norata, Elena Osto, Lea Dib, Michael Simons, Konstantinos Stellos, Seppo Yla-Herttuala, Holger Winkels, Marie-Luce Bochaton-Piallat, Claudia Monaco
Summary: The advent of single-cell biology has opened up new possibilities for understanding human biological processes and diagnosing, monitoring, and treating diseases, including cardiovascular disease (CVD). By analyzing CVD samples at the single-cell level, new cell communities that play a role in disease development can be identified, leading to new therapeutic strategies. This review focuses on the single-cell analysis of atherosclerotic plaques, highlighting the current understanding of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. The clinical impact of single-cell technologies in CVD patient care is emphasized, calling for multidisciplinary and international collaborative efforts.
EUROPEAN HEART JOURNAL
(2023)
Article
Hematology
Myrthe E. Reiche, Kikkie Poels, Laura A. Bosmans, Winnie G. Vos, Claudia M. van Tiel, Marion J. J. Gijbels, Suzanne A. B. M. Aarts, Myrthe den Toom, Linda Beckers, Christian Weber, Dorothee Atzler, Patrick C. N. Rensen, Sander Kooijman, Esther Lutgens
Summary: The CD40-CD40L dyad has an important role in chronic inflammatory diseases associated with aging. This study found that CD40 is also present on adipocytes. Deficiency of adipocyte CD40 leads to a decrease in bone marrow hematopoietic stem cells, increased T-cell activation, and elevated corticosterone levels, particularly with age. However, adipocyte CD40 deficiency also reduces atherosclerosis burden and ameliorates diet-induced obesity.
Article
Hematology
Christian Weber, Xavier Blanchet, Gregory Y. H. Lip
THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Cardiac & Cardiovascular Systems
Sarajo K. K. Mohanta, Changjun Yin, Christian Weber, Cristina Godinho-Silva, Henrique Veiga-Fernandes, Qian J. J. Xu, Rui B. B. Chang, Andreas J. R. Habenicht
Summary: The cardiovascular system is connected to the brain through complex axonal connections. Two distinct subcircuits, the artery-brain circuit and the heart-brain circuit, have recently been defined. The impact of the nervous system on the progression of cardiovascular disease is not well understood. This review explores the anatomy and inner workings of these subcircuits and discusses the possibility of a systemic cardiovascular brain circuit.
CIRCULATION RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Christian Weber, Andreas J. R. Habenicht, Philipp von Hundelshausen
Summary: This review summarizes recent progress in the therapeutic targeting of inflammatory components in atherosclerosis. Novel strategies, such as interference with the CD40L-CD40 dyad and selective targeting of TRAFs, show potential in reducing atherosclerosis and plaque instability without immune side effects. Additionally, modulation of the chemokine system and disruption of the adventitial neuroimmune cardiovascular interfaces offer promising avenues for intervention beyond anti-inflammatory approaches.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Christine Krammer, Bishan Yang, Sabrina Reichl, Simon Besson-Girard, Hao Ji, Verena Bolini, Corinna Schulte, Heidi Noels, Kai Schlepckow, Georg Jocher, Georg Werner, Michael Willem, Omar El Bounkari, Aphrodite Kapurniotu, Ozgun Gokce, Christian Weber, Sarajo Mohanta, Jurgen Bernhagen
Summary: Atherosclerosis is a chronic inflammatory condition of our arteries and the underlying pathology of heart attacks and strokes. The role of the inflammatory cytokine MIF in the progression of atherosclerosis and its relationship with age and atherogenic cytokines are not fully understood.
Meeting Abstract
Biochemistry & Molecular Biology
Lea Strohm, Steffen Daub, Matthias Oelze, Marin Kuntic, Henning Ubbens, Veronique Klein, Imo E. Hoefer, Alex Von Kriegsheim, Hartmut Kleinert, Christian Weber, Dorothee Atzler, Philipp Wild, Thomas Muenzel, Christoph Knosalla, Esther Lutgens, Andreas Daiber
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Dan-Valentin Pistritu, Anisia-Cristiana Vasiliniuc, Anda Vasiliu, Elena-Florentina Visinescu, Ioana-Elena Visoiu, Smaranda Vizdei, Paula Martinez Anghel, Antoanela Tanca, Octavian Bucur, Elisa Anamaria Liehn
Summary: Phospholipids are important components of cell membranes and have complex structures, high heterogeneity, and critical biological functions. They have been used to treat cardiovascular diseases since ancient times. Recent research has shown the increasing recognition of the roles of phospholipids in the pathophysiology and therapy of cardiovascular diseases. Phospholipids have demonstrated positive effects in protecting myocardial tissue, reducing inflammation and fibrosis, promoting angiogenesis, coagulation, and cardiac regeneration in animal models and human pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yichen Xu, Huabo Zheng, Pakhwan Nilcham, Octavian Bucur, Felix Vogt, Ioana Slabu, Elisa Anamaria Liehn, Mihaela Rusu
Summary: Extracellular collagen remodeling is a central mechanism in maintaining the coherence of myocardium after myocardial infarction. Vitamin C has the potential to modulate collagen fibrillogenesis and improve heart tissue healing. It affects cellular metabolism and the production of reactive oxygen species, while promoting collagen synthesis and tissue healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Claudia Schoenichen, Samantha J. Montague, Sanne L. N. Brouns, James J. Burston, Judith M. E. M. Cosemans, Kerstin Jurk, Beate E. Kehrel, Rory R. Koenen, Fionnuala Ni Ainle, Valerie B. O'Donnell, Oliver Soehnlein, Steve P. Watson, Marijke J. E. Kuijpers, Johan W. M. Heemskerk, Magdolna Nagy
Summary: This study reveals the key interaction mechanisms between platelets and neutrophils in arterial thrombus formation. Activated platelet integrin αIIbβ3 plays a role in preventing leukocyte adhesion, while platelet-released substances promote neutrophil activation. These findings provide insights for potential pharmacological intervention.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anne Cornelissen, Roberta Andreea Florescu, Stefanie Reese, Marek Behr, Anna Ranno, Kiran Manjunatha, Nicole Schaaps, Christian Boehm, Elisa Anamaria Liehn, Liguo Zhao, Pakhwan Nilcham, Andrea Milzi, Jorg Schroeder, Felix Jan Vogt
Summary: This study found that vessel damage caused by stent could be detected by assessing strut indentation. The assessment of strut indentation enables the evaluation of potential vessel injury during stent implantation and allows for optimization of stent implantation techniques.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xavier Blanchet, Christian Weber, Philipp von Hundelshausen
Summary: Chemoattractant cytokines or chemokines are involved in gradient formation and cell recruitment. They interact with their receptors, glycosaminoglycans, and other soluble effector proteins to form complexes. Chemokine dimerization changes their structure and confers additional biological activities. This review provides an overview of chemokine functionality and their interactions with other proteins, as well as potential therapeutic tools targeting chemokine multimeric structures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Julian U. G. Wagner, Lukas S. Tombor, Pedro Felipe Malacarne, Lisa-Maria Kettenhausen, Josefine Panthel, Haris Kujundzic, Nivethitha Manickam, Katja Schmitz, Maria Cipca, Kathrin A. Stilz, Ariane Fischer, Marion Muhly-Reinholz, Wesley T. Abplanalp, David John, Sarajo K. Mohanta, Christian Weber, Andreas J. R. Habenicht, Giulia K. Buchmann, Stephan Angendohr, Ehsan Amin, Katharina Scherschel, Nikolaj Kloecker, Malte Kelm, Dominik Schuettler, Sebastian Clauss, Stefan Guenther, Thomas Boettger, Thomas Braun, Christian Baer, Minh-Duc Pham, Jaya Krishnan, Susanne Hille, Oliver J. Mueller, Tarik Bozoglu, Christian Kupatt, Eleonora Nardini, Selma Osmanagic-Myers, Christian Meyer, Andreas M. Zeiher, Ralf P. Brandes, Guillermo Luxan, Stefanie Dimmeler
Summary: Aging reduces nerve density in the heart and dysregulates vascular-derived neuroregulatory genes, leading to impaired cardiovascular health.
Article
Hematology
M. Christella L. G. D. Thomassen, Bryan R. C. Bouwens, Kanin Wichapong, Dennis P. Suylen, Freek G. Bouwman, Tilman M. Hackeng, Rory R. Koenen
Summary: This study found that PAD4 inactivates TFPI by citrullination of its arginines, and this process is time- and concentration-dependent. Furthermore, inducers of PAD4 blocked the citrullination of TFPI. This process may play a crucial role in the increased thrombosis risk associated with inflammation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)