Article
Biochemistry & Molecular Biology
Jisu Im, Tamara Hillenaar, Hui Ying Yeoh, Priyanka Sahasrabudhe, Marjolein Mijnders, Marcel van Willigen, Azib Hagos, Eduardo de Mattos, Peter van der Sluijs, Ineke Braakman
Summary: We have discovered the sequential events involved in the proper folding of the ABC transporter CFTR, a large multi-domain, multi-spanning membrane protein. Our study revealed that CFTR folds in two distinct stages: a co-translational stage involving the folding of certain domains, followed by a post-translational stage involving the assembly of these domains. We also investigated the effects of mutations on CFTR folding and found that a disease-causing mutation disrupted the first stage of folding, but not the second stage, which could be rescued by corrector drugs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell Biology
Xue Tan, Lingling Zhang, Tianqi Li, Jianmin Zhan, Kun Qiao, Haili Wu, Shenfei Sun, Meina Huang, Fangxi Zhang, Meixing Zhang, Changwei Li, Runsheng Li, Hongjie Pan
Summary: The WNT signaling pathway plays a crucial role in the development of fallopian tubes in mice, with LGR4 regulating epithelial secretion and affecting tube size and cell number. This regulation is mediated by modulation of the WNT pathway and changes in gene expression profiles of epithelial cells. Additionally, activation of the WNT pathway triggers the expression of steroidogenic genes through the transcription factor NR5A2, facilitating epithelial secretory cell maturation and steroidogenesis for fallopian tube development and function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Shuo Wan, Xiaoqiang Sun, Wenyan Tang, Lifu Wang, Zhongdao Wu, Xi Sun
Summary: The study revealed that excretory-secretory products of Angiostrongylus cantonensis fourth stage larva could induce metabolic reprogramming in macrophages, leading to alternative activation of macrophages and worsening of eosinophilic meningitis. This finding highlights the importance of helminth-derived immunoregulatory molecules in immune-related diseases and potential drug development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mingyue Tan, Qi Pan, Hua Gong, Xinyu Zhai, Zhong Wan, Minyao Ge, Jianyi Gu, Dingguo Zhang, Xia Chen, Dongliang Xu
Summary: This study reveals the oncogenic role of small nucleolar RNA host gene 15 (SNHG15) in bladder cancer (BLCA). The novel super-enhancer of SNHG15 (SNHG15-SEs) was found to recruit transcription factor FOSL1 and promote the expression of SNHG15, leading to the activation of WNT/CTNNB1 pathway and malignance of BLCA cells.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Shana M. M. Augustin, Alexa L. L. Gracias, Guoxiang Luo, Rishitha C. C. Anumola, David M. M. Lovinger
Summary: Mice lacking the DGLα gene displayed weakened rewarding effects of ethanol and reduced eCB inhibition induced by ethanol. Additionally, these mice showed a decrease in ethanol preference and an increase in ethanol-induced water consumption in a male-specific manner. These findings reveal a novel role for dMSN mediated 2-AG signaling in modulating ethanol effects on presynaptic function and behavior.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Zhuo Li, Zhiwen Lian, Jianchao Ma, Li Zhang, Xingji Lian, Shuangxin Liu, Jianteng Xie, Zhonglin Feng, Ting Lin, Hong Zhang, Xinling Liang
Summary: The axis formed by ITG beta 3, RhoA, and YAP plays a crucial role in podocyte injury induced by high glucose exposure. ITG beta 3 overexpression promotes podocyte injury by inhibiting the RhoA-YAP axis, while ITG beta 3 inhibition mitigates the ability of wound closure and apoptosis in podocytes under high glucose conditions.
Article
Medicine, General & Internal
Yanyan Sun, Xing Zhu, Kaiyi Zhu, Jie Yu, Lin Cheng, Mingyan Hei
Summary: The study finds that HMGB1 promotes the polarization of microglia to the M1 phenotype under oxygen-glucose deprivation (OGD) conditions by activating the RAGE-PI3K/Akt signaling pathway. Inhibition of HMGB1 or the RAGE-PI3K/Akt pathway attenuates the imbalanced polarization of microglia and reduces the release of pro-inflammatory factors.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Food Science & Technology
Yu Wan, Lijun Mo, Haibin Huang, Lifen Mo, Wei Zhu, Wenxue Li, Guangyu Yang, Linquan Chen, Yongning Wu, Jia Song, Xingfen Yang
Summary: Chronic cadmium exposure contributes to the progression of atherosclerosis by promoting inflammation and macrophage polarization to M1 phenotype. The activation of JAK2/STAT3 pathway and up-regulation of interleukin-6 (IL-6) play important roles in this process.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Hong-Chieh Tsai, Han-Hsing Tsou, Chun-Chi Lin, Shao-Chen Chen, Hsiao-Wei Cheng, Tsung-Yun Liu, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Shih-Ching Chang, Hao-Wei Teng, Hsiang-Tsai Wang
Summary: Colorectal cancer is a well-known malignancy with high prevalence and poor 5-year survival, and a high-fat diet may increase the odds of developing this cancer. Acrolein plays a crucial role in oncogenic transformation through activation of the RAS/MAPK signaling pathway in colon tumorigenesis.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Haonan Zhang, Chengcheng He, Xuxue Guo, Yuxin Fang, Qiuhua Lai, Xinke Wang, Xingzhu Pan, Haolin Li, Kaiwen Qin, Aimin Li, Side Liu, Qingyuan Li
Summary: DDX39B has been found to play a pivotal role in the proliferation of human colorectal cancer cells by promoting the cell cycle transition and upregulating the expression of CDK6/CCND1, suggesting it could be a potential therapeutic target.
CELL DEATH DISCOVERY
(2022)
Article
Clinical Neurology
Yousong Su, Lu Yang, Zezhi Li, Weidi Wang, Mengjuan Xing, Yu Fang, Ying Cheng, Guan Ning Lin, Donghong Cui
Summary: The neurodevelopmental hypothesis of schizophrenia is widely accepted, with focus on the ASAH1 and NGF genes. However, evidence of their association with schizophrenia is inconclusive, and their interactions in schizophrenia have not been extensively studied. Through genetic analysis, certain SNPs were found to affect susceptibility to schizophrenia, and interactions between ASAH1, NGF, and CaMK2B in the neurotrophin signaling pathway may contribute to schizophrenia susceptibility and psychopathology.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Quanwei Li, Kai Zhang, Limin Hou, Jianzhao Liao, Hui Zhang, Qingyue Han, Jianying Guo, Ying Li, Lianmei Hu, Jiaqiang Pan, Wenlan Yu, Zhaoxin Tang
Summary: This study investigated the mechanism of endoplasmic reticulum stress-mediated pyroptosis in diabetic nephropathy and validated the expression of related factors in a large dog model and MDCK cells. The results showed that endoplasmic reticulum stress promotes pyroptosis through the NF-κB/NLRP3 pathway.
Article
Biochemistry & Molecular Biology
Yarong Guo, Bao Chai, Junmei Jia, Mudan Yang, Yanjun Li, Rui Zhang, Shunmin Wang, Jun Xu
Summary: The dysregulation of KLF7 is involved in the development of various cancers, but its association with hepatocellular carcinoma (HCC) remains unclear. This study found that the KLF7/VPS35 axis promotes HCC cell progression by activating the Ccdc85c-mediated beta-catenin pathway, suggesting that targeting this signal axis could be a potential treatment strategy for HCC.
CELL AND BIOSCIENCE
(2021)
Article
Endocrinology & Metabolism
Yang Liu, Junyan Ma, Liqi Zhang, Jun Lin, Xiaohua Liu
Summary: The expression of MPS-1 is significantly higher in endometrioma patients compared to those without the condition. Knocking down MPS-1 inhibits proliferation, migration, and invasion of ectopic endometrial stromal cells (EcESCs), resulting in cell cycle arrest and apoptosis in the G0/G1 phase, as well as suppression of the NF-kappa B signaling pathway.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Cell Biology
Yining Xu, Teng Yao, Haonan Ni, Rujie Zheng, Kangmao Huang, Yizhen Huang, Jun Gao, Di Qiao, Shuying Shen, Jianjun Ma
Summary: Recent studies have identified circSIPA1L1 as an upregulated circular RNA in osteosarcoma, which acts as a molecular sponge for miR-411-5p to increase RAB9A expression, promoting tumorigenesis. Silencing circSIPA1L1 attenuates the malignant properties of OS cells, and inhibition of miR-411-5p or overexpression of RAB9A reverses the anti-tumor effects caused by circSIPA1L1 knockdown.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)