Article
Cell Biology
Xue An, Jiwon Lee, Ga Hye Kim, Hyun-Ji Kim, Hyun-Jeong Pyo, Ilmin Kwon, Hana Cho
Summary: Recent studies have shown that PRMT1 is highly expressed in the human heart, and loss of PRMT1 contributes to cardiac remodeling in heart failure. This study demonstrates the critical role of PRMT1 in regulating the I-Ks channel and cardiac rhythm.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gonzalo Ferreira, Axel Santander, Romina Cardozo, Luisina Chavarria, Lucia Dominguez, Nicolas Mujica, Milagros Benitez, Santiago Sastre, Luis Sobrevia, Garth L. Nicolson
Summary: Inwardly rectifying potassium (Kir) channels are important for maintaining membrane potential and potassium homeostasis. These channels have various subtypes and can be regulated by molecules found in nutrients, such as phosphoinositols, polyamines, and Mg2+. Changes in Kir channels can affect metabolism and the ability to absorb nutrients and electrolytes. The study of nutrigenomics of ion channels is crucial for understanding how diet and nutrients can impact ion channel function, expression, and lead to pathological conditions that affect diet and electrolyte intake.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Shira Burg, Shir Shapiro, Asher Peretz, Elvira Haimov, Boris Redko, Adva Yeheskel, Luba Simhaev, Hamutal Engel, Avi Raveh, Ariel Ben-Bassat, Michael Murninkas, Rotem Polak, Yoni Haitin, Yoram Etzion, Bernard Attali
Summary: Phosphatidylinositol 4-5 bisphosphate (PIP2) potently activates the SK4 channel by docking to the boundary of the CaM-binding domain. An allosteric blocker, BA6b9, inhibits SK4 channels by interacting with specific residues in the linker S4-S5, preventing proper interaction between the Ca2+-CaM N-lobe and the channel linker region. Inhibition of SK4 channels by targeting drugs to the CaM-PIP2-binding domain may serve as a promising anti-arrhythmic therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Physiology
Leticia G. Marmolejo-Murillo, Ivan A. Arechiga-Figueroa, Eloy G. Moreno-Galindo, Tania Ferrer, Rodrigo Zamora-Cardenas, Ricardo A. Navarro-Polanco, Jose A. Sanchez-Chapula, Aldo A. Rodriguez-Menchaca
Summary: Studies have identified a novel intrinsic inward rectification mechanism in Kir4.1/Kir5.1 channels, which is independent of endogenous blockers and driven by the voltage-dependent behavior of potassium flux through the channel pore. This gating mechanism, induced by inward K+ flux, opens the gate, while outward flux is unable to maintain it open, and is convergent with PIP2 gating at saturating concentrations.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Martin Machacek, Olga Svecova, Marketa Bebarova
Summary: The study found that sildenafil significantly inhibits IK1 at certain concentrations, and the inhibition effect is more pronounced when used in combination with Ba2+. This combined effect leads to a significant prolongation of action potential duration, potentially contributing to arrhythmias in patients treated with sildenafil.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Fabrice Dabertrand, Osama F. Harraz, Masayo Koide, Thomas A. Longden, Amanda C. Rosehart, David C. Hill-Eubanks, Anne Joutel, Mark T. Nelson
Summary: Research suggests that impaired functional hyperemia in cerebral small vessel diseases is caused by decreased activity of Kir2.1 channels, which is linked to depletion of phosphatidylinositol 4,5-bisphosphate (PIP2). Systemic injection of soluble PIP2 has shown promising results in restoring functional hyperemia in SVD mice, providing a potential strategy for treating brain disorders with disrupted blood flow.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Hua-Qian Yang, Fabio A. Echeverry, Assmaa ElSheikh, Ivan Gando, Sophia Anez Arredondo, Natalie Samper, Timothy Cardozo, Mario Delmar, Show-Ling Shyng, William A. Coetzee
Summary: Sarcolemmal/plasmalemmal ATP-sensitive K+ (K-ATP) channels play crucial roles in various cell types and tissues. Recent studies have highlighted that the surface expression of K-ATP channels is tightly regulated and has significant implications in both health and disease.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Physiology
Chaojie Zhang, Jia Guo
Summary: The inward-rectifying potassium channel subunit Kir5.1, encoded by Kcnj16, can form functional heteromeric channels with Kir4.1 or Kir4.2. It is widely expressed in various organs and can confer intracellular pH sensitivity to Kir4.1/5.1 channels, which act as extracellular potassium sensors in the renal distal convoluted tubule segment.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Louise Reilly, Lee L. Eckhardt
Summary: The potassium inward rectifier channel Kir2 is crucial for cardiac repolarization and membrane stability. Mutations in related genes can lead to sudden cardiac death syndromes. Research focuses on the structure, physiology, and pharmacology of Kir2 channels, as well as their implications for atrial fibrillation treatment and drug safety testing.
Article
Biology
Madison Delmoe, Timothy W. Secomb
Summary: A simplified model for the electrophysiology of endothelial cells is used to investigate the conditions leading to bistability of membrane resting potential. The model considers the effects of inward-rectifying potassium (Kir) ion channels, whose current-voltage relationship exhibits a negative slope region and its maximum conductance depends on extracellular potassium concentration. The study presents a method for identifying the parameter space boundaries of background currents that correspond to bistability regions. The results reveal narrow bistability regions that depend on extracellular potassium concentration and define conditions for transitions between depolarized and hyperpolarized membrane states. These findings have implications for understanding the regulation of blood flow and conducted responses in the brain and other tissues.
MATHEMATICAL BIOSCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Ange Maguy, Yuvaraj Mahendran, Jean-Claude Tardif, David Busseuil, Jin Li
Summary: This study explores the association between autoantibodies targeting cardiac ion channels and unexplained AF. They found a common autoantibody response against K(ir)3.4 protein in patients with AF, even before the development of clinically apparent AF. Functional studies and a mouse model of K(ir)3.4 autoimmunity support the causal relationship between K(ir)3.4 autoantibodies and AF.
Article
Pharmacology & Pharmacy
Moawiah M. Naffaa, Ola A. Al-Ewaidat
Summary: KCNQ-encoded potassium channels play diverse roles in human tissues, affecting various physiological processes and pathophysiological conditions. New, more selective and potent molecules targeting Kv7 channels are desired for effective therapies. Understanding the structure and function of human KCNQ-encoded channels helps in achieving these therapeutic goals.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biology
Ljubica Mihaljevic, Zheng Ruan, James Osei-Owusu, Wei Lu, Zhaozhu Qiu
Summary: The PAC channel, encoded by PACC1 (TMEM206), is a pH-sensing ion channel that regulates endosomal acidification and macropinosome shrinkage. This study reveals that phosphatidylinositol (4,5)-bisphosphate (PIP2) inhibits PAC channel activity by stabilizing the channel in a desensitized-like conformation. The structure of PAC with PIP2 suggests a new pharmacological strategy for targeting this channel.
Article
Cell Biology
Yaopeng Hu, Qin Li, Lin-Hai Kurahara, Narumi Shioi, Keizo Hiraishi, Takayuki Fujita, Xin Zhu, Ryuji Inoue
Summary: The E7K mutation in the TRPM4 channel enhances channel function by altering its interaction with endogenous PIP2, potentially contributing to its arrhythmogenic potential.
Article
Physiology
Nuno Jorge Dourado Ramalho, Olga Svecova, Roman Kula, Milena Simurdova, Jiri Simurda, Marketa Bebarova
Summary: Aminophylline has a dual effect on the inward rectifier potassium (Kir) current I-K1 in the heart, either inhibiting or activating it. This effect is likely due to its interaction with different channel populations, leading to varying effects in individual cells. These changes in I-K1 induced by aminophylline may contribute to arrhythmogenesis associated with the use of this bronchodilator.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ulises Meza, Mayra Delgado-Ramirez, Catalina Romero-Mendez, Sergio Sanchez-Armass, Aldo A. Rodriguez-Menchaca
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Guadalupe Segura-Covarrubias, Ivan A. Arechiga-Figueroa, Jose J. De Jesus-Perez, Alfredo Sanchez-Solano, Patricia Perez-Cornejo, Jorge Arreola
SCIENTIFIC REPORTS
(2020)
Article
Pharmacology & Pharmacy
Rita Moran-Zendejas, Mayra Delgado-Ramirez, Jie Xu, Belkis Valdes-Abadia, Ivan A. Arechiga-Figueroa, Meng Cui, Aldo A. Rodriguez-Menchaca
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Cell Biology
Alfredo Sanchez-Solano, Nancy Corral, Guadalupe Segura-Covarrubias, Maria Luisa Guzman-Hernandez, Ivan Arechiga-Figueroa, Silvia Cruz-Rangel, Patricia Perez-Cornejo, Jorge Arreola
Review
Clinical Neurology
U. Meza, C. Romero-Mendez, S. Sanchez-Armass, A. A. Rodriguez-Menchaca
Summary: This article reviews the current model of membrane rafts and their role in the nervous system, as well as their relevance to various neurological diseases. Disruption/dysfunction of rafts has been associated with neurological disorders, suggesting that preserving membrane rafts may be a strategy to prevent or delay neuronal dysfunctions in these diseases.
Article
Biophysics
Pablo Luis Hernandez-Adame, Ulises Meza, Aldo A. Rodriguez-Menchaca, Sergio Sanchez-Armass, Jaime Ruiz-Garcia, Eduardo Gomez
Summary: The study developed a computational single-molecule FRET method to investigate the dynamics of fluorophores inside lipid rafts, showing that the method is robust and insensitive to variations in different parameters.
BIOPHYSICAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
David O. Pacheco-Rojas, Mayra Delgado-Ramirez, Kathya Villatoro-Gomez, Eloy G. Moreno-Galindo, Aldo A. Rodriguez-Menchaca, Jose A. Sanchez-Chapula, Tania Ferrer
Summary: The study found that riluzole mainly inhibits Kv4.2 channels by affecting the closed and closed-inactivated states.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Physiology
Leticia G. Marmolejo-Murillo, Ivan A. Arechiga-Figueroa, Eloy G. Moreno-Galindo, Tania Ferrer, Rodrigo Zamora-Cardenas, Ricardo A. Navarro-Polanco, Jose A. Sanchez-Chapula, Aldo A. Rodriguez-Menchaca
Summary: Studies have identified a novel intrinsic inward rectification mechanism in Kir4.1/Kir5.1 channels, which is independent of endogenous blockers and driven by the voltage-dependent behavior of potassium flux through the channel pore. This gating mechanism, induced by inward K+ flux, opens the gate, while outward flux is unable to maintain it open, and is convergent with PIP2 gating at saturating concentrations.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ana Laura Lopez-Serrano, Rodrigo Zamora-Cardenas, Ivan A. Arechiga-Figueroa, Pedro D. Salazar-Fajardo, Tania Ferrer, Javier Alamilla, Jose A. Sanchez-Chapula, Ricardo A. Navarro-Polanco, Eloy G. Moreno-Galindo
Summary: The inhibitory regulation of the heart is determined by both M-2 and A(1) receptors, which activate K-ACh channels. The study found that M2R has voltage sensitivity, while A(1)R has minimal voltage dependence. This finding further supports the hypothesis of agonist-specific voltage dependence in GPCRs.
Article
Multidisciplinary Sciences
Shannon Hateley, Angelica Lopez-Izquierdo, Chuanchau J. Jou, Scott Cho, Joshua G. Schraiber, Shiya Song, Colin T. Maguire, Natalia Torres, Michael Riedel, Neil E. Bowles, Cammon B. Arrington, Brett J. Kennedy, Susan P. Etheridge, Shuping Lai, Chase Pribble, Lindsay Meyers, Derek Lundahl, Jake Byrnes, Julie M. Granka, Christopher A. Kauffman, Gordon Lemmon, Steven Boyden, W. Scott Watkins, Mary Anne Karren, Stacey Knight, J. Brent Muhlestein, John F. Carlquist, Jeffrey L. Anderson, Kenneth G. Chahine, Khushi U. Shah, Catherine A. Ball, Ivor J. Benjamin, Mark Yandell, Martin Tristani-Firouzi
Summary: The study characterized a high-impact atrial fibrillation susceptibility allele, analyzed its transcontinental geographic distribution and history, and its functional effects in carriers. Through analysis of identity-by-descent networks and ancestral migration routes, the relatively recent origin of this allele was revealed.
NATURE COMMUNICATIONS
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Yadira Ramirez Rodriguez, Karina Robledo Marquez, Ricardo Espinosa Tanguma, Alejandra Medina Hernandez, Roberto Valle Aguilera, Aldo Rodriguez-Menchaca, Nancy Garcia Rojas, Victoria Ramirez Gonzalez, Francisco Bautista Redonda, Robert Winkler, Lina Riego Ruiz, Daniela Joyce Trujillo Silva
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Rita Moran-Zendejas, Aldo A. Rodriguez-Menchaca
Summary: In this study, it was found that 2-hydroxyoleic acid (2OHOA) decreases cell proliferation by regulating Kv10.1 channels, suggesting its potential as an antitumoral agent.
BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mayra Delgado-Ramirez, Ana Laura Lopez-Serrano, Sergio Sanchez-Armass, Ulises Meza, Aldo A. Rodriguez-Menchaca
Summary: The activity of neuronal Kv7.2/Kv7.3 channels is regulated by both PIP2 and cholesterol. Cholesterol depletion enhances the interaction between Kv7.2/Kv7.3 channels and PIP2, while acute membrane cholesterol depletion does not affect the sensitivity of mutant channels with different affinities for PIP2.
BIOLOGICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Mayra Delgado-Ramirez, Fanny Junue Rodriguez-Leal, Aldo Azmar Rodriguez-Menchaca, Eloy Gerardo Moreno-Galindo, Jose Antonio Sanchez-Chapula, Tania Ferrer
Summary: Terfenadine, a second-generation H1-antihistamine known for its potential severe side effects, has recently gained attention for its anticancer properties. Researchers found that terfenadine inhibits Kir2.x channels by affecting their interaction with PIP2, which may be a mechanism for its antitumor effects.
ACTA PHARMACEUTICA
(2021)