Article
Cardiac & Cardiovascular Systems
Lance Hsieh, Lan N. Tu, Alison Paquette, Quanhu Sheng, Shilin Zhao, Douglas Bittel, James O'Brien, Kasey Vickers, Peter Pastuszko, Vishal Nigam
Summary: A study on neonatal patients undergoing cardiopulmonary bypass (CPB) revealed differential expression of multiple miRNAs in circulating leukocytes during and after bypass. These miRNAs are predicted to modulate pathways related to inflammation and signal transduction, contributing to the systemic inflammatory response post-CPB.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Panagiotis Doukas, Gabriel Hellfritsch, Daniel Wendt, Mirko Magliani, Mohammad E. Barbati, Houman Jalaie, Michael J. Jacobs, Alexander Gombert
Summary: This pilot study investigated the efficacy of cytokine adsorption in controlling early inflammation cascade in patients undergoing open thoracoabdominal aortic repair. The results suggest that intraoperative hemoadsorption may be feasible and safe, but larger trials are needed to evaluate its clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Luan Oliveira Ferreira, Victoria Winkler Vasconcelos, Janielle de Sousa Lima, Jaime Rodrigues Vieira Neto, Giovana Escribano da Costa, Jordana de Castro Esteves, Sallatiel Cabral de Sousa, Jonathan Almeida Moura, Felipe Ruda Silva Santos, Joao Monteiro Leitao Filho, Matheus Ramos Protasio, Pollyana Sousa Araujo, Claudio Jose da Silva Lemos, Karina Dias Resende, Dielly Catrina Favacho Lopes
Summary: Patients undergoing coronary revascularization with extracorporeal circulation or cardiopulmonary bypass may develop systemic inflammatory response due to biochemical changes in the microcirculation. Inflammatory signaling pathways can be activated by surgical incision, reperfusion injury, and blood contact with non-endothelial membranes, leading to the production and activation of inflammatory cells, cytokine production, and oxidative stress. Addressing new perspectives for intraoperative treatment and management may reduce this inflammatory storm, improve prognosis, and potentially lower mortality rates in these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Filiberto Serraino, Federica Jiritano, Davide Costa, Nicola Ielapi, Domenica Battaglia, Umberto Marcello Bracale, Pasquale Mastroroberto, Michele Andreucci, Raffaele Serra
Summary: This systematic review aims to explore the role of matrix metalloproteinases (MMPs) in routine cardiac operations, especially cardiopulmonary bypass (CPB). The results show that MMP levels are significantly correlated with CPB and the gelatinases MMP-2 and MMP-9 are highly released during cardiac surgery with CPB. Increased MMP levels are associated with adverse post-operative outcomes. Future large-scale prospective multicenter randomized clinical trials are needed to investigate the impact of mechanical and pharmacological strategies on the inflammatory response and postoperative outcomes in cardiac surgery and CPB.
Article
Health Care Sciences & Services
Po-Shun Hsu, Jia-Lin Chen, Shih-Ying Sung, Yi-Ting Tsai, Chih-Yuan Lin, Yi-Fan Wu, Chien-Sung Tsai
Summary: This study compares the hemorheological and inflammatory changes before and after coronary artery bypass graft (CABG) surgery and finds that hyperviscosity persists for almost one week after the surgery. Inflammatory markers are also correlated with hemorheological changes. Understanding the interplay between inflammation and hemorheological properties is crucial for patient care.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Marie Vandestienne, Rayan Braik, Jean-Remi Lavillegrand, Geoffroy Hariri, Zoe Demailly, Nadine Ben Hamouda, Fabienne Tamion, Thomas Clavier, Hafid Ait-Oufella
Summary: This study investigated the role of TREM-1 in systemic inflammation during cardiac surgery with cardiopulmonary bypass (CPB). They found that TREM-1 expression on neutrophils decreased, while soluble TREM-1 levels increased after CPB. The study also showed that baseline sTREM-1 levels and early kinetics after cardiac surgery were associated with post-operative complications and prolonged length of stay.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Huzaifa Ahmad Cheema, Arsalan Ali Khan, Awab Hussain Ahmad, Abdullah Ali Khan, Amna Khalid, Abia Shahid, Alaa Hamza Hermis, Ali Syed, Neha Bansal, Koichi Yuki, Sunil J. Ghelani, Sourbha S. Dani
Summary: This study aimed to investigate the efficacy and safety of perioperative prophylactic corticosteroids in pediatric heart surgeries. The results showed that perioperative corticosteroids can reduce mechanical ventilation duration, decrease the incidence of low cardiac output syndrome and reoperation. However, their impact on all-cause mortality remains unclear.
AMERICAN HEART JOURNAL
(2023)
Article
Multidisciplinary Sciences
Parag N. Jain, Matthew Robertson, Javier J. Lasa, Lara Shekerdemian, Danielle Guffey, Yuhao Zhang, Krithika Lingappan, Paul Checchia, Cristian Coarfa
Summary: The study explored differential gene expression profiles in neonates with HLHS who develop LCOS after CPB, revealing significant changes in inflammatory and metabolic pathways. This opens up new possibilities for identifying potential therapeutic targets in this high-risk population.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Baozeng Chen, Mingjing Feng, Chen Sheng, Yinhua Wang, Wenya Cao
Summary: The incidence of DR among CPB patients was 9.79%. Significant risk factors for DR include duration of CPB, BUN levels, infusion of red blood cell suspension, duration of surgery, and age.
Article
Biochemistry & Molecular Biology
Thomas Poschner, Anne-Kristin Schaefer, Doris Hutschala, Georg Goliasch, Julia Riebandt, Klaus Distelmaier, Martin H. Bernardi, Martin Andreas, Ruud Brands, Tandis Aref, Guenther Laufer, Dominik Wiedemann
Summary: In patients with VA-ECMO support, postoperative recovery of alkaline phosphatase (AP) is correlated with patient outcomes, with a greater AP drop leading to increased need for renal replacement therapy and impacting 1-year survival.
Article
Biochemistry & Molecular Biology
Katharina Gerling, Lisa Maria Herrmann, Christoph Salewski, Melanie Wolf, Pia Muellerbader, Dorothea Siegel-Axel, Hans Peter Wendel, Christian Schlensak, Meltem Avci-Adali, Sandra Stoppelkamp
Summary: During cardiopulmonary bypass surgery, contact with cotton materials can lead to platelet and leukocyte activation in patients' blood, while synthetic materials cause less activation. This additional activation may trigger further reactions in patients after surgery, posing a risk to this vulnerable patient group.
Article
Cardiac & Cardiovascular Systems
Yun-Wen Peng, Terry Major, Kristopher B. Deatrick, Azmath Mohammed, Mark Jeakle, John R. Charpie
Summary: Nicorandil demonstrates myocardial protection by attenuating IR-induced LV dysfunction associated with oxidative stress, inflammation, apoptosis, and organ injury. It should be further explored as a potential therapeutic strategy for limiting global IR injury during open-heart surgery in humans.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Thierry Carrel
Summary: The aim of cardiopulmonary bypass is to maintain adequate perfusion and gas exchange during heart surgery. However, one major drawback is the foreign surfaces that blood has to flow through. Recent innovations, such as miniaturization of circuits and simplified cardioplegia, aim to reduce the negative effects and improve clinical outcomes.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Maxime Nguyen, Thomas Gautier, Guillaume Reocreux, Gaetan Pallot, Guillaume Maquart, Pierre-Alain Bahr, Annabelle Tavernier, Jacques Grober, David Masson, Belaid Bouhemad, Pierre-Gregoire Guinot
Summary: The study investigated the association between pre-operative PLTP activity and lipoprotein concentrations with LPS concentrations in cardiac surgery patients. The results showed that higher PLTP activity was associated with lower LPS concentration, while cholesterol-rich lipoproteins were not directly related to LPS clearance or inflammation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Miroslaw Wilczynski, Michal Krejca, Piotr Stepinski, Marcin Rozalski, Jacek Golanski
Summary: In this study, the researchers aimed to investigate the relationship between platelet reactivity/activation and inflammatory markers in patients who underwent cardiopulmonary bypass surgery. They found that inflammatory markers CRP and TNF-alpha were strongly associated with platelet reactivity, and that high platelet reactivity correlated with a higher risk of post-operative rhythm disturbances and myocardial infarction.
ARCHIVES OF MEDICAL SCIENCE
(2023)