Article
Electrochemistry
Bolu Sun, Lei Kan, Yuhong Liu, Yanlei Sun, Jinhai Liu, Yuqiong Wu, Huajie Li, Shixing Yu, Liangrong Bao, Chengyang Gao, Yanmei Yang, Lin Yang
Summary: This study presents a highly sensitive electrochemical immunosensor based on chitosan functionalized graphene oxide composites for detecting the cardiovascular disease-related biomarker cTn-I. The sensor offers a wide linear range and a low detection limit, enabling accurate detection in complex biological samples and providing new scientific basis and directions for early warning techniques of cardiovascular diseases.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Haiping Wu, Xueping Ma, Yanan Chu, Xiemin Qi, Bingjie Zou, Yunlong Liu, Guohua Zhou
Summary: This article presents an alternative analysis platform, dNASA, which is based on digital nucleic acid signal amplification in droplets. By using a bead-based controllable extension bridged cascade signal amplification reaction, the platform achieves highly efficient and specific nucleic acid signal amplification. The feasibility of the platform was demonstrated in single-base DNA mutation analysis.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yun Chen, Dehui Qiu, Xiaobo Zhang, Yuan Liu, Mingpan Cheng, Jianping Lei, Jean-Louis Mergny, Huangxian Ju, Jun Zhou
Summary: In this study, F3T-azaC-hemin, a G4-based construct, was designed to address the low activity issue of G-quadruplex/hemin (G4/hemin) DNAzymes. The performances of the G4-DNAzyme were significantly improved, resulting in a new and highly efficient molecular tool for ultrasensitive chemiluminescent detection of miRNA-221.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Feng Chen, Guodong Li, Chun Wu, Ling Wang, Chung-Nga Ko, Dik-Lung Ma, Chung-Hang Leung
Summary: In this study, a novel method was developed for the ultrasensitive and highly specific detection of miRNA-21. This method exhibited advantages such as lower and constant temperature operation, high specificity, and comparable detection limit with conventional RT-qPCR. The method utilized long-lived probes and rolling circle amplification, and could discriminate between matched and mismatched targets. The application of this method in cancer cells and mouse serum samples showed good agreement with RT-qPCR results.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Qingxuan Li, Sidi A. Bencherif, Ming Su
Summary: This study introduces a new signal amplification mechanism based on the edge enhancement technique of microwells, which can achieve ultra-sensitive protein detection and single-cell level cytokine secretion detection, showing great potential for early disease diagnosis and treatment assessment.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Hoi Kei Chiu, Tadas Kartanas, Kadi L. Saar, Carina Mouritsen Luxhoj, Sean Devenish, Tuomas P. J. Knowles
Summary: A chemiluminescence-based protein detection assay targeting primary amines in proteins was established to achieve high sensitivity quantitative protein detection without the need for signal amplification steps or complex optical systems. This approach allowed for the characterization of any protein sample and demonstrated detection over a wide concentration range, down to very low concentrations, providing a simple yet universal and sensitive protein detection strategy.
Article
Medicine, General & Internal
Christiane Gaertner, Romy Langhammer, Maria Schmidt, Martin Federbusch, Kerstin Wirkner, Markus Loeffler, Berend Isermann, Ulrich Laufs, Rolf Wachter, Thorsten Kaiser
Summary: Sex-adjusted and age-adjusted upper reference limits for hs-cTnT were identified in a large cohort without cardiac diseases. hs-cTnT values were higher in men of all age groups, and increased with age in both sexes. Renal function showed weak correlation with hs-cTnT, and was not found to have a significant additional effect on hs-cTnT levels. In individuals aged above 60 for men and above 70 for women, the calculated 99th percentiles exceeded commonly applied thresholds.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Syeda Maheen Batool, Koushik Muralidharan, Tiffany Hsia, Sarah Falotico, Austin S. Gamblin, Yulia B. Rosenfeld, Sirena K. Khanna, Leonora Balaj, Bob S. Carter
Summary: This study developed a highly sensitive and specific digital droplet PCR (ddPCR) assay for detecting EGFRvIII mutation in liquid biopsies. The study also found a higher prevalence of EGFRvIII in glioma tumor tissue than previously reported. The assay has favorable features for clinical implementation in the detection and monitoring of EGFRvIII-positive tumors.
CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Linh Tran, Sangkwon Park
Summary: A highly sensitive immunosensor using quantum dots and streptavidin was developed for detecting the dengue biomarker NS1, offering a fast, convenient, and sensitive approach. However, interference in human plasma serum solution was observed, suggesting the need for further solutions.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Yuan Ding, Yue Huang, Wanlin Sun, Fangxuan Li, Shuguang Zhang, Song Fang, Minghua Wang, Xiude Hua
Summary: By synthesizing three novel quinclorac haptens, a better anti-quinclorac antibody was obtained, and a colloidal gold immunochromatographic assay (GICA) was developed for the detection of quinclorac, which showed high sensitivity and accuracy.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Shi Xiang, Jingxian Li, Futing Wang, Hongfen Yang, Yifei Jiang, Penghui Zhang, Ren Cai, Weihong Tan
Summary: An ultralow-potential electrochemiluminescence aptasensor has been designed for zearalenone detection. The sensor utilizes a resonance energy transfer system with SnS2 QDs/g-C3N4 and CuO/NH2-UiO-66. It exhibits low detection limit, good stability, and specificity.
ANALYTICAL CHEMISTRY
(2023)
Article
Rheumatology
Julie Chezel, Nathalie Costedoat-Chalumeau, Cedric Laouenan, Diane Rouzaud, Camille Chenevier-Gobeaux, Veronique Le Guern, Alexis Mathian, Drifa Belhadi, Sebastien de Almeida Chaves, Pierre Duhaut, Olivier Fain, Lionel Galicier, Pascale Ghillani-Dalbin, Jean Emmanuel Kahn, Nathalie Morel, Laurent Perard, Micheline Pha, Fanny Saidoune, Francoise Sarrot-Reynauld, Olivier Aumaitre, Francois Chasset, Nicolas Limal, Helene Desmurs-Clavel, Felix Ackermann, Zahir Amoura, Thomas Papo, Karim Sacre
Summary: This study aimed to determine if serum levels of highly sensitive cTnT could predict cardiovascular events in SLE patients. Results showed that HS-cTnT concentration at baseline was associated with the occurrence of CVE in SLE patients.
Article
Gastroenterology & Hepatology
Kevin Tsai, Caixia Ma, Xiao Han, Joannie Allaire, Genelle R. Lunken, Shauna M. Crowley, Hongbing Yu, Kevan Jacobson, Lijun Xia, John J. Priatel, Bruce A. Vallance
Summary: This article introduces a flow cytometry-based method of measuring intestinal permeability. By detecting orally gavaged ovalbumin (OVA) leaking from the gut and using minute blood samples collected from the tail vein, it allows for repeated testing of the same animal at multiple time points to measure intestinal permeability. The OVA assay shows high sensitivity and effectiveness compared to current methods.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Chemistry, Analytical
Di Cheng, Zhenbo Zhou, Shasha Shang, Hesen Wang, Huaimin Guan, Huaixia Yang, Yanju Liu
Summary: This study developed an electrochemical immunosensor based on the ROP reaction for highly sensitive detection of cTnI, showing good linearity and low detection limit. The ROP reaction method offers easy access to raw materials and mild reaction conditions, with excellent selectivity and reliability in serum sample detection.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Fang Li, Xiuming Wu, Mengmeng Gu, Guang-Li Wang
Summary: In this study, a cathodic photoelectrochemistry method was developed to determine the activity of DNA adenine methylation methyltransferase (Dam MTase). The system can detect Dam MTase in a linear range from 0.04 to 100 U mL(-1), with a detection limit of 0.028 U mL(-1). This method shows promise for probing various biomolecules that induce configuration or charge variations at the electrode surface.
Article
Cardiac & Cardiovascular Systems
Xiaowen Wang, Muthiah Vaduganathan, Brian L. Claggett, Sheila M. Hegde, Maria Pabon, Ian J. Kulac, Orly Vardeny, Eileen O'Meara, Shelley Zieroth, Tzvetana Katova, Martina M. McGrath, Anne-Catherine Pouleur, Pardeep S. Jhund, Akshay S. Desai, Silvio E. Inzucchi, Mikhail N. Kosiborod, Rudolf A. de Boer, Lars Kober, Marc S. Sabatine, Felipe A. Martinez, Piotr Ponikowski, Sanjiv J. Shah, Adrian F. Hernandez, Anna Maria Langkilde, John J. McMurray, Scott D. Solomon, Carolyn S. P. Lam
Summary: This study analyzed the efficacy and safety of sodium-glucose cotransporter-2 inhibitors in the treatment of heart failure, and assessed the impact of sex on their effectiveness and safety. The study found that, after adjusting for baseline differences, women had fewer cardiovascular and all-cause deaths, as well as lower rates of HF hospitalizations and total events, compared to men. There were no sex-related differences in adverse events or drug discontinuation. Therefore, sex does not modify the treatment effect of sodium-glucose cotransporter-2 inhibitors.
Article
Cardiac & Cardiovascular Systems
Niklas Dyrby Johansen, Muthiah Vaduganathan, Deewa Zahir, Mona Fiuzat, Ersilia M. DeFilippis, James L. Januzzi, Javed Butler, Christopher M. O'Connor, William T. Abraham, Mitchell A. Psotka, John J. V. McMurray, Pooja Dewan, Brian L. Claggett, Scott D. Solomon, Daniel Modin, Jawad H. Butt, Jens Ulrik Staehr Jensen, Morten Schou, Christian Torp-Pedersen, Lars Kober, Gunnar H. Gislason, Tor Biering-Sorensen
Summary: This study validated the use of a composite medical therapy score in Danish heart failure patients and found that higher scores were associated with lower mortality.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Elke Platz, Brian Claggett, Karola S. Jering, Attila Kovacs, Maja Cikes, Ephraim B. Winzer, Aria Rad, Martin P. Lefkowitz, Jianjian Gong, Lars Kober, John J. McMurray, Scott D. Solomon, Marc A. Pfeffer, Amil Shah
Summary: This study examined the efficacy of sacubitril/valsartan in patients with acute myocardial infarction (AMI) and reduced left ventricular ejection fraction (LVEF), pulmonary congestion, or both. The study used lung ultrasound (LUS) to assess the trajectory of pulmonary congestion and its association with cardiac structure and function.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Jean-Claude Tardif, Jean Rouleau, Glenn M. Chertow, Ayman Al-Shurbaji, Vera Lisovskaja, Stephanie Gustavson, Yanli Zhao, Nadia Bouabdallaoui, Akshay S. Desai, Alexander Chernyavskiy, Maria Evsina, Bela Merkely, John J. V. McMurray, Marc A. Pfeffer
Summary: The PRIORITIZE-HF study, which aimed to evaluate the benefits and risks of using SZC to intensify RAAS inhibitor therapy in patients with heart failure and reduced ejection fraction (HFrEF), was prematurely terminated due to challenges related to the COVID-19 pandemic. The study did not demonstrate a statistically significant increase in the intensity of RAAS inhibitor therapies with SZC compared to placebo.
Article
Cardiac & Cardiovascular Systems
Safia Chatur, Muthiah Vaduganathan, Brian Claggett, Orly Vardeny, Akshay S. Desai, Pardeep S. Jhund, Rudolf A. de Boer, Carolyn S. P. Lam, Mikhail N. Kosiborod, Sanjiv J. Shah, Felipe Martinez, Silvio E. Inzucchi, Adrian F. Hernandez, Tariq Haddad, Sumeet S. Mitter, Zi Michael Miao, Magnus Petersson, Anna Maria Langkilde, John J. McMurray, Scott D. Solomon
Summary: In this study, the safety and efficacy of dapagliflozin were evaluated according to different diuretic therapies and its influence on diuretic use. The results showed that dapagliflozin had consistent clinical benefits in terms of reducing heart failure worsening and cardiovascular death across different diuretic categories and doses, with a similar safety profile. Dapagliflozin also significantly reduced the need for loop diuretics over time.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Khawaja M. Talha, Javed Butler, Stephen J. Greene, Rahul Aggarwal, Stefan D. Anker, Brian L. Claggett, Kieran F. Docherty, Scott D. Solomon, John J. V. McMurray, James L. Januzzi, Muthiah Vaduganathan, Gregg C. Fonarow
Summary: This study evaluated the potential implications of optimal global implementation of SGLT-2 inhibitors in heart failure, and found that it could prevent or postpone approximately 7-8 million worsening heart failure events and cardiovascular deaths worldwide, which is of great significance.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Jawad H. Butt, Kieran F. Docherty, Mikhail N. Kosiborod, Silvio E. Inzucchi, Lars Kober, Anna Maria Langkilde, Felipe A. Martinez, Olof Bengtsson, Piotr Ponikowski, Marc S. Sabatine, Mikaela Sjoestrand, Scott Solomon, Pardeep S. Jhund, John J. V. Mcmurray
Summary: This study examined the effects of dapagliflozin on physical and social limitations in patients with heart failure and found that it improved their quality of life and physical activity.
JACC-HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Robert A. Byrne, Stephen Fremes, Davide Capodanno, Martin Czerny, Torsten Doenst, Jonathan R. Emberson, Volkmar Falk, Mario Gaudino, John J. Mcmurray, Roxana Mehran, Milan Milojevic, Miguel Sousa Uva
Summary: In October 2021, the ESC and EACTS established a task force to review the 2018 guidelines on myocardial revascularization for patients with LM disease. The task force suggested updated recommendations for revascularization modality, stating that both CABG and PCI are clinically reasonable options for stable patients with LM disease. The task force also acknowledged knowledge gaps and emphasized the need for more data.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Mingming Yang, Toru Kondo, Jawad H. Butt, William T. Abraham, Inder S. Anand, Akshay S. Desai, Lars Kober, Milton Packer, Marc A. Pfeffer, Jean L. Rouleau, Marc S. Sabatine, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Pardeep S. Jhund, John J. McMurray
Summary: Patients with heart failure who have a history of stroke are at a high risk of subsequent cardiovascular events, regardless of ejection fraction. This study investigated the prevalence of stroke history in patients with heart failure and found that they had more vascular comorbidity and worse heart failure compared to those without stroke history. Targeting underutilization of guideline-recommended treatments might improve outcomes in this high-risk population.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
W. H. Wilson Tang, Wolfgang Koenig
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaowen Wang, Karola S. Jering, Maja Cikes, Mariya P. Tokmakova, Roxana Mehran, Yaling Han, Cara East, Freny Vaghaiwalla Mody, Yi Wang, Eldrin F. Lewis, Brian Claggett, John J. V. Mcmurray, Christopher B. Granger, Marc A. Pfeffer, Scott D. Solomon
Summary: This study found that women are more likely to develop heart failure after acute myocardial infarction. Sacubitril/valsartan was shown to reduce cardiovascular death and heart failure hospitalizations in patients with heart failure. In patients with reduced left ventricular ejection fraction, pulmonary congestion, or both following acute myocardial infarction, women had a higher incidence of heart failure during follow-up.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Correction
Cardiac & Cardiovascular Systems
James P. Curtain, Carly Adamson, Toru Kondo, Jawad Haider Butt, Akshay S. Desai, Faiez Zannad, Jean L. Rouleau, Luis E. Rohde, Lars Kober, Inder S. Anand, Dirk J. van Veldhuisen, Michael R. Zile, Martin P. Lefkowitz, Scott D. Solomon, Milton Packer, Mark C. Petrie, Pardeep S. Jhund, John J. V. McMurray
EUROPEAN HEART JOURNAL
(2023)
Letter
Medicine, General & Internal
Nathalie Conrad, John J. McMurray
Review
Cardiac & Cardiovascular Systems
Chiara Oriecuia, Daniela Tomasoni, Isabella Sala, Giovanni Battista Bonfioli, Marianna Adamo, Cristina Gussago, Carlo Mario Lombardi, Matteo Pagnesi, Gianluigi Savarese, Marco Metra, Claudia Specchia
Summary: In patients with HF, regardless of their LVEF and clinical status, the addition of SGLT2i to SOC showed a significant improvement in quality of life as early as at 3-month follow-up.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cell & Tissue Engineering
Satsuki Yamada, Jozef Bartunek, Thomas J. Povsic, Gad Cotter, Beth A. Davison, Christopher Edwards, Atta Behfar, Marco Metra, Gerasimos S. Filippatos, Marc Vanderheyden, William Wijns, Andre Terzic
Summary: Patients with heart failure often experience limitations in daily activities and poor quality of life. This study found that cell therapy can significantly improve the health-related quality of life in heart failure patients, particularly in those with pre-existing advanced left ventricular enlargement.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)