Review
Medicine, General & Internal
Christina Massoth, Alexander Zarbock
Summary: Acute kidney injury after cardiac surgery presents specific patterns of damage and recovery, which are crucial for management and outcomes. The KDIGO classification only partially covers the conceptual framework and is insufficient for a comprehensive diagnosis. This review discusses the strengths and limitations of recent criteria for CSA-AKI and provides an overview of biomarkers. The evolving understanding of CSA-AKI as a time-sensitive condition has led to an increased demand for enhancing diagnostic criteria and implementing biomarkers in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Yi Shun Wang, Dong Xu Chen, Min Yan, Zhong Wu, Ying Qiang Guo, Qian Li, Lei Du
Summary: This study developed and validated a model to predict the severity of acute kidney injury (AKI) after on-pump cardiac surgery using 10 predictors. The model showed good accuracy in predicting AKI severity and may be useful in clinical practice.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Urology & Nephrology
Sidharth Kumar Sethi, Rajesh Sharma, Aditi Gupta, Abhishek Tibrewal, Romel Akole, Rohan Dhir, Kritika Soni, Shyam Bihari Bansal, Pranaw Kumar Jha, Anil Bhan, Vijay Kher, Rupesh Raina
Summary: This study aimed to establish long-term renal outcomes for pediatric patients after cardiac surgery, focusing on urinary biomarker abnormalities that persist years after surgery and may contribute to a low glomerular filtration rate during follow-up. The presence of AKI, AKI stage, and younger age were not associated with low GFR at follow-up, while children with a higher surgical complexity score tended to have lower GFR.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Multidisciplinary Sciences
Yichuan Wang, Xuliang Huang, Shanshan Xia, Qingqing Huang, Jue Wang, Maochao Ding, Yunchang Mo, Jianping Yang
Summary: There is no gender gap in AKI frequency for cardiac surgery patients below and above 60 years old. However, women exhibit increased AKI severity and extended intubation duration.
Article
Critical Care Medicine
Christina Massoth, Alexander Zarbock, Melanie Meersch
Summary: The incidence of acute kidney injury (AKI) after cardiac surgery is high, with about 3% of patients requiring renal replacement therapy. According to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria, AKI is defined as a sudden deterioration of renal function, developing within a period of hours to days.
CRITICAL CARE CLINICS
(2021)
Article
Cardiac & Cardiovascular Systems
Shouqiang Zhu, Peng Lu, Zhenran Liu, Shaoyang Li, Peitong Li, Bingdi Wei, Jiayi Li, Yupei Wang
Summary: This study aimed to describe the longitudinal dynamic hemoglobin trajectories in patients undergoing cardiac surgery and explore their predictive value for AKI compared to traditional threshold values. The interaction of red blood cell transfusion was also investigated. The results showed three distinct hemoglobin trajectories, and patients in the highest and medium trajectory groups had significantly lower AKI risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Hsun-Yi Fu, Nai-Kuan Chou, Yih-Sharng Chen, Hsi-Yu Yu
Summary: This study found a high incidence of postoperative AKI in patients with pre-existing impaired renal function, which was associated with high preoperative serum creatinine levels and decreased CPB target temperature. AKI patients had higher hospital mortality and a worse two-year renal function evolution compared to non-AKI patients.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Nikolay O. Kamenshchikov, Yana J. Anfinogenova, Boris N. Kozlov, Yulia S. Svirko, Stanislav E. Pekarskiy, Vladimir V. Evtushenko, Vladimir A. Lugovsky, Vladimir M. Shipulin, Vladimir V. Lomivorotov, Yuriy K. Podoksenov
Summary: This study evaluated the effects of nitric oxide (NO) supplementation on the development of acute kidney injury (AKI) after cardiac surgery. The results showed that NO treatment during cardiopulmonary bypass (CPB) was associated with a lower incidence of AKI and higher urine output. There was also a decrease in urinary neutrophil gelatinase-associated lipocalin levels in the NO treatment group. Concentrations of NO metabolites were significantly increased in this group.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Benjamin R. Griffin, J. Pedro Teixeira, Sophia Ambruso, Michael Bronsert, Jay D. Pal, Joseph C. Cleveland, T. Brett Reece, David A. Fullerton, Sarah Faubel, Muhammad Aftab
Summary: This study aimed to investigate the association between stage 1 AKI after surgery and postoperative infection and mortality. The results showed that stage 1 AKI was independently associated with increased infection, ICU LOS, and hospital LOS. Treatment strategies focusing on AKI prevention, early recognition, and optimal medical management may reduce significant postoperative morbidity.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Sairah Sharif, Bohan Chen, Pamela Brewster, Tian Chen, Lance Dworkin, Rujun Gong
Summary: This study aims to investigate the efficacy of short term low dose lithium on CSA-AKI in human patients through renal function evaluation using creatinine and AKI biomarkers. The study compares the effects of lithium treatment and placebo treatment on kidney injury and renal function.
FRONTIERS IN MEDICINE
(2021)
Review
Anesthesiology
Yu-qin Long, Xiao-mei Feng, Xi-sheng Shan, Qing-cal Chen, Zhengyuan Xia, Fu-hai Ji, Hong Liu, Ke Peng
Summary: This meta-analysis demonstrates that RIPC reduces the incidence of AKI after cardiac surgery. This renoprotective effect of RIPC is mainly evident during volatile only anesthesia, in non-high-risk patients, and when AKIN or KDIGO criteria used for AKI diagnosis.
ANESTHESIA AND ANALGESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Won Ho Kim, Jinyoung Bae, Sang-Hwan Ji, Kyung Won Shin, Jin-Tae Kim, Young-Jin Lim, Jae-Hyon Bahk
Summary: The study identified two subgroups within KDIGO stage 1 acute kidney injury for patients undergoing cardiac or thoracic aortic surgery, with different clinical outcomes. Patients in stage 1b had worse length of hospital stay and 5-year all-cause mortality compared to those in stage 1a.
ANNALS OF THORACIC SURGERY
(2021)
Article
Anesthesiology
Mikael Barbu, Anders Hjarpe, Andreas Martinsson, Goran Dellgren, Sven-Erik Ricksten, Lukas Lannemyr, Aldina Pivodic, Amar Taha, Anders Jeppsson
Summary: This study found that longer CPB time and aortic clamp time, periods of compromised blood flow during aortic clamp time, and lower hematocrit were associated with the risk of postoperative AKI. These findings suggest that efforts should be made to minimize CPB and aortic clamp time and avoid compromised blood flow and low hematocrit during surgery.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Pediatrics
Arushi Nautiyal, Sidharth Kumar Sethi, Rajesh Sharma, Rupesh Raina, Abhishek Tibrewal, Romel Akole, Aditi Gupta, Anil Bhan, Shyam Bihari Bansal
Summary: This study demonstrates the feasibility of using albuminuria as a biomarker for predicting AKI in children following cardiac surgery, especially when combined with a clinical model. Different age groups may have varying predictive values for AKI based on urinary albumin:creatinine ratio.
PEDIATRIC NEPHROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Peng Gao, Yu Jin, Peiyao Zhang, Wenting Wang, Jinxiao Hu, Jinping Liu
Summary: This study investigated the association between nadir DO(2)i during cardiopulmonary bypass (CPB) and postoperative acute kidney injury (AKI) in low-weight infants undergoing cardiac surgery. The results suggested that in low-weight infants undergoing mild hypothermia during CPB, the critical DO(2)i for preventing AKI was 258 mL/min/m(2) in the hypothermia phase and 281 mL/min/m(2) for rewarming. It was also recommended to use an individualized critical DO(2)i threshold during CPB.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Anesthesiology
Sebastian R. Rasmussen, Kristian Kandler, Rikke Nielsen, Peter Cornelius Jakobsen, Nikoline N. Knudsen, Marco Ranucci, Jens Christian Nilsson, Hanne B. Ravn
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2019)
Letter
Anesthesiology
Frederik Holmgaard, Anne G. Vedel, Theis Lange, Jens C. Nilsson, Hanne B. Ravn
ANESTHESIA AND ANALGESIA
(2019)
Article
Anesthesiology
Lars Gronlykke, Andre Korshin, Finn Gustafsson, Jens Chr Nilsson, Hanne Berg Ravn
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2020)
Article
Anesthesiology
Sebastian Wiberg, Anne Gronborg Vedel, Frederik Holmgaard, Jesper Kjaergaard, Annika R. Langkilde, Christian Hassager, Jens Steensgaard, Lars S. Rasmussen, Jens-Christian Nilsson
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2020)
Article
Anesthesiology
Andre Korshin, Lars Gronlykke, Frederik Holmgaard, Sven Morten Kjoller, Finn Gustafsson, Jens Christian Nilsson, Hanne Berg Ravn
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2020)
Article
Anesthesiology
Mo H. Larsen, Christina Draegert, Anne G. Vedel, Frederik Holmgaard, Volkert Siersma, Jens C. Nilsson, Lars S. Rasmussen
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2020)
Article
Biochemistry & Molecular Biology
Mathias E. Jensen, Aurelio Galli, Morgane Thomsen, Kathrine L. Jensen, Gerda K. Thomsen, Mette K. Klausen, Tina Vilsboll, Mikkel B. Christensen, Jens J. Holst, Anthony Owens, Sabrina Robertson, Lynette Daws, Daniele Zanella, Ulrik Gether, Gitte M. Knudsen, Anders Fink-Jensen
NEUROCHEMISTRY INTERNATIONAL
(2020)
Article
Cardiac & Cardiovascular Systems
Anne G. Vedel, Frederik Holmgaard, Else R. Danielsen, Annika Langkilde, Olaf B. Paulson, Hanne B. Ravn, Lars S. Rasmussen, Jens C. Nilsson
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2020)
Article
Clinical Neurology
Marco Moller, Simon Fredholm, Mathias E. Jensen, Gitta Wortwein, Julie R. Larsen, Tina Vilsboll, Niels Odum, Anders Fink-Jensen
Summary: The study aimed to evaluate the relationship between the therapeutic effects of glucagon-like peptide-1 receptor agonist liraglutide and cytokines. The results showed that prediabetic patients treated with clozapine or olanzapine had increased levels of inflammatory cytokines in their serum, further confirming the link between inflammation and type 2 diabetes. However, treatment with liraglutide did not affect these cytokines.
Article
Anesthesiology
Sebastian Wiberg, Frederik Holmgaard, Henrik Zetterberg, Jens-Christian Nilsson, Jesper Kjaergaard, Michael Wanscher, Annika R. Langkilde, Christian Hassager, Lars S. Rasmussen, Kaj Blennow, Anne Gronborg Vedel
Summary: The study evaluated the ability of biomarkers NSE, tau, NFL, and GFAP to predict postoperative cognitive dysfunction (POCD) in cardiac surgery patients. Elevated levels of tau and GFAP were found in patients with POCD at discharge, but the biomarkers only had moderate predictive abilities for POCD. Postoperative levels of NSE were not associated with POCD at discharge.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Medicine, General & Internal
Sebastian Wiberg, Jesper Kjaergaard, Rasmus Mogelvang, Christian Holdflod Moller, Kristian Kandler, Hanne Ravn, Christian Hassager, Lars Kober, Jens Christian Nilsson
Summary: This study aims to evaluate the efficacy of GLP-1 analogue exenatide versus placebo and restrictive versus liberal oxygenation strategies in patients undergoing open heart surgery. It includes sub-studies to assess cardiac, pulmonary, renal, and cerebral dysfunction, with a targeted inclusion of 1400 patients and 323 primary endpoints.
Article
Psychiatry
Tobias Sogaard Juul, Mathias Ebbesen Jensen, Anders Fink-Jensen
Summary: This study investigated the patterns of classic psychedelic drug use among Danish adults and found that these drugs were mostly used for therapeutic or spiritual purposes. They were associated with positive persisting effects on well-being, social relationships, meaning of life, and mood. However, they were also associated with hazardous alcohol use.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Mette Kruse Klausen, Mathias Ebbesen Jensen, Marco Moller, Nina Le Dous, Anne-Marie Ostergaard Jensen, Victoria Alberte Zeeman, Claas-Frederik Johannsen, Alycia Lee, Gerda Krog Thomsen, Julian Macoveanu, Patrick MacDonald Fisher, Matthew Paul Gillum, Niklas Rye Jorgensen, Marianne Lerbaek Bergmann, Henrik Enghusen Poulsen, Ulrik Becker, Jens Juul Holst, Helene Benveniste, Nora D. Volkow, Sabine Vollstaedt-Klein, Kamilla Woznica Miskowiak, Claus Thorn Ekstrom, Gitte Moos Knudsen, Tina Vilsboll, Anders Fink-Jensen
Summary: This study provides new knowledge on the effects of a glucagon-like peptide-1 (GLP-1) receptor agonist, exenatide, in patients with alcohol use disorder (AUD). Although exenatide did not significantly reduce the number of heavy drinking days compared to placebo, it attenuated fMRI alcohol cue reactivity and dopamine transporter availability in crucial brain areas for drug reward and addiction. In a subgroup of obese patients, exenatide significantly reduced heavy drinking days and total alcohol intake. Adverse events mainly consisted of gastrointestinal reactions.
Article
Cardiac & Cardiovascular Systems
Jonas Henrik Kristensen, Clara Amalie Wistisen Koczulab, Emil Anton Frandsen, Rasmus Bo Hasselbalch, Nina Strandkjaer, Nicoline Jorgensen, Morten Ostergaard, Peter Hasse Moller-Sorensen, Jens Christian Nilsson, Shoaib Afzal, Pia Rorbaek Kamstrup, Morten Dahl, Mustafa Vakur Bor, Ruth Frikke-Schmidt, Niklas Rye Jorgensen, Line Rode, Lene Holmvang, Jesper Kjaergaard, Lia Evi Bang, Julie Forman, Kim Dalhoff, Henning Bundgaard, Kasper Karmark Iversen
Summary: This study aims to examine the changes in concentration, time-to-peak, and half-life of cardiac biomarkers in patients with myocardial infarction. Blood samples were collected every three hours within 24 hours after percutaneous coronary intervention (PCI) in patients with ST elevation myocardial infarction. The results showed no notable differences in time-to-peak or half-life between different high-sensitivity cardiac troponin (hs-cTn) assays.
IJC HEART & VASCULATURE
(2023)
Article
Cardiac & Cardiovascular Systems
Sebastian Wiberg, Frederik Holmgaard, Kaj Blennow, Jens C. Nilsson, Jesper Kjaergaard, Michael Wanscher, Annika R. Langkilde, Christian Hassager, Lars S. Rasmussen, Henrik Zetterberg, Anne Gronborg Vedel
Summary: This study found no significant differences in levels of biomarkers of neurological injury in patients undergoing elective or subacute CABG and/or aortic valve replacement randomized to either a target MAP of 40-50 mmHg or a target MAP of 70-80 mmHg during CBP.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2021)