Article
Cardiac & Cardiovascular Systems
Johanna Gueckel, Christian Puelacher, Noemi M. Glarner, Danielle Gualandro, Ivo Strebel, Tobias Zimmermann, Ketina Arslani, Reka Hidvegi, Marcel Liffert, Alessandro Genini, Stella Marbot, Maria Schlaepfer, Luzius Steiner, Daniel Bolliger, Andreas Lampart, Lorenz Guerke, Christoph Kindler, Stefan Scharen, Stefan Osswald, Martin Clauss, Daniel Rikli, Giovanna Lurati Buse, Christian Mueller
Summary: This study evaluated the contributions of patient and procedure-related factors to perioperative myocardial infarction/injury (PMI) in noncardiac surgery. The results showed that procedure-related factors were more strongly associated with PMI occurrence, but patient factors also played a role in PMI development.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Geriatrics & Gerontology
Darcy Banco, John A. Dodson, Jeffrey S. Berger, Nathaniel R. Smilowitz
Summary: This study examined the risk of major adverse cardiovascular events in older adults undergoing noncardiac surgery, finding that older adults had a higher risk compared to middle-aged adults. Over time, the proportion of perioperative MACE declined among older adults, despite an increase in ischemic stroke occurrences.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Editorial Material
Medicine, General & Internal
Lynne W. Stevenson, Andrew P. DeFilippis
Summary: The evolution of the fight-or-flight response system is to help humans deal with acute physiological threats, which are now less common than chronic cardiovascular stress. The study shows that pharmacologic inhibition of RAAS improves chronic heart failure and the natriuretic peptide system provides a counterbalance to RAAS. Neprilysin, a key neutral endopeptidase, degrades a variety of peptides including natriuretic peptides and angiotensin II.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ah Ran Oh, Jungchan Park, Jong-Hwan Lee, Hara Kim, Kwangmo Yang, Jin-Ho Choi, Joonghyun Ahn, Ji Dong Sung, Seung-Hwa Lee
Summary: This study found that perioperative adverse cardiac events (PACE) in noncardiac surgery were associated with 1-year mortality. Further research is needed to determine the acceptability of PACE as an endpoint in clinical studies.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Anesthesiology
Michelle S. Chew, Bernd Saugel, Giovanna Lurati-Buse
Summary: Myocardial injury is a recognized complication in noncardiac surgery patients. Preoperative cTns measurement aids risk stratification, while systematic measurement allows early identification of myocardial injury.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Medicine, General & Internal
Ekaterine Popova, Pilar Paniagua-Iglesias, Jesus Alvarez-Garcia, Miquel Vives-Borras, Aranzazu Gonzalez-Osuna, Alvaro Garcia-Osuna, Mercedes Rivas-Lasarte, Gisela Hermenegildo-Chavez, Ruben Diaz-Jover, Gonzalo Azparren-Cabezon, Montserrat Barcelo-Trias, Abdel-Hakim Moustafa, Raul Aguilar-Lopez, Jordi Ordonez-Llanos, Pablo Alonso-Coello
Summary: Perioperative myocardial injury (PMI) is a common cardiac complication, and recent guidelines recommend systematic screening using high-sensitivity cardiac troponin (hs-cTn). We conducted a prospective study to evaluate the feasibility and outcomes of implementing PMI screening and found that it is recommendable, especially for high-risk patients. However, achieving optimal screening implementation is challenging.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jeppe K. Petersen, Abdulrahman N. Shams-Eldin, Emil L. Fosbol, Rasmus Rorth, Rikke Sorensen, Reza Jabbari, Thomas Engstrom, Lene Holmvang, Frants Pedersen, Amna Alhakak, Johanna Kroll, Christian Torp-Pedersen, Lars Kober, Jawad H. Butt
Summary: Employment status prior to acute myocardial infarction is associated with long-term risk of mortality and recurrent MI. Patients who were not part of the workforce had a higher risk of death and new heart attacks following discharge compared to those who were part of the workforce.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Anesthesiology
Esther M. Wesselink, Sjors H. Wagemakers, Judith A. R. Van Waes, Jonathan P. Wanderer, Wilton A. Van Klei, Teus H. Kappen
Summary: Intraoperative hypotension appears to have a continuous association with postoperative myocardial injury and mortality, with depth of hypotension contributing more than duration.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Medicine, Research & Experimental
T. Schmitz, E. Harmel, M. Heier, A. Peters, J. Linseisen, C. Meisinger
Summary: This study investigated the association between inflammatory markers and 28-day mortality in ST-elevation myocardial infarction patients. Certain biomarkers were found to be significantly associated with mortality, and a combined biomarker score showed improved predictive ability compared to the established GRACE score. These inflammatory markers may play a significant role in the pathophysiology of acute myocardial infarction.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Anesthesiology
Kurt Ruetzler, Esra Kutlu Yalcin, Praveen Chahar, Nathaniel R. Smilowitz, Faith Factora, Xuan Pu, Elyad Ekrami, Kamal Maheshwari, Daniel I. Sessler, Alparslan Turan
Summary: The study retrospectively analyzed noncardiac surgical inpatients who experienced postoperative chest pain triggering a multidisciplinary Rapid Response System (RRS) activation. The results indicated that chest pain postoperatively may be a serious sign of myocardial infarction and should be taken seriously.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Medicine, General & Internal
Matthew B. Allen, Ariela R. Orkaby, Samuel Justice, Daniel E. Hall, Frances Y. Hu, Zara Cooper, Rachelle E. Bernacki, Angela M. Bader
Summary: Frailty is associated with mortality following surgery and cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest. The association between frailty and outcomes following perioperative CPR is unknown. Evaluating the association between frailty and outcomes following perioperative CPR can inform preoperative risk stratification, CPR decision-making, and surgical care.
Article
Cardiac & Cardiovascular Systems
Xiaoyuan Zhang, Shanjie Wang, Shaohong Fang, Bo Yu
Summary: The study found that high sensitivity CRP is associated with the incidence of in-hospital HF, HF post-discharge, and all-cause mortality in patients with acute myocardial infarction (AMI).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Gali Cohen, Daniel Nevo, Tal Hasin, Yael Benyamini, Uri Goldbourt, Yariv Gerber
Summary: Resumption of sexual activity frequency within the first months after myocardial infarction is strongly associated with improved long-term survival, particularly for non-cardiovascular mortality.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yan Guangyu, Lou Jingfeng, Liu Xing, Yuan Hong, Lu Yao
Summary: Postoperative AKI in hypertensive patients undergoing noncardiac surgery is associated with a significantly higher risk of fatal stroke, fatal MI, and all-cause mortality within 5 years. The risk is even higher in patients receiving ACEI/ARB and CCB perioperatively.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Surgery
Yolanda Ya-Chin Huang, Ling Chen, Jason D. Wright
Summary: HF patients with reduced ejection fraction have increased risks of noncardiopulmonary complications, mortality, and readmission after noncardiac surgery compared to those with preserved ejection fraction. Targeted perioperative care for different HF subtypes may be crucial for improving outcomes in this patient population. Despite no statistically significant difference in cardiopulmonary complications between HF subtypes, interventions to reduce the occurrence rate may still be clinically meaningful.