Article
Cardiac & Cardiovascular Systems
Olivier Desebbe, Etienne Bachelard, Marie Deperdu, Romain Manet, Brenton Alexander, Johanne Beuvelot, Joseph Nloga, Alexandre Joosten, Laurent Gergele
Summary: Maintaining a mean arterial pressure within the range of cerebral autoregulation is important during cardiac surgery to prevent postoperative morbidity. This study compared a quick determination of the lower limit of cerebral autoregulation using a two second averaging period with the reference lower limit using a ten second averaging period. The results showed that the quick determination had a higher detection rate but had large limits of agreement and significant interobserver variability, limiting its clinical utility.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Critical Care Medicine
Eva A. Rocha, Felipe Rocha, Izadora Deliberalli, Joao Brainer C. de Andrade, Irapua F. Ricarte, Aneesh B. Singhal, Gisele S. Silva
Summary: The study found that over one-third of patients with acute ICH have micro-embolic signals, which are associated with a higher likelihood of cerebral microembolism in patients with ICH, particularly in those with lobar hemorrhages and dyslipidemia. Further research is needed to understand the sources of cerebral microembolism and their relationship with small acute infarcts in ICH.
NEUROCRITICAL CARE
(2021)
Article
Cardiac & Cardiovascular Systems
Mahmoud Diab, Thomas Lehmann, Wolfgang Bothe, Payam Akhyari, Stephanie Platzer, Daniel Wendt, Antje-Christin Deppe, Justus Strauch, Stefan Hagel, Albrecht Guenther, Gloria Faerber, Christoph Sponholz, Marcus Franz, Andre Scherag, Ilia Velichkov, Miriam Silaschi, Jens Fassl, Britt Hofmann, Sven Lehmann, Rene Schramm, Georg Fritz, Gabor Szabo, Thorsten Wahlers, Klaus Matschke, Artur Lichtenberg, Mathias W. Pletz, Jan F. Gummert, Friedhelm Beyersdorf, Christian Hagl, Michael A. Borger, Michael Bauer, Frank M. Brunkhorst, Torsten Doenst
Summary: This study investigated the effect of hemoadsorption during cardiac surgery for infective endocarditis (IE) on postoperative organ dysfunction and found that hemoadsorption did not reduce the occurrence of organ dysfunction. Although hemoadsorption reduced cytokine levels during surgery, it did not have an impact on clinically relevant outcome measures.
Review
Biochemistry & Molecular Biology
Giuseppe Filiberto Serraino, Federica Jiritano, Davide Costa, Nicola Ielapi, Domenica Battaglia, Umberto Marcello Bracale, Pasquale Mastroroberto, Michele Andreucci, Raffaele Serra
Summary: This systematic review aims to explore the role of matrix metalloproteinases (MMPs) in routine cardiac operations, especially cardiopulmonary bypass (CPB). The results show that MMP levels are significantly correlated with CPB and the gelatinases MMP-2 and MMP-9 are highly released during cardiac surgery with CPB. Increased MMP levels are associated with adverse post-operative outcomes. Future large-scale prospective multicenter randomized clinical trials are needed to investigate the impact of mechanical and pharmacological strategies on the inflammatory response and postoperative outcomes in cardiac surgery and CPB.
Review
Health Care Sciences & Services
Luan Oliveira Ferreira, Victoria Winkler Vasconcelos, Janielle de Sousa Lima, Jaime Rodrigues Vieira Neto, Giovana Escribano da Costa, Jordana de Castro Esteves, Sallatiel Cabral de Sousa, Jonathan Almeida Moura, Felipe Ruda Silva Santos, Joao Monteiro Leitao Filho, Matheus Ramos Protasio, Pollyana Sousa Araujo, Claudio Jose da Silva Lemos, Karina Dias Resende, Dielly Catrina Favacho Lopes
Summary: Patients undergoing coronary revascularization with extracorporeal circulation or cardiopulmonary bypass may develop systemic inflammatory response due to biochemical changes in the microcirculation. Inflammatory signaling pathways can be activated by surgical incision, reperfusion injury, and blood contact with non-endothelial membranes, leading to the production and activation of inflammatory cells, cytokine production, and oxidative stress. Addressing new perspectives for intraoperative treatment and management may reduce this inflammatory storm, improve prognosis, and potentially lower mortality rates in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Jia-Lin Chen, Yung-Chi Hsu, Go-Shine Huang, Chih-Yuan Lin, Hung-Yen Ke, Po-Shun Hsu, Chi-Hsiang Chung, Chien-Sung Tsai, Tso-Chou Lin
Summary: The purpose of this study was to investigate the effects of nitroglycerin on tissue perfusion during cardiac surgery. The results showed that nitroglycerin use may cause transient profound hypotension, but does not improve cerebral oxygenation, tissue perfusion, and coagulation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Christina Massoth, Alexander Zarbock
Summary: Acute kidney injury after cardiac surgery presents specific patterns of damage and recovery, which are crucial for management and outcomes. The KDIGO classification only partially covers the conceptual framework and is insufficient for a comprehensive diagnosis. This review discusses the strengths and limitations of recent criteria for CSA-AKI and provides an overview of biomarkers. The evolving understanding of CSA-AKI as a time-sensitive condition has led to an increased demand for enhancing diagnostic criteria and implementing biomarkers in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Paul Philipp Heinisch, Maks Mihalj, Markus Huber, Joerg C. Schefold, Alexander Hartmann, Michael Walter, Elisabeth Steinhagen-Thiessen, Juerg Schmidli, Frank Stueber, Lorenz Raeber, Markus M. Luedi
Summary: This study aimed to investigate the impact of the metabolic product Lp(a) on complications and clinical outcomes in high-risk cardiovascular patients undergoing cardiac surgery. Findings showed a general decrease in Lp(a) levels after all types of cardiac surgery, with elevated Lp(a) levels not being associated with perioperative events or mortality rates.
Article
Cardiac & Cardiovascular Systems
Xinglong Xiong, Dongxu Chen, Shuang Cai, Li Qiu, Jing Shi
Summary: This study found that intraoperative hyperglycemia is associated with an increased risk of postoperative infections in patients undergoing cardiac surgery. The optimal blood glucose level during surgery should be maintained below 150 mg/dL to reduce infection risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Annewil van Saet, Gerdien A. Zeilmaker-Roest, Kevin M. Veen, Saskia N. de Wildt, Fritz Sorgel, Robert J. Stolker, Ad J. J. C. Bogers, Dick Tibboel
Summary: The pharmacokinetics and plasma concentrations of methylprednisolone have not been comprehensively studied in children with congenital heart disease undergoing cardiac surgery with cardiopulmonary bypass. There may be a significant influence of cardiopulmonary bypass on the plasma concentrations of methylprednisolone, which could explain the limited efficacy of steroid administration in this context.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Chantal A. Boly, Margot Venhuizen, Nicole A. M. Dekker, Alexander B. A. Vonk, Christa Boer, Charissa E. van den Brom
Summary: Cardiac surgery with cardiopulmonary bypass impairs microcirculatory perfusion equally in metabolically healthy obese patients and lean patients, with recovery observed in both groups within three days post-surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Xiuyun Liu, Kei Akiyoshi, Mitsunori Nakano, Ken Brady, Brian Bush, Rohan Nadkarni, Archana Venkataraman, Raymond C. Koehler, Jennifer K. Lee, Charles W. Hogue, Marek Czosnyka, Peter Smielewski, Charles H. Brown
Summary: This study identified thresholds for intact and impaired cerebral autoregulation for three indices and showed that mean arterial blood pressure below lower limit of autoregulation is a risk factor for acute kidney injury after cardiac surgery.
CRITICAL CARE MEDICINE
(2021)
Review
Medical Laboratory Technology
Giuseppe Lapergola, Alessandro Graziosi, Ebe D'Adamo, Patrizia Brindisino, Mariangela Ferrari, Anna Romanelli, Mariachiara Strozzi, Roberta Libener, Danilo A. W. Gavilanes, Antonio Maconi, Angela Satriano, Alessandro Varrica, Diego Gazzolo
Summary: Recent advances in perioperative management have significantly reduced mortality rate in open heart surgery and cardiopulmonary bypass for heart disease repair. However, the morbidity rate remains unchanged. The measurement of neuro-biomarkers, particularly S100B protein, can be useful in detecting early stage brain damage during the perioperative period. This review provides an updated overview of the pros and cons of using S100B protein for perioperative monitoring in both adult and pediatric patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Critical Care Medicine
Mathieu Lesouhaitier, Fabrice Uhel, Murielle Gregoire, Arnaud Gacouin, Aurelien Frerou, Baptiste Gaudriot, Claude Bendavid, Sarrah Boukthir, Yves Le Tulzo, Jean-Philippe Verhoye, Erwan Flecher, Mikael Roussel, Karin Tarte, Jean-Marc Tadie
Summary: Cardiac surgery with cardiopulmonary bypass (CPB) leads to immunosuppression, characterized by decreased lymphocyte subsets, expansion of monocytic MDSCs, increased T-cell apoptosis, and decreased proliferation capacity. The activity of indoleamine 2,3-dioxygenase and IL-10 plasma level increase after CPB, while arginine plasma level decreases. Only arginine supplementation partially restores T-cell proliferation.
Article
Cardiac & Cardiovascular Systems
Bogdan A. Kindzelski, Faisal G. Bakaeen, Michael Z. Tong, Eric E. Roselli, Edward G. Soltesz, Douglas R. Johnston, Per Wierup, Gosta B. Pettersson, Penny L. Houghtaling, Eugene H. Blackstone, A. Marc Gillinov, Lars G. Svensson
Summary: This study evaluates the practice and outcomes of reoperative cardiac surgery via re-sternotomy. It finds that reoperative cardiac surgery is associated with low operative morbidity and mortality at an experienced center. The study also suggests that early and late cardiopulmonary bypass strategies have similar outcomes in the context of an image-guided, team-based strategy.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Psychiatry
Elisabetta Patron, Simone Messerotti Benvenuti, Paolo Zanatta, Elvio Polesel, Daniela Palomba
GENERAL HOSPITAL PSYCHIATRY
(2013)
Article
Psychiatry
Simone Messerotti Benvenuti, Elisabetta Patron, Paolo Zanatta, Elvio Polesel, Carlotta Bonfa, Daniela Palomba
GENERAL HOSPITAL PSYCHIATRY
(2013)
Article
Psychiatry
Simone Messerotti Benvenuti, Elisabetta Patron, Paolo Zanatta, Elvio Polesel, Daniela Palomba
GENERAL HOSPITAL PSYCHIATRY
(2014)
Article
Emergency Medicine
Alessandro Forti, Giovanna Zilio, Paolo Zanatta, Marialuisa Ferramosca, Cristiano Gatto, Antonio Gheno, Paolo Rosi
JOURNAL OF EMERGENCY MEDICINE
(2014)
Article
Anesthesiology
Paolo Zanatta, Enrico Bosco, Alessandra Comin, Anna Paola Mazzarolo, Piero Di Pasquale, Alessandro Forti, Pierluigi Longatti, Elvio Polesel, Mark Stecker, Carlo Sorbara
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2014)
Article
Neurosciences
Paolo Zanatta, Gianna Maria Toffolo, Elisa Sartori, Anna Bet, Fabrizio Baldanzi, Nivedita Agarwal, Eugene Golanov
Article
Cardiac & Cardiovascular Systems
P. Zanatta, S. Messerotti Benvenuti, C. Valfre, F. Baldanzi, D. Palomba
Article
Cardiac & Cardiovascular Systems
S. Messerotti Benvenuti, P. Zanatta, C. Valfre, E. Polesel, D. Palomba
Article
Psychology, Biological
Simone Messerotti Benvenuti, Christopher Ring, Daniela Palomba, Fabrizio Baldanzi, Paolo Zanatta
Article
Psychiatry
Simone Messerotti Benvenuti, Paolo Zanatta, Carolina Longo, Anna Paola Mazzarolo, Daniela Palomba
PSYCHOSOMATIC MEDICINE
(2012)
Article
Critical Care Medicine
Paolo Zanatta, Federico Linassi, Anna Paola Mazzarolo, Maria Arico, Enrico Bosco, Matteo Bendini, Carlo Sorbara, Carlo Ori, Michele Carron, Bruno Scarpa
Article
Anesthesiology
Enrico Bosco, Paolo Zanatta, Diego Ponzin, Elisabetta Marton, Alberto Feletti, Bruno Scarpa, Pierluigi Longatti, Adolfo Paolin
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2014)
Letter
Anesthesiology
E. Bosco, E. Marton, A. Feletti, P. Zanatta, C. Sorbara, P. Longatti
MINERVA ANESTESIOLOGICA
(2012)
Article
Anesthesiology
P. Zanatta, S. Messerotti Benvenuti, F. Baldanzi, E. Bosco
MINERVA ANESTESIOLOGICA
(2012)