Review
Pharmacology & Pharmacy
Ekaterina Yu Podyacheva, Ekaterina A. Kushnareva, Andrei A. Karpov, Yana G. Toropova
Summary: Currently, there is an expansion in the pharmacological possibilities of treating cancer, leading to an increase in life expectancy with chemotherapy and supportive treatment. However, complications such as anthracycline-induced cardiomyopathy are a significant concern, requiring further research to understand its development mechanisms through new models.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Claudia Richter, Rabea Hinkel
Summary: Research on diabetic cardiomyopathy relies heavily on animal models, particularly transgenic rodent models. While these models have advantages in terms of genetic traceability and direct measurable effects, they also face challenges in clinical relevance. Other spontaneous diabetes models in larger mammals like dogs and pigs could be more representative for testing translational approaches.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Urology & Nephrology
Carolina Victoria Cruz Junho, Janina Frisch, Josefin Soppert, Julia Wollenhaupt, Heidi Noels
Summary: The cardiorenal syndrome is a multi-organ disease involving the heart and kidney. In chronic kidney disease, the heart can be damaged, leading to cardiomyopathy. Various pathological mechanisms contribute to the development of CKD-induced cardiomyopathy, including neurohormonal dysregulation, disturbances in mineral metabolism, and accumulation of uremic toxins. This review summarizes the clinical features, biomarkers, and underlying pathophysiological mechanisms of CKD-induced cardiomyopathy.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Hiroki Kitakata, Jin Endo, Hidehiko Ikura, Hidenori Moriyama, Kohsuke Shirakawa, Yoshinori Katsumata, Motoaki Sano
Summary: This review discusses the molecular mechanisms of DOX-induced cardiotoxicity, focusing on apoptosis and ferroptosis as the two forms of programmed cell death. Possible therapeutic strategies to prevent DOX cardiotoxicity are also outlined, along with the significance of mitochondrial homeostasis disruption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Michael P. Gannon, Mark S. Link
Summary: Hypertrophic cardiomyopathy (HCM) presents with variable clinical manifestations due to diverse genetic mutations. Animal models help study genotypic expression, protein function, and potential targeted therapies for the disease. Understanding the cascade of mutations and their functional significance can lead to the development of effective treatments.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Julia Wollenhaupt, Janina Frisch, Eva Harlacher, Dickson W. L. Wong, Han Jin, Corinna Schulte, Sonja Vondenhoff, Julia Moellmann, Barbara Mara Klinkhammer, Li Zhang, Adelina Baleanu-Curaj, Elisa A. Liehn, Thimoteus Speer, Andrey Kazakov, Christian Werner, Emiel P. C. van der Vorst, Simina-Ramona Selejan, Mathias Hohl, Michael Bohm, Rafael Kramann, Erik A. L. Biessen, Michael Lehrke, Nikolaus Marx, Joachim Jankowski, Christoph Maack, Peter Boor, Leticia Prates Roma, Heidi Noels
Summary: CKD increases cardiac oxidative stress responses in the heart, but additional hits are required to induce uremic cardiomyopathy.
Article
Fisheries
Eduardo da Silva, Gabriel Tobias Deschamps, Fabiano de Lima Matter, Fabiano Cleber Bertoldi, Manuel Aldegunde, Deivisson Ferreira da Silva, Carlize Lopes, Adolfo Jatoba, Robilson Antonio Weber
Summary: The study determined the lowest effective concentration of eucalyptus essential oil as an anaesthetic for Rhamdia quelen. While it proved to be effective, caution is advised as it did not prevent changes in plasma glucose and lactate levels.
AQUACULTURE RESEARCH
(2021)
Article
Pharmacology & Pharmacy
E. Belen, I. P. Canbolat, G. Yigitturk, O. Cetinarslan, C. S. Akdeniz, M. Karaca, M. Sonmez, O. Erbas
Summary: Dapagliflozin can prevent doxorubicin-induced cardiac damage and may be promising in preventing cardiac damage in cancer treatment.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hye Min Jang, Jong Youl Lee, Hyeong Seok An, Yu Jeong Ahn, Eun Ae Jeong, Hyun Joo Shin, Kyung Eun Kim, Jaewoong Lee, Jin Sin Koh, Gu Seob Roh
Summary: The deletion of Lipocalin-2 (LCN2) increases autophagic flux in Doxorubicin-treated hearts, leading to partial restoration of cardiac function and amelioration of cardiomyocyte diameter. Results suggest that LCN2 may exacerbate Doxorubicin-induced cardiomyopathy by inhibiting autophagic flux.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Longxiao Hu, Longxin Qian, Aochuan Sun, Guida Cai, Yunxiao Gao, Yue Yuan, Xiaoxiao Chen, Yunyao Jiang, Jianxun Liu, Junguo Ren
Summary: Diabetic cardiomyopathy is a severe complication of diabetes, and research has shown that Traditional Chinese Medicine (TCM) can effectively reduce blood sugar levels and protect cardiovascular function. This study systematically reviewed the efficacy of TCM in animal models of DCM, and the results demonstrated significant improvements in various parameters, including body weight, heart weight to body weight ratio, blood lipid levels, and cardiac function.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Michael A. Bauer, Valentina K. Todorova, Annjanette Stone, Weleetka Carter, Matthew D. Plotkin, Ping-Ching Hsu, Jeanne Y. Wei, Joseph L. Su, Issam Makhoul
Summary: This study investigated the DNA methylation state of peripheral blood mononuclear cells (PBMCs) as a potential predictor of cardiotoxicity in breast cancer patients receiving doxorubicin (DOX)-based chemotherapy. Significant differences in DNA methylation patterns of PBMCs were associated with the risk of cardiotoxicity, suggesting a potential for personalized medicine to tailor treatment and reduce heart toxicity. Further studies are needed to confirm these preliminary findings and assess the utility of PBMC DNA methylation profiles in predicting DOX-induced cardiotoxicity.
Article
Medicine, Research & Experimental
Sheng Zhang, Xueping Wei, Haijin Zhang, Youping Wu, Junsong Jing, Rongrong Huang, Ting Zhou, Jingjin Hu, Yueguo Wu, Yuanyuan Li, Zhenqiang You
Summary: This study establishes a model of DOX-induced dilated cardiomyopathy and reveals the role of mTOR in DOX-induced cardiomyocyte apoptosis and autophagy. Rapamycin and metformin protect cardiomyocytes from DOX-induced damage by regulating the AMPK/mTOR axis, maintaining energy metabolism balance, reducing oxidative stress, and decreasing cardiomyocyte apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Melissa S. Cobb, Shixin Tao, Katherine Shortt, Magdy Girgis, Jeryl Hauptman, Jill Schriewer, Zaphrirah Chin, Edward Dorfman, Kyle Campbell, Daniel P. Heruth, Ralph V. Shohet, Buddhadeb Dawn, Eugene A. Konorev
Summary: Many anticancer therapies cause cardiovascular complications, especially doxorubicin which leads to cardiomyopathy. This study shows that endothelial cells accumulate more doxorubicin than other cardiac cell types and that the TGF-beta/Smad3 pathway plays a critical role in cardiac damage caused by doxorubicin.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Medical Laboratory Technology
Yan Xia, Jiayu Jin, Ao Chen, Danbo Lu, Xinyu Che, Jiaqi Ma, Su Li, Ming Yin, Zheng Yang, Hao Lu, Chenguang Li, Jinxiang Chen, Muyin Liu, Yuan Wu, Hui Gong, Yunzeng Zou, Zhangwei Chen, Juying Qian, Junbo Ge
Summary: This study investigates the role of aspartate-glutamate carrier1 (AGC1) and dynamin-related protein 1 (Drp1) in mitochondrial fission and its contribution to doxorubicin (DOX)-induced cardiomyopathy. The results suggest that AGC1 regulates cardiac function through Drp1-mediated mitochondrial fission in dilated cardiomyopathy (DCM), and targeting the AGC1-Drp1 axis could be a potential therapeutic strategy for DOX-induced cardiomyopathy.
TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Mateusz M. Tomczyk, Kyle G. Cheung, Bo Xiang, Nahid Tamanna, Ana L. Fonseca Teixeira, Prasoon Agarwal, Stephanie M. Kereliuk, Victor Spicer, Ligen Lin, Jason Treberg, Qiang Tong, Vernon W. Dolinsky
Summary: The study found that SIRT3 expression can attenuate doxorubicin-induced changes in cardiac structure and function by preventing the acetylation of mitochondrial proteins, suggesting SIRT3 as a potential therapeutic target for mitigating doxorubicin-induced dilated cardiomyopathy.
CIRCULATION-HEART FAILURE
(2022)
Letter
Psychiatry
Michael Weightman
AUSTRALASIAN PSYCHIATRY
(2022)
Article
Cardiac & Cardiovascular Systems
Adam J. Nelson, Neha J. Pagidipati, Michelle D. Kelsey, Maddalena Ardissino, Vanita R. Aroda, Matthew A. Cavender, Renato D. Lopes, Hussein R. Al-Khalidi, Rogelio Braceras, Tanya Gaynor, Lisa A. Kaltenbach, Julienne K. Kirk, Ildiko Lingvay, Melissa L. Magwire, Emily C. O'Brien, Jonathan Pak, Rodica Pop-Busui, Caroline R. Richardson, Monica Levya, Cagri Senyucel, Laura Webb, Darren K. McGuire, Jennifer B. Green, Christopher B. Granger
Summary: There is a lack of utilization of proven medications for reducing cardiovascular events in individuals with type 2 diabetes mellitus and atherosclerotic cardiovascular disease. The COORDINATE-Diabetes trial aims to identify strategies to improve the implementation and adoption of evidence-based therapies. The trial involves a multifaceted intervention in cardiology clinics, focusing on evidence-based care for patients with type 2 diabetes.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Adam J. Nelson, Taku Inohara, Sunil Rao, Lisa A. Kaltenbach, Daniel Wojdyla, Tracy Y. Wang
Summary: This study analyzed the agreement between the original 2012 Appropriate Use Criteria (AUC) and the updated 2017 AUC for percutaneous coronary intervention (PCI) in the United States. The results showed only fair agreement between the two versions, indicating the challenges in implementing the updated AUC guidance. The findings suggest the need for further improvement in documenting and following contemporary AUC recommendations.
AMERICAN HEART JOURNAL
(2023)
Letter
Psychiatry
Michael Weightman, Tuan Anh Bui, Oliver D'Arcy Robertson
AUSTRALASIAN PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Christie M. Ballantyne, Marc Ditmarsch, John J. P. Kastelein, Adam J. Nelson, Douglas Kling, Andrew Hsieh, Danielle L. Curcio, Kevin C. Maki, Michael H. Davidson, Stephen J. Nicholls
Summary: This study evaluated the efficacy and safety of obicetrapib plus ezetimibe combination therapy as an adjunct to high-intensity statin therapy. The results showed that the combination therapy significantly lowered atherogenic lipid and lipoprotein parameters and was safe and well tolerated.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Luke P. Dawson, Emily Nehme, Ziad Nehme, Esther Davis, Jason Bloom, Shelley Cox, Adam J. Nelson, Daniel Okyere, David Anderson, Michael Stephenson, Jeffrey Lefkovits, Andrew J. Taylor, Stephen J. Nicholls, Louise Cullen, David Kaye, Karen Smith, Dion Stub
Summary: This study aimed to assess sex differences in the epidemiology and care pathways of chest pain management. The study found significant discrepancies in care for women throughout the entire patient journey, and women had higher mortality for ST-segment elevation myocardial infarction but better outcomes for other etiologies of chest pain.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Adam J. Nelson, Rebecca Young, Imran H. Tarrar, Daniel Wojdyla, Tracy Y. Wang, Rajendra H. Mehta
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Psychiatry
Andrew Amos, Michael James Weightman, Edward Miller
Summary: This study analyzed the decision to remove the Objective Structured Clinical Examination (OSCE) from the Royal Australian and New Zealand College of Psychiatrists' (RANZCP) training program and compared the impact of the Alternative Assessment Pathway (AAP) and OSCE on the progression of pre-competent trainees to fellowship. The results showed that the less reliable and accurate AAP increased the number of trainees progressing to fellowship, highlighting the need for robust public analyses of alternative assessment methods.
AUSTRALASIAN PSYCHIATRY
(2023)
Article
Psychiatry
Edward Miller, Michael James Weightman, Ashna Basu, Andrew Amos
Summary: This paper describes the importance of scientifically rigorous journal clubs in psychiatric education and provides a framework for effectively running journal clubs and appraising articles. It discusses the concept of journal clubs and the issues with current academic science. Factors associated with the effectiveness of journal clubs are listed, as well as a structure for appraising articles relevant to psychiatric practice in a journal club format.
AUSTRALASIAN PSYCHIATRY
(2023)
Article
Psychiatry
Michael James Weightman, Andrew Amos, Edward Miller
Summary: Position Statement 48 focuses on the safety and wellbeing of psychiatrists and trainees, covering five key domains and providing suggestions. This statement provides a framework for trainees and their supporters to understand, anticipate, and successfully manage potential risks, safeguarding the wellbeing and safety of trainees.
AUSTRALASIAN PSYCHIATRY
(2023)
Article
Psychology, Experimental
Amy L. Jarvis, Hannah A. D. Keage, Stephanie Wong, Michael Weightman, Rachel G. Stephens
Summary: Theory of mind involves multiple dimensions, including affective and cognitive tasks, as well as first-order and second-order cognitive tasks. Previous evidence based on analysis of variance was insufficient to evaluate dimensionality, but state-trace analysis provided a more appropriate statistical technique. The current study reanalyzed previous datasets and applied state-trace analysis to a more detailed dataset, finding support for a multidimensional account of theory of mind across cognitive, affective, and second-order cognitive subdomains.
MEMORY & COGNITION
(2023)
Review
Gerontology
Amy L. Jarvis, Stephanie Wong, Michael Weightman, Erica S. Ghezzi, Rhianna L. S. Sharman, Hannah A. D. Keage
Summary: Emotional empathy may increase across adulthood, according to a meta-analysis of existing data. The study clarified mixed findings regarding the functioning of emotional empathy in later life and highlighted the potential influence of emotional empathy measures. Further research is recommended to include diverse samples and longitudinal designs.
PSYCHOLOGY AND AGING
(2023)
Meeting Abstract
Psychiatry
O. D. Robertson, T. A. Bui, M. Weightman
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Meeting Abstract
Psychiatry
M. Weightman, T. A. Bui, O. D. Robertson
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Review
Cardiac & Cardiovascular Systems
Nicholas J. Montarello, Mau T. Nguyen, Dennis T. L. Wong, Stephen J. Nicholls, Peter J. Psaltis
Summary: Inflammation plays a crucial role in the development and complications of atherosclerotic coronary artery disease. Despite current treatment, residual inflammation remains a concern, leading to recurrent cardiovascular events. Targeting inflammation through novel pathway-specific agents and repurposing established drugs has shown promise. This article discusses the importance of inflammation in mediating atherosclerosis and provides an update on new and old anti-inflammatory therapies.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
