Article
Radiology, Nuclear Medicine & Medical Imaging
Horacio Murillo, Lior Molvin, Anne S. Chin, Dominik Fleischmann
Summary: Acute aortic dissection is the prototype of acute aortic syndromes, and diagnostic imaging, particularly CT, is crucial for accurate diagnosis and intervention planning. Involvement of the ascending aorta carries the most rapid lethal complications and requires surgical intervention, while lesions not involving the ascending aorta have a lesser rate of complications in the acute phase.
Article
Cardiac & Cardiovascular Systems
Kevin R. An, Charles de Mestral, Derrick Y. Tam, Feng Qiu, Maral Ouzounian, Thomas F. Lindsay, Harindra C. Wijeysundera, Jennifer C-Y Chung
Summary: This study found poor adherence to guideline-directed imaging surveillance following ATAAD repair, while long-term mortality and reinterventions rates remained high. Further research is needed to determine if guidelines should be modified.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Thierry Carrel, Thoralf M. Sundt, Yskert von Kodolitsch, Martin Czerny
Summary: Despite advancements in the prevention, diagnosis, and treatment of acute aortic dissection, it remains a complex cardiovascular event with high mortality and morbidity rates. Recent research has improved our understanding of the disease's pathophysiology and led to reevaluations of existing classifications. There is a shift towards a unified naming system based on morphology and function. The location and extent of the initial tear, as well as the affected aortic segments, determine the appropriate management approach - emergency surgery, endovascular intervention, or medical treatment. Ongoing scientific evidence continues to shape the management and follow-up of acute aortic dissection, the most severe form of acute aortic syndrome.
Article
Cardiac & Cardiovascular Systems
Dane C. Paneitz, Sandeep Hedgire, Arminder S. Jassar
Summary: Collaboration between cardiac surgeons and radiologists is crucial for the diagnosis and treatment of aortic dissection cases. By utilizing advanced imaging technologies and conducting thorough scan evaluations, the accuracy and comprehensiveness of disease diagnosis, as well as the effectiveness of preoperative planning, can be enhanced.
JOURNAL OF CARDIAC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Pieter A. J. van Bakel, Matthew Henry, Karen M. Kim, Bo Yang, Joost A. van Herwaarden, C. Alberto Figueroa, Himanshu J. Patel, David M. Williams, Nicholas S. Burris
Summary: This study investigated the association between renal enhancement and renal malperfusion in patients with aortic dissection. The findings suggest that differential enhancement of the kidney on computed tomography angiography can predict the presence of renal malperfusion. However, the diagnosis of renal malperfusion requires close monitoring and often invasive assessment.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Anja Forrer, Felix Schoenrath, Michael Torzewski, Jens Schmid, Urlich F. W. Franke, Nora Goebel, Drahomir Aujesky, Christian M. Matter, Thomas F. Luscher, Francois Mach, David Nanchen, Nicolas Rodondi, Volkmar Falk, Arnold von Eckardstein, Joanna Gawinecka
Summary: IL-10 shows potential to be a rule-in biomarker for acute aortic dissection, while the addition of PAI1 and IL-6 to hs-TnT and D-dimers may improve the discrimination of suspected AAD, AMI, and PE in patients presenting with acute chest pain.
Editorial Material
Medicine, General & Internal
Jayson R. Baman, S. Chris Malaisrie
Summary: This article describes aortic dissection, a condition characterized by a tear in the aorta, and discusses its diagnosis and treatment.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Xinyu Hao, Shuai Cheng, Bo Jiang, Shijie Xin
Summary: Acute aortic dissection is a sudden and fatal cardiovascular disease with a lack of specific early symptoms, leading to difficulty in diagnosis and treatment. It is crucial to find and utilize unique biomarkers for AAD in clinical practice and research. The advancement of omics technologies and integration of histology data have made this goal attainable over the past 20 years.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Changcun Fang, Shan Gao, Xiao Ren, Xinyan Pang, Xin Zhao, Zengshan Ma, Chen Wang, Kai Liu
Summary: The adventitial eversion and prosthesis eversion technique for proximal anastomosis in AAAD patients showed advantages such as shorter operation time, cardiopulmonary bypass time, aortic cross-clamp time, and decreased fresh frozen plasma transfusion requirements.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Chien-Hua Chen, Cheng-Li Lin, Chia-Hung Kao
Summary: This nationwide population-based cohort study found that patients with gallstone disease (GD) have a greater risk of aortic dissection (AD) or aortic aneurysm (AN) compared to those without GD, but the risk decreases after cholecystectomy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jody Shen, Domenico Mastrodicasa, Yarab Al Bulushi, Margaret C. Lin, Justin R. Tse, Amelia C. Watkins, Jason T. Lee, Dominik Fleischmann
Summary: Aortic dissection is a chronic disease that requires lifelong clinical and imaging surveillance. Important anatomic features at preprocedural imaging influence the treatment strategy. Challenges of repair in the chronic phase include a small true lumen, complex anatomy, and retrograde perfusion from distal reentry tears.
Editorial Material
Medicine, General & Internal
Irbaz Hameed, Adam S. Cifu, Prashanth Vallabhajosyula
Summary: This JAMA Clinical Guidelines Synopsis provides a summary of the 2021 guidelines from the American Association for Thoracic Surgery and the Society of Thoracic Surgeons on the management of type A and type B thoracic aortic dissection.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aishwarya Gulati, Harit Kapoor, Achala Donuru, Kunal Gala, Maansi Parekh
Summary: Aortoenteric fistulas are rare but potentially fatal, often associated with trauma or vascular interventions, but can also occur spontaneously in patients with weakened vasculature. Clinical presentation is nonspecific, with manifestations such as bleeding, pain, fever, and shock. Imaging plays a crucial role in diagnosis and management.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuehuan Zhang, Dianpeng Wang, Xuyang Zhang, Shichao Liang, Ziheng Wu, Zipeng Wen, Yiannis Ventikos, Jiang Xiong, Duanduan Chen
Summary: This study aimed to establish a predictive model for distal stent-induced new entry (distal SINE) after thoracic endovascular aortic repair (TEVAR) based on preoperative data. Two predictive models were developed and validated using CT-based measurements and calculations. These models can assist in evaluating the risk of distal SINE and aid in personalized treatment planning.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lauren Huckaby, Ibrahim Sultan, Santi Trimarchi, Bradley Leshnower, Edward P. Chen, Derek R. Brinster, Truls Myrmel, Anthony L. Estrera, Daniel G. Montgomery, Amit Korach, Hans -Henning Eckstein, Joseph S. Coselli, Takeyoshi Ota, Clayton A. Kaiser, Kim A. Eagle, Himanshu J. Patel, Thomas G. Gleason
Summary: In-hospital mortality remains higher among women with TAAD but shows improvement in the last decade. Significant differences in presentation were noted in women, including older age and greater evidence of malperfusion. Although no distinctions in 5-year mortality or reintervention were observed, a tailored surgical approach should be considered to reduce sex disparities in early mortality rates for TAAD.
ANNALS OF THORACIC SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Daniela Carnevale, Giuseppe Lembo
Summary: Our body continuously interacts with the external environment through the nervous system and the immune system to maintain homeostasis; the integration of these two systems provides a unique opportunity to regulate the body's internal balance.
CARDIOVASCULAR RESEARCH
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Sara Perrotta, Daniela Carnevale
CARDIOVASCULAR RESEARCH
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Lorenzo Carnevale, Raimondo Carnevale, Francesco Mastroiacovo, Giuseppe Cifelli, Daniela Carnevale, Giuseppe Lembo
CARDIOVASCULAR RESEARCH
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Giuseppe Lembo, Marialuisa Perrotta
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Marialuisa Perrotta, Daniela Carnevale
Summary: Hypertension is a multifactorial disease with pathophysiological mechanisms involving not only classical factors but also the immune system. Studies have shown the important role of neuroimmune interactions in hypertension, with specific brain areas modulating immune responses playing a crucial role in the development of high blood pressure.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Editorial Material
Peripheral Vascular Disease
Daniela Carnevale
Article
Peripheral Vascular Disease
Daniela Carnevale, Lorenzo Carnevale, Sara Perrotta, Fabio Pallante, Agnese Migliaccio, Daniele Iodice, Marialuisa Perrotta, Giuseppe Lembo
Summary: Chronic exposure to high blood pressure leads to vascular remodeling, dysfunction, and inflammation through the interaction between vascular and immune cells. Establishing a reliable experimental model of the vascular-immune interface is crucial for developing effective therapies.
Article
Nutrition & Dietetics
Alessandra D'Amico, Elena Cavarretta, Chiara Fossati, Paolo Borrione, Fabio Pigozzi, Giacomo Frati, Sebastiano Sciarretta, Vincenzo Costa, Fabrizio De Grandis, Antonia Nigro, Mariangela Peruzzi, Fabio Miraldi, Wael Saade, Antonella Calogero, Paolo Rosa, Gioacchino Galardo, Lorenzo Loffredo, Pasquale Pignatelli, Cristina Nocella, Roberto Carnevale
Summary: This study aimed to explore the relationship between platelet activation, oxidative stress, and muscular injuries in elite football players compared to amateur athletes during physical exercise. The results showed that elite football players were more susceptible to muscle damage induced by oxidative stress compared to amateur athletes.
Article
Biochemistry & Molecular Biology
Francesco Versaci, Valentina Valenti, Maurizio Forte, Vittoria Cammisotto, Cristina Nocella, Simona Bartimoccia, Leonardo Schirone, Sonia Schiavon, Daniele Vecchio, Luca D'Ambrosio, Giulia Spinosa, Alessandra D'Amico, Isotta Chimenti, Francesco Violi, Giacomo Frati, Pasquale Pignatelli, Sebastiano Sciarretta, Daniele Pastori, Roberto Carnevale
Summary: This study provides evidence that the autophagy process may represent a mechanism for increased cardiovascular risk in the AF population, and demonstrates its correlation with oxidative stress, platelet activation, and endothelial dysfunction.
Review
Peripheral Vascular Disease
Monica M. Santisteban, Costantino Iadecola, Daniela Carnevale
Summary: Hypertension is a significant risk factor for vascular cognitive impairment and late-life dementia. It induces various harmful effects on cerebral vasculature and can disrupt blood-brain barrier integrity, leading to cognitive impairment.
Article
Cardiac & Cardiovascular Systems
Mateusz Siedlinski, Lorenzo Carnevale, Xiaoguang Xu, Daniela Carnevale, Evangelos Evangelou, Mark J. Caulfield, Pasquale Maffia, Joanna Wardlaw, Nilesh J. Samani, Maciej Tomaszewski, Giuseppe Lembo, Michael Holmes, Tomasz J. Guzik
Summary: Observational and genetic data were used to study the relationship between blood pressure and cognitive function. The study identified brain structures associated with blood pressure and found that higher systolic blood pressure may have an adverse effect on cognitive function. These findings contribute to our understanding of the negative impact of hypertension on cognitive performance.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Peripheral Vascular Disease
Sara Perrotta, Daniela Carnevale