Article
Cardiac & Cardiovascular Systems
Takatoshi Shigeta, Shinsuke Miyazaki, Osamu Inaba, Yukihiro Inamura, Junichi Nitta, Yukio Sekiguchi, Atsushi Takahashi, Hitoshi Hachiya, Yasutoshi Nagata, Yasuteru Yamauchi, Tatsuya Hayashi, Shinsuke Iwai, Akira Mizukami, Yuichi Ono, Keita Handa, Makoto Suzuki, Atsushi Suzuki, Jun Nakajima, Kenzo Hirao, Hiroyuki Okada, Miho Negishi, Takashi Ikenouchi, Tasuku Yamamoto, Kentaro Goto, Takuro Nishimura, Susumu Tao, Masateru Takigawa, Akihiro Hirakawa, Masahiko Goya, Tetsuo Sasano
Summary: The CORNERSTONE AF study is a prospective, randomized, multicenter trial designed to evaluate the efficacy and safety of an adjunctive empirical LAPWI following standard AF ablation in persistent AF patients. A total of 331 patients have been enrolled in the study, and the primary endpoint of whether there is documented atrial arrhythmia postprocedure will be evaluated through a clinical follow-up period of 18 months.
CLINICAL CARDIOLOGY
(2023)
Article
Critical Care Medicine
Oyvind Jervan, Stacey Haukeland-Parker, Jostein Gleditsch, Mazdak Tavoly, Frederikus A. Klok, Kjetil Steine, Hege Holmo Johannessen, Martijn A. Spruit, Dan Atar, Rene Holst, Anders Erik Astrup Dahm, Per Anton Sirnes, Knut Stavem, Waleed Ghanima
Summary: This study aimed to investigate whether an exercise-based rehabilitation program could improve exercise capacity in pulmonary embolism patients with persistent dyspnea. The results showed that patients who underwent rehabilitation had better exercise capacity at follow-up compared to those who received usual care.
Article
Behavioral Sciences
Guttorm Eldoen, Stine E. Kvalheim, Terje Thesen, Ase Mygland, Unn Ljostad, Siri Bakke, Marit Horsgaard Holo, Ingard Loge, Egil Jonsbu
Summary: The study investigated the feasibility and preliminary outcome of a Norwegian web-based self-help application for vestibular rehabilitation among patients with chronic dizziness. Results showed that most patients were able to complete the program, and the average improvement on the VSS score was 6.9 points.
BRAIN AND BEHAVIOR
(2021)
Article
Rehabilitation
Leah J. Mercier, Kristina Kowalski, Tak S. Fung, Julie M. Joyce, Keith Owen Yeates, Chantel T. Debert
Summary: The study found that individuals with persistent postconcussive symptoms (PPCS) experienced a significant decrease in physical activity compared to preinjury levels. Patients meeting physical activity guidelines postinjury were associated with better clinical outcomes, while sedentary behavior was negatively correlated with quality of life.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Endocrinology & Metabolism
Daniel Weiman, Farid H. Mahmud, Antoine B. M. Clarke, Esther Assor, Charlotte McDonald, Fred Saibil, Heather A. Lochnan, Zubin Punthakee, Margaret A. Marcon
Summary: This study found that the adoption of a GFD in T1D patients with asymptomatic CD did not significantly affect HRQoL and SPW, but worsened with symptom onset and increased HbA(1c). The findings suggest that the transition to a GFD can be successfully made in this population without adversely impacting quality of life.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Ju Youn Kim, Hyoung-Seob Park, Hyung Wook Park, Eue-Keun Choi, Jin-Kyu Park, Jin-Bae Kim, Ki-Woon Kang, Jaemin Shim, Boyoung Joung, Kyoung-Min Park
Summary: This study compared AF-related outcomes based on baseline symptom scores and determined the optimal treatment strategy for asymptomatic AF patients. The results showed poorer outcomes in symptomatic patients and rhythm control significantly improved outcomes in asymptomatic patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Neeltje A. E. Allard, Lando Janssen, Thorben Aussieker, Anouk A. F. Stoffels, Richard J. Rodenburg, Willem J. J. Assendelft, Paul D. Thompson, Tim Snijders, Maria T. E. Hopman, Silvie Timmers
Summary: This study found that a moderate intensity exercise training program improved muscle performance, capillarization, and mitochondrial content in both symptomatic and asymptomatic statin users without worsening muscle symptoms.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Mohammad Iqbal, Iwan Cahyo Santosa Putra, William Kamarullah, Raymond Pranata, Chaerul Achmad, Giky Karwiky, Miftah Pramudyo, Hanna Goenawan, Mohammad Rizki Akbar, Arief Sjamsulaksan Kartasasmita, Young Hoon Kim
Summary: Premature ventricular complexes (PVCs) during exercise test are associated with an elevated risk of mortality in asymptomatic individuals, especially frequent PVCs. Recovery phase PVCs have higher specificity than exercise phase PVCs in predicting outcomes. Regular exercise ECG examination is recommended for middle-aged asymptomatic individuals to assess the risk of mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Green & Sustainable Science & Technology
Theingi Maung Maung, Timsi Jain, Jagannathan Madhanagopal, Sawri Rajan L. Rajagopal Naidu, Hnin Pwint Phyu, Win Myint Oo
Summary: Aerobic and strengthening exercises for a minimum of 12 weeks may improve mental health and quality of life among the elderly during the COVID-19 pandemic.
Review
Immunology
Rafael Giovani Misse, Isabela Bruna Pires Borges, Alexandre Moura dos dantos, Latika Gupta, Samuel Katsuyuki Shinjo
Summary: Systemic autoimmune myopathies are rare rheumatic diseases characterized by muscle weakness due to inflammation. There is a lack of research on the effects of pharmacological and non-pharmacological therapies, such as exercise training, on pain and fatigue perception in these patients. Therefore, systematic reviews on the effectiveness of exercise training on pain and fatigue perception can contribute to clinical management.
AUTOIMMUNITY REVIEWS
(2021)
Article
Multidisciplinary Sciences
Endre Takacs, Iren Barkaszi, Istvan Czigler, Livia Gabriella Pato, Anna Altbacker, Joseph McIntyre, Guy Cheron, Laszlo Balazs
Summary: The study found that cognitive performance can suffer marked decrements during spaceflight, with astronauts being slower and more error-prone, and brain potentials reflecting diminished attentional resources. Results indicate restricted adaptability to spaceflight conditions and calls for new research prior to deep space explorations.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Kirsty Bannister, Rory V. Smith, Patrick Wilkins, Tatum M. Cummins
Summary: Patients with Parkinson's disease may live for many years after diagnosis, experiencing a range of symptoms including persistent pain. However, limited treatment options and incomplete understanding of the mechanisms underlying pain in PD pose challenges. The heterogeneity and methodological differences in research studies lead to inconclusive evidence and a lack of clear conclusions.
NPJ PARKINSONS DISEASE
(2021)
Article
Behavioral Sciences
Alexandra M. Rogers, Brianna N. Lauren, Jennifer A. Woo Baidal, Elissa M. Ozanne, Chin Hur
Summary: This study examined the sustained impacts of COVID-19 prevention measures on diet, exercise, risk for food insecurity, and quality of life among adults in the U.S. Findings showed that issues present at the beginning of the pandemic had evolved 8 months later, highlighting the importance of encouraging healthy eating and supporting mental health.
Article
Cardiac & Cardiovascular Systems
Tomasz M. Ksiazczyk, Anna Jaron, Radoslaw Pietrzak, Bozena Werner
Summary: Pre-excitation syndrome can lead to supraventricular tachycardias and sudden cardiac death. This study assessed the impact of pre-excitation on physical performance in children using cardio-pulmonary exercise testing.
Article
Surgery
Bhamini Vadhwana, Chelise Carrow, David Bowers, Thomas Groot-Wassink
Summary: The study showed that parathyroidectomy in asymptomatic PHPT patients was significantly associated with improvement in health-related quality of life, including a reduction in anxiety and depression levels. In symptomatic patients, the primary improvement was seen in anxiety and depression levels, suggesting an important cognitive and social aspect of the disease.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Marco Valerio Mariani, Nicola Pierucci, Giovanni Battista Forleo, Marco Schiavone, Alessia Bernardini, Alessio Gasperetti, Gianfranco Mitacchione, Mariachiara Mei, Giuseppe Giunta, Agostino Piro, Cristina Chimenti, Fabio Miraldi, Carmine Dario Vizza, Carlo Lavalle
Summary: The feasibility and effectiveness of virtual visits (VVs) for cardiac electrophysiology patients were evaluated and patient experience with virtual care was described. The study found that VVs were as feasible and effective as in-person visits, with no significant differences in remote monitoring alert disappearance rate, improvement in symptoms, and patient satisfaction. Virtual visits proved to be a viable and effective alternative to in-person visits.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Luigi Di Biase, Jacopo Marazzato
Article
Cardiac & Cardiovascular Systems
Sanjeev Saksena, April Slee, Andrea Natale, Dhanunjaya R. Lakkireddy, Dipen Shah, Luigi Di Biase, Thorsten Lewalter, Rangadham Nagarakanti, Pasquale Santangeli
Summary: Prevalent atrial fibrillation is associated with increased cardiovascular death and hospitalizations in heart failure patients with preserved ejection fraction. It has an independent impact on cardiovascular disease and heart failure morbidity.
Article
Cardiac & Cardiovascular Systems
Sanghamitra Mohanty, John D. Burkhardt, Luigi Di Biase, Prasant Mohanty, Sai Shishir Shetty, Carola Gianni, Domenico G. Della Rocca, Karim K. Baho, Trevor Morris, Angel Mayedo, Bryan MacDonald, Amin Al-Ahmad, Mohamed Bassiouny, Gerald Joseph Gallinghouse, Rodney Horton, Andrea Natale
Summary: This study aimed to compare the clinical benefits between targeted ablation of all Premature ventricular complex (PVC) morphologies and ablation of predominant PVC only. Analysis of 171 patients with reduced LVEF and high PVC burden (>10%/day) showed that ablation of all PVC morphologies was associated with significantly lower PVC burden and improvement of LVEF at long-term follow-up, compared with ablation of the dominant morphology only.
Article
Cardiac & Cardiovascular Systems
Juan Carlos Diaz, Jorge E. Marin, Julian M. Aristizabal, Oriana Bastidas, Carolina Hoyos, Carlos Matos, Nestor Lopez-Cabanillas, Jose Matias, Luigi Di Biase, Jorge Romero
Summary: This study evaluated the use of chlorhexidine gluconate (CHG) lavage as an alternative to capsulectomy for treating CIED infections. The findings showed that using CHG lavage can reduce hematoma formation and shorten procedural times without increasing the risk of reinfection or adverse events associated with CHG use.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Lucas Boersma, Jason G. Andrade, Tim Betts, Mattias Duytschaever, Helmut Purerfellner, Francesco Santoro, Stylianos Tzeis, Atul Verma
Summary: Over the past 25 years, there has been a significant interest in developing new catheters and energy sources to optimize the durability and safety of ablation, as well as studying the mechanisms for atrial fibrillation and devising ablation strategies. Although pulmonary vein ablation has been the basis for every AF ablation, it has been recognized that this is not enough to cure all patients, especially those with non-paroxysmal AF.
Article
Cardiac & Cardiovascular Systems
Francesco Santoro, Scott Sharkey, Rodolfo Citro, Tetsuji Miura, Luca Arcari, Jose Angel Urbano-Moral, Thomas Stiermaier, Ivan Javier Nunez-Gil, Angelo Silverio, Nicola Di Nunno, Ilaria Ragnatela, Rosa Cetera, Junichi Nishida, Ingo Eitel, Natale Daniele Brunetti
Summary: This study evaluated the effectiveness of beta-blockers (BB) and ACE inhibitors/angiotensin receptor blockers (ACEi/ARBs), alone or in combination, in preventing recurrences of Takotsubo syndrome (TTS). The results showed that neither BB nor ACEi/ARBs, either alone or in combination, were effective in reducing the risk of TTS recurrence.
Article
Cardiac & Cardiovascular Systems
Paige Mass, Justin Opfermann, R. T. Vito Grupposo, Luigi DiBiase, Charles I. Berul, Bradley C. Clark
Summary: This study evaluated the impact of a novel catheter torque tool (Peritorq) on catheter integrity during the use of diagnostic and ablation catheters in an adult porcine model. The results showed that there were no significant differences in catheter measurements with and without the torque tool. Subjective assessment by the operator indicated significant improvements in maneuverability and stability using the torque tool, with no significant impact on catheter integrity.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ayman A. Hussein, M. Craig Delaughter, George Monir, Andrea Natale, Srinivas Dukkipati, Saumil Oza, Emile Daoud, Luigi Di Biase, Moussa Mansour, Robert Fishel, Miguel Valderrabano, Kenneth Ellenbogen, Jose Osorio, Q-FFICIENCY investigators
Summary: Paroxysmal AF ablation with the novel temperature-controlled RF catheter leads to significant improvement in QOL, reduction in AAD use, cardioversion, and cardiovascular hospitalization.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Julian Chestaro Feliz, Priscilla Duran Luciano, Nehemias Guevara, Lynn Zaremski, Salim Baghdadi, Jacopo Marazzato, Luigi Di Biase
Summary: Pseudo-pacemaker syndrome (PPMS) is a rare complication of first-degree atrio-ventricular (AV) block that causes symptoms of hemodynamic instability without an implanted pacemaker. This article provides a comprehensive review on PPMS, presenting a unique case and analyzing 14 articles, including our case report. The most common age group affected by PPMS is middle-aged and young adults, with palpitations being the most common symptom. Treatment should be tailored to the specific etiology, although the management of PPMS due to dual AV nodal physiology (DAVNP) without AV nodal re-entrant tachycardia (AVNRT) presentation remains unclear.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Marco Schiavone, Alessio Gasperetti, Annalisa Filtz, Gaia Vantaggiato, Cecilia Gobbi, Claudio Tondo, Giovanni Battista Forleo
Summary: This study investigated the safety and efficacy of an uninterrupted DOAC strategy during catheter ablation for AF with different techniques. The results showed that the uninterrupted DOAC strategy was safe and effective regardless of the ablation technique used.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biology
Fabrizio Guarracini, Alberto Preda, Eleonora Bonvicini, Alessio Coser, Marta Martin, Silvia Quintarelli, Lorenzo Gigli, Matteo Baroni, Sara Vargiu, Marisa Varrenti, Giovanni Battista Forleo, Patrizio Mazzone, Roberto Bonmassari, Massimiliano Marini, Andrea Droghetti
Summary: The difference between subcutaneous implantable cardioverter defibrillators (S-ICDs) and transvenous ICDs (TV-ICDs) lies in the extra-thoracic implantation of S-ICDs, without endovascular components. S-ICDs have been rapidly adopted due to their improved safety profile, especially among younger patients. Although S-ICDs show comparable efficacy, reliability, and safety outcomes to TV-ICDs, technical issues limit their employment, making them an alternative rather than a mainstream option.
Article
Cardiac & Cardiovascular Systems
Nicola Susca, Antonio Giovanni Solimando, Paola Borrelli, Donatello Marziliano, Francesco Monitillo, Pasquale Raimondo, Domenico Vestito, Agostino Lopizzo, Gaetano Brindicci, Mohammad Abumayyaleh, Ibrahim El-Battrawy, Annalisa Saracino, Salvatore Grasso, Natale Daniele Brunetti, Vito Racanelli, Francesco Santoro
Summary: This retrospective cohort study investigates the use of ECG as a screening tool to predict the severity of COVID-19 upon admission to the emergency department. The study finds that abnormal ECG rhythm is associated with decreased survival and increased risk of death. This finding suggests the potential for using ECG as a cheap and simple procedure to identify high-risk patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Medicine, General & Internal
Marco Schiavone, Annalisa Filtz, Alessio Gasperetti, Alexander Breitenstein, Pietro Palmisano, Gianfranco Mitacchione, Simone Gulletta, Gian Battista Chierchia, Elisabetta Montemerlo, Giovanni Statuto, Giulia Russo, Michela Casella, Francesco Vitali, Patrizio Mazzone, Daniel Hofer, Gianmarco Arabia, Fabrizio Tundo, Diego Ruggiero, Nicolai Fierro, Massimo Moltrasio, Matteo Bertini, Antonio Dello Russo, Ennio C. L. Pisano, Paolo Della Bella, Giovanni Rovaris, Carlo de Asmundis, Mauro Biffi, Antonio Curnis, Claudio Tondo, Ardan M. M. Saguner, Giovanni B. B. Forleo
Summary: This study investigated the feasibility of using leadless pacemakers (LPM) for the treatment of emergency bradyarrhythmia. The results showed that emergency LPM implantation did not increase the rate of major complications compared to elective patients, but it was associated with longer procedural times.
MEDICINA-LITHUANIA
(2023)
Article
Cardiac & Cardiovascular Systems
Francesco Santoro, Enrica Vitale, Ilaria Ragnatela, Rosa Cetera, Alessandra Leopzzi, Adriana Mallardi, Annalisa Matera, Marco Mele, Michele Correale, Natale Daniele Brunetti
Summary: Cardiomyopathies are heart diseases characterized by dysfunction of the heart muscle, which can result in heart failure and life-threatening arrhythmias. Accurate patient history, thorough physical examination, and electrocardiogram are important for raising diagnostic suspicion, but cardiovascular imaging techniques are essential for diagnosing specific cardiomyopathies, assessing disease-related risk, and monitoring therapy response. Echocardiography is commonly the first exam used due to its non-invasiveness, wide availability, and cost-effectiveness. Cardiac magnetic resonance imaging can complement the information obtained from echocardiography. The genetic basis of cardiomyopathies has also been studied, and the list of potentially pathogenic genetic mutations is expected to expand. This review aims to discuss the echocardiographic, cardiac magnetic resonance imaging, and genetic features of several cardiomyopathies.
HEART FAILURE REVIEWS
(2023)
