Article
Nutrition & Dietetics
Alyann Otrante, Amal Trigui, Roua Walha, Hicham Berrougui, Tamas Fulop, Abdelouahed Khalil
Summary: EVOO intake improves cholesterol efflux capacity of HDL in elderly subjects by modulating the distribution of HDL subclasses, leading to enhanced anti-atherogenic activity of HDL.
Review
Pharmacology & Pharmacy
Alankrita Rani, Gunther Marsche
Summary: High-density lipoproteins (HDL) are complex nanoparticles involved in important metabolic and vascular functions. Dysregulation of HDL can lead to inflammatory remodeling and dysfunction. Monocytes and macrophages play a critical role in vascular inflammation. HDL-based nanotherapeutics show potential in treating vascular diseases by targeting these cells.
Review
Chemistry, Medicinal
Saba Soltani, Motahareh Boozari, Arrigo F. G. Cicero, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: HDL plays a crucial role in cardiovascular diseases, while phytochemicals have the potential to enhance cholesterol efflux. Current research mostly focuses on preclinical studies, indicating a need for more clinical research to develop novel clinical applications.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Irina N. Gorshkova, Nathan L. Meyers, Haya Herscovitz, Xiaohu Mei, David Atkinson
Summary: Population studies have found a strong association between the natural human apoA-I variant apoA-I[K107del] and low HDL-C but normal apoA-I levels. This variant has unique properties, including faster adsorption to lipid surfaces, greater surface remodeling, and higher surface pressures on compression. These properties lead to increased binding to triglyceride-rich lipoproteins and impaired formation of large HDL particles. These factors contribute to the unusual phenotype associated with atherosclerosis.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Antonino Picataggi, Amrith Rodrigues, Debra A. Cromley, Hu Wang, Joel P. Wiener, Viktor Garliyev, Jeffrey T. Billheimer, Brian C. Grabiner, Jessica A. Hurt, Allen C. Chen, Xianlin Han, Daniel J. Rader, Domenico Pratico, Nicholas N. Lyssenko
Summary: ABCA7 functions differently from ABCA1 in lipid efflux and HDL synthesis. ABCA7 exhibits more efficient efflux of serine-lipid and phosphatidylinositol to apo A-I, but less efflux of cholesterol compared to ABCA1. Shotgun lipidomic analysis reveals lower phosphatidylcholine content and higher serine-lipid and phosphatidylinositol content in ABCA7-HDL, whereas ABCA1-HDL contains more cholesterol.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Endocrinology & Metabolism
Nathaniel L. Baker, Samar M. Hammad, Kelly J. Hunt, Andrea Semler, Richard L. Klein, Maria F. Lopes-Virella
Summary: This study found that plasma apoM levels are associated with the development of diabetic kidney disease. Higher apoM levels are associated with increased risk of progression to macroalbuminuria and chronic kidney disease in patients with type 1 diabetes, suggesting that alterations in apoM may play a role in the development of nephropathy.
Review
Cell Biology
Maria Pia Adorni, Nicoletta Ronda, Franco Bernini, Francesca Zimetti
Summary: HDL cholesterol efflux capacity (CEC) has emerged as a better predictor of cardiovascular risk compared to plasma HDL-cholesterol levels, and is often impaired in various genetic and pathological conditions associated with high cardiovascular risk.
Article
Multidisciplinary Sciences
Shahan Syed, Eija Nissila, Hanna Ruhanen, Satoshi Fudo, Meztlli O. Gaytan, Sanna P. Sihvo, Martina B. Lorey, Jari Metso, Katariina Oorni, Samantha J. King, Oommen P. Oommen, Matti Jauhiainen, Seppo Meri, Reijo Kakela, Karita Haapasalo
Summary: Streptococcus pneumoniae pneumolysin (PLY) and neuraminidase A (NanA) can impair HDL function by causing chemical and structural modifications to HDL particles, resulting in significant changes in sialic acid, protein, and lipid compositions. Accumulation of these modified HDL particles in the arterial intima may trigger complement activation, inflammatory response, and promote the progression of atherogenic disease.
Article
Cardiac & Cardiovascular Systems
Alexandre Vallee
Summary: The association between lipid parameters and arterial stiffness index (ASI) is mainly determined by the TG/HDL ratio, which is more instructive in preventing AS progression than other modifiable factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Alexander Sorokin, Christin G. Hong, Angel M. Aponte, Elizabeth M. Florida, Jingrong Tang, Nidhi Patel, Irina N. Baranova, Haiou Li, Philip M. Parel, Vicky Chen, Sierra R. Wilson, Emily L. Ongstad, Anna Collen, Martin P. Playford, Thomas L. Eggerman, Marcus Y. Chen, Kazuhiko Kotani, Alexander Bocharov, Alan T. Remaley
Summary: In this study, we found that oxidized apolipoprotein B and oxidized ApoA-I are associated with high-risk coronary plaque features and progression in patients with cardiovascular disease.
Article
Biochemistry & Molecular Biology
Ryoko Shinohata, Misako Shibakura, Yujiro Arao, Shogo Watanabe, Satoshi Hirohata, Shinichi Usui
Summary: A high-fat/high-cholesterol diet increases serum levels of apoE-rich HDL, while a high-cholesterol diet does not. This study investigates the effects of dietary fat and cholesterol on gene expression and HDL production. The results suggest that increased apoE-rich HDL induced by fat and cholesterol may be mediated by increased ABCA1-mediated cholesterol efflux from the liver.
Article
Cardiac & Cardiovascular Systems
Marc P. Allard-Ratick, Bryan R. Kindya, Jay Khambhati, Marc C. Engels, Pratik B. Sandesara, Robert S. Rosenson, Laurence S. Sperling
Summary: The measurement of high-density lipoprotein cholesterol is commonly used to predict cardiovascular risk, but it is not causally associated with atherosclerotic cardiovascular disease events. Dysfunctional high-density lipoprotein may better predict future cardiovascular events.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Naoki Nanashima, Kayo Horie, Maiko Kitajima, Shizuka Takamagi, Kasumi Mikami, Naoya In, Toshiko Tomisawa
Summary: The daily intake of blackcurrant extract for 29 days can lower total cholesterol levels in healthy women, particularly affecting total very-low-density lipoprotein (VLDL) cholesterol, small VLDL cholesterol, and large low-density lipoprotein cholesterol, showing efficacy in preventing arteriosclerosis.
Review
Nutrition & Dietetics
Malgorzata Sidorkiewicz
Summary: The maintenance of cholesterol homeostasis involves complicated processes such as regulation of cholesterol synthesis, dietary uptake, and bile acid synthesis and excretion. Reverse cholesterol transport, mediated by high-density lipoproteins, plays a vital role in transferring cholesterol from non-hepatic cells to the liver for excretion. MicroRNA-33 has been identified as a key regulator of cholesterol homeostasis, impacting both cellular cholesterol efflux and bile metabolism in the liver. Understanding these mechanisms could lead to new perspectives in microRNA-targeted treatment for cholesterol imbalance.
Article
Biochemical Research Methods
Cameron Lloyd-Jones, Henrique dos Santos Seckler, Nicholas DiStefano, Allan Sniderman, Phillip D. Compton, Neil L. Kelleher, John T. Wilkins
Summary: This study investigated the relationship between the types and abundance of proteins in high-density lipoprotein (HDL) and the size of HDL using a new gel electrophoresis technique combined with intact protein mass spectrometry. The results showed that fatty-acylated forms of APOA1 were associated with larger HDL particles and had four times higher abundance in larger particles compared to total serum. The abundance of APOA2 protein forms was similar across different sizes of HDL particles. These findings suggest a connection between acylated APOA1 protein forms and larger HDL particles.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ricquita D. Pollard, Brian Fulp, Mary G. Sorci-Thomas, Michael J. Thomas
Article
Cardiac & Cardiovascular Systems
Mary G. Sorci-Thomas, Michael J. Thomas
CIRCULATION RESEARCH
(2016)
Article
Medicine, Research & Experimental
Hsin-Yuan Cheng, Dalia E. Gaddis, Runpei Wu, Chantel McSkimming, LaTeira D. Haynes, Angela M. Taylor, Coleen A. McNamara, Mary Sorci-Thomas, Catherine C. Hedrick
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Biochemistry & Molecular Biology
Mi-Hye Lee, Kathryn M. Appleton, Hesham M. El-Shewy, Mary G. Sorci-Thomas, Michael J. Thomas, Maria F. Lopes-Virella, Louis M. Luttrell, Samar M. Hammad, Richard L. Klein
JOURNAL OF LIPID RESEARCH
(2017)
Article
Cardiac & Cardiovascular Systems
Sushma Kaul, Hao Xu, Manal Zabalawi, Elisa Maruko, Brian E. Fulp, Theresa Bluemn, Kristina L. Brzoza-Lewis, Mark Gerelus, Ranjuna Weerasekera, Rachel Kallinger, Roland James, Yi (Sherry) Zhang, Michael J. Thomas, Mary G. Sorci-Thomas
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2016)
Editorial Material
Biochemistry & Molecular Biology
Mary G. Sorci-Thomas, Michael J. Thomas
JOURNAL OF LIPID RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
John T. Melchior, Ryan G. Walker, Allison L. Cooke, Jamie Morris, Mark Castleberry, Thomas B. Thompson, Martin K. Jones, Hyun D. Song, Kerry-Anne Rye, Michael N. Oda, Mary G. Sorci-Thomas, Michael J. Thomas, Jay W. Heinecke, Xiaohu Mei, David Atkinson, Jere P. Segrest, Sissel Lund-Katz, Michael C. Phillips, W. Sean Davidson
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
John T. Melchior, Ryan G. Walker, Allison L. Cooke, Jamie Morris, Mark Castleberry, Thomas B. Thompson, Martin K. Jones, Hyun D. Song, Kerry-Anne Rye, Michael N. Oda, Mary G. Sorci-Thomas, Michael J. Thomas, Jay W. Heinecke, Xiaohu Mei, David Atkinson, Jere P. Segrest, Sissel Lund-Katz, Michael C. Phillips, W. Sean Davidson
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2017)
Review
Biochemistry & Molecular Biology
Amber B. Ouweneel, Michael J. Thomas, Mary G. Sorci-Thomas
JOURNAL OF LIPID RESEARCH
(2020)
Article
Hematology
Bandana Singh, Ramoji Kosuru, Sribalaji Lakshmikanthan, Mary Sorci-Thomas, David Zhang, Rodney Sparapani, Jeannette Vasquez-Vivar, Magdalena Chrzanowska
Summary: The study reveals that Rap1 can protect endothelial cells from atherosclerosis progression in the presence and absence of laminar flow, primarily through promoting NO release and restricting proinflammatory signaling.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Savannah D. Neu, Anna Strzepa, Dustin Martin, Mary G. Sorci-Thomas, Kirkwood A. Pritchard, Bonnie N. Dittel
Summary: This study found that myeloperoxidase inhibition can alleviate the severity of plaque psoriasis in mice. These findings support the role of oxidative damage in psoriasis pathology and suggest potential new therapeutic avenues for further exploration.
Editorial Material
Hematology
Ann Marie Schmidt, Mary G. Sorci-Thomas, Yabing Chen, Robert A. Hegele
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhi-Wei Mo, Yue-Ming Peng, Yi-Xin Zhang, Yan Li, Bi-Ang Kang, Ya-Ting Chen, Le Li, Mary G. G. Sorci-Thomas, Yi-Jun Lin, Yang Cao, Si Chen, Ze-Long Liu, Jian-Jun Gao, Zhan-Peng Huang, Jia-Guo Zhou, Mian Wang, Guang-Qi Chang, Meng-Jie Deng, Yu-Jia Liu, Zhen-Sheng Ma, Zuo-Jun Hu, Yu-Gang Dong, Zhi-Jun Ou, Jing-Song Ou
Summary: This study identified a long non-coding RNA, HDRACA, that plays a crucial role in the regulation of angiogenesis by HDL. Normal HDL downregulates the expression of HDRACA, while HDL from patients with coronary artery disease fails to inhibit HDRACA expression effectively, which explains the decreased ability of dysfunctional HDL to stimulate angiogenesis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Jesse W. Williams, Andrew Elvington, Stoyan Ivanov, Skyler Kessler, Hannah Luehmann, Osamu Baba, Brian T. Saunders, Ki-Wook Kim, Michael W. Johnson, Clarissa S. Craft, Jae-Hoon Choi, Mary G. Sorci-Thomas, Bernd H. Zinselmeyer, Jonathan R. Brestoff, Yongjian Liu, Gwendalyn J. Randolph
CIRCULATION RESEARCH
(2017)
Review
Biochemistry & Molecular Biology
Menno Hoekstra, Mary Sorci-Thomas
CURRENT OPINION IN LIPIDOLOGY
(2017)