Review
Biotechnology & Applied Microbiology
R. Sahaya Glingston, Jyoti Yadav, Jitika Rajpoot, Neha Joshi, Shirisha Nagotu
Summary: Yeast has been proven to be a valuable model system for studying viral infection and expression of viral proteins, advancing our understanding of important viruses. Through high-throughput analysis, genetic manipulation, and its compact genome, yeast provides insights into various aspects related to virus replication.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lois Mourrain, Guylain Boissonneault
Summary: Understanding DNA repair pathways is crucial for maintaining genetic integrity, especially in haploid and diploid organisms, where differences in repair capacity may lead to distinct transgenerational outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Nuoya Wang, Yuyan Zhu, Ruixue Zhu, Yue Xiao, Jinghong Qiu, Yanping Wu, Kai Zhong, Hong Gao
Summary: This study aimed to explore the interaction between S. cerevisiae and S. pombe on the quality of cider fermentation. The results showed that the optimal fermentation temperature promoted the growth of yeasts and accelerated the fermentation progress, while ensuring the safety and quality of cider. Co-fermentation degraded malic acid, reduced acidity, adjusted polyphenol content, decreased bitterness, and improved the diversity and richness of volatile compounds. Transcriptomic analysis revealed that differentially expressed genes in co-fermentation were mainly enriched in carbohydrate and amino acid metabolism.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Phillip Minnaar, Neil Jolly, Louisa Beukes, Santiago Benito-Saez
Summary: Research has shown that wines and vinegars produced through different fermentation methods have varying pH levels, total acidity, soluble solids, and concentrations of specific compounds such as phenolic acids and malic acid. The selection of different fermenting agents can have a significant impact on the composition of the final product, with some combinations resulting in higher levels of certain acids and compounds. The choice of acetic acid bacteria for acetous fermentation may need to be reconsidered based on the findings of this study.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Review
Biotechnology & Applied Microbiology
Mariana Hernandez-Elvira, Per Sunnerhagen
Summary: To remain competitive, cells need to balance growth and proliferation with stress protection. Different levels of gene expression control are engaged in stress responses depending on the time scale of stress exposure. Post-transcriptional control is appropriate for minute-scale responses to transient stress and recovery. It regulates the turnover rate, translational activity, covalent modifications, and subcellular localization of RNA species through multiple cellular pathways to achieve appropriate signaling intensity, avoid undue triggering of stress-activated pathways, and timely down-regulate the response.
FEMS YEAST RESEARCH
(2022)
Article
Multidisciplinary Sciences
Maria Angeles Marquez-Monino, Raquel Ortega-Garcia, Megan L. Shipton, Elsa Franco-Echevarria, Andrew M. Riley, Julia Sanz-Aparicio, Barry V. L. Potter, Beatriz Gonzalez
Summary: DDP1 is a Nudix enzyme that exhibits activity on various substrates, with the molecular basis for its activity and different substrate binding modes revealed in this study. The findings have implications for inositide research and inhibitor design.
Article
Biochemistry & Molecular Biology
Kunal Chatterjee, William A. Marshall, Anita K. Hopper
Summary: This study identifies a new tRNA nuclear exporter and reveals exporter preferences for specific tRNA families. Additionally, it demonstrates the importance of tRNA nuclear import in tRNA quality control.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Mayuki Sasaki, Shinichi Nishimura, Yoko Yashiroda, Akihisa Matsuyama, Hideaki Kakeya, Minoru Yoshida
Summary: FKBP12 promotes serine utilization, regulates isoleucine biosynthesis, and negatively regulates threonine deaminase Tda1 in fission yeast, playing important roles in amino acid biosynthesis and nitrogen metabolism homeostasis.
Review
Genetics & Heredity
Junsoo Oh, Soojin Yeom, Jiyeon Park, Jung-Shin Lee
Summary: Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are good models for heterochromatin study, although they have different mechanisms for heterochromatin formation and maintenance, they share important common features in the heterochromatin structural proteins.
EPIGENETICS & CHROMATIN
(2022)
Article
Genetics & Heredity
R. Blake Billmyre, Michael T. Eickbush, Caroline J. Craig, Jeffrey J. Lange, Christopher Wood, Rachel M. Helston, Sarah E. Zanders
Summary: This study developed a high-throughput insertional mutagenesis approach to identify genes involved in sexual reproduction in fission yeast. They identified hundreds of novel genes contributing to sexual reproduction, including some that affect spore viability and others that are required for growth in low-density conditions. This research provides valuable insights into the genetic contributions to sexual reproduction and identifies potential candidate genes in other eukaryotes, including humans.
Article
Biochemistry & Molecular Biology
Io Yamamoto, Hidenori Nakaoka, Masahiro Takikawa, Sanki Tashiro, Junko Kanoh, Tomoichiro Miyoshi, Fuyuki Ishikawa
Summary: The telomere binding protein Stn1 plays a crucial role in maintaining the stability of repetitive DNAs at subtelomeres and rDNA regions. Lack of Stn1 results in dynamic rearrangements in telomere-proximal regions of subtelomere and ribosomal DNA repeats. Additionally, Stn1 is involved in the maintenance of arrested replication forks in coordination with the replication fork barrier-forming protein Reb1.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yusuke Oizumi, Takuto Kaji, Sanki Tashiro, Yumiko Takeshita, Yuko Date, Junko Kanoh
Summary: The complete sequences of subtelomeric homologous (SH) regions of the fission yeast Schizosaccharomyces pombe were reported, revealing highly polymorphic and hot spots for genome variation features. These subtelomeric regions may contribute to genome diversity and potentially lead to various diseases.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Philipp Gaugler, Robin Schneider, Guizhen Liu, Danye Qu, Jonathan Weber, Jochen Schmid, Nikolaus Jork, Markus Haener, Kevin Ritter, Nicolas Fernandez-Rebollo, Ricardo F. H. Giehl, Minh Nguyen Trung, Ranjana Yadav, Dorothea Fiedler, Verena Gaugler, Henning J. Jessen, Gabriel Schaaf, Debabrata Laha
Summary: Inositol pyrophosphates are signaling molecules that regulate cellular processes in eukaryotes. Recent research has uncovered their important functions in nutrient sensing, hormone signaling, and plant immunity. However, the molecular identity of the enzymes that convert these messengers back to their precursors is still largely unknown. This study shows that Arabidopsis PFA-DSP1-5 proteins display phosphohydrolase activity and have high specificity for inositol pyrophosphates.
Article
Biology
Negar Afshar, Bilge Argunhan, Maierdan Palihati, Goki Taniguchi, Hideo Tsubouchi, Hiroshi Iwasaki
Summary: The study identified a conserved acidic patch on Rad51 that plays a crucial role in homologous recombination, as neutralization of this patch leads to defects in DNA repair and impairs interactions with auxiliary factors. This acidic patch is essential for the recruitment of Rad51, its interaction with Rad55-Rad57 and Rad52, as well as for the interaction with Rad54, highlighting its importance in recombinational DNA repair.
Review
Food Science & Technology
Javier Vicente, Yasemin Baran, Eva Navascues, Antonio Santos, Fernando Calderon, Domingo Marquina, Doris Rauhut, Santiago Benito
Summary: Climate change poses problems in wine technology, such as acidity deficiency and difficulties in performing malolactic fermentation. Microbiological approaches, including increasing malic acid content and using non-Saccharomyces yeasts, provide reliable solutions. For red wine stability, malic acid removal is necessary, and alternatives to Oenococcus oeni, such as Lactiplantibacillus plantarum and Schizosaccharomyces genus, are being studied.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Carla L. Esposito, Silvia Nuzzo, Swati A. Kumar, Anna Rienzo, Clare L. Lawrence, Roberto Pallini, Lisa Shaw, Jane E. Alder, Lucia Ricci-Vitiani, Silvia Catuogno, Vittorio de Franciscis
JOURNAL OF CONTROLLED RELEASE
(2016)
Letter
Chemistry, Medicinal
Mark Wainwright, William J. Stockburn, Clare L. Lawrence, Harry J. Stevens, Allison E. Jones, Robert B. Smith
PHYTOTHERAPY RESEARCH
(2018)
Article
Chemistry, Analytical
Charnete Casimero, Aaron McConville, John-Joe Fearon, Clare L. Lawrence, Charlotte M. Taylor, Robert B. Smith, James Davis
ANALYTICA CHIMICA ACTA
(2018)
Article
Chemistry, Analytical
Catherine Hegarty, Stephanie Kirkwood, Marco F. Cardosi, Clare L. Lawrence, Charlotte M. Taylor, Robert B. Smith, James Davis
MICROCHEMICAL JOURNAL
(2018)
Article
Biochemistry & Molecular Biology
Clare L. Lawrence, Nic Jones, Caroline R. M. Wilkinson
Article
Chemistry, Medicinal
Andrew R. Tyler, Adeyi Okoh Okoh, Clare L. Lawrence, Vicky C. Jones, Colin Moffatt, Robert B. Smith
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Wolfgang Reiter, Stephen Watt, Keren Dawson, Clare L. Lawrence, Juerg Bahler, Nic Jones, Caroline R. M. Wilkinson
JOURNAL OF BIOLOGICAL CHEMISTRY
(2008)
Article
Multidisciplinary Sciences
Shraddha Aptekar, Mohit Arora, Clare Louise Lawrence, Robert William Lea, Katherine Ashton, Tim Dawson, Jane Elizabeth Alder, Lisa Shaw
Article
Materials Science, Multidisciplinary
Anna McLister, Charnete Casimero, Aaron McConville, Charlotte M. Taylor, Clare L. Lawrence, Robert B. Smith, Ashish Mathur, James Davis
JOURNAL OF MATERIALS SCIENCE
(2019)
Article
Cell Biology
Anton Khmelinskii, Clare Lawrence, Johanna Roostalu, Elmar Schiebel
JOURNAL OF CELL BIOLOGY
(2007)
Article
Biochemistry & Molecular Biology
Clare L. Lawrence, Hiromi Maekarwa, Jessica L. Worthington, Wolfgang Reiter, Caroline R. M. Wilkinson, Nic Jones
JOURNAL OF BIOLOGICAL CHEMISTRY
(2007)
Article
Biochemistry & Molecular Biology
CL Lawrence, CH Botting, R Antrobus, PJ Coote
MOLECULAR AND CELLULAR BIOLOGY
(2004)