Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 13, Issue 1, Pages 54-60Publisher
WILEY
DOI: 10.1111/j.1582-4934.2008.00520.x
Keywords
microRNA; drosha; dicer; Microprocessor; exportin-5
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Funding
- American Heart Association
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM086701] Funding Source: NIH RePORTER
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MicroRNAs (miRNA) are small RNAs that regulate the translation of thousands of message RNAs and play a profound role in mammalian biology. Over the past 5 years, significant advances have been made towards understanding the pathways that generate miRNAs and the mechanisms by which miRNAs exert their regulatory functions. An emerging theme is that miRNAs are both generated by and utilized by large and complex macromolecular assemblies. Here, we review the biology of mammalian miRNAs with a focus on the macromolecular complexes that generate and control the biogenesis of miRNAs.
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