Article
Materials Science, Ceramics
Monika Furko, Rainer Detsch, Istvan Tolnai, Katalin Balazsi, Aldo R. Boccaccini, Csaba Balazsi
Summary: A biomimetic mineralized (Mg, Zn, Sr) carbonated amorphous calcium phosphate (cACP) coating containing biodegradable polycaprolactone (PCL) was prepared using spin coating technology. The PCL provided a controlled release of cACP and acted as a bioadhesive, improving adherence compared to pure cACP powder. The cACP coatings and the cACP-PCL composite showed increased cell viability and biocompatibility on a titanium alloy substrate.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Physical
Hung-Yang Lin, Yi-Jung Lu, Hsin-Hua Chou, Keng-Liang Ou, Bai-Hung Huang, Wen-Chien Lan, Takashi Saito, Yung-Chieh Cho, Yu-Hsin Ou, Tzu-Sen Yang, Pei-Wen Peng
Summary: This study successfully synthesized biphasic calcium phosphate ceramics from coral, which showed good biocompatibility and was non-cytotoxic. Different from autogenous bone, this ceramic did not induce significant differences in local tissue reaction.
Article
Biophysics
Fupo He, Jin Rao, Jielin Zhou, Wenhao Fu, Yao Wang, Yihang Zhang, Fei Zuo, Haishan Shi
Summary: Magnesium calcium phosphate composite bioceramic scaffolds were fabricated using 3D printing technology with Mg3(PO4)2 and β-Ca3(PO4)2 as starting materials. The porosity and compressive strength of the scaffolds could be adjusted by altering the sintering temperature and the formula of starting materials. The Ca3Mg3(PO4)4-based bioceramic scaffolds, prepared from 60 wt% Mg3(PO4)2 and 40 wt% β-Ca3(PO4)2, showed the highest compressive strength and stimulated cellular growth and osteoblastic differentiation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Ceramics
Zilgma Irbe, Dagnija Loca
Summary: Premixed calcium phosphate cement pastes have been proposed as biomaterials for bone tissue repair and regeneration, with alpha-Tricalcium phosphate (alpha-TCP) based cements setting to form calcium deficient hydroxyapatite. The use of mixture of basic and acidic potassium phosphate salts showed the best overall results in terms of cohesion, pH value, hydrolysis, and compressive strength of the cement.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Enrique Frayssinet, Lucas Colabella, Adrian P. Cisilino
Summary: This study evaluates the biomimetic capabilities of the Voronoi-based cancellous bone microstructure and adjusts the generative process to account for anisotropy and elastic properties. The results show that the mimetic microstructures have histomorphometric features and elastic properties that are in very good accordance to those of the natural samples. This work is a step towards integrating the Voronoi-based microstructure into multiscale design tools.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Engineering, Biomedical
Matheus C. Tronco, Julia B. Cassel, Luis A. dos Santos
Summary: This review paper focuses on the synthesis and properties of alpha-tricalcium phosphate (alpha TCP), a promising material for bone repair and substitution. It discusses the complexity of alpha TCP synthesis, the impact of synthesis parameters on material properties, and provides guidance for selecting the most suitable process for each application.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Wei Zhi, Xiaohua Wang, Dong Sun, Taijun Chen, Bo Yuan, Xiangfeng Li, Xuening Chen, Jianxin Wang, Zhao Xie, Xiangdong Zhu, Kai Zhang, Xingdong Zhang
Summary: This study successfully repaired large segmental bone defects in a goat femur model by combining osteoinductive biphasic calcium phosphate (BCP) bioceramic scaffolds with intramedullary nail fixation. The results showed that the BCP scaffold promoted cell proliferation and osteogenic differentiation, and the intramedullary nail fixation maintained stability and structural integrity of the implants. Good integration of the implants with host bone and complete bone substitution in the defect area were observed at 9 and 18 months postoperatively, respectively.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Multidisciplinary
Irina S. Fadeeva, Anastasia Yu. Teterina, Vladislav V. Minaychev, Anatoliy S. Senotov, Igor V. Smirnov, Roman S. Fadeev, Polina V. Smirnova, Vladislav O. Menukhov, Yana V. Lomovskaya, Vladimir S. Akatov, Sergey M. Barinov, Vladimir S. Komlev
Summary: This study proposes a method to develop composite biomimetic bone material for reconstructive surgery through deposition (remineralization) of calcium phosphate layers on high-purity, demineralized bone collagen matrix. The results show reproduction of bone tissue matrix architectonics and high-purity collagen scaffolds, as well as high biocompatibility of the materials obtained. Various analysis techniques confirm the efficiency of calcium phosphate deposition on the surface of bone collagen scaffolds. Heterotopic implantation experiments in rats demonstrate that remineralized bone collagen matrices have a higher osteostimulating ability compared to demineralized ones, indicating the potential for creating effective osteoplastic materials for bone tissue regeneration and augmentation.
Article
Engineering, Biomedical
Fupo He, Chao Qiu, Teliang Lu, Xuetao Shi, Jiandong Ye
Summary: In this study, tricalcium phosphate (TCP) bioceramics were modified by gallium doping in conjunction with incorporation of calcium silicate (CS). The results showed that the incorporation of CS promoted the transition and densification process of the bioceramics, and reduced the inhibition effect of gallium on osteoblast activities while maintaining its effect on restraining osteoclast activities.
BIOMEDICAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Albena Daskalova, Liliya Angelova, Anton Trifonov, Marie Lasgorceix, Stephane Hocquet, Mendy Minne, Heidi Declercq, Anne Leriche, Dante Aceti, Ivan Buchvarov
Summary: This study focused on improving the morphological properties of the surface of β-TCP pellets using an innovative laser-based technique. The research found that the patterned surface of the material had an impact on cell behavior.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Biomedical
Pan Jin, Lei Liu, Lin Cheng, Xichi Chen, Shanshan Xi, Tongmeng Jiang
Summary: Calcium phosphate bioceramics, such as hydroxyapatite, biphasic calcium phosphate, and beta-tricalcium phosphate, have been widely used for bone reconstruction. This study investigated the osteoconductivity and osteoinductivity of these bioceramics through in vitro and in vivo experiments. The results showed that the osteoblast differentiation ranking was BCP > beta-TCP > HA, while the mesenchymal stem cell differentiation ranking was beta-TCP > BCP > HA. In vivo experiments demonstrated that calvarial defect repair ranking was BCP > beta-TCP >= HA, while intramuscular implantation ranking was beta-TCP >= BCP > HA. The Ca/P ratio surrounding the bioceramics was found to affect their osteoconductivity and osteoinductivity, emphasizing the importance of manipulating this ratio in bone tissue engineering.
BIOMEDICAL ENGINEERING ONLINE
(2023)
Article
Engineering, Biomedical
B. Le Gars Santoni, L. Niggli, S. Dolder, O. Loeffel, G. A. Sblendorio, R. Heuberger, Y. Maazouz, C. Staehli, N. Doebelin, P. Bowen, W. Hofstetter, M. Bohner
Summary: This study assessed the effect of small fractions of β-CPP on the in vitro osteoclastic resorption of β-TCP and found that β-CPP fractions significantly inhibited the resorption of β-TCP. The study also examined the impact of β-CPP and HA impurities on the physico-chemical properties of β-TCP powders and sintered cylinders.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Samit K. Nandi, Mangal Roy, Amit Bandyopadhyay, Susmita Bose
Summary: The study evaluated the effects of strontium and magnesium doping on the bone healing performance of brushite cement in a rabbit model. The results showed that the addition of SrO and MgO significantly enhanced new bone formation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Engineering, Biomedical
Alaa Mansour, Lina Abu Nada, Amir A. El-hadad, Mohamed Amine Mezour, Ala' Ersheidat, Ahmed Al-Subaie, Hanan Moussa, Marco Laurenti, Mari T. Kaartinen, Faleh Tamimi
Summary: The bone regenerative capacity of synthetic calcium phosphates can be enhanced by enriching them with metal trace ions found in natural bone hydroxyapatite. This study demonstrates that bioceramic scaffolds made from natural hydroxyapatite can outperform those made from synthetic apatite in terms of in vivo bone regeneration. The research provides new insights for developing biomimetic CaPs and highlights the importance of the inorganic phase and composition of bone in regenerative properties of natural bone xenografts.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Claire Guillet, Ulrik Birgersson, Thomas Engstrand, Jonas aberg, Viviana R. Lopes, Andreas Thor, Hakan Engqvist, Franck Forterre
Summary: This study explores bone neoformation beyond the skeletal envelope using a collagen pouch filled with calcium phosphate granules placed over the frontal bone in sheep. The results show colonization of the implant by newly formed bone and fibrous connective tissue. The use of a collagen sleeve as a container for calcium phosphate granules allows for good neoformation and bridging bone formation between the test article and recipient bone. This method opens new perspectives for bone augmentation and treatment of cranio-maxillofacial defects and malformations.
BIOMEDICAL MATERIALS
(2023)