Characterization of the Adenosine Pharmacology of Ticagrelor Reveals Therapeutically Relevant Inhibition of Equilibrative Nucleoside Transporter 1

Ticagrelor Enhances Adenosine-Induced Coronary Vasodilatory Responses in Humans

(2013) Ann Wittfeldt et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events

(2013) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ticagrelor induces adenosine triphosphate release from human red blood cells

(2012) Jenny Öhman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Randomized, Double-Blind, Active-Controlled Phase 2 Trial to Evaluate a Novel Selective and Reversible Intravenous and Oral P2Y 12 Inhibitor Elinogrel Versus Clopidogrel in Patients Undergoing Nonurgent Percutaneous Coronary Intervention

(2012) Robert C. Welsh et al.   Circulation-Cardiovascular Interventions

Why does ticagrelor induce dyspnea?

(2012) Elena Faioni et al.   THROMBOSIS AND HAEMOSTASIS

Ticagrelor Inhibits Adenosine Uptake In Vitro and Enhances Adenosine-Mediated Hyperemia Responses in a Canine Model

(2011) J. J. J. van Giezen et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Absorption, Distribution, Metabolism, and Excretion of Ticagrelor in Healthy Subjects

(2010) R. Teng et al.   DRUG METABOLISM AND DISPOSITION

Incidence of Dyspnea and Assessment of Cardiac and Pulmonary Function in Patients With Stable Coronary Artery Disease Receiving Ticagrelor, Clopidogrel, or Placebo in the ONSET/OFFSET Study

(2010) Robert F. Storey et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases

(2009) Jolanta M Siller-Matula et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nucleoside Transporter Proteins

(2009) Miriam Molina-Arcas et al.   Current Vascular Pharmacology

Ticagrelor binds to human P2Y12independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation

(2009) J. J. J. VAN GIEZEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Intravenous Platelet Blockade with Cangrelor during PCI

(2009) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platelet Inhibition with Cangrelor in Patients Undergoing PCI

(2009) Robert A. Harrington et al.   NEW ENGLAND JOURNAL OF MEDICINE