Article
Medicine, General & Internal
Gueclue Aykut, Halim Ulugoel, Ugur Aksu, Sakir Akin, Hasan Karabulut, Cem Alhan, Fevzi Toraman, Can Ince
Summary: This study suggests that blood cardioplegia may offer better preservation of microcirculation compared to crystalloid cardioplegia in patients undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB), potentially through attenuating the systemic inflammatory response.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Cristina Barbero, Marco Pocar, Giovanni Marchetto, Erik Cura Stura, Claudia Calia, Bianca Dalbesio, Claudia Filippini, Stefano Salizzoni, Massimo Boffini, Mauro Rinaldi, Davide Ricci
Summary: This study compared single-shot St. Thomas cardioplegia with Custodiol (R) cardioplegia in patients undergoing mini-thoracotomy mitral valve (MV) surgery. The results showed that single-dose St. Thomas cardioplegia can provide effective myocardial protection exceeding 1 hour of ischemic arrest in selected patients. No differences were found in postoperative markers of myocardial injury, but ventricular fibrillation was more frequent following Custodiol (R) cardioplegia at the resumption of electric activity.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chloe Bernard, Marie Catherine Morgant, Aline Jazayeri, Thomas Perrin, Ghislain Malapert, Saed Jazayeri, Alain Bernard, Olivier Bouchot
Summary: During the acute phase of myocardial infarction, revascularization with angioplasty is essential and emergency surgery should be avoided if possible. The timing of surgical revascularization and the patient's preoperative state are important factors that influence the mortality rate.
Article
Health Care Sciences & Services
Po-Shun Hsu, Jia-Lin Chen, Shih-Ying Sung, Yi-Ting Tsai, Chih-Yuan Lin, Yi-Fan Wu, Chien-Sung Tsai
Summary: This study compares the hemorheological and inflammatory changes before and after coronary artery bypass graft (CABG) surgery and finds that hyperviscosity persists for almost one week after the surgery. Inflammatory markers are also correlated with hemorheological changes. Understanding the interplay between inflammation and hemorheological properties is crucial for patient care.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Wenda Gu, Hongkun Qing, Xiang Luo, Xin Zang, Kan Zhou, Haijiang Guo, Chengbin Zhou, Huiming Guo, Jian Liu
Summary: This study compared the safety and efficacy of del-Nido cardioplegia (DNC) with traditional cold blood cardioplegia (CBC) in elderly patients undergoing coronary artery bypass grafting and/or valve surgeries. The results showed similar mortality and ECMO implantation rate between the DNC and CBC groups, but lower incidence of postoperative IABP implantation and higher LVEF at discharge in the DNC group. The eGFR and serum lactate values were also more favorable in the DNC group. Overall, del-Nido cardioplegia is a safe and effective option for elderly patients undergoing these surgeries.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Nicola Colangelo, Alessandra Sala, Giulia Gallio, Andrea Blasio, Francesco De Simone, Alessandro Aina, Antonino Buffa, Alessandro Verzini, Ottavio Alfieri, Francesco Maisano, Alessandro Castiglioni, Michele De Bonis
Summary: Nowadays, the adaptability of a cardioplegia circuit to administer various types of cardioplegia is crucial. The ReverseTWO system allows for immediate changes in cardioplegia setup, provides versatility, reduces cost and risk, and simplifies storage.
Review
Cardiac & Cardiovascular Systems
Qianlei Lang, Chaoyi Qin, Wei Meng
Summary: This article evaluated the optimal timing for coronary artery bypass grafting (CABG) after acute myocardial infarction (AMI). The results showed that for STEMI patients, CABG should be delayed until 24 hours later as far as possible, while there was no time limit for NSTEMI patients. There was no significant difference in the incidence of perioperative myocardial infarction (MI) and cerebrovascular accidents between early and late CABG.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sripal Bangalore, Eric R. Bates, Theresa M. Beckie, James M. Bischoff, John A. Bittl, Mauricio G. Cohen, J. Michael DiMaio, Creighton W. Don, Stephen E. Fremes, Mario F. Gaudino, Zachary D. Goldberger, Michael C. Grant, Jang B. Jaswal, Paul A. Kurlansky, Roxana Mehran, Thomas S. Metkus, Lorraine C. Nnacheta, Sunil V. Rao, Frank W. Sellke, Garima Sharma, Celina M. Yong, Brittany A. Zwischenberger, Patrick T. O'Gara, Joshua A. Beckman, Glenn N. Levine, Sana M. Al-Khatib, Anastasia L. Armbruster, Kim K. Birtcher, Joaquin E. Cigarroa, Lisa de las Fuentes, Anita Deswal, Dave L. Dixon, Lee A. Fleisher, Federico Gentile, Zachary D. Goldberger, Bulent Gorenek, Norrisa Haynes, Adrian F. Hernandez, Mark A. Hlatky, Jose A. Joglar, W. Schuyler Jones, Joseph E. Marine, Daniel B. Mark, Debabrata Mukherjee, Latha P. Palaniappan, Mariann R. Piano, Tanveer Rab, Erica S. Spatz, Jacqueline E. Tamis-Holland, Duminda N. Wijeysundera, Y. Joseph Woo
Summary: This article introduces the importance and application of coronary artery revascularization guidelines, which provide a patient-centric approach for treating patients with significant coronary artery disease. The guidelines are supported by relevant literature.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Surgery
Cuneyt Eris, Mesut Engin, Burak Erdolu, Ahmet Kagan As
Summary: This study compared the operative and early postoperative outcomes of using del Nido Cardioplegia solution (dNCS) with traditional blood cardioplegia (BC) in adult aortic surgery. The results showed that compared to BC, dNCS significantly reduced aortic cross-clamp time, decreased the need for intraoperative defibrillation, and lowered postoperative levels of high sensitive troponin I (hsTnI). The study concluded that dNCS is a safe and efficient alternative to BC in adult aortic cardiac surgery, providing comparable clinical outcomes.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Purna Bahadur Moktan Lama, Prabhat Khakural, Shailendra Sigdel, Mahendra Raj Bhatta, Rabindra Sah Teli, Ravi Kumar Baral, Anil Bhattarai, Bishwas Pradhan, Bhagawan Koirala
Summary: The study concluded that del Nido cardioplegia is a more efficacious, safe, and cost-effective alternative to St. Thomas solution in patients undergoing coronary artery bypass grafting in Nepal.
Review
Medicine, General & Internal
Mario Gaudino, Felicita Andreotti, Takeshi Kimura
Summary: Coronary artery revascularisation can be done through surgery or percutaneous intervention. Surgery has higher risks and longer recovery time, but offers long-term reduction of recurrent cardiac events. The choice between surgical or percutaneous intervention depends on clinical and anatomical reasons or personal preferences. Medical therapy is crucial in combination with coronary revascularisation, and some patients may achieve similar results with medical therapy alone. The existing revascularisation data mainly focus on white, non-elderly, male populations in high-income countries, so there is an urgent need for robust data in other populations.
Article
Respiratory System
Xuefeng Lin, Yanping Jiang, Peng Zhu, Qinbao Peng, Weipeng Meng, Shaoyi Zheng
Summary: This study examines the cardioprotective effect of del Nido cardioplegia in adult multivessel coronary artery bypass grafting (CABG) surgery. The results demonstrate that del Nido cardioplegia leads to a significantly shorter surgical time and higher hemoglobin concentration in the early postoperative period.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Surgery
Mikko S. Mattila, Kati M. Jarvela, Timo T. Rinne, Kjell C. Nikus, Markku J. Rantanen, Juho A. A. Siltanen, Jenna-Juulia Helea, Jari O. Laurikka
Summary: This study evaluated the use of adenosine in patients after bypass surgery for coronary artery disease. The results showed that adenosine shortened the time to asystole and partially improved ventricular performance.
SCANDINAVIAN JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Tzu-Hsiang Lin, Chi-Wei Wang, Ching-Hui Shen, Keng-Hao Chang, Chih-Hung Lai, Tsun-Jui Liu, Kuan-Ju Chen, Yu-Wei Chen, Wen-Lieng Lee, Chieh-Shou Su
Summary: The study found that in real-world practice, robotic-assisted CABG (R-CABG) for patients with multivessel coronary artery disease (MVD) was associated with lower in-hospital and long-term mortalities compared to conventional CABG (C-CABG). However, there were no significant differences between the two groups in terms of target lesion revascularization, target vessel revascularization, myocardial infarction, and stroke.
Article
Cardiac & Cardiovascular Systems
Jennifer S. Lawton, Jacqueline E. Tamis-Holland, Sripal Bangalore, Eric R. Bates, Theresa M. Beckie, James M. Bischoff, John A. Bittl, Mauricio G. Cohen, J. Michael DiMaio, Creighton W. Don, Stephen E. Fremes, Mario F. Gaudino, Zachary D. Goldberger, Michael C. Grant, Jang B. Jaswal, Paul A. Kurlansky, Roxana Mehran, Thomas S. Metkus, Lorraine C. Nnacheta, Sunil V. Rao, Frank W. Sellke, Garima Sharma, Celina M. Yong, Brittany A. Zwischenberger
Summary: The executive summary of the guideline provides top 10 key points that clinicians should know about coronary revascularization for patients with significant coronary artery disease. This summary offers a patient-centric approach and encourages the use of supporting documentation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Arnaldo Dimagli, Umberto Benedetto
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Mario Gaudino, Katia Audisio, Mohamed Rahouma, N. Bryce Robinson, Giovanni J. Soletti, Gianmarco Cancelli, Ruth M. Masterson Creber, Alastair Gray, Belinda Lees, Stephen Gerry, Umberto Benedetto, Marcus Flather, David P. Taggart, Arterial Revascularization Trial Arterial Revascularizat Trial Investigators
Summary: This study evaluated the association between sternal wound complications (SWC) and long-term mortality in the Arterial Revascularization Trial. The results showed that postoperative SWC was significantly associated with long-term mortality and increased rates of major adverse cardiovascular events.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Fabrizio Ricci, Gabriella Bufano, Victor Galusko, Baskar Sekar, Umberto Benedetto, Wael Awad, Michele di Mauro, Sabina Gallina, Adrian Ionescu, Luigi Badano, Mohammed Y. Khanji
Summary: Tricuspid regurgitation is a prevalent condition with varying clinical guidelines for diagnosis and management. While there are areas of consensus, discrepancies and lack of evidence exist in certain aspects.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Review
Cardiac & Cardiovascular Systems
Andrea Amabile, Markus Krane, Keith Dufendach, Christopher W. Baird, Nikhil Ganjoo, Friedrich S. Eckstein, Alberto Albertini, Peter J. Gruber, Mubashir A. Mumtaz, Emile A. Bacha, Umberto Benedetto, Joanna Chikwe, Arnar Geirsson, Johannes Holfeld, Yasunori Iida, Rudiger Lange, Victor O. Morell, Danny Chu
Summary: AVNeo is a reliable and standardized alternative to aortic valve replacement, with excellent short to midterm outcomes demonstrating the safety and durability of the procedure. Long-term outcomes and clinical trial data are needed to determine the most suitable patients for this surgery.
ANNALS OF THORACIC SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Jeremy Chan, Shwe Oo, Salman Butt, Umberto Benedetto, Massimo Caputo, Gianni D. Angelini, Hunaid A. Vohra
Summary: This study indicates that there is no difference in clinical outcomes between blood and crystalloid cardioplegia in adult minimally invasive cardiac surgery. The choice of cardioplegia in minimally invasive cardiac surgery remains dependent on the surgeon's decision and preference.
Article
Cardiac & Cardiovascular Systems
Daniel Paul Fudulu, Arnaldo Dimagli, Shubhra Sinha, James Ackah, Pradeep Narayan, Jeremy Chan, Marco Gemelli, Tim Dong, Umberto Benedetto, Gianni Davide Angelini
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Surgery
Daisy A. Elliott, Cynthia A. Ochieng, Jesmond Zahra, Angus G. K. G. McNair, Barry G. Main, Anni S. Skilton, Natalie S. Blencowe, Sian Cousins, Sangeetha Paramasivan, Christin L. Hoffmann, Jenny L. M. Donovan, Jane M. Blazeby, Lotus Clin Innovator Collaborators
Summary: This study investigated how information about innovative surgical procedures is communicated to patients. Through qualitative research on seven case studies in hospitals across the United Kingdom, interviews were conducted with clinician innovators, preoperative consultations were recorded, and postoperative interviews were conducted with patients. The study found inconsistencies between clinicians' intentions to inform patients about uncertain outcomes and their actual discussions with patients. Many patients were unaware of the unknown risks associated with the procedure.
Article
Cardiac & Cardiovascular Systems
Natalia Ivascu Girardi, Melissa M. Cushing, Lisbeth A. Evered, Umberto Benedetto, Thomas A. Schwann, Paul Kurlansky, Robert H. Habib, Mario F. L. Gaudino
Summary: Isolated single-unit red blood cell transfusions are common in cardiac surgery patients and are associated with higher morbidity.
ANNALS OF THORACIC SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Mario Gaudino, John Alexander, Umberto Benedetto, Andreas Boening, Arnaldo Dimagli, Stephen Fremes, Joanna Chikwe, Leonard Girardi, David Hare, Paul Kurlansky, Andre Lamy, Katia Audisio, Antonino Di Franco, P. J. Devereaux, Anno Diegeler, Marcus Flather, Jennifer S. Lawton, Derrick Y. Tam, Wilko Reents, Mohamed Rahouma
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Health Care Sciences & Services
Jessica Harris, Koen B. Pouwels, Thomas Johnson, Jonathan Sterne, Christalla Pithara, Kalaivani Mahadevan, Barney Reeves, Umberto Benedetto, Yoon Loke, Daniel Lasserson, Brett Doble, Noreen Hopewell-Kelly, Sabi Redwood, Sarah Wordsworth, Andrew Mumford, Chris Rogers, Maria Pufulete
Summary: This study quantified the bleeding risk among patients undergoing different antiplatelet and triple therapy regimens for percutaneous coronary intervention or coronary artery bypass grafting, as well as conservatively managed acute coronary syndrome. The results suggest that more potent dual antiplatelet therapy may increase the risk of bleeding without reducing the incidence of major adverse cardiovascular events.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Medicine, General & Internal
Mai Baquedano, Samantha E. de Jesus, Filippo Rapetto, Gavin J. Murphy, Gianni Angelini, Umberto Benedetto, Patricia Caldas, Prashant K. Srivastava, Orhan Uzun, Karen Luyt, Cecilia Gonzalez Corcia, Demetris Taliotis, Serban Stoica, Deborah A. Lawlor, Andrew R. Bamber, Alison Perry, Katie L. Skeffington, Ikenna Omeje, John Pappachan, Andrew D. Mumford, Richard J. M. Coward, Damien Kenny, Massimo Caputo
Summary: This study aims to establish a prospective cohort of patients with congenital heart disease (CHD) undergoing cardiac procedures. It will collect clinical data, biological samples, and participant questionnaires to investigate risk factors, predictors, and the effects of surgery on outcomes.
Article
Health Care Sciences & Services
Tim Dong, Shubhra Sinha, Ben Zhai, Daniel P. Fudulu, Jeremy Chan, Pradeep Narayan, Andy Judge, Massimo Caputo, Arnaldo Dimagli, Umberto Benedetto, Gianni D. Angelini
Summary: This study combines EuroSCORE I and EuroSCORE II data using ensemble learning methods to predict cardiac surgery risk. The results show that both homogeneous and heterogeneous machine learning ensembles perform better than dynamic model averaging ensembles.
Article
Cardiac & Cardiovascular Systems
Shubhra Sinha, Tim Dong, Arnaldo Dimagli, Hunaid A. Vohra, Chris Holmes, Umberto Benedetto, Gianni D. Angelini
Summary: This study systematically compared the in-hospital mortality risk prediction post-cardiac surgery using different approaches, including the EuroSCORE II, logistic regression, and various machine learning techniques. The results showed that machine learning techniques, such as XGBoost and random forest, had some statistical improvements over traditional models. However, the clinical impact of these improvements is currently modest.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Mathematical & Computational Biology
Solon Karapanagiotis, Umberto Benedetto, Sach Mukherjee, Paul D. W. Kirk, Paul J. Newcombe
Summary: Risk prediction models are crucial in healthcare, but the assumption that the costs of different classification errors are equal may not be valid in many healthcare applications. Tailored Bayes (TB) is introduced as a Bayesian framework to optimize predictive performance with respect to unbalanced misclassification costs, showing improvement over standard methods in simulation studies and real-world applications.
Article
Cardiac & Cardiovascular Systems
Matthew Little, Alastair M. Gray, Douglas G. Altman, Umberto Benedetto, Marcus Flather, Stephen Gerry, Belinda Lees, Jacqueline Murphy, Mario Gaudino, David P. Taggart
Summary: Using bilateral internal thoracic arteries (BITAs) for coronary artery bypass grafting (CABG) has been suggested to improve survival compared to CABG using single internal thoracic arteries (SITAs) for patients with advanced coronary artery disease. This study found that while BITA grafting has significantly higher costs, it offers similar quality-adjusted survival at 10 years compared to SITA grafting. Extrapolation suggests that this cost-effectiveness advantage of BITA grafting could potentially change over a patient's lifetime.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)