Article
Anesthesiology
Stefano Fresilli, Rosa Labanca, Fabrizio Monaco, Alessandro Belletti, Filippo D'Amico, Andrea Blasio, Yuki Kotani, Giovanni Landoni
Summary: This systematic review and meta-analysis compares the outcomes of patients receiving del Nido solution with other types of cardioplegia in cardiac surgery. The results indicate that del Nido cardioplegia is associated with a lower rate of postoperative stroke and/or transient ischemic attack. It also reduces aortic cross-clamp time, the need for defibrillation, and the risk of postoperative acute kidney injury, without affecting mortality.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Medicine, Research & Experimental
Ahmed F. Elmahrouk, Mohammad S. Shihata, Osman O. AL-Radi, Amr A. Arafat, Musleh Altowaity, Bayan A. Alshaikh, Mohamed N. Galal, Abdulbadee A. Bogis, Haneen Y. Al Omar, Wesal J. Assiri, Ahmed A. Jamjoom
Summary: This study compares the effectiveness of Custadiol and blood-based cardioplegia in protecting myocardium in pediatric cardiac surgery, and finds no significant difference between the two in the primary outcome measures.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Faisal Kamal, Muhammad Ali Khan, Wade Lee-Smith, Sachit Sharma, Ashu Acharya, Umer Farooq, Amit Agarwal, Muhammad Aziz, Justin Chuang, Anand Kumar, Alexander Schlachterman, David Loren, Thomas Kowalski, Douglas Adler
Summary: This meta-analysis compared cold snare polypectomy (CSP) and cold forceps polypectomy (CFP) for resection of diminutive polyps. The study found that CSP had a significantly higher rate of complete resection of all diminutive polyps compared to CFP. There was no significant difference in the rates of complete resection of polyps <= 3 mm in size and polypectomy time between the groups. However, the rate of failure of tissue retrieval was significantly higher in the CSP group.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Cardiac & Cardiovascular Systems
Gonzalo Saco-Ledo, Pedro L. Valenzuela, Luis M. Ruilope, Alejandro Lucia
Summary: Physical exercise is effective in reducing blood pressure in patients with resistant hypertension, with acute exercise leading to short-term reduction and regular exercise leading to long-term reduction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Nutrition & Dietetics
Shuaishuai Zhou, Teng Xu, Xu Zhang, Junjie Luo, Peng An, Yongting Luo
Summary: The supplementation of casein hydrolysate can effectively reduce blood pressure without affecting blood lipids or glycemic status.
Review
Food Science & Technology
Elahe Mokhtari, Sahar Rafiei, Nafiseh Shokri-Mashhadi, Parvane Saneei
Summary: Astaxanthin supplementation leads to a slight decrease in diastolic blood pressure in adults, especially in patients and participants from Asian countries. This effect is more pronounced with a dosage of > 12 mg/day supplementation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Pharmacology & Pharmacy
Jingyi Ren, Jiaqi An, Mengyuan Chen, Haiyue Yang, Yuxia Ma
Summary: PCs supplementation can significantly reduce systolic blood pressure, diastolic blood pressure, and mean arterial pressure, but has no significant effect on pulse pressure. Stratified analysis by study duration and BMI revealed different trends in the effects. Low-dose PCs were found to significantly lower blood pressure. Meta-regression analysis did not show dose effects of PCs on blood pressure.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Mehmet Kanbay, Sidar Copur, Dimitrie Siriopol, Abdullah Burak Yildiz, Abduzhappar Gaipov, Daniel H. Van Raalte, Katherine R. Tuttle
Summary: This study demonstrates that tirzepatide significantly reduces blood pressure and lipid levels, including total cholesterol, LDL cholesterol, and triglycerides, while increasing HDL cholesterol levels.
DIABETES OBESITY & METABOLISM
(2023)
Review
Nutrition & Dietetics
Taegwang Nam, Anna Kim, Yongtaek Oh
Summary: Diabetes is a growing global health issue. Dietary control, including the consumption of chickpeas, may help in lowering blood sugar levels. Further research is needed to fully understand the effectiveness of chickpeas in managing diabetes.
Review
Cardiac & Cardiovascular Systems
Mohammad Ahmed, Matthew Nudy, Rahul Bussa, Alexander Hajduczok, Gerald V. Naccarelli, Edward J. Filippone, Andrew J. Foy
Summary: Renal denervation (RD) is a novel treatment for lowering blood pressure. This meta-analysis examined the efficacy of RD and factors associated with treatment effect heterogeneity. The results showed that RD was associated with significant reductions in most blood pressure measures. Studies with longer follow-up had smaller reductions, but there were no significant differences between subgroups.
TRENDS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Physiology
Yi-Bang Cheng, Jia-Hui Xia, Yan Li, Ji-Guang Wang
Summary: Newer antihypertensive agents, such as RAS inhibitors and CCBs, were found to be significantly more efficacious than older agents in their effects on central hemodynamics.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Food Science & Technology
Mehdi Sadeghian, Sepideh Rahmani, Arash Jafarieh, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: A meta-analysis was conducted to evaluate the effect of oral curcumin on serum levels of creatinine and blood urea nitrogen (BUN). The results showed that oral curcumin supplementation significantly improved creatinine levels but increased BUN levels. Subgroup analysis indicated that longer duration of curcumin intervention had a more favorable effect on serum BUN levels. This suggests that oral curcumin with high bioavailability can positively impact creatinine and BUN levels in patients with inflammatory diseases when supplemented for > 8 weeks.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Food Science & Technology
Zeinab Gholami, Zamzam Paknahad
Summary: This systematic review and meta-analysis explored the impact of psyllium consumption on metabolic syndrome indices. The findings indicate that psyllium consumption significantly reduces fasting blood glucose and systolic blood pressure, while the effects on high-density lipoprotein cholesterol, diastolic blood pressure, and waist circumference are not statistically significant. The level of triglycerides also slightly decreases.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Chemistry, Medicinal
Zeynab Kavyani, Vali Musazadeh, Ehsan Safaei, Mina Mohammadi Asmaroud, Fatemeh Khashakichafi, Sana Sedgh Ahrabi, Parvin Dehghan
Summary: This study aims to examine the effects of N. sativa on blood pressure in adults. The meta-analysis suggests that N. sativa supplementation can effectively reduce both systolic and diastolic blood pressure, indicating that it could be used as an effective approach to blood pressure management.
PHYTOTHERAPY RESEARCH
(2023)
Article
Clinical Neurology
Vincent Wing-Hei Wong, Fiona Yan-Yee Ho, Nga-Kwan Shi, Jerome Sarris, Ka-Fai Chung, Wing-Fai Yeung
Summary: The study found that multi-component lifestyle interventions have a certain alleviating effect on depressive symptoms, but the clinical effect is small, and future research is needed for more comprehensive and individualized interventions.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Multidisciplinary Sciences
Xingsheng Hu, Ke Pu, Xuqin Feng, Shimin Wen, Xi Fu, Cuihua Guo, Wenwu He
Article
Multidisciplinary Sciences
Xingsheng Hu, Wenwu He, Shimin Wen, Xuqin Feng, Xi Fu, Yusong Liu, Ke Pu
Article
Respiratory System
Wenwu He, Linxin Chen, Kun Yuan, Qiuxi Zhou, Lin Peng, Yongtao Han
JOURNAL OF THORACIC DISEASE
(2018)
Article
Oncology
Wenwu He, Liangmin Fu, Qunlun Yan, Qiuxi Zhou, Kun Yuan, Linxin Chen, Yongtao Han
Article
Oncology
Wenwu He, Qunlun Yan, Liangmin Fu, Yongtao Han
Article
Surgery
Xuefeng Leng, Wenwu He, Hong Yang, Yuping Chen, Chengchu Zhu, Wentao Fang, Zhentao Yu, Weimin Mao, Jiaqing Xiang, Zhijian Chen, Haihua Yang, Jiaming Wang, Qingsong Pang, Xiao Zheng, Hui Liu, Huanjun Yang, Tao Li, Xu Zhang, Qun Li, Geng Wang, Teng Mao, Xufeng Guo, Ting Lin, Mengzhong Liu, Jianhua Fu, Yongtao Han
Summary: The study found that pathologic lymph node metastasis is a strong poor prognostic factor in esophageal squamous cell carcinoma patients after neoadjuvant chemoradiotherapy. Pathologic complete response does not guarantee a cure, and active surveillance and adjuvant therapy should be considered for these patients.
Article
Oncology
Wenwu He, Xuefeng Leng, Kangning Wang, Tiaoqin Mao, Lin Peng, Qiang Fang, Wenguang Xiao, Yongtao Han
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2020)
Article
Oncology
Wenwu He, Tianqin Mao, Jiaxin Yan, Xuefeng Leng, Xuyang Deng, Qin Xie, Lin Peng, Qiong Liao, Marco Scarpa, Yongtao Han
Summary: The study revealed that patients with poorly differentiated tumors have a higher pathological complete response rate after NCRT but poorer long-term survival, while patients with moderately differentiated tumors show poor outcomes in both short and long term. Lymph node status after NCRT is a crucial prognostic factor for ESCC treatment.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Xuyang Deng, Wenwu He, Yingchun Jiang, Sijie Deng, Tianqin Mao, Xuefeng Leng, Qiyu Luo, Kai Zheng, Yongtao Han
Summary: This study found that postoperative adjuvant therapy, especially chemotherapy, can prolong overall survival and disease-free survival in patients with esophageal squamous cell carcinoma (ESCC) who have pathologically node-negative disease. Additionally, T3 stage tumors and <15 lymph node dissections were identified as independent risk factors for overall survival and disease-free survival in pN0 ESCC patients.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Wenwu He, Xuefeng Leng, Tianqin Mao, Xi Luo, Lingxiao Zhou, Jiaxin Yan, Lin Peng, Qiang Fang, Guangyuan Liu, Xing Wei, Kangning Wang, Chenghao Wang, Sha Zhang, Xudong Zhang, Xudong Shen, Depei Huang, Huan Yi, Ting Bei, Xueke She, Wenguang Xiao, Yongtao Han
Summary: This study focuses on locally advanced resectable esophageal squamous cell carcinoma (ESCC), investigating the safety, feasibility, and efficacy of neoadjuvant toripalimab plus paclitaxel and carboplatin treatment. The results indicate that this combination therapy shows potential as a neoadjuvant treatment for ESCC, with increased CD8(+) T cells and decreased M2-type tumor-associated macrophages in responders. Furthermore, certain molecular signatures were associated with treatment response.
Article
Oncology
Qiyu Luo, Wenwu He, Tianqin Mao, Xuefeng Leng, Hong Wu, Wen Li, Xuyang Deng, Tingci Zhao, Ming Shi, Chuan Xu, Yongtao Han
Summary: Long-term survival in oesophageal squamous cell carcinoma (ESCC) is closely linked to the pathological response following neoadjuvant chemoradiotherapy (NCRT) and surgery. A study identified 101 genes associated with the efficacy of chemoradiotherapy, with MMS22L gene showing significant correlation with ESCC patient outcomes. Low MMS22L expression is associated with poor response to NCRT, worse survival, lymph node metastasis, and enhanced migration of tumor cells in ESCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Wenwu He, Chenghao Wang, Lei Wu, Gang Wan, Baisen Li, Yongtao Han, Haojun Li, Xuefeng Leng, Kunyi Du, Haijun Chen, Qifeng Wang, Lin Peng
Summary: This study explored the safety and efficacy of tislelizumab plus chemotherapy sequential neoadjuvant therapy for non-cCR patients and provided a novel neoadjuvant therapy model that can benefit patients with locally advanced ESCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Surgery
Kai Zheng, Wenwu He, Haijun Wang, Yongtao Han
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Ye-Han Zhou, Jia-Yu Li, Jia-Xin Yan, Peng Guo, Wen-Wu He, Yang Liu
Summary: This study compared the effects of neoadjuvant immunochemotherapy (NICT) and neoadjuvant chemoradiotherapy (NCRT) in esophageal squamous cell carcinoma (ESCC), and evaluated the correlation between the expression and changes of PD-L1 and the efficacy of NICT. The results showed that both NICT and NCRT could upregulate the expression of PD-L1, with NCRT having a more significant effect. The preoperative expression levels of PD-L1 were not effective in predicting the degree of pathological response, but high IPS and high IPS downregulation were associated with better response. Some patients with low preoperative expression of PD-L1 could still achieve a good response with NICT.
Article
Medicine, Research & Experimental
Lin Peng, Wenwu He, Feng Ye, Yane Song, Xinying Shi, Jiao Zhang, Qingyun Li, Qiang Fang, Wenguang Xiao, Yongtao Han
Summary: By analyzing genetic variations and tumor-infiltrating lymphocytes levels, 488 differentially expressed genes related to esophageal squamous cell carcinoma prognosis were identified. The levels of MDSCs and Th2 cells can serve as biomarkers for assessing the prognosis of patients with ESCC.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)