Article
Medicine, Research & Experimental
Karina Motta Melo, Luiz Fernando Silva Oliveira, Rossineide Martins da Rocha, Maria Auxiliadora Pantoja Ferreira, Maria Luiza Fascineli, Susana Suely Rodrigues Milhomem-Paixao, Cesar Koppe Grisolia, Alberdan Silva Santos, Hugo Leonardo Crisostomo Salgado, Luiz Alexandre Muehlmann, Ricardo Bentes Azevedo, Julio Cesar Pieczarka, Cleusa Yoshiko Nagamachi
Summary: This study investigated the potential of andiroba oil (AO) and a nanoemulsion of andiroba oil (AN) to reduce the side effects of Doxorubicin (DOX) in treating cancer. It was found that andiroba oil reduced the severity of lesions caused by DOX, decreasing hematotoxicity and histological changes, while also reducing apoptotic cell death. In some cases, the nanoemulsion AN showed greater efficacy than AO alone, highlighting the potential of nanotechnology to improve the pharmacokinetics of lipid compounds in the body.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, General & Internal
Francisco Tustumi
Summary: This article discusses non-conventional treatments for achalasia, including cardiectomy, endoluminal substances injection, stents, and drugs. Currently available studies on non-conventional treatments lack high-quality evidence, and future randomized trials are still needed.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Emily Romanoff, Justin Zhuo, Annsa C. Huang, Deron Amador, Fouad Otaki, Afrin N. Kamal, Priya Kathpalia, David A. Leiman
Summary: This study aimed to determine adherence to established quality indicators for achalasia management. Through a retrospective multicenter evaluation, it was found that there is incomplete adherence to quality indicators in the diagnosis and treatment of achalasia, particularly in patient education.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Review
Medicine, General & Internal
Edoardo Savarino, Shobna Bhatia, Sabine Roman, Daniel Sifrim, Jan Tack, Sarah K. Thompson, C. Prakash Gyawali
Summary: Achalasia is a rare disorder of the oesophageal smooth muscle characterized by impaired relaxation of the lower oesophageal sphincter (LES) and absent or spastic contractions in the oesophageal body. It can affect individuals of all ages and both sexes, with symptoms including dysphagia, regurgitation, chest pain, and weight loss. Diagnosis involves endoscopy, high-resolution manometry, and/or barium radiography. Treatment options include pharmacotherapy, botulinum toxin injection, and surgical procedures.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Gastroenterology & Hepatology
Matteo Ghisa, Giorgio Laserra, Elisa Marabotto, Sebastiano Ziola, Salvatore Tolone, Nicola de Bortoli, Marzio Frazzoni, Aurelio Mauro, Roberto Penagini, Vincenzo Savarino, Brigida Barberio, Edoardo Giovanni Giannini, Patrizia Zentilin, C. Prakash Gyawali, Edoardo Savarino
Summary: Achalasia and obstructive motor disorders were found in almost 15% of patients with EoE, suggesting that esophageal eosinophilia might be causing these disorders. Patients who do not respond to standard treatments may require targeted muscle disruption.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Surgery
Alexander J. Podboy, Joo Ha Hwang, Homero Rivas, Dan Azagury, Mary Hawn, James Lau, Afrin Kamal, Shai Friedland, George Triadafilopoulos, Thomas Zikos, John O. Clarke
Summary: This study compared the long-term clinical efficacy of POEM versus HM for the treatment of achalasia. The results showed that both procedures have similar long-term efficacy, adverse event rates, and reflux rates, with POEM showing greater efficacy in Type III Achalasia.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Microbiology
Natalia Salomao, Kissila Rabelo, Elyzabeth Avvad-Portari, Carlos Basilio-de-Oliveira, Rodrigo Basilio-de-Oliveira, Fatima Ferreira, Luiz Ferreira, Thiara Manuele de Souza, Priscila Nunes, Monique Lima, Anna Paula Sales, Regina Fernandes, Luiz Jose de Souza, Laura Dias, Patricia Brasil, Flavia dos Santos, Marciano Paes
Summary: This study investigates the role of placenta in the transmission of CHIKV and the effects of infection on the maternal-fetal interface. Results show that CHIKV infection disrupts placental homeostasis, leading to histopathological alterations and increased cellularity and cytokine release, creating an altered and harmful environment for the pregnant woman and fetus.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maysaa Abdulla, Christer Sundstrom, Cecilia Lindskog, Peter Hollander
Summary: The study aimed to investigate the expression patterns of IDO1 and PD-L2 in benign lymphadenopathies in patients with autoimmune diseases (AD) compared to patients without AD. The results showed that IDO1 and PD-L2 were generally expressed by leukocytes to low degrees, while follicular IDO1+ cells were very rare. Five patients had IDO1+ cells in single germinal centers, and there was a high co-occurrence of follicular EBV+ cells in these cases. Significant correlations were found between interfollicular EBV+ cells and interfollicular IDO1+ cells, as well as follicular IDO1+ cells. High or low amounts of IDO1+ or PD-L2+ cells were not statistically significantly associated with patients with AD. However, the lymphadenopathy with the highest amount of interfollicular IDO1+ cells, which was also the only lymphadenopathy in which endothelial cells expressed IDO1, was in a patient with sarcoidosis. This study supports the induction of IDO1 expression by EBV and suggests that future studies on IDO1 and PD-L2 should consider their role in inflammatory and malignant conditions.
Article
Environmental Sciences
Abd El-Nasser A. Madboli, Mohamed M. Seif
Summary: This study aimed to investigate the impact of CdCl2 toxicity on NF-B P65 and the anti-inflammatory effect of purslane plant extract. The results showed that CdCl2 induced damage to ovarian and brain tissues, while purslane plant protected rats and decreased the presence of NF-B P65.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Yasmine H. Ahmed, Huda O. AbuBakr, Ismail M. Ahmad, Zainab Sabry Othman Ahmed
Summary: The harmful effects of the herbicide ATZ on the brain and submandibular salivary gland of adult male albino rats are mainly due to oxidative stress, leading to damage such as cell degeneration, DNA fragmentation, and altered gene expression.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Surgery
Arielle M. Lee, Josefin Holmgren, Ryan C. Broderick, Joslin N. Cheverie, Bryan J. Sandler, Garth R. Jacobsen, Wilson T. Kwong, David C. Kunkel, Santiago Horgan
Summary: This study evaluated the utility of EUS in distinguishing primary achalasia from opioid-induced achalasia. The results showed significant differences in esophageal muscle layer thickness and length between opioid users and non-opioid users, as well as variations in intervention rates and symptom resolution post-therapy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Cardiac & Cardiovascular Systems
Valentina Tassi, Marialuisa Lugaresi, Benedetta Mattioli, Niccolo Daddi, Vladimiro Pilotti, Luca Ferruzzi, Maurizio Longaroni, Sandro Mattioli
Summary: The study compared pull-down Heller-Dor and esophagectomy for end-stage achalasia patients in terms of quality of life and objective outcomes. The results showed no significant differences in dysphagia, reflux symptoms, or esophagitis, but pull-down Heller-Dor had better outcomes in physical functioning, emotional functioning, vitality, mental health, and social functioning compared to esophagectomy.
ANNALS OF THORACIC SURGERY
(2022)
Article
Agriculture, Dairy & Animal Science
Iwona Otrocka-Domagala, Katarzyna Pazdzior-Czapula, Joanna Fiedorowicz, Mateusz Mikiewicz, Agnieszka Piotrowska, Michal Gesek
Summary: This study evaluated the incidence of cutaneous tumors in small mammals pets from 2014-2021, finding that malignant tumors constitute a significant percentage in many species of small mammal pets, emphasizing the importance of sampling each cutaneous tumor for further diagnosis and treatment.
Article
Agriculture, Dairy & Animal Science
Veronica Molina-Hernandez, Maria T. Ruiz-Campillo, Francisco J. Martinez-Moreno, Leandro Buffoni, Alvaro Martinez-Moreno, Rafael Zafra, Maria J. Bautista, Alejandro Escamilla, Raul Perez-Caballero, Jose Perez
Summary: The study evaluated hepatic lesions in sheep vaccinated with a partly protective vaccine, a non-protective vaccine, and an infected control group. The partially protective vaccine group showed less severe hepatic lesions compared to the infected control group, with dead flukes surrounded by severe granulomatous inflammation observed in the protective vaccine group. This finding suggests that the host response induced by the vaccine may have contributed to the death of adult flukes.
Article
Infectious Diseases
Tais M. Wilson, Jana M. Ritter, Roosecelis B. Martines, Alexandra A. B. Goncalves, Pamela Fair, Renee Galloway, Zachary Weiner, Alessandro P. M. Romano, Gabriela R. T. Costa, Cristiano B. Melo, Sherif R. Zaki, Marcio B. Castro
Summary: Leptospirosis is a zoonotic neglected disease with global public health concern, leading to a spectrum of disease in a wide range of wild and domestic mammals. A fatal Leptospira interrogans infection in a free-ranging black-tufted marmoset was reported for the first time, with main findings of icterus, pulmonary haemorrhage, interstitial nephritis, and hepatocellular dissociation. The study discusses the One Health-related implications of free-ranging NHPs in anthropized areas and transmission dynamics of human and animal leptospirosis.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Pathology
Amy A. Lo, Juehua Gao, M. Sambasivia Rao, Guang-Yu Yang
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2016)
Article
Endocrinology & Metabolism
Anton E. Ludvik, Carolina M. Pusec, Medha Priyadarshini, Anthony R. Angueira, Cong Guo, Amy Lo, Korri S. Hershenhouse, Guang-Yu Yang, Xianzhong Ding, Timothy E. Reddy, William L. Lowe, Brian T. Layden
Article
Gastroenterology & Hepatology
Rajesh N. Keswani, Ryan Law, Jody D. Ciolino, Amy A. Lo, Adam B. Gluskin, David J. Bentrem, Sri Komanduri, Jennifer A. Pacheco, David Grande, William K. Thompson
GASTROINTESTINAL ENDOSCOPY
(2016)
Article
Oncology
Danielle Mandikian, Nene Takahashi, Amy A. Lo, Ji Li, Jeffrey Eastham-Anderson, Dionysos Slaga, Jason Ho, Maria Hristopoulos, Robyn Clark, Klara Totpal, Kedan Lin, Sean B. Joseph, Mark S. Dennis, Saileta Prabhu, Teemu T. Junttila, C. Andrew Boswell
MOLECULAR CANCER THERAPEUTICS
(2018)
Article
Cell Biology
Dionysos Slaga, Diego Ellerman, T. Noelle Lombana, Rajesh Vij, Ji Li, Maria Hristopoulos, Robyn Clark, Jennifer Johnston, Amy Shelton, Elaine Mai, Kapil Gadkar, Amy A. Lo, James T. Koerber, Klara Totpal, Rodney Prell, Genee Lee, Christoph Spiess, Teemu T. Junttila
SCIENCE TRANSLATIONAL MEDICINE
(2018)
Review
Oncology
Jan Hudecek, Leonie Voorwerk, Maartje van Seijen, Iris Nederlof, Michiel de Maaker, Jose van den Berg, Koen K. van de Vijver, Karolina Sikorska, Sylvia Adams, Sandra Demaria, Giuseppe Viale, Torsten O. Nielsen, Sunil S. Badve, Stefan Michiels, William Fraser Symmans, Christos Sotiriou, David L. Rimm, Stephen M. Hewitt, Carsten Denkert, Sibylle Loibl, Sherene Loi, John M. S. Bartlett, Giancarlo Pruneri, Deborah A. Dillon, Maggie C. U. Cheang, Andrew Tutt, Jacqueline A. Hall, Zuzana Kos, Roberto Salgado, Marleen Kok, Hugo M. Horlings
Article
Oncology
Zuzana Kos, Elvire Roblin, Rim S. Kim, Stefan Michiels, Brandon D. Gallas, Weijie Chen, Koen K. van de Vijver, Shom Goel, Sylvia Adams, Sandra Demaria, Giuseppe Viale, Torsten O. Nielsen, Sunil S. Badve, W. Fraser Symmans, Christos Sotiriou, David L. Rimm, Stephen Hewitt, Carsten Denkert, Sibylle Loibl, Stephen J. Luen, John M. S. Bartlett, Peter Savas, Giancarlo Pruneri, Deborah A. Dillon, Maggie Chon U. Cheang, Andrew Tutt, Jacqueline A. Hall, Marleen Kok, Hugo M. Horlings, Anant Madabhushi, Jeroen van der Laak, Francesco Ciompi, Anne-Vibeke Laenkholm, Enrique Bellolio, Tina Gruosso, Stephen B. Fox, Juan Carlos Araya, Giuseppe Floris, Jan Hudecek, Leonie Voorwerk, Andrew H. Beck, Jen Kerner, Denis Larsimont, Sabine Declercq, Gert Van den Eynden, Lajos Pusztai, Anna Ehinger, Wentao Yang, Khalid AbdulJabbar, Yinyin Yuan, Rajendra Singh, Crispin Hiley, Maise al Bakir, Alexander J. Lazar, Stephen Naber, Stephan Wienert, Miluska Castillo, Giuseppe Curigliano, Maria-Vittoria Dieci, Fabrice Andre, Charles Swanton, Jorge Reis-Filho, Joseph Sparano, Eva Balslev, I-Chun Chen, Elisabeth Ida Specht Stovgaard, Katherine Pogue-Geile, Kim R. M. Blenman, Frederique Penault-Llorca, Stuart Schnitt, Sunil R. Lakhani, Anne Vincent-Salomon, Federico Rojo, Jeremy P. Braybrooke, Matthew G. Hanna, M. Teresa Soler-Monso, Daniel Bethmann, Carlos A. Castaneda, Karen Willard-Gallo, Ashish Sharma, Huang-Chun Lien, Susan Fineberg, Jeppe Thagaard, Laura Comerma, Paula Gonzalez-Ericsson, Edi Brogi, Sherene Loi, Joel Saltz, Frederick Klaushen, Lee Cooper, Mohamed Amgad, David A. Moore, Roberto Salgado
Article
Pathology
Manana Javey, Christina Reinsch, Mirjam Feldkamp, Sandra Siemann, Anja Blueher, Corinna Woestmann, Lingling Cai, Ian Tran, Theresa May, Charles Havnar, Amy A. Lo, Bernd Hinzmann, Gabrielle Heilek, John F. Palma
Summary: This study compared the performance of an automated tissue dissection tool with manual dissection methods in FFPE tissue specimens, with the automated method resulting in significantly higher yields of nucleic acids and proteins. The downstream analysis showed highly concordant results for EGFR mutation testing and significantly higher allelic frequencies for next-generation sequencing when tissue was dissected by the automated method.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2021)
Article
Oncology
Amy A. Lo, Jennifer Johnston, Ji Li, Danielle Mandikian, Maria Hristopoulos, Robyn Clark, Dorothee Nickles, Wei-Ching Liang, Kathy Hotzel, Debra Dunlap, Thinh Pham, Hao Cai, Meric Ovacik, Daniel Bravo-Perez, Elaine Mai, Dionysos Slaga, Diego Ellerman, James Ziai, Klara Totpal, Genee Lee, C. Andrew Boswell, Jian Payandeh, Yan Wu, Teemu T. Junttila
Summary: LYPD1 is a novel target for therapeutic antibodies for the treatment of ovarian cancer, showing broad expression in both primary and metastatic ovarian cancer, particularly in the serous cancer subset. The anti-LYPD1/CD3 T-cell-dependent bispecific antibody demonstrates significant clinical activity in inducing T-cell responses and killing LYPD1 expressing ovarian cancer cells with efficient anti-tumor responses in preclinical studies.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Oncology
Amy A. Lo, Andrew Wallace, Daniel Oreper, Nicolas Lounsbury, Charles Havnar, Ximo Pechuan-Jorge, Thomas D. Wu, Richard Bourgon, Ryan Jones, Katrina Krogh, Guang-Yu Yang, Oliver A. Zill
Summary: The distribution of clonal neoantigens varies across different cancer types, and factors influencing neoantigen targeting include tumor type, multilesion sampling, neoantigen expression, and HLA allele retention. Prioritizing mutations with higher purity-adjusted and ploidy-adjusted variant allele frequency enriches for globally clonal neoantigens.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Andrew Wallace, Sima P. Porten, Amy A. Lo, Daniel Oreper, Nicolas Lounsbury, Charles Havnar, Ximo Pechuan-Jorge, Oliver A. Zill, Maxwell V. Meng
Summary: This study analyzed the genomic alterations and molecular pathways associated with renal cell carcinoma (RCC) with venous tumor thrombus (VTT) and distant metastasis. The results showed that VTT did not have specific genomic alterations, while metastasis and disease recurrence were associated with certain copy-number alterations and secondary driver alterations. The study also found that metastasis generally occurred before VTT, with the earliest metastases predicted to emerge years before diagnosis. Furthermore, VTT upregulated immediate-early genes and transcriptional targets of the TNF alpha/NF-kappa B pathway, while metastases upregulated MTOR and transcriptional targets downstream of mTORC1 activation.
MOLECULAR CANCER RESEARCH
(2022)
Article
Oncology
Peiyin Wang, Liping L. Sun, Robyn Clark, Maria Hristopoulos, Cecilia P. C. Chiu, Michael Dillon, WeiYu Lin, Amy A. Lo, Sreedevi Chalsani, Meghna Das Thakur, Kristin M. Zimmerman Savill, Lionel Rouge, Patrick Lupardus, Robert Piskol, Bushra Husain, Diego Ellerman, Vittal Shivva, Steven R. Leong, Meric Ovacik, Klara Totpal, Yan Wu, Christoph Spiess, Genee Lee, Douglas D. Leipold, Andrew G. Polson
Summary: New discoveries in the treatment of colorectal cancer have shown significant clinical improvements, but certain subsets of patients still do not benefit from current immune modulators. This article describes the development of a novel T-cell-dependent bispecific antibody (TDB) that targets colorectal cancer. The antibody demonstrates potent antitumor activity and enhanced efficacy when combined with PD-1 blockade. These findings provide evidence for the therapeutic potential of LY6G6D-TDB in colorectal cancer.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Oncology
Robyn Silberman, David F. Steiner, Amy A. Lo, Adam Gomez, James L. Zehnder, Gilbert Chu, Carlos J. Suarez
JCO PRECISION ONCOLOGY
(2019)
Review
Pathology
Shona Hendry, Roberto Salgado, Thomas Gevaert, Prudence A. Russell, Tom John, Bibhusal Thapa, Michael Christie, Koen van de Vijver, M. V Estrada, Paula I Gonzalez-Ericsson, Melinda Sanders, Benjamin sss Solomon, Cinzia Solinas, Gert G. G. M. Van den Eynden, Yves Allory, Matthias Preusser, Johannes Hainfellner, Giancarlo Pruneri, Andrea Vingiani, Sandra Demaria, Fraser Symmans, Paolo Nuciforo, Laura Comerma, E. A. Thompson, Sunil Lakhani, Seong-Rim Kim, Stuart Schnitt, Cecile Colpaert, Christos Sotiriou, Stefan J. Scherer, Michail Ignatiadis, Sunil Badve, Robert H. Pierce, Giuseppe Viale, Nicolas Sirtaine, Frederique Penault-Llorca, Tomohagu Sugie, Susan Fineberg, Soonmyung Paik, Ashok Srinivasan, Andrea Richardson, Yihong Wang, Ewa Chmielik, Jane Brock, Douglas B. Johnson, Justin Balko, Stephan Wienert, Veerle Bossuyt, Stefan Michiels, Nils Ternes, Nicole Burchardi, Stephen J. Luen, Peter Savas, Frederick Klauschen, Peter H. Watson, Brad H. Nelson, Carmen Criscitiello, Sandra O'Toole, Denis Larsimont, Roland de Wind, Giuseppe Curigliano, Fabrice Andre, Magali Lacroix-Triki, Mark van de Vijver, Federico Rojo, Giuseppe Floris, Shahinaz Bedri, Joseph Sparano, David Rimm, Torsten Nielsen, Zuzana Kos, Stephen Hewitt, Baljit Singh, Gelareh Farshid, Sibylle Loibl, Kimberly H. Allison, Nadine Tung, Sylvia Adams, Karen Willard-Gallo, Hugo M. Horlings, Leena Gandhi, Andre Moreira, Fred Hirsch, Maria V. Dieci, Maria Urbanowicz, Iva Brcic, Konstanty Korski, Fabien Gaire, Hartmut Koeppen, Amy Lo, Jennifer Giltnane, Marlon C. Rebelatto, Keith E. Steele, Jiping Zha, Kenneth Emancipator, Jonathan W. Juco, Carsten Denkert, Jorge Reis-Filho, Sherene Loi, Stephen B. Fox
ADVANCES IN ANATOMIC PATHOLOGY
(2017)