Combined Cardioprotectant and Antithrombotic Actions of Platelet P2Y12 Receptor Antagonists in Acute Coronary Syndrome

Two Classes of Anti-Platelet Drugs Reduce Anatomical Infarct Size in Monkey Hearts

(2013) Xi-Ming Yang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Triple Therapy Greatly Increases Myocardial Salvage During Ischemia/Reperfusion in the in situ Rat Heart

(2013) Xi-Ming Yang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Reduction in First and Recurrent Cardiovascular Events With Ticagrelor Compared With Clopidogrel in the PLATO Study

(2013) Payal Kohli et al.   CIRCULATION

Current State of Clinical Translation of Cardioprotective Agents for Acute Myocardial Infarction

(2013) Robert A. Kloner   CIRCULATION RESEARCH

Comparison of Prasugrel and Ticagrelor Loading Doses in ST-Segment Elevation Myocardial Infarction Patients

(2013) Guido Parodi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clopidogrel Pharmacokinetics and Pharmacodynamics Vary Widely Despite Exclusion or Control of Polymorphisms (CYP2C19, ABCB1, PON1), Noncompliance, Diet, Smoking, Co-Medications (Including Proton Pump Inhibitors), and Pre-Existent Variability in Platelet Function

(2013) Andrew L. Frelinger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of Platelet Inhibition with Cangrelor during PCI on Ischemic Events

(2013) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pretreatment with Prasugrel in Non–ST-Segment Elevation Acute Coronary Syndromes

(2013) Gilles Montalescot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Door-to-Balloon Time and Mortality among Patients Undergoing Primary PCI

(2013) Daniel S. Menees et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular risk among patients on clopidogrel anti-platelet therapy after placement of drug-eluting stents is modified by genetic variants in both the CYP2C19 and ABCB1 genes

(2013) Stacey Knight et al.   THROMBOSIS AND HAEMOSTASIS

A high loading dose of clopidogrel reduces myocardial infarct size in patients undergoing primary percutaneous coronary intervention: A magnetic resonance imaging study

(2012) Young Bin Song et al.   AMERICAN HEART JOURNAL

Reduced immediate ischemic events with cangrelor in PCI: A pooled analysis of the CHAMPION trials using the universal definition of myocardial infarction

(2012) Harvey D. White et al.   AMERICAN HEART JOURNAL

Cardioprotection by clopidogrel in acute ST-elevated myocardial infarction patients: a retrospective analysis

(2012) François Roubille et al.   BASIC RESEARCH IN CARDIOLOGY

Update on acute coronary syndromes: the pathologists' view

(2012) Erling Falk et al.   EUROPEAN HEART JOURNAL

Postconditioning during coronary angioplasty in acute myocardial infarction: the POST-AMI trial

(2012) Giuseppe Tarantini et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Association of Clopidogrel Pretreatment With Mortality, Cardiovascular Events, and Major Bleeding Among Patients Undergoing Percutaneous Coronary Intervention

(2012) Anne Bellemain-Appaix et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Platelet P2Y12 Blockers Confer Direct Postconditioning-Like Protection in Reperfused Rabbit Hearts

(2012) Xi-Ming Yang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Prognostic Value of a High On-Clopidogrel Treatment Platelet Reactivity in Bivalirudin Versus Abciximab Treated Non–ST-Segment Elevation Myocardial Infarction Patients

(2012) Dirk Sibbing et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Prasugrel versus Clopidogrel for Acute Coronary Syndromes without Revascularization

(2012) Matthew T. Roe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biological efficacy of a 600 mg loading dose of clopidogrel in ST-elevation myocardial infarction

(2012) Julie Berbis et al.   THROMBOSIS AND HAEMOSTASIS

Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity

(2011) Xiulan Yang et al.   BASIC RESEARCH IN CARDIOLOGY

Ischaemic postconditioning revisited: lack of effects on infarct size following primary percutaneous coronary intervention

(2011) X. Freixa et al.   EUROPEAN HEART JOURNAL

Myocardial salvage in acute myocardial infarction - Challenges in clinical translation

(2011) Daria Mochly-Rosen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A comparison between upfront high-dose tirofiban versus provisional use in the real-world of non-selected STEMI patients undergoing primary PCI

(2011) A.A.C.M. Heestermans et al.   Netherlands Heart Journal

Ischemic Postconditioning: From Receptor to End-Effector

(2010) Michael V. Cohen et al.   ANTIOXIDANTS & REDOX SIGNALING

Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers

(2010) Kathleen Butler et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cardioprotective Effects of Ischemic Postconditioning in Patients Treated With Primary Percutaneous Coronary Intervention, Evaluated by Magnetic Resonance

(2010) Jacob L�nborg et al.   Circulation-Cardiovascular Interventions

Effect of postconditioning on infarct size in patients with ST elevation myocardial infarction

(2010) P. Sorensson et al.   HEART

Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial

(2010) Shamir R Mehta et al.   LANCET

Adjunctive treatment with ticagrelor, but not clopidogrel, added to tPA enables sustained coronary artery recanalisation with recovery of myocardium perfusion in a canine coronary thrombosis model

(2010) Xiaorong Zhou et al.   THROMBOSIS AND HAEMOSTASIS

Antagonism of P2Y12 or GPIIb/IIIa receptors reduces platelet-mediated myocardial injury after ischaemia and reperfusion in isolated rat hearts

(2010) José A. Barrabés et al.   THROMBOSIS AND HAEMOSTASIS

Effect of the Novel Thienopyridine Prasugrel Compared With Clopidogrel on Spontaneous and Procedural Myocardial Infarction in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis in Myocardial Infarction 38

(2009) David A. Morrow et al.   CIRCULATION

Randomized Double-Blind Assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease

(2009) Paul A. Gurbel et al.   CIRCULATION

Influence of different antiplatelet treatment regimens for primary percutaneous coronary intervention on all-cause mortality

(2009) A. Witkowski et al.   EUROPEAN HEART JOURNAL

Role of Clopidogrel Loading Dose in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Angioplasty

(2009) George Dangas et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial

(2009) Gilles Montalescot et al.   LANCET

Intravenous Platelet Blockade with Cangrelor during PCI

(2009) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platelet Inhibition with Cangrelor in Patients Undergoing PCI

(2009) Robert A. Harrington et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sodium-Hydrogen Exchange Inhibition by Cariporide to Reduce the Risk of Ischemic Cardiac Events in Patients Undergoing Coronary Artery Bypass Grafting: Results of the EXPEDITION Study

(2008) Robert M. Mentzer et al.   ANNALS OF THORACIC SURGERY

Clopidogrel pre-treatment in stable angina: for all patients >6 h before elective coronary angiography or only for angiographically selected patients a few minutes before PCI? A randomized multicentre trial PRAGUE-8

(2008) P. Widimsky et al.   EUROPEAN HEART JOURNAL

Impaired platelet function reduces myocardial infarct size in Gαq knock-out mice in vivo

(2007) Hans-Joerg Weig et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY