Journal
JOURNAL OF CELL BIOLOGY
Volume 205, Issue 4, Pages 447-455Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201312029
Keywords
-
Categories
Funding
- Mach-Gaensslen Foundation of Canada through the COPSE (Comite d'organisation du programme des stages d'ete)
- Faculte de medecine de l'Universite de Montreal
- Fonds de Recherche du Quebec-Sante (FRQS)
- City of Paris
- French National Research Agency [ANR-2012-BSV2-0001-01]
- Canadian Institutes of Health Research [2300431]
- Canadian Center of Excellence in Commercialization and Research
- Canada Foundation for Innovation
- FRQS
Ask authors/readers for more resources
Regulation of cell cycle duration is critical during development, yet the underlying molecular mechanisms are still poorly understood. The two-cell stage Caenorhabditis elegans embryo divides asynchronously and thus provides a powerful context in which to study regulation of cell cycle timing during development. Using genetic analysis and high-resolution imaging, we found that deoxyribonucleic acid (DNA) replication is asymmetrically regulated in the two-cell stage embryo and that the PAR-4 and PAR-1 polarity proteins dampen DNA replication dynamics specifically in the posterior blastomere, independently of regulators previously implicated in the control of cell cycle timing. Our results demonstrate that accurate control of DNA replication is crucial during C. elegans early embryonic development and further provide a novel mechanism by which PAR proteins control cell cycle progression during asynchronous cell division.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available