Article
Multidisciplinary Sciences
Daniel Enriquez-Vazquez, Jorge G. Quintanilla, Alba Garcia-Escolano, Marinela Couselo-Seijas, Ana Simon-Chica, Peter Lee, Jose Manuel Alfonso-Almazan, Patricia Mahia, Andres Redondo-Rodriguez, Javier Modrego, Adriana Ortega-Hernandez, Pedro Marcos-Alberca, Ricardo Magni, Enrique Calvo, Ruben Gomez-Gordo, Ping Yan, Giulio La Rosa, Jose Bustamante-Madrion, Carlos Nicolas Perez-Garcia, F. Javier Martin-Sanchez, David Calvo, Jesus M. de la Hera, Maria Jesus Garcia-Torrent, Alvaro Garcia-Osuna, Jordi Ordonez-Llanos, Jesus Vazquez, Julian Perez-Villacastin, Nicasio Perez-Castellano, Leslie M. Loew, Javier Sanchez-Gonzalez, Dulcenombre Gomez-Garre, David Filgueiras-Rama
Summary: The authors use non-invasive atrial electromechanical assessment during atrial fibrillation to identify early remodeling changes associated with underlying myopathy, which decreases the probability of successful rhythm control. This study provides mechanistic insights into the electromechanical remodeling process associated with AF progression and demonstrates its prognostic value in the clinic.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Oussama M. Wazni, Gopi Dandamudi, Nitesh Sood, Robert Hoyt, Jaret Tyler, Sarfraz Durrani, Mark Niebauer, Kevin Makati, Blair Halperin, Andre Gauri, Gustavo Morales, Mingyuan Shao, Jeffrey Cerkvenik, Rachelle E. Kaplon, Steven E. Nissen
Summary: In this multicenter trial, cryoballoon ablation as initial therapy was found to be superior to drug therapy in preventing atrial arrhythmia recurrence in patients with paroxysmal atrial fibrillation. Serious procedure-related adverse events were uncommon.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Medicine, General & Internal
Paritosh Prasai, Dhan Bahadur Shrestha, Eltaib Saad, Angkawipa Trongtorsak, Aarya Adhikari, Suman Gaire, Prakash Raj Oli, Jurgen Shtembari, Pabitra Adhikari, Yub Raj Sedhai, Muhammad Sikander Akbar, Islam Y. Elgendy, Ghanshyam Shantha
Summary: There is no clear consensus on the preference for pharmacological cardioversion (PC) compared to electric cardioversion (EC) for hemodynamically stable new-onset atrial fibrillation (NOAF) patients. This meta-analysis suggests that there is no difference in successful restoration of sinus rhythm with either modality among patients with hemodynamically stable NOAF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Emmanouil Charitakis, Elena Dragioti, Maria Stratinaki, Dafni Korela, Stylianos Tzeis, Henrik Almroth, Ioan Liuba, Anders Hassel Jonsson, Georgios Charalambous, Lars O. Karlsson, Dimitrios Tsartsalis
Summary: This umbrella review systematically evaluates the risk and protective factors for arrhythmia recurrence after catheter ablation (CA) and direct current (DC) cardioversion of atrial fibrillation (AF) through published meta-analyses. The results showed that although CA and DC cardioversion are established treatments for rhythm control of AF, there is limited evidence regarding the risk and protective factors for recurrence.
Review
Biochemistry & Molecular Biology
Ozan Demirel, Alexander E. Berezin, Moritz Mirna, Elke Boxhammer, Sarah X. Gharibeh, Uta C. Hoppe, Michael Lichtenauer
Summary: Atrial fibrillation (AF) is associated with atrial remodeling, cardiac dysfunction, and poor clinical outcomes. External direct current electrical cardioversion is an effective urgent treatment strategy for recent-onset AF. However, accurate predictive serum biomarkers for AF relapse after cardioversion are lacking. Many biomarkers have been associated with AF occurrence, but their predictive ability for post-cardioversion outcomes remains controversial. Novel circulating biomarkers are needed to improve the predictive tools for AF treatment.
Article
Biochemistry & Molecular Biology
Javier Garcia-Seara, Laila Gonzalez Melchor, Javier Rodriguez Garcia, Francisco Gude, Jose Luis Martinez Sande, Moises Rodriguez Manero, Xesus Alberte Fernandez Lopez, Carlos Minguito Carazo, Teba Gonzalez Ferrero, Sonia Eiras, Ricardo Lage, Isabel Moscoso, Sandra Feijoo Bandin, Francisca Lago, Ezequiel Alvarez, Clara V. Alvarez, Jose Ramon Gonzalez Juanatey
Summary: This study aims to determine the predictive value of the sST2 biomarker in atrial fibrillation (AF) recurrence. The results showed that sST2 values at 3 months may provide utility in predicting AF recurrence at 6 months in patients who underwent electrical cardioversion (ECV), but not in patients who underwent pulmonary vein isolation (PVI).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Rangrang Zhang, Weidong Jin, Minglei Han, Yonglan Hou
Summary: Atrial fibrillation (AF) is a common clinical arrhythmia associated with increased risk of death, stroke, and peripheral vascular embolism. Catheter ablation (CA) is an effective treatment, but a high recurrence rate remains a challenge. Identifying biomarkers for prediction of AF recurrence after CA is important for personalized treatment. Carbohydrate antigen 125 (CA-125) has been widely studied and may serve as a useful marker for AF.
CLINICA CHIMICA ACTA
(2023)
Article
Medicine, General & Internal
Jason G. Andrade, George A. Wells, Marc W. Deyell, Matthew Bennett, Vidal Essebag, Jean Champagne, Jean-Francois Roux, Derek Yung, Allan Skanes, Yaariv Khaykin, Carlos Morillo, Umjeet Jolly, Paul Novak, Evan Lockwood, Guy Amit, Paul Angaran, John Sapp, Stephan Wardell, Sandra Lauck, Laurent Macle, Atul Verma
Summary: In patients with symptomatic, paroxysmal atrial fibrillation, catheter cryoballoon ablation was associated with a significantly lower rate of atrial fibrillation recurrence compared to antiarrhythmic drug therapy. The ablation group also had better outcomes in terms of atrial tachyarrhythmia occurrence and atrial fibrillation burden.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Farzad Rahbar Kouibaran, Mario Sabatino, Chiara Barozzi, Igor Diemberger
Summary: ANP is synthesized by the atria and serves the purposes of vasodilation and increasing renal excretion of sodium and water. Understanding ANP's role in cardiac systems has improved in recent decades. This review focuses on analyzing the regulations between the endocrine and mechanical function of the heart and emphasizes the impact of ANP on atrial fibrillation (AF) and related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Girish M. Nair, David H. Birnie, Pablo B. Nery, Calum J. Redpath, Jean-Francois Sarrazin, Jean-Francois Roux, Ratika Parkash, Martin Bernier, Laurence D. Sterns, John Sapp, Paul Novak, George Veenhuyzen, Carlos A. Morillo, Sheldon M. Singh, Mouhannad M. Sadek, Mehrdad Golian, Andres Klein, Marcio Sturmer, Vijay S. Chauhan, Paul Angaran, Martin S. Green, Jordan Bernick, George A. Wells, Vidal Essebag
Summary: In this study, an augmented double wide-area circumferential ablation (WACA) did not show superiority in preventing recurrent atrial arrhythmias compared to a standard single WACA in patients with paroxysmal AF. The additional ablation did not improve freedom from atrial arrhythmias or safety.
Review
Biochemistry & Molecular Biology
Homa Nomani, Sara Saei, Thomas P. Johnston, Amirhossein Sahebkar, Amir Hooshang Mohammadpour
Summary: Inflammation has been associated with the recurrence of Atrial Fibrillation (AF), and using anti-inflammatory drugs may help reduce recurrences. However, current studies on the efficacy of specific drugs remain inconclusive, and further clinical trials are needed to explore the impact of different factors on AF recurrence.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Zhenyu Zhai, Zirong Xia, Zhen Xia, Jinzhu Hu, Jianxin Hu, Bo Zhu, Qinmei Xiong, Yanqing Wu, Kui Hong, Qi Chen, JianHua Yu, Juxiang Li
Summary: The study found that in the cardioversion of atrial fibrillation, the use of 0.4 and 0.5 mg/kg doses of nifekalant was more effective than 0.3 mg/kg, and also had certain advantages in terms of safety.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Lucas Boersma, Jason G. Andrade, Tim Betts, Mattias Duytschaever, Helmut Purerfellner, Francesco Santoro, Stylianos Tzeis, Atul Verma
Summary: Over the past 25 years, there has been a significant interest in developing new catheters and energy sources to optimize the durability and safety of ablation, as well as studying the mechanisms for atrial fibrillation and devising ablation strategies. Although pulmonary vein ablation has been the basis for every AF ablation, it has been recognized that this is not enough to cure all patients, especially those with non-paroxysmal AF.
Article
Cardiac & Cardiovascular Systems
Yuxia Miao, Min Xu, Ling Yang, Chunxu Zhang, Huannian Liu, Xiaoliang Shao
Summary: This study found a linear and positive association between P wave duration within 72 hours after radiofrequency ablation and the risk of atrial fibrillation recurrence in patients with early persistent atrial fibrillation. This association was consistent across different subgroups and there was no significant interaction.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Nassir F. Marrouche, Oussama Wazni, Christopher McGann, Tom Greene, J. Michael Dean, Lilas Dagher, Eugene Kholmovski, Moussa Mansour, Francis Marchlinski, David Wilber, Gerhard Hindricks, Christian Mahnkopf, Darryl Wells, Pierre Jais, Prashanthan Sanders, Johannes Brachmann, Jeroen J. Bax, Leonie Morrison-de Boer, Thomas Deneke, Hugh Calkins, Christian Sohns, Nazem Akoum
Summary: Among patients with persistent atrial fibrillation, MRI-guided fibrosis ablation in addition to PVI did not show significant reduction in atrial arrhythmia recurrence compared to PVI catheter ablation alone. The findings do not support the use of MRI-guided fibrosis ablation for the treatment of persistent AF.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Igor Vendramin, Daniela Piani, Andrea Lechiancole, Nunzio Davide de Manna, Sandro Sponga, Michela Puppato, Daniele Muser, Uberto Bortolotti, Ugolino Livi
Summary: The objective of this study was to analyze the effects of chronic oral anticoagulation on long-term outcomes after repair of type A acute aortic dissection and its influence on false lumen fate. The results showed that chronic anticoagulation had no significant effect on long-term survival or risk of reintervention. However, it did favor persistent late false lumen patency, which was not associated with increased risk of mortality or reoperation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea Perrotti, Alessandra Francica, Francesco Monaco, Edward Quintana, Sandro Sponga, Zein El-Dean, Stefano Salizzoni, Tommaso Loizzo, Antonio Salsano, Alessandro Di Cesare, Filippo Benassi, Manuel Castella, Mauro Rinaldi, Sidney Chocron, Igor Vendramin, Giuseppe Faggian, Francesco Santini, Francesco Nicolini, Aldo Domenico Milano, Vito Giovanni Ruggieri, Francesco Onorati
Summary: This study compared quality of life (QoL) after full sternotomy aortic valve replacement (fsAVR) and ministernotomy AVR (msAVR) and found no significant differences in patient baseline characteristics, hospital outcomes, and improvements in physical and mental health between the two surgical approaches over a one-year period.
ANNALS OF THORACIC SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Gino Gerosa, Vinod H. Thourani, Michael Borger, Augusto D'Onofrio
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Igor Vendramin, Daniela Piani, Andrea Lechiancole, Sandro Sponga, Concetta Di Nora, Francesco Londero, Daniele Muser, Francesco Onorati, Uberto Bortolotti, Ugolino Livi
Summary: The study compares the outcomes of two different surgical strategies for patients with acute Type A aortic dissection (A-AAD). It shows that an aggressive approach to A-AAD provides better long-term results without increasing mortality, and immediate aortic arch replacement during A-AAD repair leads to a lower incidence of late aortic-related complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Igor Vendramin, Nunzio Davide de Manna, Sandro Sponga, Andrea Lechiancole, Massimo Sponza, Elisabetta Auci, Uberto Bortolotti, Ugolino Livi
Summary: We reported a case of paraplegia following ascending aorta and arch replacement with the frozen elephant trunk technique. Immediate postoperative cerebrospinal fluid drainage was successful in reversing spinal cord injury. Early awakening of patients after the frozen elephant trunk technique is essential for prompt recognition and treatment of this complication through cerebrospinal fluid drainage.
INDIAN JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Vassili Panagides, David Del Val, Mohamed Abdel-Wahab, Norman Mangner, Eric Durand, Nikolaj Ihlemann, Marina Urena, Costanza Pellegrini, Francesco Giannini, Piotr Scislo, Zenon Huczek, Martin Landt, Vincent Auffret, Jan Malte Sinning, Asim N. Cheema, Luis Nombela-Franco, Chekrallah Chamandi, Francisco Campelo-Parada, Erika Munoz-Garcia, Howard C. Herrmann, Luca Testa, Won-Keun Kim, Juan Carlos Castillo, Alberto Alperi, Didier Tchetche, Antonio L. Bartorelli, Samir Kapadia, Stefan Stortecky, Ignacio Amat-Santos, Harindra C. Wijeysundera, John Lisko, Enrique Gutierrez-Ibanes, Vicenc Serra, Luisa Salido, Abdullah Alkhodair, Ugolino Livi, Tarun Chakravarty, Stamatios Lerakis, Victoria Vilalta, Ander Regueiro, Rafael Romaguera, Utz Kappert, Marco Barbanti, Jean-Bernard Masson, Frederic Maes, Claudia Fiorina, Antonio Miceli, Susheel Kodali, Henrique B. Ribeiro, Jose Armando Mangione, Fabio Sandoli de Brito Jr, Guglielmo Mario Actis Dato, Francesco Rosato, Maria-Cristina Ferreira, Valter Correia de Lima, Alexandre Siciliano Colafranceschi, Alexandre Abizaid, Marcos Antonio Marino, Vinicius Esteves, Julio Andrea, Roger R. Godinho, Fernando Alfonso, Helene Eltchaninoff, Lars Sondergaard, Dominique Himbert, Oliver Husser, Azeem Latib, Herve Le Breton, Clement Servoz, Isaac Pascual, Saif Siddiqui, Paolo Olivares, Rosana Hernandez-Antolin, John G. Webb, Sandro Sponga, Raj Makkar, Annapoorna S. Kini, Marouane Boukhris, Philippe Gervais, Axel Linke, Lisa Crusius, David Holzhey, Josep Rodes-Cabau
Summary: This multicenter study investigates the incidence, characteristics, management, and outcomes of mitral valve infective endocarditis after transcatheter aortic valve implantation. The study finds that the use of self-expanding valves and the presence of aortic regurgitation are associated with mitral valve infective endocarditis. Patients with mitral valve infective endocarditis have lower surgical management rates and poor prognosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Marco Russo, Michele Di Mauro, Guglielmo Saitto, Antonio Lio, Paolo Berretta, Maurizio Taramasso, Roberto Scrofani, Alessandro Della Corte, Sandro Sponga, Ernesto Greco, Matteo Saccocci, Antonio Calafiore, Giacomo Bianchi, Dror B. Leviner, Andrea Biondi, Ugolino Livi, Erez Sharoni, Carlo De Vincentiis, Marco Di Eusanio, Carlo Antona, Giovanni Troise, Marco Solinas, Guenther Laufer, Francesco Musumeci, Martin Andreas
Summary: This study retrospectively analyzed the early and long-term outcomes of isolated tricuspid valve surgery, and found that repair surgery had lower early and late mortality rates compared to replacement surgery, with no difference in reoperation rates.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Martina Casarin, Tiago Moderno Fortunato, Saima Imran, Martina Todesco, Deborah Sandrin, Giulia Borile, Ilaria Toniolo, Massimo Marchesan, Gino Gerosa, Andrea Bagno, Filippo Romanato, Emanuele Luigi Carniel, Alessandro Morlacco, Fabrizio Dal Moro
Summary: Bladder cancer is a common malignancy that often requires bladder removal surgery for treatment. However, the use of autologous intestine segments can lead to complications and affect patients' quality of life. This study aims to develop a bio-engineered material as a replacement, and the preliminary evaluation shows promising results for decellularized porcine small intestinal submucosa as a suitable candidate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
A. D'Onofrio, F. Mastro, M. Nadali, A. Fiocco, D. Pittarello, P. Aruta, G. Evangelista, G. Lorenzoni, D. Gregori, G. Gerosa
Summary: This single-center retrospective study compared the outcomes of transapical neochordae implantation (NC) versus conventional surgical (CS) mitral valve repair. The results showed that freedom from moderate and severe mitral regurgitation (MR) was worse in patients undergoing NC at 5-year follow-up. However, in patients with isolated P2 prolapse, the freedom from MR was similar between the two groups. Reoperation freedom was lower in the NC group, but similar in patients with isolated P2 prolapse.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Letter
Cardiac & Cardiovascular Systems
Augusto D'Onofrio, Gino Gerosa
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Polymer Science
Marika Faggioli, Arianna Moro, Salman Butt, Martina Todesco, Deborah Sandrin, Giulia Borile, Andrea Bagno, Assunta Fabozzo, Filippo Romanato, Massimo Marchesan, Saima Imran, Gino Gerosa
Summary: The most common aortic valve diseases in adults are stenosis and regurgitation. Pediatric patients have a lower incidence of aortic pathologies. Replacement of native valve with prosthetic valve requires consideration of durability. Both mechanical and biological prosthetic valves need to be replaced in pediatric patients. Acellular porcine aortic valve may be an alternative with lower immunogenic risk and longer lifespan. This study reports an efficient protocol for decellularization and evaluates the structural integrity, cell and nuclear component removal, and biomechanical properties.
Article
Cardiac & Cardiovascular Systems
Michele Di Mauro, Marco Russo, Guglielmo Saitto, Antonio Lio, Paolo Berretta, Maurizio Taramasso, Roberto Scrofani, Alessandro Della Corte, Sandro Sponga, Ernesto Greco, Matteo Saccocci, Antonio Calafiore, Giacomo Bianchi, Dror B. Leviner, Andrea Biondi, Ugolino Livi, Erez Sharoni, Carlo De Vincentiis, Marco Di Eusanio, Carlo Antona, Giovanni Troise, Marco Solinas, Guenther Laufer, Francesco Musumeci, Martin Andreas
Summary: This study aimed to analyze the outcomes of isolated tricuspid valve surgery in patients with endocarditis compared to other pathologies. The results showed that patients with endocarditis had lower risk of cardiac death and reoperation within six years, but lower overall survival. Therefore, a multi-disciplinary approach, repair strategy, and early treatment may improve outcomes for these patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Samuel Heuts, Roberto Lorusso, Michele di Mauro, Federica Jiritano, Roberto Scrofani, Carlo Antona, Guglielmo Actis Dato, Paolo Centofanti, Sandro Ferrarese, Matteo Matteucci, Antonio Miceli, Mattia Glauber, Enrico Vizzardi, Sandro Sponga, Igor Vendramin, Andrea Garatti, Carlo de Vincentiis, Michele De Bonis, Marina Pieri, Giovanni Troise, Margherita Dalla Tomba, Giuseppe Filiberto Serraino
Summary: This study aimed to evaluate the differences in vascular complications between the sheathless and the sheathed IABP implantation technique in cardiac surgery patients. A retrospective multi-center cohort study demonstrated that the use of sheathless implantation technique was associated with a significant reduction in vascular complication rate. Future studies should focus on less invasive implantation techniques, smaller-sized catheters, sheathless implantation, and imaging guiding.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Natasha Aleksova, Tayler A. Buchan, Farid Foroutan, Alice Zhu, Sean Conte, Peter Macdonald, Pierre-Emmanuel Noly, Michel Carrier, Silvana F. Marasco, Koji Takeda, Matteo Pozzi, Guillaume Baudry, Fernando A. Atik, Sven Lehmann, Khalil Jawad, Gavin W. Hickey, Antoine Defontaine, Oliver Baron, Antonio Loforte, Giulio Giovanni Cavalli, Daniel O. Absi, Masashi Kawabori, Michael A. Mastroianni, Maria Simonenko, Sandro Sponga, Yasbanoo Moayedi, Ani Orchanian-cheff, Heather J. Ross, Vivek Rao, Gordon Guyatt, Filio Billia, Ana C. Alba
Summary: This study evaluates the outcomes of VA-ECMO in adult heart transplant recipients through a systematic review and meta-analysis. The short-term and one-year mortality rates for patients receiving VA-ECMO were 33% and 50% respectively. Older age and prior sternotomy were associated with increased risk of short-term mortality. Early intraoperative cannulation and peripheral cannulation may reduce the risk of short-term death.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Polymer Science
Susanna Tondato, Arianna Moro, Salman Butt, Martina Todesco, Deborah Sandrin, Giulia Borile, Massimo Marchesan, Assunta Fabozzo, Andrea Bagno, Filippo Romanato, Saima Jalil Imran, Gino Gerosa
Summary: Right ventricle outflow tract obstruction (RVOTO), accounting for about 15% of congenital heart diseases, often requires pulmonary valve replacement. This study investigated the use of a new detergent (Tergitol) to decellularize porcine pulmonary valves for scaffold production. The decellularized scaffolds were evaluated for structural integrity, and their compatibility with mesenchymal stem cells was assessed. Tergitol efficiently removed nuclear material while preserving the matrix's structural proteins, making it a potential alternative to Triton X-100.
