Article
Cardiac & Cardiovascular Systems
Xueqi Dong, Xu Meng, Ting Zhang, Lin Zhao, Fang Liu, Xu Han, Yecheng Liu, Huadong Zhu, Xianliang Zhou, Qi Miao, Shuyang Zhang
Summary: Cardiac paragangliomas (CPGLs) are rare and difficult to diagnose tumors with non-specific manifestations and are hard to detect on imaging exams. Surgical resection can relieve symptoms and achieve biochemical remission.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Endocrinology & Metabolism
Dan Granberg, Carl Christofer Juhlin, Henrik Falhammar
Summary: PPGLs are believed to have malignant potential, and a combination of histological workup and molecular predictive markers is important for determining metastatic potential. Patients with PPGLs should receive individualized treatment, including surgery, biochemical tests, genetic testing, and molecular imaging studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Pediatrics
Kevin Yen, Maya Lodish
Summary: Genetics play a crucial role in pediatric PPGLs, with somatostatin receptor-based imaging technologies like Ga-68-DOTATATE and Cu-64-DOTATATE being the preferred modalities. Peptide receptor radionuclide therapy (PRRT) has shown efficacy in treating PPGLs, alongside surgical intervention.
CURRENT OPINION IN PEDIATRICS
(2021)
Letter
Clinical Neurology
Michael Bockmayr, Meik Koerner, Leonille Schweizer, Ulrich Schueller
Summary: HOXB13 is expressed in the tail bud of the developing embryo, cauda equina paragangliomas, and myxopapillary ependymomas, but is negative in pheochromocytomas and paraganglioma in other locations as well as many other tumors in spinal cord regions.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Review
Oncology
Jan Calissendorff, Carl Christofer Juhlin, Irina Bancos, Henrik Falhammar
Summary: Pheochromocytomas and abdominal paragangliomas (PPGLs) are rare tumors that can be discovered incidentally or during hormonal surveillance. Most cases are asymptomatic or have non-specific symptoms. PPGLs have malignant potential and require close surveillance. Genetic susceptibility is important for predicting the risk of recurrence or metastasis and identifying affected family members. Multidisciplinary management is essential for patients with PPGLs.
Article
Endocrinology & Metabolism
Maria Savvateeva, Anna Kudryavtseva, Elena Lukyanova, Anastasiya Kobelyatskaya, Vladislav Pavlov, Maria Fedorova, Elena Pudova, Zulfiya Guvatova, Dmitry Kalinin, Alexander Golovyuk, Elizaveta Bulavkina, Irina Katunina, George Krasnov, Anastasiya Snezhkina
Summary: This study analyzed somatic mutation profiles in HNPGLs and found that most patients had germline and somatic variants in paraganglioma susceptibility genes or related genes. The study also identified six significantly mutated genes and four mutational signatures associated with HNPGLs. These findings provide important insights into the molecular mechanisms involved in the development of HNPGLs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lin Zhao, ZhiMao Li, Xu Meng, Hua Fan, ZengLei Zhang, ZhaoCai Zhang, YeCheng Liu, XianLiang Zhou, HuaDong Zhu
Summary: This study found significant differences in clinical characteristics between large and small pheochromocytomas and paragangliomas (PPGLs). Male patients were more likely to have large tumors, and large tumors were more likely to be located on the adrenal glands. Catecholamine measurements also helped predict tumor size of PPGLs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Xu Wang, Yang Zhao, Zhangcheng Liao, Yushi Zhang
Summary: PCC/PGL are neuroendocrine tumors that secrete catecholamines, also known as PPGL due to their histological and pathophysiological similarities. In addition to the typical triad of symptoms, PPGL may also present with symptoms involving multiple organs and systems. Surgical resection is currently the preferred treatment for PPGL, with the goal of safe and effective management. This paper discusses the surgical management strategy based on complicated PPGL cases, aiming to share our experience.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Balazs Sarkadi, Eva Saskoi, Henriett Butz, Attila Patocs
Summary: Pheochromocytomas and paragangliomas are the most heritable endocrine tumors, most of which are benign and can be resolved through surgical removal. However, a small percentage are malignant with limited therapeutic options available.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Anastasiya Snezhkina, Vladislav Pavlov, Alexey Dmitriev, Nataliya Melnikova, Anna Kudryavtseva
Summary: Paragangliomas and pheochromocytomas are rare neuroendocrine tumors with potential for metastasis. Challenges in diagnosis and treatment remain, but research on predictors of malignancy risk could lead to more effective strategies.
Article
Cardiac & Cardiovascular Systems
Jianjie Zheng, Jianpeng Li, Jing Li, Liang Zhong, Suochun Xu, Heping Zhou
Summary: Cardiac paragangliomas are rare neuroendocrine tumors that require surgical resection as the preferred treatment option. Patients generally have good postoperative recovery, but lifelong surveillance is recommended to detect possible recurrence.
HEART SURGERY FORUM
(2021)
Editorial Material
Clinical Neurology
Sundarakrishnan Dharanipathy, Hitesh Gurjar, Amandeep Kumar
Summary: Two normotensive male patients presented with low back pain and were diagnosed with an enhancing intradural extramedullary lesion in the lumbosacral spine, located at the L4-L5 vertebral level in the first patient and at the L2-L3 vertebral level in the second patient. The tumor demonstrated a tadpole-like appearance, resembling the head and caudal blood vessels, thus termed the tadpole sign. This sign is valuable for the preoperative diagnosis of spinal paraganglioma, providing important radiologic and histopathologic correlation.
WORLD NEUROSURGERY
(2023)
Article
Medical Laboratory Technology
Karin Eijkelenkamp, Thamara E. Osinga, Martijn van Faassen, Ido P. Kema, Michiel N. Kerstens, Karel Pacak, Wim J. Sluiter, Thera P. Links, Anouk N. A. van der Horst-Schrivers
Summary: The study suggests that salivary metanephrines have high sensitivity and accuracy in diagnosing PPGL, with a significant correlation to plasma metanephrines. However, salivary metanephrines cannot fully replace the measurement of plasma free metanephrines at present.
CLINICAL CHEMISTRY
(2021)
Review
Oncology
Anne-Paule Gimenez-Roqueplo, Mercedes Robledo, Patricia L. M. Dahia
Summary: Adrenal and extra-adrenal PGLs are often caused by single pathogenic variants in genes involved in various cellular processes. The discovery of these driver mutations has led to active clinical surveillance and potential targeted therapies. Recent progress in genetics and molecular pathogenesis of PGLs, along with new disease models and ongoing clinical trials, were discussed at the ISP2022 conference.
ENDOCRINE-RELATED CANCER
(2023)
Article
Endocrinology & Metabolism
Constance Lamy, Hubert Tissot, Matthieu Faron, Eric Baudin, Livia Lamartina, Caroline Pradon, Abir Al Ghuzlan, Sophie Leboulleux, Jean-Luc Perfettini, Angelo Paci, Julien Hadoux, Sophie Broutin
Summary: In this study, serum succinate levels were found to be a potential biomarker for identifying carriers of SDHB gene mutations and a marker of metabolic tumor burden in patients with metastatic PPGL. It may also serve as a marker for treatment response and follow-up.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Ji-Gang Wang, Juan Yu, Ji-Lin Hu, Wen-Lin Yang, Hong Ren, Di Ding, Lei Zhang, Xiu-Ping Liu
CELLULAR SIGNALLING
(2015)
Article
Biochemistry & Molecular Biology
Wenlin Yang, Ji-Gang Wang, Qiangxiu Wang, Yejun Qin, Xiaoyan Lin, Danmei Zhou, Kehan Ren, Chenjian Hou, Jiawen Xu, Xiuping Liu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Cardiac & Cardiovascular Systems
Ji-Gang Wang, Bing Liu, Han Gao, Yu-Jun Li, Peng Zhao, Xiu-Ping Liu
HEART LUNG AND CIRCULATION
(2016)
Article
Pathology
Wei Wang, Huiting Zhu, Jigang Wang, Shuyang Wang, Diyi Wang, Jingling Zhao, Hongguang Zhu
Article
Cell Biology
X-H Liao, J-G Wang, L-Y Li, D-M Zhou, K-H Ren, Y-T Jin, L. Lv, J-G Yu, J-Y Yang, Q. Lu, Q. Zou, J. Yu, X-P Liu, P. Zhou
CELL DEATH & DISEASE
(2016)
Article
Medicine, Legal
Peng Zhao, Ji-Gang Wang, Peng Gao, Xia Li, Rubell Brewer
JOURNAL OF FORENSIC AND LEGAL MEDICINE
(2016)
Article
Oncology
Juan Yu, Ji-Gang Wang, Lei Zhang, Hai-Ping Yang, Lei Wang, Di Ding, Qi Chen, Wen-Lin Yang, Ke-Han Ren, Dan-Mei Zhou, Qiang Zou, Yi-Ting Jin, Xiu-Ping Liu
Article
Pathology
Jie Zhao, Dong-Liang Lin, Li-Hui Zhai, Ji-Gang Wang
Article
Oncology
Dong-Liang Lin, Ji-Lin Hu, Shi-Hong Shao, Dong-Mei Sun, Ji-Gang Wang
Article
Pathology
Xin Liu, Wei-Na Jiang, Ji-Gang Wang, Hua Chen
PATHOLOGY RESEARCH AND PRACTICE
(2014)
Article
Pathology
Yanjiao Hu, Guangqi Li, Lili Wang, Longxiao Zhang, Jingjing Guan, Jigang Wang
Summary: The study investigated MED12 and TERT gene mutations in primary and recurrent fibroepithelial tumors, revealing that recurrent phyllodes tumors tend to retain original mutations while recurrent fibroadenomas often acquire new mutations. These findings suggest that recurrent phyllodes tumors may represent true recurrence, and benign fibroepithelial tumors with TERT mutations should be treated as phyllodes tumors.
PATHOLOGY INTERNATIONAL
(2021)
Article
Pathology
Haiyan Gu, Lingling Sun, Jiufa Cui, Lan Yu, Jigang Wang
Summary: This article reports a case of non-epiphyseal chondroblastoma in an 11-year-old girl. The lesion was located in the cortical bone of the distal femur and showed typical morphology and H3F3B mutation.
FETAL AND PEDIATRIC PATHOLOGY
(2023)
Article
Obstetrics & Gynecology
Yixuan Liu, Dong Li, Xueqing Li, Jingnan Wang, Jigang Wang
Summary: Benign metastasizing leiomyoma (BML) is a rare condition primarily affecting women with a history of uterine leiomyoma. This study aimed to investigate its clinical characteristics and outcomes by reviewing 385 cases from previous reports. The common sites for metastasis were the lung, abdomen/pelvis/retroperitoneum, bone, lymph nodes, and heart. Hormone deprivation treatment, such as oophorectomy and hormone drugs, was found to be the most effective strategy for managing unresectable tumors. This study may serve as a valuable resource for diagnosing and managing BMLs.
REPRODUCTIVE SCIENCES
(2023)
Review
Respiratory System
Dongliang Lin, Yanxia Jiang, Jigang Wang, Li Ding, Fangjie Xin, Han Zhao, Yujun Li
JOURNAL OF THORACIC DISEASE
(2013)
