Article
Cardiac & Cardiovascular Systems
Eric J. Stohr, Ruiping Ji, Koichi Akiyama, Giulio Mondellini, Lorenzo Braghieri, Alberto Pinsino, John R. Cockcroft, Melana Yuzefpolskaya, Amrin Amlani, Veli K. Topkara, Hiroo Takayama, Yoshifumi Naka, Nir Uriel, Koji Takeda, Paolo C. Colombo, Barry J. McDonnell, Joshua Z. Willey
Summary: The study compared cerebrovascular metabolic reactivity in patients with HM3 and HMII CF-LVADs, finding significantly improved CVR in HM3 patients, but remained lower than healthy controls. While CF-LVAD therapy has an impact on cerebral hemodynamics, it does not completely reverse the changes.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Pharmacology & Pharmacy
Bradley S. Fleenor, Nicholas A. Carlini, An Ouyang, Matthew P. Harber
Summary: Cardiovascular diseases are the leading cause of death in modern societies, and arterial stiffening plays a crucial role in the development of these diseases. Perivascular adipose tissue, a relatively understudied fat depot, has direct and profound effects on arterial stiffening. Identifying it as a therapeutic target to lower arterial stiffness and reduce cardiovascular disease risk has significant clinical implications.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Hairuo Lin, Yingqi Zhu, Cankun Zheng, Donghong Hu, Siyuan Ma, Lin Chen, Qiancheng Wang, Zhenhuan Chen, Jiahe Xie, Yi Yan, Xiaobo Huang, Wangjun Liao, Masafumi Kitakaze, Jianping Bin, Yulin Liao
Summary: Exercise-induced myocardial hypertrophy preconditioning can increase myocardial resistance to pathological stress through an antihypertrophic effect mediated by the Mhrt779/Brg1/Hdac2/p-Akt/p-GSK3 beta signaling pathway.
Article
Cardiac & Cardiovascular Systems
Satyam Sarma, Erin Howden, Justin Lawley, Mitchel Samels, Benjamin D. Levine
Summary: Patients with HFpEF have lower peak oxygen consumption and heart rate compared to senior controls, but there were no significant differences in peak heart rate response during static handgrip exercise and metaboreceptor function between the two groups. The key reflex autonomic pathways regulating exercise heart rate responsiveness are intact in HFpEF despite lower peak exercise heart rates.
Article
Physiology
Kanokwan Bunsawat, Stephen M. Ratchford, Jeremy K. Alpenglow, Soung Hun Park, Catherine L. Jarrett, Josef Stehlik, Adam S. Smith, Russell S. Richardson, D. Walter Wray
Summary: The study shows that treatment with sacubitril-valsartan improves conduit vessel function, functional capacity, and inflammation in patients with HFrEF. There was an improvement in %FMD, increased 6MWT distance, and a reduction in TNF-alpha and IL-18 levels after 3 months of therapy, indicating the potential of this new drug class to positively impact HFrEF pathophysiology.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Satyam Sarma, James P. MacNamara, Bryce N. Balmain, Christopher M. Hearon, Denis J. Wakeham, Andrew R. Tomlinson, Linda S. Hynan, Tony G. Babb, Benjamin D. Levine
Summary: Exercise intolerance is a common symptom in patients with heart failure with preserved ejection fraction (HFpEF), which is believed to be caused by a marked rise in pulmonary capillary wedge pressure (PCWP). This study investigated the effect of nitroglycerin on PCWP and exercise capacity in patients with HFpEF. The results showed that nitroglycerin successfully reduced PCWP during exercise, but did not improve peak oxygen uptake. These findings suggest that reducing PCWP alone is not sufficient to enhance exercise capacity in patients with HFpEF.
Article
Medicine, Research & Experimental
Giuseppe Potrick Stefani, Lucas Capalonga, Lucas Ribeiro da Silva, Thiago Gomes Heck, Matias Nunes Frizzo, Lucas Machado Sulzbacher, Maicon Machado Sulzbacher, Diovana de Batista, Samlai Vedovatto, Ana Paula Santin Bertoni, Marcia Rosangela Wink, Pedro Dal Lago
Summary: The study found that combined exercise training (CET) with 13-alanine and L-histidine supplementation in rats with heart failure (HF) can improve functional capacity and biochemical variables, reduce oxidative stress and inflammation, and affect mRNA expression of calcium transporters in the skeletal muscle.
Article
Chemistry, Multidisciplinary
Jin-Su Kim, Do Gyun Lee, Moon-Hyon Hwang
Summary: This study aimed to compare the vascular responses to moderate-intensity treadmill running in high PM2.5 (HPM2.5) and low PM2.5 (LPM2.5) conditions in healthy young males. The results showed that acute PM2.5 exposure can counteract the positive effect of aerobic exercise on vascular endothelial function in young males.
APPLIED SCIENCES-BASEL
(2023)
Review
Physiology
Lawrence P. Cahalin, Magno F. Formiga, Johnny Owens, Brady Anderson, Luke Hughes
Summary: BFRE can be safely performed in patients with different types of heart disease and heart failure, and can improve multiple cardiac-related measures and functions.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Soeren J. Backhaus, Torben Lange, Elisabeth F. George, Kristian Hellenkamp, Roman J. Gertz, Marcus Billing, Rolf Wachter, Michael Steinmetz, Shelby Kutty, Uwe Raaz, Joachim Lotz, Tim Friede, Martin Uecker, Gerd Hasenfuss, Tim Seidler, Andreas Schuster
Summary: Real-time cardiac magnetic resonance (RT-CMR) exercise imaging can accurately diagnose HFpEF, providing a suitable noninvasive diagnostic alternative, which may be beneficial for routine clinical use pending further multicenter studies.
Article
Cardiac & Cardiovascular Systems
Barry A. Borlaug, Yogesh N. V. Reddy, Amanda Braun, Hidemi Sorimachi, Massar Omar, Dejana Popovic, Alessio Alogna, Michael D. Jensen, Rickey Carter
Summary: This study found that treatment with dapagliflozin can reduce pulmonary capillary wedge pressure (PCWP) at rest and during exercise in patients with HFpEF, and has favorable effects on plasma volume and body weight.
Article
Physiology
Andrea Tryfonos, Joseph Mills, Daniel J. Green, Anton J. M. Wagenmakers, Ellen A. Dawson, Matthew Cocks
Summary: This study examined the relationships between in vivo measures of vascular function and the expression of atherogenic risk-modulating proteins in endothelial cells (ECs) isolated from the radial artery of CAD patients. The results revealed a difference in the regulation of endothelium-dependent vasodilation measured in vivo between patients with CAD compared to previously reported data in subjects without a clinical diagnosis, suggesting that eNOS Ser(1177) phosphorylation may be the key to maintain vasodilation in CAD patients.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Abdulbaset Maroofi, Tatiana Moro, Jacopo Agrimi, Fatemeh Safari
Summary: Heart failure is a pathological condition that affects the structure and function of all organs in the body, including the brain. Insufficient pumping of blood by the heart leads to the inability of HF patients to carry out daily activities and a decline in their cognitive capacity. There is a complex bidirectional relationship between the heart and the brain, involving not only hemodynamics but also bioelectric and endocrine signaling. Exercise can help mitigate cognitive dysfunction associated with HF, but further understanding of the underlying mechanisms is needed.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Jeremy K. Alpenglow, Kanokwan Bunsawat, Michael A. Francisco, Jesse C. Craig, Jarred J. Iacovelli, John J. Ryan, D. Walter Wray
Summary: Data from this study suggest that functional sympatholysis, or the ability to adequately attenuate sympathetic nervous system (SNS)-mediated vasoconstriction during exercise, is impaired in patients with heart failure with preserved ejection fraction (HFpEF). These observations extend the current understanding of HFpEF pathophysiology by implicating inadequate functional sympatholysis as an important contributor to reduced exercising muscle blood flow in this patient group.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Katie E. Cohen, Boran Katunaric, Mary E. Schulz, Gopika SenthilKumar, Micaela S. Young, James E. Mace, Julie K. Freed
Summary: This study found that chronic administration of exogenous adiponectin can restore nitric oxide as the mediator of flow-induced dilation in arterioles from patients with coronary artery disease. The Adiponectin Receptor 1 (AdipoR1) plays a critical role in adiponectin-induced NO signaling during shear. Additionally, osmotin, a plant-derived protein, showed similar effects to adiponectin.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Maria Diaz, Jasmin Jo, Mark Smolkin, Sarah Jane Ratcliffe, David Schiff
Summary: The study found that patients with lower-grade gliomas have a higher VTE risk, which is decreased in the presence of an IDH mutation. The incidence of VTE in glioblastoma patients is not affected by MGMT promoter methylation status.
Article
Cardiac & Cardiovascular Systems
Evan P. Rotar, Jared P. Beller, Mark E. Smolkin, William Z. Chancellor, Gorav Ailawadi, Leora T. Yarboro, Mathew Hulse, Sarah J. Ratcliffe, Nicholas R. Teman
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Public, Environmental & Occupational Health
Eleni-Rosalina Andrinopoulou, Michael O. Harhay, Sarah J. Ratcliffe, Dimitris Rizopoulos
Summary: Personalized prediction is a key component in clinical medicine and decision making, allowing for dynamic adjustments to patient prognosis based on available information. Joint models can enhance individual predictions and improve accuracy, while resources and measures provided in this article support the development and evaluation of dynamic risk predictions.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Pediatrics
Amanda M. Zimmet, Brynne A. Sullivan, Karen D. Fairchild, J. Randall Moorman, Joseph R. Isler, Aaron W. Wallman-Stokes, Rakesh Sahni, Zachary A. Vesoulis, Sarah J. Ratcliffe, Douglas E. Lake
Summary: The study analyzed heart rate and oxygenation metrics of VLBW infants at three NICUs, finding similar trends across the sites for these metrics, but differences in bradycardia and desaturation events in the first two weeks after birth.
PEDIATRIC RESEARCH
(2021)
Article
Obstetrics & Gynecology
Laura N. Homewood, Eesha D. Dave, Riyas Ali, Indika V. Mallawaarachchi, Sarah J. Ratcliffe, Goundappa K. Balasubramani, Ted T. M. Lee
Summary: This study aimed to identify preoperative and intraoperative risk factors for adnexal torsion after hysterectomy, and estimate the incidence of the disease in the modern era of laparoscopic surgery. The study found that the laparoscopic approach to hysterectomy, younger age at the time of hysterectomy, and a history of endometriosis were associated with subsequent risk of adnexal torsion.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Statistics & Probability
Tianhao Wang, Sarah J. Ratcliffe, Wensheng Guo
Summary: In this paper, a flexible semiparametric curve registration model is introduced to estimate the time origin in observational studies. The model assumes a flexible common shape function for the longitudinal trajectories, characterized by a random curve registration function that represents person-specific disease progression patterns. The unknown time origin is modeled as a random start time, which is used to jointly model the longitudinal and survival data. The proposed models are proved to be asymptotically consistent and semiparametrically efficient. Simulation studies and real data applications demonstrate the effectiveness of this new approach.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Biophysics
William B. Ashe, Sarah E. Innis, Julia N. Shanno, Camille J. Hochheimer, Ronald D. Williams, Sarah J. Ratcliffe, J. Randall Moorman, Shrirang M. Gadrey
Summary: This study developed a method to detect breaths using motion sensors, which can provide high-resolution respiratory rate signals by separating individual breaths. The relationship between respiratory kinematics and flow varies between individuals and exercise stages.
PHYSIOLOGICAL MEASUREMENT
(2022)
Article
Multidisciplinary Sciences
Courtney M. Lattimore, William J. Kane, Mark A. Fleming, Allison N. Martin, J. Hunter Mehaffey, Mark E. Smolkin, Sarah J. Ratcliffe, Victor M. Zaydfudim, Shayna L. Showalter, Traci L. Hedrick
Summary: During the COVID-19 pandemic, telemedicine was more likely to be used by patients from the least socioeconomically distressed communities, with activated MyChart, and with non-government or commercial insurance. Telemedicine users were more likely to be female and have non-government or commercial insurance compared to those who used in-person visits.
Meeting Abstract
Clinical Neurology
Jackson A. Narrett, Ethan D. Assefa, Arti Patel, Indika Mallawaarachchi, Johanna J. Loomba, Sarah Ratcliffe, Ofer Sadan, Teshamae Monteith, Bradford B. Worrall, Donald E. Brown, Karen C. Johnston, Andrew M. Southerland
Article
Surgery
Katherine M. Marsh, Florence E. Turrentine, Worthington G. Schenk, John B. Hanks, Bruce D. Schirmer, John P. Davis, Timothy L. McMurry, Sarah J. Ratcliffe, Victor M. Zaydfudim, R. S. Jones
Summary: This study characterized errors in the care of surgical patients and found an association between errors and postoperative morbidity, especially technical errors. The results of the study revealed a strong independent relationship between errors and morbidity.
Article
Obstetrics & Gynecology
Lisa Letzkus, Karen Fairchild, Genevieve Lyons, Harshini Pyata, Sarah Ratcliffe, Doug Lake
Summary: This study found that atypical heart rate (HR) patterns in neonatal intensive care unit (NICU) patients can predict the eventual diagnosis of cerebral palsy (CP), while patterns of pulse oximetry (SpO (2) ) are not associated with CP prediction.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Prerna Sharma, Kajal Shah, Johanna Loomba, Arti Patel, Indika Mallawaarachchi, Olivia Blazek, Sarah Ratcliffe, Khadijah Breathett, Amber E. Johnson, Angela M. Taylor, Michael Salerno, Michael Ragosta, Nishtha Sodhi, Daniel Addison, Selma Mohammed, Kenneth C. Bilchick, Sula Mazimba
Summary: This study aimed to assess the outcomes of COVID-19 positive patients with acute myocardial infarction (AMI) undergoing early invasive treatment strategies. The results showed that COVID-19 positive patients who underwent coronary angiography had a higher risk of respiratory failure compared to COVID-19 negative patients, and the odds of prolonged length of stay were also higher in patients who underwent coronary angiography and CABG.
CLINICAL CARDIOLOGY
(2022)
Meeting Abstract
Surgery
Nathan S. Haywood, Sarah J. Ratcliffe, Xinyan Zheng, Jialin Mao, Behzad Farivar, Margaret C. Tracci, Mahmoud B. Malas, Philip P. Goodney, W. Darrin Clouse
JOURNAL OF VASCULAR SURGERY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Megan Whitham, Shannon Barter, Gabrielle Smith, L. Brett Whalen, Alexis Allihien, Amanda Urban, Sarah Ratcliffe, Donald J. Dudley
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Meeting Abstract
Surgery
Katherine M. Marsh, Florence E. Turrentine, Worthington G. Schenk, John B. Hanks, Bruce D. Schirmer, John P. Davis, Timothy L. McMurry, Mark E. Smolkin, Sarah J. Ratcliffe, R. Scott Jones
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)