Article
Biotechnology & Applied Microbiology
Mi Tian, Xiaoyu Zhang, Weijun Jian, Ling Sun, Yang Shen, Xingtao Zhou
Summary: This study evaluated the long-term efficacy and safety of accelerated transepithelial corneal crosslinking (ATE-CXL) for patients with post-laser-assisted in situ keratomileusis (LASIK) ectasia. Results showed improvements in corrected distance visual acuity (CDVA) and stabilization in corneal keratometry and posterior elevation after ATE-CXL treatment, indicating that ATE-CXL is a safe and effective treatment option for progressive post-LASIK ectasia.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Ayesha Gulzar, Erdost Yildiz, Humeyra N. Kaleli, Muhammad A. Nazeer, Noushin Zibandeh, Anjum N. Malik, Ayse Y. Tas, Ismail Lazoglu, Afsun Sahin, Seda Kizilel
Summary: This study proposes a new method for corneal crosslinking using a ruthenium-based water-soluble photoinitiator and visible light. The results demonstrate that the ruthenium-based approach has superior biomechanical properties, biocompatibility, and optical transparency compared to the riboflavin/UV-A method. It offers a promising non-surgical therapy option for all ectatic corneal pathologies.
ACTA BIOMATERIALIA
(2022)
Article
Medicine, General & Internal
Sami Saad, Rana Saad, Isabelle Goemaere, Roxane Cuyaubere, Marie Borderie, Vincent Borderie, Nacim Bouheraoua
Summary: This retrospective study compared the outcomes of accelerated corneal crosslinking (A-CXL) and iontophoresis corneal crosslinking (I-CXL) in the treatment of progressive keratoconus. The results showed that A-CXL was more effective than I-CXL in stabilizing the condition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiangjun Wang, Bo Zhang, Zhiwei Li, Mengyao Li, Jia Wang, Guoying Mu
Summary: The study assessed the keratectasia volume (KEV) before and after corneal cross-linking (CXL) in pediatric patients. The support vector machine (SVM) algorithm was used to calculate the KEV from corneal topography. There was a strong positive correlation between KEV and the maximum keratometry (Kmax). KEV showed a more drastic decreasing trend compared to Kmax at the 6th month after surgery.
JOURNAL OF DIGITAL IMAGING
(2023)
Review
Pharmacology & Pharmacy
Danyi Qin, Yi Han, Lixiang Wang, Hongbo Yin
Summary: Corneal crosslinking (CXL) is a technique that strengthens corneal collagen fibers to prevent changes in corneal shape, and it has undergone significant improvements over the past few decades. CXL involves various materials, and summarizing these materials provides a comprehensive understanding of the technique. Innovations in the use of existing materials or the development of new materials can further enhance the safety, effectiveness, stability, and applicability of CXL, benefiting patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Ophthalmology
Julia Friedrich, Alexandra Sandner, Ali Nasseri, Mathias Maier, Daniel Zapp
Summary: The study showed that accelerated corneal cross-linking (ACXL) is an effective and safe treatment for patients with progressive keratoconus. Long-term follow-ups (56 months) demonstrated improvements in functional and tomographical outcomes, with stability observed during the final year. The treatment failure rate was 4%.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Samantha Bradford, Shangbang Luo, Donald Brown, Tibor Juhasz, James Jester
Summary: This review analyzes the research findings on the effects and mechanisms of using UVA CXL in the treatment of corneal ectasia and Keratoconus. While some effects are widely accepted, others are still controversial. Understanding and analyzing these effects and mechanisms are essential for predicting treatment outcomes.
Article
Ophthalmology
Marcony R. Santhiago, J. Bradley Randleman
Summary: Corneal crosslinking (CXL) surgery halts the progression of keratoconus through a photochemical reaction involving UV light and riboflavin-induced apoptosis of corneal cells. The stiffening effect of CXL primarily occurs in the anterior third of the cornea, and shorter irradiation times may not have the same biological effect.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Engineering, Biomedical
Hamed Hatami-Marbini, Md Esharuzzaman Emu
Summary: Corneal collagen crosslinking (CXL) is a treatment option that improves the mechanical properties of the cornea. This study aimed to characterize the effects of CXL on the viscoelastic shear properties of the porcine cornea. The results showed that the shear properties were dependent on shear strain magnitude, loading frequency, and compressive strain. CXL treatment significantly increased the shear storage and loss moduli.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Ophthalmology
Ofri Vorobichik Berar, Michael Rotenberg, Yoav Berger, Adham Matani, Noa Avni-Zauberman, Irina S. Barequet
Summary: This study reports the efficacy and safety of repeated CXL for significant progression of keratoconus after a single CXL procedure. The results show that repeated CXL can stabilize the condition and prevent visual deterioration, making it a safe and effective treatment option, especially for young patients.
Article
Engineering, Biomedical
Nils Wilharm, Marko Bertmer, Wolfgang Knolle, Jan Griebel, Christian Elsner, Stefan G. Mayr
Summary: Energetic electrons can be used for crosslinking bio-derived hydrogels without adding potentially hazardous reagents. This study provides a detailed analysis of the reaction kinetics between hydroxyl radicals and collagen, elastin, glycine, and l-lysine. The results show that energetic electron-based crosslinking enables the synthesis of highly biomimetic and compatible hybrid hydrogels.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Madison E. Bates, Leia Troop, M. Ethan Brown, Jennifer L. Puetzer
Summary: The application of exogenous LOX protein significantly improves the mechanical performance of tissue engineered constructs, with timing of application being crucial. This study provides insights into the cellular regulation of LOX crosslinking.
ACTA BIOMATERIALIA
(2023)
Review
Cell Biology
Yanhong Hou, Felix Bock, Deniz Hos, Claus Cursiefen
Summary: Lymphangiogenesis in the cornea is a critical risk factor for allograft rejection, and modulating lymphatic trafficking may promote corneal graft survival. Inhibition of lymphangiogenesis or regression of existing lymphatic vessels has been shown to improve transplant survival. Blocking antigen presenting cell trafficking to lymph nodes can also enhance allograft survival in high-risk eyes.
Article
Biochemical Research Methods
Zhenzhou Cheng, Nan Zhang, Le Chang, Pengfei Qi, Lin Zhang, Lie Lin, Yan Wang, Weiwei Liu
Summary: Myopia and keratoconus are common corneal diseases that affect human vision. Collagen crosslinking (CXL) using riboflavin and ultraviolet A (UVA) light is an effective treatment, but it has risks. This study introduces a new method using near-infrared femtosecond laser to perform two-photon CXL, which enhances corneal stiffness without affecting transparency.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Materials Science, Characterization & Testing
Luca Salvatore, Emanuela Calo, Valentina Bonfrate, Deborah Pedone, Nunzia Gallo, Maria Lucia Natali, Alessandro Sannino, Marta Madaghiele
Summary: The optimization of collagen-based scaffolds for tissue engineering involves careful selection of crosslinking methods to achieve the desired properties without negatively impacting cellular responses. Different crosslinking treatments led to varying degrees of chemical and elastic effective crosslink density. EDC treatment promoted intramolecular crosslinks and intermolecular crosslinks, resulting in higher denaturation temperature and lower elastic effective crosslink density compared to aldehyde-based treatments. There was a correlation between denaturation temperature and chemical effective crosslink density, as well as water uptake and elastic effective crosslink density. An exponential relationship was also found between elastic effective crosslink density and in vitro half-life.
Article
Ophthalmology
Cosimo Mazzotta, Farhad Hafezi, George Kymionis, Stefano Caragiuli, Soosan Jacob, Claudio Traversi, Stefano Barabino, J. Bradley Randleman
Letter
Ophthalmology
Farhad Hafezi, Sabine Kling
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2016)
Article
Ophthalmology
Alireza Peyman, Alireza Nouralishahi, Farhad Hafezi, Sabine Kling, Mohamadreza Peyman
JOURNAL OF REFRACTIVE SURGERY
(2016)
Article
Ophthalmology
Zisis Gatzioufas, Frederik Raiskup, David O'Brart, Eberhard Spoerl, Georgios D. Panos, Farhad Hafezi
JOURNAL OF REFRACTIVE SURGERY
(2016)
Article
Ophthalmology
Lyndon da Cruz, Jessy D. Dorn, Mark S. Humayun, Gislin Dagnelie, James Handa, Pierre-Olivier Barale, Jose-Alain Sahel, Paulo E. Stanga, Farhad Hafezi, Avinoam B. Safran, Joel Salzmann, Arturo Santos, David Birch, Rand Spencer, Artur V. Cideciyan, Eugene de Juan, Jacque L. Duncan, Dean Eliott, Amani Fawzi, Lisa C. Olmos de Koo, Allen C. Ho, Gary Brown, Julia Haller, Carl Regillo, Lucian V. Del Priore, Aries Arditi, Robert J. Greenberg
Article
Ophthalmology
R. Ghaffari, M. Mortazavi, P. Anvari, A. Salamat Rad, F. Alipour, F. Hafezi, S. Asgari, H. Hashemi
Article
Ophthalmology
Sabine Kling, Farhad Hafezi
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2017)
Article
Ophthalmology
Sabine Kling, Arthur Hammer, Emilio A. Torres Netto, Farhad Hafezi
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2017)
Article
Ophthalmology
Paul Z. Lang, Praneetha Thulasi, Sumitra S. Khandelwal, Farhad Hafezi, J. Bradley Randleman
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2018)
Article
Ophthalmology
Boris Knyazer, Yonit Krakauer, Yael Baumfeld, Tova Lifshitz, Sabine Kling, Farhad Hafezi
Article
Ophthalmology
Ilyse D. Haberman, Paul Z. Lang, Alvaro Fidalgo Broncano, Sang Woo Kim, Farhad Hafezi, J. Bradley Randleman
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2018)
Article
Ophthalmology
Ramon Lee, Farhad Hafezi, J. Bradley Randleman
JOURNAL OF REFRACTIVE SURGERY
(2018)
Article
Ophthalmology
Bogdan Spiru, Sabine Kling, Farhad Hafezi, Walter Sekundo
JOURNAL OF REFRACTIVE SURGERY
(2018)
Article
Ophthalmology
David Tabibian, Begona M. de Tejada, Zisis Gatzioufas, Sabine Kling, Vanessa S. Meiss, Marc-Olivier Bold, Veronique Othenin-Girard, Antonina Chilin, Julien Lambiel, Florence Hoogewoud, Farhad Hafezi
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Mohammad Miraftab, Hassan Hashemi, Farhad Hafezi, Soheila Asgari