Review
Chemistry, Physical
Xu Wang, Jun Pu
Summary: Cardiac magnetic resonance (CMR) imaging technology is considered the gold standard for evaluating myocardial function and viability in acute myocardial infarction (AMI). Various CMR techniques can specifically display and evaluate the pathophysiological changes in each stage of AMI. This article reviews the recent advances of CMR technology in AMI and prospects its future development directions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ke Shi, Meng-Xi Yang, Chun-Chao Xia, Wan-Lin Peng, Kun Zhang, Zhen-Lin Li, Ying-Kun Guo, Zhi-Gang Yang
Summary: This study found that breathing maneuvers in healthy rabbits induced oxygenation changes comparable to stress testing, while in acute MI rabbits, the effects induced by breathing maneuvers were equally effective as adenosine stress. This suggests that combined breathing maneuvers with OS-MRI have the potential to be used as a nonpharmacological alternative for assessing myocardial oxygenation in patients with acute MI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Walid El-Saadi, Jan Edvin Engvall, Joakim Alfredsson, Jan-Erik Karlsson, Marcelo Martins, Sofia Sederholm, Shaikh Faisal Zaman, Tino Ebbers, Johan Kihlberg
Summary: This study compared the performance of fast-strain encoding (fast-SENC) and feature tracking (FT) in ST-elevated myocardial infarction (STEMI) patients and found no significant differences in global longitudinal strain (GLS) and global circumferential strain (GCS) between the two methods. Both methods showed acceptable agreement with 2D speckle tracking echocardiography (2DEcho) for longitudinal strain.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gabriel Broocks, Lukas Meyer, Reza Kabiri, Helge C. Kniep, Rosalie McDonough, Matthias Bechstein, Noel van Horn, Thomas Lindner, Jan Sedlacik, Bastian Cheng, Goetz Thomalla, Gerhard Schoen, Jens Fiehler, Uta Hanning, Michael H. Schoenfeld
Summary: This study found that additional intravenous alteplase did not significantly reduce peripheral emboli after successful mechanical thrombectomy. Higher eTICI scores post-reperfusion were associated with decreased peripheral emboli, while the use of alteplase did not impact the number or volume of emboli.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Liang Jiang, Zhengfei Miao, Huiyou Chen, Wen Geng, Wei Yong, Yu-Chen Chen, Hong Zhang, Shaofeng Duan, Xindao Yin, Zhiqiang Zhang
Summary: This study aimed to construct a prognostic model for patients with acute ischemic stroke by using diffusion-weighted imaging radiomics. The CrrScore model, based on clinical and imaging features, accurately predicted unfavorable outcomes and could potentially guide rehabilitation therapies.
Article
Cardiac & Cardiovascular Systems
S. Neil Holby, Tadarro Lee Richardson Jr, J. Lukas Laws, Thomas A. McLaren, Jonathan H. Soslow, Michael T. Baker, Jeffrey M. Dendy, Daniel E. Clark, Sean G. Hughes
Summary: Infection with SARS-CoV-2, the virus that causes COVID, can lead to various cardiovascular complications. Cardiac imaging has become crucial in differentiating pulmonary and cardiovascular complications due to the non-specific symptoms and laboratory findings of COVID patients. This review summarizes the existing literature and major societal guidelines to provide an overview of the indications and utility of different cardiac imaging modalities for diagnosing cardiovascular complications of COVID.
CIRCULATION RESEARCH
(2023)
Article
Medicine, General & Internal
Ik Hyun Park, Hyun Kyu Cho, Ju Hyeon Oh, Woo Jung Chun, Yong Hwan Park, Mirae Lee, Min Sun Kim, Ki Hong Choi, Jihoon Kim, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Sang-Chol Lee, Hyeon-Cheol Gwon, Yeon Hyeon Choe, Woo Jin Jang
Summary: This study found a correlation between high serum lactate levels and larger myocardial infarct size in patients with AMI. This indicates that high serum lactate is a predictive factor for advanced myocardial injury in AMI patients undergoing PCI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Paul Steffen, Lara-Sophie Beyer, Rosalie McDonough, Christian Thaler, Tobias Faizy, Jens Fiehler, Joystone Gbadamosi, Christian R. Habermann, Michael H. Schoenfeld
Summary: The study evaluated the benefit of coronal DWI in detecting brain stem infarctions, showing that combined coronal and axial DWI can improve detection rates with minimal increase in scan times.
Article
Cardiac & Cardiovascular Systems
Benjamin P. Bonner, Salva R. Yurista, Jaume Coll-Font, Shi Chen, Robert A. Eder, Anna N. Foster, Khoi D. Nguyen, Peter Caravan, Eric M. Gale, Christopher Nguyen
Summary: The experimental manganese-based contrast agent RVP-001 appears to be an effective alternative to gadolinium-based agents for assessing myocardial infarction location, size, and transmurality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Zi-Yang Fan, Chong-wen Wu, Dong-Aolei An, Bing-Hua Chen, Luke D. Wesemann, Jie He, Jia-ni Hu, Jun Bu, Jian-rong Xu, Yan Zhou, Lian-Ming Wu
Summary: Texture analysis of T2-Mapping can accurately differentiate between area at risk and infarct zone in non-LGE imaging reperfused AMI patients, but is not predictive of patients' functional recovery in the convalescent stage.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Yader Sandoval, Bradley R. Lewis, Ramila A. Mehta, Olatunde Ola, Jonathan D. Knott, Laura De Michieli, Ashok Akula, Ronstan Lobo, Eric H. Yang, S. Michael Gharacholou, Marshall Dworak, Erika Crockford, Nicholas Rastas, Eric Grube, Swetha Karturi, Scott Wohlrab, David O. Hodge, Tahir Tak, Charles Cagin, Rajiv Gulati, Allan S. Jaffe
Summary: Using a single hs-cTnT below the limit of quantitation of 6 ng/L is a safe and rapid method to identify a substantial number of patients at very low risk for acute myocardial injury and infarction.
Article
Engineering, Biomedical
Bing Li, Luyi Han, Hao Wang, Yuanyuan Zheng
Summary: A new type of nanoparticles as an MRI contrast agent for accurate detection of myocardial infarction has been developed. The nanoparticles showed excellent chemical stability and targeting capability, and exhibited low cytotoxicity to cardiomyocytes and good hemocompatibility. Therefore, these nanoparticles have great potential for sensitive and specific detection of the infarcted regions during acute myocardial ischemia/reperfusion injury.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Review
Cardiac & Cardiovascular Systems
Doralisa Morrone, Francesco Gentile, Alberto Aimo, Matteo Cameli, Andrea Barison, Maria Elena Picoi, Marco Guglielmo, Angelo Villano, Antonio DeVita, Giulia Elena Mandoli, Maria Concetta Pastore, Francesco Barilla, Massimo Mancone, Roberto Pedrinelli, Ciro Indolfi, Pasquale Perrone Filardi, Saverio Muscoli, Isabella Tritto, Luca Bergamaschi, Carmine Pizzi, Paolo G. Camici, Mario Marzilli, Filippo Crea, Raffaele De Caterina, Gianluca Pontone, Danilo Neglia, Gaetano A. Lanza
Summary: The latest guidelines emphasize the importance of noninvasive imaging for selecting patients for further invasive angiography. In addition to coronary stenosis, other mechanisms such as vasospasm, microvascular disease, and energetic inefficiency have been shown to be important. Therefore, a pathophysiology-driven treatment approach has become a crucial objective, and multimodality imaging can provide deeper insights into the underlying mechanisms.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Zhengguang Xiao, Jingyu Zhong, Lingna Zhong, Shun Dai, Wenjie Lu, Lei Song, Huan Zhang, Jun Yang, Weiwu Yao
Summary: This study aimed to assess the prognostic value of myocardial salvage index (MSI) by cardiac magnetic resonance (CMR) in ST-segment elevation myocardial infarction (STEMI) patients. The results showed that MSI can predict major adverse cardiovascular events (MACE) in STEMI patients. However, further investigation is needed to evaluate the prognostic value of MSI using advanced CMR techniques for adverse cardiovascular events.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ke Shi, Min Ma, Meng-Xi Yang, Chun-Chao Xia, Wan-Lin Peng, Yong He, Zhen-Lin Li, Ying-Kun Guo, Zhi-Gang Yang
Summary: This study found that acute oxygenation signal intensity in reperfused acute ST-segment elevation myocardial infarction (STEMI) patients showed a stepwise rise among different LV segments compared with healthy myocardium. Acute oxygenation signal intensity was associated with early myocardial injury and predicted adverse LV segment remodeling after STEMI.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sujata M. Shanbhag, Anders M. Greve, Thor Aspelund, Erik B. Schelbert, J. Jane Cao, Ragnar Danielsen, Gudmundur Thorgeirsson, Sigurdur Sigurdsson, Gudndy Eiriksdottir, Tamara B. Harris, Lenore J. Launer, Vilmundur Gudnason, Andrew E. Arai
EUROPEAN HEART JOURNAL
(2019)
Article
Cardiac & Cardiovascular Systems
Ankur Gulati, Tevfik F. Ismail, Aamir Ali, Li-Yueh Hsu, Carla Goncalves, Nizar A. Ismail, Kaushiga Krishnathasan, Natasha Davendralingam, Pedro Ferreira, Brian P. Halliday, Daniel A. Jones, Ricardo Wage, Simon Newsome, Peter Gatehouse, David Firmin, Andrew Jabbour, Ravi G. Assomull, Anthony Mathur, Dudley J. Pennell, Andrew E. Arai, Sanjay K. Prasad
JACC-CARDIOVASCULAR IMAGING
(2019)
Letter
Cardiac & Cardiovascular Systems
Tushar Acharya, Lenore Launer, Andrew E. Arai
Article
Clinical Neurology
Alexander E. Merkler, Sigurdur Sigurdsson, Gudny Eiriksdottir, Monika M. Safford, Caroline L. Phillips, Costantino Iadecola, Vilmundur Gudnason, Jonathan W. Weinsaft, Hooman Kamel, Andrew E. Arai, Lenore J. Launer
Article
Cardiac & Cardiovascular Systems
Borja Ibanez, Anthony H. Aletras, Andrew E. Arai, Hakan Arheden, Jeroen Bax, Colin Berry, Chiara Bucciarelli-Ducci, Pierre Croisille, Erica Dall'Armellina, Rohan Dharmakumar, Ingo Eitel, Rodrigo Fernandez-Jimenez, Matthias G. Friedrich, David Garcia-Dorado, Derek J. Hausenloy, Raymond J. Kim, Sebastian Kozerke, Christopher M. Kramer, Michael Salerno, Javier Sanchez-Gonzalez, Javier Sanz, Valentin Fuster
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Michael P. Gannon, Faraz Kureshi, Thomas R. Burklow, Charles Benton, Arlene Sirajuddin, Andrew E. Arai
CIRCULATION-CARDIOVASCULAR IMAGING
(2019)
Article
Clinical Neurology
Benjamin T. Cocanougher, Lauren Flynn, Pomi Yun, Minal Jain, Melissa Waite, Ruhi Vasavada, Jason D. Wittenbach, Sabine de Chastonay, Sameer Chhibber, A. Micheil Innes, Linda MacLaren, Tahseen Mozaffar, Andrew E. Arai, Sandra Donkervoort, Carsten G. Bonnemann, A. Reghan Foley
Review
Cardiac & Cardiovascular Systems
Arlene Sirajuddin, Marcus Y. Chen, Charles S. White, Andrew E. Arai
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2020)
Article
Cardiac & Cardiovascular Systems
Raymond Y. Kwong, Yin Ge, Kevin Steel, Scott Bingham, Shuaib Abdullah, Kana Fujikura, Wei Wang, Ankur Pandya, Yi-Yun Chen, J. Ronald Mikolich, Sebastian Boland, Andrew E. Arai, W. Patricia Bandettini, Sujata M. Shanbhag, Amit R. Patel, Akhil Narang, Afshin Farzaneh-Far, Benjamin Romer, John F. Heitner, Jean Y. Ho, Jaspal Singh, Chetan Shenoy, Andrew Hughes, Steve W. Leung, Meera Marji, Jorge A. Gonzalez, Sandeep Mehta, Dipan J. Shah, Dany Debs, Subha V. Raman, Avirup Guha, Victor A. Ferrari, Jeanette Schulz-Menger, Rory Hachamovitch, Matthias Stuber, Orlando P. Simonetti
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Andrew E. Arai, Li-Yueh Hsu
Article
Radiology, Nuclear Medicine & Medical Imaging
Arlene Sirajuddin, S. Mojdeh Mirmomen, Seth J. Kligerman, Daniel W. Groves, Allen P. Burke, Faraz Kureshi, Charles S. White, Andrew E. Arai
Summary: Ischemic heart disease is a major cause of death worldwide, with invasive coronary angiography being the standard method for diagnosing coronary artery stenosis. However, the high cost and risks associated with invasive procedures highlight the importance of noninvasive cardiac imaging modalities in the management of ischemic heart disease.
Editorial Material
Cardiac & Cardiovascular Systems
Andrew E. Arai, Arlene Sirajuddin
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew E. Arai, Jeanette Schulz-Menger, Dipan J. Shah, Yuchi Han, W. Patricia Bandettini, Arun Abraham, Pamela K. Woodard, Joseph B. Selvanayagam, Christian Hamilton-Craig, Ru-San Tan, James Carr, Lynette Teo, Christopher M. Kramer, Bernd J. Wintersperger, Mukesh G. Harisinghani, Scott D. Flamm, Matthias G. Friedrich, Igor Klem, Subha Raman, Daniel Haverstock, Zheyu Liu, Guenther Brueggenwerth, Marta Santiuste, Daniel S. Berman, Dudley J. Pennell
Summary: The study demonstrates that vasodilator stress perfusion cardiovascular magnetic resonance (CMR) performed with gadobutrol has superior diagnostic accuracy for the diagnosis and exclusion of significant coronary artery disease (CAD) compared to gated single-photon emission computed tomography (SPECT).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Andrew E. Arai, Raymond Y. Kwong, Michael Salerno, John P. Greenwood, Chiara Bucciarelli-Ducci
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)
Article
Computer Science, Information Systems
Matthew Jacobs, Mitchel Benovoy, Lin-Ching Chang, David Corcoran, Colin Berry, Andrew E. Arai, Li-Yueh Hsu
Summary: A fully automatic method of segmenting left ventricular myocardium from MBF pixel maps was developed and validated on a dataset of clinical CMR perfusion studies. The automated segmentation method showed high consistency and accuracy when compared to manually defined reference standards, with good correlation and minimal bias in sector-wise MBF and MPR values. This validated method has the potential to aid in quantitative assessment of myocardial perfusion in CMR studies.